PE20030986A1 - Derivados de n-bifenil-aminocicloalcancarboxamida (con sustitucion con metilo) - Google Patents
Derivados de n-bifenil-aminocicloalcancarboxamida (con sustitucion con metilo)Info
- Publication number
- PE20030986A1 PE20030986A1 PE2003000132A PE2003000132A PE20030986A1 PE 20030986 A1 PE20030986 A1 PE 20030986A1 PE 2003000132 A PE2003000132 A PE 2003000132A PE 2003000132 A PE2003000132 A PE 2003000132A PE 20030986 A1 PE20030986 A1 PE 20030986A1
- Authority
- PE
- Peru
- Prior art keywords
- amino
- alkyl
- biphenyl
- methyl
- fluor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A DERIVADOS DE N-BIFENIL-AMINOCICLOALCANCARBOXAMIDA (CON SUSTITUCION CON METILO) DE FORMULA I DONDE R1 Y R2 SON H, ALQUILO C1-C4; R3a ES H, ALQUILO C1-C4; R3b ES ALQUILO C1-C4 CON 1-5 ATOMOS DE HALOGENO; R4a Y R4b SON H, HALOGENO Y ALQUILO C1-C4; R5 ES ALQUILO C1-C6, CICLOALQUILO C3-C8, ALQUINILO C3-C6, ALQUENILO C2-C6, ENTRE OTROS; R6b Y R6c SON H, R6a CON LA CONDICION DE QUE NO MAS DE UNO DE R6a, R6b Y R6c SEA UN HETEROCICLO; R7a Y R7b SON H, HALOGENO, CIANO, NITRO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS METIL -3-FLUOR-4´{(1R)-1-[({1-[(3,3,3-TRIFLUORPROPANOIL)AMINO]CICLOPROPIL}CARBONIL)AMINO]ETIL}-1,1'-BIFENIL-2-CARBOXILATO, -3-FLUOR-N-METOXI-4´{(1R)-1-[({1-[(3,3,3-TRIFLUORPROPANOIL)AMINO]CICLOPROPIL}CARBONIL)AMINO]ETIL}-1,1'-BIFENIL-2-CARBOXAMIDA, METIL 3-FLUOR-4´{1-METIL-1-[({1-[(TRIFLUOROACETIL)AMINO]CICLOPROPIL}CARBONIL)AMINO]ETIL}-1,1'-BIFENIL-2-CARBOXILATO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA UTIL EN EL TRATAMIENTO DEL DOLOR, OSTEOARTRITIS, ENFERMEDAD OBSTRUCTIVA CRONICA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35506202P | 2002-02-08 | 2002-02-08 | |
US41017202P | 2002-09-12 | 2002-09-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030986A1 true PE20030986A1 (es) | 2003-11-19 |
Family
ID=27737481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000132A PE20030986A1 (es) | 2002-02-08 | 2003-02-04 | Derivados de n-bifenil-aminocicloalcancarboxamida (con sustitucion con metilo) |
Country Status (27)
Country | Link |
---|---|
US (2) | US6919343B2 (es) |
EP (1) | EP1501787B1 (es) |
JP (1) | JP4098249B2 (es) |
KR (1) | KR20040083440A (es) |
CN (1) | CN1328247C (es) |
AR (1) | AR038377A1 (es) |
AT (1) | ATE309202T1 (es) |
AU (1) | AU2003216169B2 (es) |
BR (1) | BR0307508A (es) |
CA (1) | CA2474373C (es) |
DE (1) | DE60302240T2 (es) |
DK (1) | DK1501787T3 (es) |
EA (1) | EA007297B1 (es) |
EC (1) | ECSP045217A (es) |
ES (1) | ES2250899T3 (es) |
HR (1) | HRP20040677A2 (es) |
IS (1) | IS7372A (es) |
JO (1) | JO2356B1 (es) |
MA (1) | MA27108A1 (es) |
MX (1) | MXPA04007660A (es) |
NO (1) | NO20043739L (es) |
NZ (1) | NZ534062A (es) |
PE (1) | PE20030986A1 (es) |
PL (1) | PL371664A1 (es) |
RS (1) | RS65404A (es) |
TW (1) | TWI259079B (es) |
WO (1) | WO2003066577A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1466904A4 (en) * | 2001-12-28 | 2005-12-14 | Takeda Pharmaceutical | BIARYL CONNECTION AND ITS USE |
WO2003065789A2 (en) * | 2002-02-08 | 2003-08-14 | Merck & Co., Inc. | N-biphenylmethyl aminocycloalkanecarboxamide derivatives |
CN1678320A (zh) * | 2002-08-29 | 2005-10-05 | 麦克公司 | N-联芳基甲基氨基环烷酰胺衍生物 |
AU2003299757A1 (en) * | 2002-12-19 | 2004-07-14 | Elan Pharmaceuticals Inc. | Substituted n-phenyl sulfonamide bradykinin antagonists |
