DK1501787T3 - N-biphenylmethylaminocycloalkancarboxamid-derivater med en substituerent på methyl, der er nyttige som bradykininantagonister - Google Patents
N-biphenylmethylaminocycloalkancarboxamid-derivater med en substituerent på methyl, der er nyttige som bradykininantagonisterInfo
- Publication number
- DK1501787T3 DK1501787T3 DK03737624T DK03737624T DK1501787T3 DK 1501787 T3 DK1501787 T3 DK 1501787T3 DK 03737624 T DK03737624 T DK 03737624T DK 03737624 T DK03737624 T DK 03737624T DK 1501787 T3 DK1501787 T3 DK 1501787T3
- Authority
- DK
- Denmark
- Prior art keywords
- biphenylmethylaminocycloalkanecarboxamide
- derivatives
- methyl substituent
- bradykinin antagonists
- substituent useful
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35506202P | 2002-02-08 | 2002-02-08 | |
US41017202P | 2002-09-12 | 2002-09-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1501787T3 true DK1501787T3 (da) | 2006-03-20 |
Family
ID=27737481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03737624T DK1501787T3 (da) | 2002-02-08 | 2003-02-04 | N-biphenylmethylaminocycloalkancarboxamid-derivater med en substituerent på methyl, der er nyttige som bradykininantagonister |
Country Status (27)
Country | Link |
---|---|
US (2) | US6919343B2 (da) |
EP (1) | EP1501787B1 (da) |
JP (1) | JP4098249B2 (da) |
KR (1) | KR20040083440A (da) |
CN (1) | CN1328247C (da) |
AR (1) | AR038377A1 (da) |
AT (1) | ATE309202T1 (da) |
AU (1) | AU2003216169B2 (da) |
BR (1) | BR0307508A (da) |
CA (1) | CA2474373C (da) |
DE (1) | DE60302240T2 (da) |
DK (1) | DK1501787T3 (da) |
EA (1) | EA007297B1 (da) |
EC (1) | ECSP045217A (da) |
ES (1) | ES2250899T3 (da) |
HR (1) | HRP20040677A2 (da) |
IS (1) | IS7372A (da) |
JO (1) | JO2356B1 (da) |
MA (1) | MA27108A1 (da) |
MX (1) | MXPA04007660A (da) |
NO (1) | NO20043739L (da) |
NZ (1) | NZ534062A (da) |
PE (1) | PE20030986A1 (da) |
PL (1) | PL371664A1 (da) |
RS (1) | RS65404A (da) |
TW (1) | TWI259079B (da) |
WO (1) | WO2003066577A1 (da) |
Families Citing this family (30)
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US7507753B2 (en) * | 2001-12-28 | 2009-03-24 | Takeda Chemical Industries Ltd. | Biaryl compound and use thereof |
ES2256727T3 (es) * | 2002-02-08 | 2006-07-16 | MERCK & CO., INC. | Derivados de n-bifenilmetil aminocicloalcanocarboxamida. |
IL166426A0 (en) * | 2002-08-29 | 2006-01-15 | Merck & Co Inc | N-biarylmethyl aminocycloalkanecarboxamide derivatives |
AU2003299757A1 (en) * | 2002-12-19 | 2004-07-14 | Elan Pharmaceuticals Inc. | Substituted n-phenyl sulfonamide bradykinin antagonists |
CA2534188A1 (en) * | 2003-08-07 | 2005-02-24 | Merck & Co., Inc. | Sulfonyl substituted n-(biarylmethyl) aminocyclopropanecarboxamides |
KR20060115753A (ko) * | 2003-12-22 | 2006-11-09 | 머크 앤드 캄파니 인코포레이티드 | 브라디키닌 길항제 또는 역 효능제로서의 알파-하이드록시아미드 |
US20070189865A1 (en) * | 2004-03-02 | 2007-08-16 | Bock Mark G | Amino cyclopropane carboxamide derivatives as bradykinin antagonists |
US20050245543A1 (en) * | 2004-04-30 | 2005-11-03 | Pfizer Inc | Histamine-3 receptor antagonists |
CA2575706A1 (en) * | 2004-08-02 | 2006-02-23 | Bebaas, Inc. | Vitamin b12 compositions |
DE102004060542A1 (de) * | 2004-12-16 | 2006-07-06 | Sanofi-Aventis Deutschland Gmbh | Hydroxybiphenyl-Carbonsäuren und Derivate, Verfahren zu deren Herstellung und deren Verwendung |
ES2425567T3 (es) | 2004-12-24 | 2013-10-16 | Spinifex Pharmaceuticals Pty Ltd | Método de tratamiento o profilaxis |
US20130131007A1 (en) | 2005-09-07 | 2013-05-23 | Bebaas, Inc. | Vitamin b12 compositions |
US20070178141A1 (en) * | 2005-09-07 | 2007-08-02 | Bebaas, Inc. | Vitamin B12 compositions |
EP2952185A1 (en) | 2006-03-20 | 2015-12-09 | Spinifex Pharmaceuticals Pty Ltd | Method of treatment or prophylaxis of inflammatory pain |
US8945505B2 (en) | 2007-02-02 | 2015-02-03 | Panaphix, Inc. | Use of arsenic compounds for treatment of pain and inflammation |
ES2601856T3 (es) | 2007-06-08 | 2017-02-16 | Mannkind Corporation | Inhibidores de la IRE-1A |
ATE550321T1 (de) | 2007-08-29 | 2012-04-15 | Boehringer Ingelheim Int | Neue bradykinin b1-antagonisten |
WO2009132453A1 (en) * | 2008-04-28 | 2009-11-05 | Neuromed Pharmaceuticals Ltd. | Cyclylamine derivatives as calcium channel blockers |
WO2010097373A1 (de) * | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin b1 antagonisten |
UA105923C2 (uk) * | 2009-02-26 | 2014-07-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Сполуки як антагоністи брадикініну b1 |
