DK152045C - 2- phenyl-3-aroylbenzothiophenforbindelser eller syreadditionssalte deraf til anvendelse som antifertilitetsmidler - Google Patents

2- phenyl-3-aroylbenzothiophenforbindelser eller syreadditionssalte deraf til anvendelse som antifertilitetsmidler

Info

Publication number
DK152045C
DK152045C DK484876A DK484876A DK152045C DK 152045 C DK152045 C DK 152045C DK 484876 A DK484876 A DK 484876A DK 484876 A DK484876 A DK 484876A DK 152045 C DK152045 C DK 152045C
Authority
DK
Denmark
Prior art keywords
phenyl
acid addition
addition salts
benzothiophene compounds
antifertility agents
Prior art date
Application number
DK484876A
Other languages
Danish (da)
English (en)
Other versions
DK484876A (da
DK152045B (da
Inventor
Charles David Jones
Tulio Suarez
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK484876A publication Critical patent/DK484876A/da
Priority to DK265885A priority Critical patent/DK265885A/da
Publication of DK152045B publication Critical patent/DK152045B/da
Application granted granted Critical
Publication of DK152045C publication Critical patent/DK152045C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK484876A 1975-10-28 1976-10-27 2- phenyl-3-aroylbenzothiophenforbindelser eller syreadditionssalte deraf til anvendelse som antifertilitetsmidler DK152045C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK265885A DK265885A (da) 1975-10-28 1985-06-13 Analogifremgangsmaade til fremstilling af 2-phenyl-3-aroylbenzothiophener

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62601075A 1975-10-28 1975-10-28
US62601075 1975-10-28

Publications (3)

Publication Number Publication Date
DK484876A DK484876A (da) 1977-04-29
DK152045B DK152045B (da) 1988-01-25
DK152045C true DK152045C (da) 1988-06-20

Family

ID=24508581

Family Applications (1)

Application Number Title Priority Date Filing Date
DK484876A DK152045C (da) 1975-10-28 1976-10-27 2- phenyl-3-aroylbenzothiophenforbindelser eller syreadditionssalte deraf til anvendelse som antifertilitetsmidler

Country Status (31)

Country Link
US (1) US4133814A (de)
JP (1) JPS5253851A (de)
AR (3) AR222959A1 (de)
AT (1) AT357520B (de)
AU (1) AU505360B2 (de)
BE (1) BE847719A (de)
BG (2) BG28065A4 (de)
CA (1) CA1090795A (de)
CH (3) CH635336A5 (de)
CS (2) CS205047B2 (de)
DD (1) DD127461A5 (de)
DE (1) DE2647907C2 (de)
DK (1) DK152045C (de)
ES (2) ES452694A1 (de)
FR (1) FR2329271A1 (de)
GB (1) GB1570610A (de)
GR (1) GR61776B (de)
HU (1) HU179012B (de)
IE (1) IE44392B1 (de)
IL (1) IL50773A (de)
MX (1) MX4584E (de)
NL (1) NL7611975A (de)
NZ (1) NZ182429A (de)
PH (1) PH14219A (de)
PL (2) PL114190B1 (de)
PT (1) PT65755B (de)
RO (1) RO70769A (de)
SE (1) SE426945B (de)
SU (2) SU701539A3 (de)
YU (1) YU262076A (de)
ZA (1) ZA766440B (de)

Families Citing this family (301)

* Cited by examiner, † Cited by third party
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US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5391557A (en) * 1993-10-15 1995-02-21 Eli Lilly And Company Methods for the treatment of peri-menopausal syndrome
US5482950A (en) * 1993-10-15 1996-01-09 Eli Lilly And Company Methods for lowering serum cholesterol
US5418252A (en) * 1993-10-15 1995-05-23 Eli Lilly And Company Method for inhibiting cartilage degradation
US5441964A (en) * 1993-10-15 1995-08-15 Eli Lilly And Company Methods for inhibiting bone loss using substituted benzothiophene
US5457116A (en) * 1993-10-15 1995-10-10 Eli Lilly And Company Methods of inhibiting uterine fibrosis
US5461065A (en) * 1993-10-15 1995-10-24 Eli Lilly And Company Methods for inhibiting endometriosis
US5457113A (en) * 1993-10-15 1995-10-10 Eli Lilly And Company Methods for inhibiting vascular smooth muscle cell proliferation and restinosis
CN1058390C (zh) * 1993-10-15 2000-11-15 伊莱利利公司 苯并噻吩类化合物的用途
KR950010891A (ko) * 1993-10-15 1995-05-15 피터 지. 스트링거 내성 종양을 치료하는 방법
US5480904A (en) * 1993-10-28 1996-01-02 Eli Lilly And Company Methods for inhibiting uterine fibrosis
US6489355B2 (en) * 1993-12-01 2002-12-03 Eli Lilly And Company Methods of inhibiting the effects of amyloidogenic proteins
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US5972383A (en) * 1994-03-02 1999-10-26 Eli Lilly And Company Solid orally administerable raloxifene hydrochloride pharmaceutical formulation
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US5811120A (en) * 1994-03-02 1998-09-22 Eli Lilly And Company Solid orally administerable raloxifene hydrochloride pharmaceutical formulation
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US5466810A (en) * 1994-06-10 1995-11-14 Eli Lilly And Company 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes
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DE2647907C2 (de) 1985-01-24
IE44392L (en) 1977-04-28
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US4133814A (en) 1979-01-09
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RO70769A (ro) 1982-10-26
IL50773A (en) 1980-03-31
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CH635336A5 (de) 1983-03-31
AR215930A1 (es) 1979-11-15
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FR2329271B1 (de) 1979-07-27
PH14219A (en) 1981-04-02
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SE426945B (sv) 1983-02-21
JPS61343B2 (de) 1986-01-08
AU1900576A (en) 1978-05-04
PT65755B (en) 1978-04-27
ATA800876A (de) 1979-12-15
BG27553A3 (en) 1979-11-12
MX4584E (es) 1982-06-25
IE44392B1 (en) 1981-11-18
ZA766440B (en) 1978-06-28
IL50773A0 (en) 1976-12-31
ES452695A1 (es) 1977-11-16
NZ182429A (en) 1978-11-13
PL107979B1 (pl) 1980-03-31
SU764610A3 (ru) 1980-09-15
PT65755A (en) 1976-11-01
HU179012B (en) 1982-08-28
CH634316A5 (de) 1983-01-31
CS205046B2 (en) 1981-04-30
DE2647907A1 (de) 1977-05-12
CS205047B2 (en) 1981-04-30
NL7611975A (nl) 1977-05-02
GB1570610A (en) 1980-07-02
DD127461A5 (de) 1977-09-28
JPS5253851A (en) 1977-04-30
PL193308A1 (pl) 1978-03-28
AR222959A1 (es) 1981-07-15
AR222796A1 (es) 1981-06-30
AT357520B (de) 1980-07-10
DK152045B (da) 1988-01-25
GR61776B (en) 1979-01-16
FR2329271A1 (fr) 1977-05-27

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