EA200401054A1 - Производные n-бифенилметиламиноциклоалканкарбоксамида с заместителем на метиле, в качестве антагонистов брадикинина - Google Patents

Производные n-бифенилметиламиноциклоалканкарбоксамида с заместителем на метиле, в качестве антагонистов брадикинина

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Publication number
EA200401054A1
EA200401054A1 EA200401054A EA200401054A EA200401054A1 EA 200401054 A1 EA200401054 A1 EA 200401054A1 EA 200401054 A EA200401054 A EA 200401054A EA 200401054 A EA200401054 A EA 200401054A EA 200401054 A1 EA200401054 A1 EA 200401054A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antagonists
derivatives
methyl
biphenylmethylaminocyclo
alkankarboxamide
Prior art date
Application number
EA200401054A
Other languages
English (en)
Other versions
EA007297B1 (ru
Inventor
Майкл Р. Вуд
Невилл Дж. Энтони
Марк Дж. Бок
Донг-Мей Фенг
Скотт Д. Кудук
Дай-Си Су
Дженни Миу-чун Вэй
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA200401054A1 publication Critical patent/EA200401054A1/ru
Publication of EA007297B1 publication Critical patent/EA007297B1/ru

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract

Производные N-бифенил(замещенный метил)аминоциклоалканкарбоксамида являются антагонистами или обратными агонистами брадикинина B1, применимыми в лечении или предупреждении таких симптомов, как боль и воспаление, связанных с путем брадикинина B1.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401054A 2002-02-08 2003-02-04 Производные n-бифенилметиламиноциклоалканкарбоксамида с заместителем на метиле в качестве антагонистов брадикинина EA007297B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35506202P 2002-02-08 2002-02-08
US41017202P 2002-09-12 2002-09-12
PCT/US2003/003338 WO2003066577A1 (en) 2002-02-08 2003-02-04 N-biphenylmethyl aminocycloalkanecarboxamide derivatives with a substiituent on the methyl useful as bradykinin antagonists

Publications (2)

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EA200401054A1 true EA200401054A1 (ru) 2005-02-24
EA007297B1 EA007297B1 (ru) 2006-08-25

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US (2) US6919343B2 (ru)
EP (1) EP1501787B1 (ru)
JP (1) JP4098249B2 (ru)
KR (1) KR20040083440A (ru)
CN (1) CN1328247C (ru)
AR (1) AR038377A1 (ru)
AT (1) ATE309202T1 (ru)
AU (1) AU2003216169B2 (ru)
BR (1) BR0307508A (ru)
CA (1) CA2474373C (ru)
DE (1) DE60302240T2 (ru)
DK (1) DK1501787T3 (ru)
EA (1) EA007297B1 (ru)
EC (1) ECSP045217A (ru)
ES (1) ES2250899T3 (ru)
HR (1) HRP20040677A2 (ru)
IS (1) IS7372A (ru)
JO (1) JO2356B1 (ru)
MA (1) MA27108A1 (ru)
MX (1) MXPA04007660A (ru)
NO (1) NO20043739L (ru)
NZ (1) NZ534062A (ru)
PE (1) PE20030986A1 (ru)
PL (1) PL371664A1 (ru)
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ES2250899T3 (es) 2006-04-16
JP2005517006A (ja) 2005-06-09
WO2003066577A1 (en) 2003-08-14
EA007297B1 (ru) 2006-08-25
PE20030986A1 (es) 2003-11-19
PL371664A1 (en) 2005-06-27
CN1328247C (zh) 2007-07-25
CA2474373A1 (en) 2003-08-14
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US20050084463A1 (en) 2005-04-21
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US6919343B2 (en) 2005-07-19
DE60302240D1 (de) 2005-12-15
US20030220375A1 (en) 2003-11-27
KR20040083440A (ko) 2004-10-01
MA27108A1 (fr) 2004-12-20
NO20043739L (no) 2004-10-29
AR038377A1 (es) 2005-01-12
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