WO2010097374A1 (de) * | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin-b1-antagonisten |
US10457810B2 (en) | 2009-08-24 | 2019-10-29 | Board Of Trustees Of Michigan State University | Densified biomass products containing pretreated biomass fibers |
AP3218A (en) | 2010-02-23 | 2015-04-30 | Boehringer Ingelheim Int | Compounds as bradykinin B1 antagonists |
CA2797193C (en) | 2010-04-19 | 2015-12-15 | Board Of Trustees Of Michigan State University | Digestible lignocellulosic biomass and extractives and methods for producing same |
US8937073B2 (en) | 2010-08-20 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists |
HUP1000598A2 (en) * | 2010-11-05 | 2012-09-28 | Richter Gedeon Nyrt | Indole derivatives |
US8912221B2 (en) * | 2010-12-27 | 2014-12-16 | Hoffmann-La Roche Inc. | Biaryl amide derivatives |
US8592426B2 (en) * | 2011-01-24 | 2013-11-26 | Hoffmann—La Roche Inc. | Aryl-benzocycloalkyl amide derivatives |
JP2021501785A (ja) * | 2017-11-02 | 2021-01-21 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤 |
TWI771621B (zh) | 2018-10-11 | 2022-07-21 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
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EP0655461B1 (en) | 1993-11-16 | 2000-06-07 | Novartis AG | Cyclic amino acid derivatives having ACE and NEP inhibiting activity |
AU7211696A (en) | 1995-09-27 | 1997-04-17 | Ciba-Geigy Ag | Treatment of chronic progressive renal failure |
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FR2743562B1 (fr) | 1996-01-11 | 1998-04-03 | Sanofi Sa | Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant |
IL138246A0 (en) | 1998-04-23 | 2001-10-31 | Novartis Ag | Certain thiol inhibitors of endothelin-converting enzyme |
JP3646062B2 (ja) | 1998-04-23 | 2005-05-11 | ノバルティス アクチエンゲゼルシャフト | エンドセリン変換酵素のヘテロアリール置換チオール型阻害剤 |
US20020052370A1 (en) | 2000-07-06 | 2002-05-02 | Barber Christopher Gordon | Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase |
DE10036121A1 (de) | 2000-07-25 | 2002-02-07 | Merck Patent Gmbh | N-Substituierte-1-amino-1,1-dialkyl-carbonsäurederivate |
ES2256727T3 (es) | 2002-02-08 | 2006-07-16 | MERCK & CO., INC. | Derivados de n-bifenilmetil aminocicloalcanocarboxamida. |
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2003
- 2003-01-30 AR ARP030100276A patent/AR038377A1/es not_active Application Discontinuation
- 2003-01-30 US US10/354,674 patent/US6919343B2/en not_active Expired - Lifetime
- 2003-01-30 TW TW092102107A patent/TWI259079B/zh not_active IP Right Cessation
- 2003-02-04 NZ NZ534062A patent/NZ534062A/en unknown
- 2003-02-04 MX MXPA04007660A patent/MXPA04007660A/es unknown
- 2003-02-04 EP EP03737624A patent/EP1501787B1/en not_active Expired - Lifetime
- 2003-02-04 JP JP2003565952A patent/JP4098249B2/ja not_active Expired - Fee Related
- 2003-02-04 BR BR0307508-7A patent/BR0307508A/pt not_active IP Right Cessation
- 2003-02-04 AU AU2003216169A patent/AU2003216169B2/en not_active Ceased
- 2003-02-04 AT AT03737624T patent/ATE309202T1/de not_active IP Right Cessation
- 2003-02-04 DK DK03737624T patent/DK1501787T3/da active
- 2003-02-04 RS YUP-654/04A patent/RS65404A/sr unknown
- 2003-02-04 ES ES03737624T patent/ES2250899T3/es not_active Expired - Lifetime
- 2003-02-04 EA EA200401054A patent/EA007297B1/ru not_active IP Right Cessation
- 2003-02-04 DE DE60302240T patent/DE60302240T2/de not_active Expired - Lifetime
- 2003-02-04 WO PCT/US2003/003338 patent/WO2003066577A1/en active IP Right Grant
- 2003-02-04 PL PL03371664A patent/PL371664A1/xx unknown
- 2003-02-04 CA CA002474373A patent/CA2474373C/en not_active Expired - Fee Related
- 2003-02-04 CN CNB03803560XA patent/CN1328247C/zh not_active Expired - Fee Related
- 2003-02-04 KR KR10-2004-7012238A patent/KR20040083440A/ko not_active Application Discontinuation
- 2003-02-04 PE PE2003000132A patent/PE20030986A1/es not_active Application Discontinuation
- 2003-02-04 US US10/503,501 patent/US20050084463A1/en not_active Abandoned
- 2003-02-06 JO JO200315A patent/JO2356B1/en active
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2004
- 2004-07-23 HR HR20040677A patent/HRP20040677A2/hr not_active Application Discontinuation
- 2004-07-26 IS IS7372A patent/IS7372A/is unknown
- 2004-08-02 EC EC2004005217A patent/ECSP045217A/es unknown
- 2004-08-10 MA MA27820A patent/MA27108A1/fr unknown
- 2004-09-07 NO NO20043739A patent/NO20043739L/no not_active Application Discontinuation
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