PL2558462T3 - Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1 - Google Patents

Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1

Info

Publication number
PL2558462T3
PL2558462T3 PL11714317T PL11714317T PL2558462T3 PL 2558462 T3 PL2558462 T3 PL 2558462T3 PL 11714317 T PL11714317 T PL 11714317T PL 11714317 T PL11714317 T PL 11714317T PL 2558462 T3 PL2558462 T3 PL 2558462T3
Authority
PL
Poland
Prior art keywords
chinolines
pyrazolo
pyridyl
vinyl
par1 inhibitors
Prior art date
Application number
PL11714317T
Other languages
English (en)
Inventor
Karl Schoenafinger
Henning Steinhagen
Bodo Scheiper
Uwe Heinelt
Volkmar Wehner
Matthias Herrmann
Jacques Mauger
Pavel Safar
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PL2558462T3 publication Critical patent/PL2558462T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL11714317T 2010-04-16 2011-04-14 Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1 PL2558462T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10305395 2010-04-16
PCT/EP2011/055964 WO2011128420A1 (de) 2010-04-16 2011-04-14 Pyridyl-vinyl-pyrazolo-chinoline als par1-inhibitoren
EP11714317.2A EP2558462B1 (de) 2010-04-16 2011-04-14 Pyridyl-vinyl-pyrazolo-chinoline als par1-inhibitoren

Publications (1)

Publication Number Publication Date
PL2558462T3 true PL2558462T3 (pl) 2015-03-31

Family

ID=42246248

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11714317T PL2558462T3 (pl) 2010-04-16 2011-04-14 Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1

Country Status (5)

Country Link
US (1) US8791133B2 (pl)
EP (1) EP2558462B1 (pl)
ES (1) ES2527535T3 (pl)
PL (1) PL2558462T3 (pl)
WO (1) WO2011128420A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI906428B (zh) 2020-12-10 2025-12-01 南韓商Ｌｇ化學股份有限公司 酸（Ｂｏｒｏｎｉｃ Ａｃｉｄ）化合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ504218A (en) 1997-11-25 2002-04-26 Schering Corp Thrombin receptor antagonists
US6063847A (en) 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
US20040192753A1 (en) 2000-06-15 2004-09-30 Samuel Chackalamannil Methods of use of thrombin receptor antagonists
US7488742B2 (en) 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
US6645987B2 (en) 2000-06-15 2003-11-11 Schering Corporation Nor-seco himbacine derivatives useful as thrombin receptor antagonists
US7235567B2 (en) 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
DE60233043D1 (de) 2001-04-19 2009-09-03 Eisai R&D Man Co Ltd 2-iminoimidazolderivate
US6956046B2 (en) 2001-05-25 2005-10-18 Mochida Pharmaceutical Co., Ltd. 4-hydroxypiperidine derivatives having analgesic activity
DE60335679D1 (de) 2002-04-16 2011-02-17 Schering Corp Tricyclischer Thrombinrezeptorantagonist
ATE526358T1 (de) 2003-03-25 2011-10-15 Sekisui Plastics Expandierbare harzteilchen aus styrolmodifiziertem linearen polyethylen niederer dichte
MY143987A (en) 2004-05-28 2011-07-29 Schering Corp Constrained himbacine analogs as thrombin receptor antagonists
CN101072772A (zh) 2004-10-08 2007-11-14 先灵公司 凝血酶受体拮抗剂
AR052870A1 (es) 2005-01-14 2007-04-11 Schering Corp Sintesis de analogos de himbacina
JP2008534604A (ja) 2005-03-31 2008-08-28 シェーリング コーポレイション スピロ環式トロンビンレセプターアンタゴニスト
AR058400A1 (es) 2005-12-22 2008-01-30 Schering Corp Derivados de oxazoloisoquinolina como antagonistas del receptor de trombina
CN101460463A (zh) 2006-03-29 2009-06-17 先灵公司 可作为凝血酶受体拮抗剂的单环和双环喜巴辛衍生物
CA2667082A1 (en) 2006-10-04 2008-04-10 Schering Corporation Bicyclic and tricyclic derivatives as thrombin receptor antagonists
WO2009124103A2 (en) * 2008-04-02 2009-10-08 Schering Corporation Combination therapies comprising par1 antagonists with par4 antagonists

Also Published As

Publication number Publication date
EP2558462B1 (de) 2014-10-22
ES2527535T3 (es) 2015-01-26
US8791133B2 (en) 2014-07-29
WO2011128420A1 (de) 2011-10-20
EP2558462A1 (de) 2013-02-20
US20130040981A1 (en) 2013-02-14

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