DK1495018T3 - Tricykliske trombinreceptorantagonister - Google Patents

Tricykliske trombinreceptorantagonister

Info

Publication number
DK1495018T3
DK1495018T3 DK03718393T DK03718393T DK1495018T3 DK 1495018 T3 DK1495018 T3 DK 1495018T3 DK 03718393 T DK03718393 T DK 03718393T DK 03718393 T DK03718393 T DK 03718393T DK 1495018 T3 DK1495018 T3 DK 1495018T3
Authority
DK
Denmark
Prior art keywords
receptor antagonists
thrombin receptor
tricyclic thrombin
tricyclic
antagonists
Prior art date
Application number
DK03718393T
Other languages
Danish (da)
English (en)
Inventor
Samuel Chackalamannil
Martin C Clasby
William J Greenlee
Yuguang Wang
Yan Xia
Enrico P Veltri
Mariappan Chelliah
Wenxue Wu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29250954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1495018(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK1495018T3 publication Critical patent/DK1495018T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK03718393T 2002-04-16 2003-04-14 Tricykliske trombinreceptorantagonister DK1495018T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37307202P 2002-04-16 2002-04-16
PCT/US2003/011510 WO2003089428A1 (en) 2002-04-16 2003-04-14 Tricyclic thrombin receptor antagonists

Publications (1)

Publication Number Publication Date
DK1495018T3 true DK1495018T3 (da) 2008-02-18

Family

ID=29250954

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03718393T DK1495018T3 (da) 2002-04-16 2003-04-14 Tricykliske trombinreceptorantagonister
DK09150995.0T DK2065384T3 (da) 2002-04-16 2003-04-14 Tricyklisk thrombinreceptor-antagonist

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK09150995.0T DK2065384T3 (da) 2002-04-16 2003-04-14 Tricyklisk thrombinreceptor-antagonist

Country Status (34)

Country Link
US (3) US7304078B2 (xx)
EP (5) EP1860106B1 (xx)
JP (2) JP4558331B2 (xx)
KR (1) KR101026929B1 (xx)
CN (1) CN1659162B (xx)
AR (1) AR039570A1 (xx)
AT (3) ATE494284T1 (xx)
AU (1) AU2003221932B2 (xx)
BR (1) BRPI0309309B8 (xx)
CA (1) CA2482858C (xx)
CY (3) CY1107184T1 (xx)
DE (3) DE60317493T3 (xx)
DK (2) DK1495018T3 (xx)
EC (1) ECSP045368A (xx)
ES (3) ES2357876T3 (xx)
FR (1) FR15C0047I2 (xx)
HK (3) HK1070887A1 (xx)
IL (1) IL164585A (xx)
LT (1) LTC1495018I2 (xx)
LU (1) LU92759I2 (xx)
MX (1) MXPA04010308A (xx)
MY (1) MY144040A (xx)
NL (1) NL300746I1 (xx)
NO (2) NO330500B1 (xx)
NZ (2) NZ535880A (xx)
PE (1) PE20040412A1 (xx)
PL (1) PL214718B1 (xx)
PT (2) PT1495018E (xx)
RU (2) RU2329264C9 (xx)
SG (1) SG164279A1 (xx)
SI (2) SI2065384T1 (xx)
TW (1) TWI343919B (xx)
WO (1) WO2003089428A1 (xx)
ZA (1) ZA200408342B (xx)