AU2004265300A1 (en) * | 2003-08-07 | 2005-02-24 | Merck & Co., Inc. | Sulfonyl substituted N-(biarylmethyl) aminocyclopropanecarboxamides |
AU2004309357B2 (en) * | 2003-12-22 | 2010-10-07 | Merck Sharp & Dohme Corp. | Alpha-hydroxy amides as bradykinin antagonists or inverse agonists |
CA2557858A1 (en) * | 2004-03-02 | 2005-09-15 | Merck & Co., Inc. | Amino cyclopropane carboxamide derivatives as bradykinin antagonists |
US20050245543A1 (en) * | 2004-04-30 | 2005-11-03 | Pfizer Inc | Histamine-3 receptor antagonists |
EP1773354A4 (en) * | 2004-08-02 | 2010-05-05 | Bebaas Inc | COMPOSITIONS OF VITAMIN B12 |
DE102004060542A1 (de) * | 2004-12-16 | 2006-07-06 | Sanofi-Aventis Deutschland Gmbh | Hydroxybiphenyl-Carbonsäuren und Derivate, Verfahren zu deren Herstellung und deren Verwendung |
PL1830869T3 (pl) | 2004-12-24 | 2013-11-29 | Novartis Ag | Sposób leczenia lub profilaktyki |
US20070178141A1 (en) * | 2005-09-07 | 2007-08-02 | Bebaas, Inc. | Vitamin B12 compositions |
US20130131007A1 (en) | 2005-09-07 | 2013-05-23 | Bebaas, Inc. | Vitamin b12 compositions |
CN101443001B (zh) | 2006-03-20 | 2013-11-13 | 西芬克斯医药有限公司 | 治疗或预防炎性痛的方法 |
US8945505B2 (en) | 2007-02-02 | 2015-02-03 | Panaphix, Inc. | Use of arsenic compounds for treatment of pain and inflammation |
EP2155643B1 (en) | 2007-06-08 | 2016-08-10 | MannKind Corporation | Ire-1a inhibitors |
EP2188254B1 (de) * | 2007-08-29 | 2012-03-21 | Boehringer Ingelheim International GmbH | Neue bradykinin b1-antagonisten |
WO2009132453A1 (en) * | 2008-04-28 | 2009-11-05 | Neuromed Pharmaceuticals Ltd. | Cyclylamine derivatives as calcium channel blockers |
WO2010097374A1 (de) * | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin-b1-antagonisten |
RS52801B (en) * | 2009-02-26 | 2013-10-31 | Boehringer Ingelheim International Gmbh | UNITS AS BRADIKININ-B1 ANTAGONISTS |
WO2010097373A1 (de) * | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin b1 antagonisten |
US10457810B2 (en) | 2009-08-24 | 2019-10-29 | Board Of Trustees Of Michigan State University | Densified biomass products containing pretreated biomass fibers |
KR101843341B1 (ko) * | 2010-02-23 | 2018-03-30 | 베링거 인겔하임 인터내셔날 게엠베하 | 브라디키닌 b1 길항제로서의 화합물 |
CN102939388B (zh) | 2010-04-19 | 2016-08-03 | 密歇根州立大学董事会 | 可消化木质纤维素生物质和提取物及其制备方法 |
US8937073B2 (en) | 2010-08-20 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists |
HUP1000598A2 (en) * | 2010-11-05 | 2012-09-28 | Richter Gedeon Nyrt | Indole derivatives |
US8912221B2 (en) * | 2010-12-27 | 2014-12-16 | Hoffmann-La Roche Inc. | Biaryl amide derivatives |
US8592426B2 (en) * | 2011-01-24 | 2013-11-26 | Hoffmann—La Roche Inc. | Aryl-benzocycloalkyl amide derivatives |
MX2020004557A (es) | 2017-11-02 | 2020-10-05 | Calico Life Sciences Llc | Moduladores de la vía de estrés integrada. |
TWI771621B (zh) | 2018-10-11 | 2022-07-21 | 美商嘉來克生命科學有限責任公司 | 整合應激路徑之前藥調節劑 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
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US5270317A (en) | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
IL99372A0 (en) | 1990-09-10 | 1992-08-18 | Ciba Geigy Ag | Azacyclic compounds |
US5208236A (en) | 1992-09-23 | 1993-05-04 | Schering Corporation | N-(acylaminomethyl)glutaryl amino acids and use |
