DK1383734T3 - Forbindelser, der er anvendelige som mellemprodukter til 4-aminoquinolinderivater - Google Patents

Forbindelser, der er anvendelige som mellemprodukter til 4-aminoquinolinderivater

Info

Publication number
DK1383734T3
DK1383734T3 DK02722569T DK02722569T DK1383734T3 DK 1383734 T3 DK1383734 T3 DK 1383734T3 DK 02722569 T DK02722569 T DK 02722569T DK 02722569 T DK02722569 T DK 02722569T DK 1383734 T3 DK1383734 T3 DK 1383734T3
Authority
DK
Denmark
Prior art keywords
intermediates
compounds useful
aminoquinoline derivatives
aminoquinoline
derivatives
Prior art date
Application number
DK02722569T
Other languages
Danish (da)
English (en)
Inventor
David B Damon
Robert DUGGER
Robert William Scott
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of DK1383734T3 publication Critical patent/DK1383734T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK02722569T 2001-04-30 2002-04-08 Forbindelser, der er anvendelige som mellemprodukter til 4-aminoquinolinderivater DK1383734T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28752201P 2001-04-30 2001-04-30

Publications (1)

Publication Number Publication Date
DK1383734T3 true DK1383734T3 (da) 2006-05-15

Family

ID=23103272

Family Applications (2)

Application Number Title Priority Date Filing Date
DK02722567T DK1425270T3 (da) 2001-04-30 2002-04-08 Fremgangsmåder og intermediater til fremstilling af 4-aminoquinolin CETP inhibitorer
DK02722569T DK1383734T3 (da) 2001-04-30 2002-04-08 Forbindelser, der er anvendelige som mellemprodukter til 4-aminoquinolinderivater

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK02722567T DK1425270T3 (da) 2001-04-30 2002-04-08 Fremgangsmåder og intermediater til fremstilling af 4-aminoquinolin CETP inhibitorer

Country Status (25)