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US7488742B2 (en) * 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
US7235567B2 (en) * 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
US20040192753A1 (en) * 2000-06-15 2004-09-30 Samuel Chackalamannil Methods of use of thrombin receptor antagonists
ATE406366T1 (de) * 2004-05-28 2008-09-15 Schering Corp Gehinderte himbacinanaloga als thrombinrezeptorantagonisten
JP2008515908A (ja) * 2004-10-06 2008-05-15 ユニバーシティー オブ ロチェスター 組織因子経路を阻害する薬剤を使用する、肺高血圧症の治療
WO2006076565A2 (en) * 2005-01-14 2006-07-20 Schering Corporation Preparation of chiral propargylic alcohol and ester intermediates of himbacine analogs
US7541471B2 (en) * 2005-01-14 2009-06-02 Schering Corporation Synthesis of himbacine analogs
AR052870A1 (es) * 2005-01-14 2007-04-11 Schering Corp Sintesis de analogos de himbacina
US7605275B2 (en) 2005-01-14 2009-10-20 Schering Corporation Exo- and diastereo- selective syntheses of himbacine analogs
CA2594807A1 (en) * 2005-01-14 2006-07-20 Schering Corporation An exo-selective synthesis of himbacine analogs
EP1863778B1 (en) * 2005-03-31 2015-12-30 Merck Sharp & Dohme Corp. Spirocyclic thrombin receptor antagonists
US20070219154A1 (en) * 2005-12-20 2007-09-20 Suxing Liu Methods for preventing and/or treating a cell proliferative disorder
WO2007075964A2 (en) * 2005-12-22 2007-07-05 Schering Corporation Thrombin receptor antagonists as prophylaxis to complications from cardiopulmonary surgery
AR060354A1 (es) * 2006-04-06 2008-06-11 Schering Corp Terapias de combinacion antagonistas receptor trombina (tra)
US8003803B2 (en) * 2006-04-13 2011-08-23 Schering Corporation Fused ring thrombin receptor antagonists
AR061664A1 (es) * 2006-06-29 2008-09-10 Schering Corp Derivados de himbacina como antagonistas del receptor de trombina biciclicos y triciclicos sustituidos. composiciones farmaceuticas.
AR061727A1 (es) * 2006-06-30 2008-09-17 Schering Corp Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato
TWI367112B (en) 2006-06-30 2012-07-01 Schering Corp Immediate-release tablet formulations of a thrombin receptor antagonist
DE102006036023A1 (de) 2006-08-02 2008-02-07 Sanofi-Aventis Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität
TWI343262B (en) * 2006-09-26 2011-06-11 Schering Corp Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist
MX2009003758A (es) * 2006-10-04 2009-04-22 Schering Corp Antagonistas del receptor de trombina basados en la unidad triciclica modificada de himbacina.
WO2008042422A2 (en) 2006-10-04 2008-04-10 Schering Corporation Bicyclic and tricyclic derivatives as thrombin receptor antagonists
EP2120879A2 (en) * 2006-12-22 2009-11-25 Schering Corporation Disintegration promoters in solid dose wet granulation formulations
BRPI0809095A2 (pt) * 2007-03-23 2014-09-09 Schering Corp Redução de eventos adversos após intervenção percutânea através de uso de um antagonista de receptor de trombina
NZ587142A (en) 2008-02-05 2012-04-27 Sanofi Aventis Triazolium salts as par1 inhibitors, production thereof, and use as medicaments
CA2713550C (en) 2008-02-05 2016-06-14 Sanofi-Aventis Triazolopyridazines as par1 inhibitors, production thereof, and use as medicaments
WO2009124103A2 (en) * 2008-04-02 2009-10-08 Schering Corporation Combination therapies comprising par1 antagonists with par4 antagonists
CN102099340A (zh) 2008-05-19 2011-06-15 先灵公司 作为因子ixa抑制剂的杂环化合物
PT2438060E (pt) * 2009-06-04 2013-12-16 Merck Sharp & Dohme Metabolito ativo de um antagonista do recetor da trombina
US20120141586A1 (en) 2009-06-08 2012-06-07 Rubi Burlage Thrombin receptor antagonist and clopidogrel fixed dose tablet
EP2462123B1 (en) 2009-08-04 2013-10-02 Merck Sharp & Dohme Corp. 4,5,6-trisubstituted pyrimidine derivatives as factor ixa inhibitors