DE69424846T2 (de) | 1993-11-16 | 2000-11-16 | Novartis Ag | Zyklische Aminosäure-Derivate mit ACE und NEP inhibierender Aktivität |
AU7211696A (en) | 1995-09-27 | 1997-04-17 | Ciba-Geigy Ag | Treatment of chronic progressive renal failure |
US6433185B1 (en) | 1996-01-11 | 2002-08-13 | Sanofi-Synthelabo | N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them |
FR2743562B1 (fr) | 1996-01-11 | 1998-04-03 | Sanofi Sa | Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant |
IL138688A0 (en) | 1998-04-23 | 2001-10-31 | Novartis Ag | Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme |
RU2000129510A (ru) | 1998-04-23 | 2002-11-10 | Новартис АГ (CH) | Определенные тиольные ингибиторы эндотелинпревращающих ферментов |
US20020052370A1 (en) | 2000-07-06 | 2002-05-02 | Barber Christopher Gordon | Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase |
DE10036121A1 (de) | 2000-07-25 | 2002-02-07 | Merck Patent Gmbh | N-Substituierte-1-amino-1,1-dialkyl-carbonsäurederivate |
WO2003065789A2 (en) | 2002-02-08 | 2003-08-14 | Merck & Co., Inc. | N-biphenylmethyl aminocycloalkanecarboxamide derivatives |
-
2003
- 2003-01-30 TW TW092102107A patent/TWI259079B/zh not_active IP Right Cessation
- 2003-01-30 US US10/354,674 patent/US6919343B2/en not_active Expired - Lifetime
- 2003-01-30 AR ARP030100276A patent/AR038377A1/es not_active Application Discontinuation
- 2003-02-04 KR KR10-2004-7012238A patent/KR20040083440A/ko not_active Application Discontinuation
- 2003-02-04 EP EP03737624A patent/EP1501787B1/en not_active Expired - Lifetime
- 2003-02-04 WO PCT/US2003/003338 patent/WO2003066577A1/en active IP Right Grant
- 2003-02-04 NZ NZ534062A patent/NZ534062A/en unknown
- 2003-02-04 BR BR0307508-7A patent/BR0307508A/pt not_active IP Right Cessation
- 2003-02-04 DE DE60302240T patent/DE60302240T2/de not_active Expired - Lifetime
- 2003-02-04 PL PL03371664A patent/PL371664A1/xx unknown
- 2003-02-04 AU AU2003216169A patent/AU2003216169B2/en not_active Ceased
- 2003-02-04 CN CNB03803560XA patent/CN1328247C/zh not_active Expired - Fee Related
- 2003-02-04 CA CA002474373A patent/CA2474373C/en not_active Expired - Fee Related
- 2003-02-04 PE PE2003000132A patent/PE20030986A1/es not_active Application Discontinuation
- 2003-02-04 DK DK03737624T patent/DK1501787T3/da active
- 2003-02-04 JP JP2003565952A patent/JP4098249B2/ja not_active Expired - Fee Related
- 2003-02-04 US US10/503,501 patent/US20050084463A1/en not_active Abandoned
- 2003-02-04 EA EA200401054A patent/EA007297B1/ru not_active IP Right Cessation
- 2003-02-04 MX MXPA04007660A patent/MXPA04007660A/es unknown
- 2003-02-04 AT AT03737624T patent/ATE309202T1/de not_active IP Right Cessation
- 2003-02-04 RS YUP-654/04A patent/RS65404A/sr unknown
- 2003-02-04 ES ES03737624T patent/ES2250899T3/es not_active Expired - Lifetime
- 2003-02-06 JO JO200315A patent/JO2356B1/en active
-
2004
- 2004-07-23 HR HR20040677A patent/HRP20040677A2/hr not_active Application Discontinuation
- 2004-07-26 IS IS7372A patent/IS7372A/is unknown
- 2004-08-02 EC EC2004005217A patent/ECSP045217A/es unknown
- 2004-08-10 MA MA27820A patent/MA27108A1/fr unknown
- 2004-09-07 NO NO20043739A patent/NO20043739L/no not_active Application Discontinuation
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