Country Link
US (3) US6689897B2 (pt)
EP (2) EP1425270B1 (pt)
JP (2) JP3924250B2 (pt)
KR (2) KR100591998B1 (pt)
CN (3) CN1297541C (pt)
AR (3) AR035963A1 (pt)
AT (2) ATE316957T1 (pt)
AU (1) AU2002253448B2 (pt)
BR (2) BR0209238A (pt)
CA (2) CA2445623A1 (pt)
CZ (2) CZ20032900A3 (pt)
DE (2) DE60210265T2 (pt)
DK (2) DK1425270T3 (pt)
ES (2) ES2256461T3 (pt)
HK (1) HK1062294A1 (pt)
HU (2) HU225777B1 (pt)
IL (2) IL157544A0 (pt)
MX (2) MXPA03009936A (pt)
PL (2) PL366700A1 (pt)
PT (1) PT1425270E (pt)
RU (2) RU2259355C2 (pt)
TW (1) TWI250974B (pt)
WO (2) WO2002088069A2 (pt)
YU (2) YU84303A (pt)
ZA (2) ZA200306599B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
US20040002615A1 (en) * 2002-06-28 2004-01-01 Allen David Robert Preparation of chiral amino-nitriles
JP2006021999A (ja) * 2002-07-12 2006-01-26 Kaneka Corp 光学活性β−アミノニトリル化合物およびその対掌体アミド化合物の製造方法
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
JP2006508077A (ja) * 2002-10-04 2006-03-09 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 炎症疾患を治療するためのｐｇｄ２レセプタアンタゴニスト
CA2508840A1 (en) 2002-12-20 2004-07-08 Pfizer Products Inc. Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor
JP4644658B2 (ja) * 2003-02-18 2011-03-02 高砂香料工業株式会社 光学活性テトラヒドロキノリン類の製造方法
EP1604975A4 (en) * 2003-03-17 2006-11-02 Kaneka Corp PROCESSES FOR PRODUCING (R) -3- 4- (TRIFLUOROMETHYL) -PHENYLAMINO-PENTANAMIDE DERIVATIVES
US7223859B2 (en) 2003-03-17 2007-05-29 Pfizer Inc. Method for producing (R)-3-[4-(trifluoromethyl) phenylamino]-pentanoic acid amide derivative
CA2554982A1 (en) 2003-09-26 2005-04-07 Japan Tobacco Inc. Method of inhibiting remnant lipoprotein production
MXPA06003927A (es) * 2003-10-08 2008-02-07 Lilly Co Eli Compuestos y metodos para tratar dislipidemia.
CA2543596A1 (en) * 2003-11-07 2005-05-26 Jj Pharma, Inc. Hdl-boosting combination therapy complexes
KR20070002085A (ko) * 2004-04-07 2007-01-04 밀레니엄 파머슈티컬스 인코퍼레이티드 염증 질병을 치료하기 위한 ｐｇｄ２ 수용체 길항제
JP2008504266A (ja) * 2004-06-24 2008-02-14 イーライ リリー アンド カンパニー 異脂肪血症を治療するための化合物及び方法
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
US7700774B2 (en) * 2004-12-20 2010-04-20 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds and their pharmaceutical compositions
CA2598133A1 (en) 2005-02-24 2006-08-31 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
CA2610205A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the production of (alkoxycarbonylamino)alkyl sulfonates
UY30244A1 (es) 2006-03-30 2007-11-30 Tanabe Seiyaku Co Un proceso para preparar derivados de tetrahidroquinolina
DE102006031149A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006032391A1 (de) * 2006-07-04 2008-01-17 Merck Patent Gmbh Fluortenside
DE102006031151A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031143A1 (de) * 2006-07-04 2008-01-24 Merck Patent Gmbh Fluortenside
DE102006031262A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
EP2134169A2 (en) 2007-03-09 2009-12-23 Indigene Pharmaceuticals Inc. Combination of metformin r-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
JP2011256110A (ja) * 2008-09-30 2011-12-22 Takeda Chem Ind Ltd ヘキサヒドロピロロキノリンの製造法
AR077208A1 (es) * 2009-06-30 2011-08-10 Lilly Co Eli Derivados del acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil] (2-metil-2h-tetrazol-5-il) amino) -2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il) metil)-ciclohexancarboxilico y sus formas cristalinas, composiciones farmaceuticas que los comprenden, su uso para preparar un medicam
HUE032075T2 (en) 2011-04-12 2017-08-28 Chong Kun Dang Pharmaceutical Corp 3- (2-Arylcycloalkenylmethyl) -oxazolidin-2-one derivatives as cholesterol ester transfer protein (CETP) inhibitors
AU2012282109B2 (en) 2011-07-08 2016-06-23 Novartis Ag Method of treating atherosclerosis in high triglyceride subjects
PT2943474T (pt) 2013-01-31 2017-08-08 Chong Kun Dang Pharmaceutical Corp Compostos biarilo ou biarilo heterocíclico como inibidores de cetp
KR20160072265A (ko) * 2013-11-11 2016-06-22 론자 아게 (론자 엘티디.) 루이스 산을 갖는 13 족의 시아노 화합물의 제조 방법
MX367908B (es) * 2014-08-12 2019-09-11 Dezima Pharma B V Proceso para preparar intermediarios sinteticos para preparar derivados de tetrahidroquinolina.
CN105294559B (zh) * 2015-06-24 2017-11-14 厦门法茉维特动物药业有限公司 一种医药中间体4‑氨基喹啉类化合物的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5035813B2 (ja) 1998-07-10 2012-09-26 マサチューセッツ インスティテュート オブ テクノロジー 金属用のリガンドおよびそれらに基づいて改善された金属触媒法
GT199900147A (es) 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines

Also Published As

Publication number Publication date
RU2003131870A (ru) 2005-01-27
AR035963A1 (es) 2004-07-28
CA2445623A1 (en) 2002-11-07
PT1425270E (pt) 2006-07-31
DE60209004D1 (de) 2006-04-13
JP2004531541A (ja) 2004-10-14
HU225777B1 (en) 2007-08-28
HUP0304039A2 (hu) 2004-03-29
WO2002088069A9 (en) 2003-12-04
KR100591998B1 (ko) 2006-06-22
JP3924250B2 (ja) 2007-06-06
IL157546A0 (en) 2004-03-28
US6689897B2 (en) 2004-02-10
US20030216576A1 (en) 2003-11-20
CA2445693A1 (en) 2002-11-07
KR20040015200A (ko) 2004-02-18
ATE316957T1 (de) 2006-02-15
CN1267411C (zh) 2006-08-02
HUP0304041A2 (hu) 2004-04-28
RU2259355C2 (ru) 2005-08-27
PL366700A1 (en) 2005-02-07
CN1297541C (zh) 2007-01-31
US6706881B2 (en) 2004-03-16
CZ20032898A3 (cs) 2004-07-14
AU2002253448B2 (en) 2007-07-05
US20030073843A1 (en) 2003-04-17
EP1383734B1 (en) 2006-02-01
US6600045B2 (en) 2003-07-29
EP1425270B1 (en) 2006-03-29
EP1383734A2 (en) 2004-01-28
CN1529696A (zh) 2004-09-15
TWI250974B (en) 2006-03-11
BR0209291A (pt) 2004-07-13
YU84403A (sh) 2006-08-17
ZA200306600B (en) 2004-08-25
AR044706A2 (es) 2005-09-21
WO2002088069A3 (en) 2003-02-20
RU2265010C2 (ru) 2005-11-27
IL157544A0 (en) 2004-03-28
YU84303A (sh) 2006-05-25
MXPA03009935A (es) 2004-01-29
CN100357265C (zh) 2007-12-26
CZ20032900A3 (cs) 2004-06-16
DE60209004T2 (de) 2006-09-28
WO2002088069A2 (en) 2002-11-07
HK1062294A1 (en) 2004-10-29
DE60210265T2 (de) 2006-10-12
EP1425270A2 (en) 2004-06-09
KR20040030603A (ko) 2004-04-09
MXPA03009936A (es) 2004-01-29
KR100639745B1 (ko) 2006-10-30
JP3924251B2 (ja) 2007-06-06
US20020177716A1 (en) 2002-11-28
AR036331A1 (es) 2004-09-01
BR0209238A (pt) 2004-06-15
WO2002088085A2 (en) 2002-11-07
DE60210265D1 (de) 2006-05-18
ES2259080T3 (es) 2006-09-16
CN1680292A (zh) 2005-10-12
ATE321755T1 (de) 2006-04-15
HUP0304041A3 (en) 2005-08-29
JP2004527556A (ja) 2004-09-09
ES2256461T3 (es) 2006-07-16
PL366584A1 (en) 2005-02-07
DK1425270T3 (da) 2006-07-03
HUP0304039A3 (en) 2005-10-28
ZA200306599B (en) 2004-10-22
RU2003131871A (ru) 2005-04-10
CN1505609A (zh) 2004-06-16
WO2002088085A3 (en) 2004-03-25

Similar Documents

Publication Publication Date Title
DK1383734T3 (da) Forbindelser, der er anvendelige som mellemprodukter til 4-aminoquinolinderivater
NO20053340D0 (no) Substituerte dihydropyrano-indol-3,4-dion-derivater som inhibitorer for plasmigogenaktivator-1 (CPAI-1).
DK1491540T3 (da) Intermediater, der er anvendelige til syntese af pyridazinon-aldosereduktase inhibitorer
DK2301544T3 (da) Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer
LTPA2016037I1 (lt) Nauji heterocikliniai junginiai, veiksmingi kaip beta-laktamazės slopikliai
DK1386921T3 (da) Mellemprodukter til fremstilling af anti-trombotiske 4H-cycolopenta-1,3-dioxol-derivater
LTC1436271I2 (lt) Fenilpiperazino dariniai, kaip serotonino grįžtamos absorbcijos inhibitoriai
DK1551511T5 (da) Heterocykliske aromatiske forbindelser, der er anvendelige som væksthormonsekretagoger
DK1171443T3 (da) Bicykliske, heteroaromatiske forbindelser, der er nyttige som LH-agonister
NO20035193D0 (no) Nye pyrrolderivater som farmasöytiske midler
NO20033683D0 (no) 2,4-disubstituerte pyrimidin-5-karboksamidderivater som KCNQ kaliumkanal modulatorer
DK1539742T3 (da) Indolderivater, der er nyttige som histamin H3-antagonister
NO20052884D0 (no) Substituerte indolpyridinforbindelser som anti-infeksjonsmidler.
DK1944305T3 (da) Quinolinderivater som phosphodiesteraseinhibitorer
WO2005087700A3 (en) Bisphenyl compounds useful as vitamin d3 receptor agonists
DE60225563D1 (de) 4-amino-6-phenyl-pyrroloä2,3-düpyrimidin derivate
DK1414440T3 (da) N-phenylpyrrolguanidinderivater som melanocortinreceptorligander
NO20041504L (no) Lactamderivater som antagonister for humane 11CBY reseptorer.
DK1638928T3 (da) N-alkynyl-2-(substituerede aryloxy)alkylthio-amidderivater som fungicider
DK1104420T3 (da) Substituerede 1,8-naphthyridin-4(1H)-oner som phosphodiesterase-4-inhibitorer
DK1501787T3 (da) N-biphenylmethylaminocycloalkancarboxamid-derivater med en substituerent på methyl, der er nyttige som bradykininantagonister
DK1756049T3 (da) Fremgangsmåde til fremstilling af 1,4-diphenylazetidinon-derivater
DK1840125T3 (da) Mellemprodukter til fremstilling af dioxan-2-alkylcarbamater
DK1651640T3 (da) Nicotinamid derivater, der er anvendelige som PDE4 inhibitorer
NO20060603L (no) Fremgangsmate for fremstillingen av fenyltetrazolderivater