WO2011128421A1 (de) 2010-04-16 2011-10-20 Sanofi Trizyklische pyridyl-vinyl-pyrrole als par1-inhibitoren
PL2558462T3 (pl) 2010-04-16 2015-03-31 Sanofi Sa Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1
KR101303348B1 (ko) 2010-06-25 2013-09-03 한국화학연구원 트롬빈 수용체 길항제인 ［6＋5］접합 바이사이클, 그의 제조방법 및 그를 포함하는 약제학적 조성물
WO2013134012A1 (en) 2012-03-06 2013-09-12 Merck Sharp & Dohme Corp. Preparation and use of bicyclic himbacine derivatives as par-receptor antagonists
US9604971B2 (en) 2013-07-22 2017-03-28 Aralez Pharmaceuticals Trading Dac Co-crystal of the PAR-1 receptor antagonists vorapaxar and aspirin
US9808473B2 (en) 2013-08-22 2017-11-07 Merck Sharp & Dohme Corp. Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
US9701669B2 (en) 2013-08-22 2017-07-11 Merck Sharp & Dohme Corp. Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists
WO2015026685A1 (en) * 2013-08-22 2015-02-26 Merck Sharp & Dohme Corp. 7a-heterocycle substituted- 6, 6-difluoro bicyclic himbacine derivatives
FR3014693B1 (fr) 2013-12-16 2016-01-08 Pf Medicament Utilisation de la 3-(2-chloro-phenyl)-1-[4-(4-fluoro-benzyl)-piperazin-1-yl]-propenone pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales
US9969724B2 (en) 2014-04-16 2018-05-15 Merck Sharp & Dohme Corp. Factor IXa inhibitors
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
CN105985303B (zh) * 2015-02-13 2020-08-14 上海彩迩文生化科技有限公司 抗凝血剂的制备方法、中间体及其制备方法
CN106478608A (zh) * 2015-09-01 2017-03-08 博瑞生物医药（苏州）股份有限公司 沃拉帕沙的硫酸盐的结晶多晶型物
CN106749201A (zh) * 2015-11-25 2017-05-31 博瑞生物医药（苏州）股份有限公司 一种沃拉帕沙及其中间体的制备方法
WO2017134200A1 (en) * 2016-02-05 2017-08-10 Sanovel Ilac Sanayi Ve Ticaret A.S. A novel pharmaceutical composition of vorapaxar and metoprolol
TR201601548A2 (tr) * 2016-02-05 2018-03-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Vorapaksar ve metoprololün bi̇r farmasöti̇k kompozi̇syonu
WO2017181993A1 (zh) * 2016-04-22 2017-10-26 江苏天士力帝益药业有限公司 一种新的喜巴辛类似物及其在医药中的应用
CN106236779A (zh) * 2016-08-22 2016-12-21 孔五 一种脐带血富血小板血浆prp的制备方法
FR3090317B1 (fr) 2018-12-19 2021-05-07 Cvasthera Utilisation d’un antagoniste de par-1 pour le traitement d’une maladie inflammatoire chronique intestinale
CN110407819B (zh) * 2019-08-02 2020-06-26 牡丹江医学院 一种作为预防外科手术并发症的凝血酶受体拮抗剂
US20210113536A1 (en) * 2019-10-21 2021-04-22 United States Government as Represented by the Department of Veteran Affairs Methods and compositions for detecting and treating venous thromboembolism
FR3109089B1 (fr) 2020-04-08 2023-04-14 Cvasthera Composition pharmaceutique pour le traitement des maladies inflammatoires intestinales
WO2022018156A1 (en) 2020-07-22 2022-01-27 Janssen Pharmaceutica Nv Compounds useful as factor xia inhibitors
US11845748B2 (en) 2021-03-18 2023-12-19 Janssen Pharmaceutica Nv Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11814364B2 (en) 2021-03-18 2023-11-14 Janssen Pharmaceutica Nv Pyridine N-oxide derivatives useful as factor XIa inhibitors
US11919881B2 (en) 2021-03-18 2024-03-05 Janssen Pharmaceutica Nv Substituted pyridine N-oxide derivatives useful as a factor XIa inhibitors
EP4070658A1 (de) 2021-04-06 2022-10-12 BIORoxx GmbH Verwendung von blutgerinnungshemmenden verbindungen als rodentizide
US11897880B2 (en) 2021-04-30 2024-02-13 Janssen Pharmaceutica Nv 7,8-dihydrobenzo[e]pyrido[3,4-c]azocine-2,5(3H,6H)-dione derivatives useful as a factor XIa inhibitors
US11958856B2 (en) 2021-07-22 2024-04-16 Janssen Pharmaceutica Nv Substituted 1,2,3,8,9,9a-hexahydro-5H-pyrrolo[1,2-a]azepin-5-ones as factor XIa inhibitors
FR3134314A1 (fr) 2022-04-08 2023-10-13 Cvasthera Composition pharmaceutique à base de vorapaxar et son utilisation pour le traitement des maladies inflammatoires intestinales

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Also Published As

Publication number Publication date
BR0309309A (pt) 2005-02-15
ATE378330T1 (de) 2007-11-15
FR15C0047I2 (fr) 2016-05-06
LTC1495018I2 (lt) 2017-04-10
WO2003089428A1 (en) 2003-10-30
DE60317493D1 (en) 2011-01-13
MXPA04010308A (es) 2005-02-03
DE60317493T3 (de) 2018-07-12
AR039570A1 (es) 2005-02-23
SI1495018T1 (sl) 2008-04-30
HK1123302A1 (en) 2009-06-12
JP2005528406A (ja) 2005-09-22
DE60317493T2 (de) 2008-09-18
SG164279A1 (en) 2010-09-29
DK2065384T3 (da) 2011-05-02
ZA200408342B (en) 2006-05-31
MY144040A (en) 2011-07-29
TWI343919B (en) 2011-06-21
EP1495018B1 (en) 2007-11-14
CY1111363T1 (el) 2015-08-05
NL300746I2 (xx) 2016-01-21
NL300746I1 (xx) 2016-01-21
LU92759I2 (en) 2015-08-31
PL214718B1 (pl) 2013-09-30
HK1129893A1 (en) 2009-12-11
PL373332A1 (en) 2005-08-22
PE20040412A1 (es) 2004-07-12
CN1659162B (zh) 2011-08-31
NZ535880A (en) 2007-11-30
ATE455774T1 (de) 2010-02-15
EP1982984A2 (en) 2008-10-22
EP1860106B1 (en) 2010-01-20
RU2329264C2 (ru) 2008-07-20
ES2297150T3 (es) 2008-05-01
CA2482858A1 (en) 2003-10-30
NO2015016I2 (no) 2015-07-09
EP1495018A1 (en) 2005-01-12
RU2329264C9 (ru) 2009-04-20
BRPI0309309B8 (pt) 2021-05-25
EP2065384B1 (en) 2011-01-05
CN1659162A (zh) 2005-08-24
KR20040099441A (ko) 2004-11-26
ATE494284T1 (de) 2011-01-15
DE60335679D1 (de) 2011-02-17
CY2015029I2 (el) 2016-04-13
US20030216437A1 (en) 2003-11-20
HK1070887A1 (en) 2005-06-30
DE60331114D1 (de) 2010-03-11
JP2010132710A (ja) 2010-06-17
KR101026929B1 (ko) 2011-04-04
US7304078B2 (en) 2007-12-04
EP1860106A1 (en) 2007-11-28
PT1495018E (pt) 2008-02-19
ES2297150T7 (es) 2012-03-16
TW200404068A (en) 2004-03-16
IL164585A (en) 2010-11-30
US20070179187A1 (en) 2007-08-02
US20070270439A1 (en) 2007-11-22
EP2062890B1 (en) 2011-01-05
EP1982984B1 (en) 2013-02-13
ES2357876T3 (es) 2011-05-03
AU2003221932A1 (en) 2003-11-03
AU2003221932B2 (en) 2007-11-22
CY1107184T1 (el) 2012-10-24
US7713999B2 (en) 2010-05-11
CY2015029I1 (el) 2016-04-13
BRPI0309309B1 (pt) 2018-09-04
EP1495018B3 (en) 2011-03-16
PT2065384E (pt) 2011-03-16
NZ575139A (en) 2010-08-27
EP2062890A1 (en) 2009-05-27
NO2015016I1 (no) 2015-07-20
NO20044963L (no) 2004-11-15
EP2065384A1 (en) 2009-06-03
SI2065384T1 (sl) 2011-05-31
ES2338171T3 (es) 2010-05-04
ECSP045368A (es) 2005-01-03
EP1982984A3 (en) 2008-10-29
JP4558331B2 (ja) 2010-10-06
RU2004133375A (ru) 2005-07-10
NO330500B1 (no) 2011-05-02
FR15C0047I1 (xx) 2015-08-28
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IL164585A0 (en) 2005-12-18
CA2482858C (en) 2010-11-30

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