ECSP045217A - Derivados de n-bifenilmetil aminocicloalcancarboxamida con un sustituyente en el metilo, util como antagonistas de bradicinina - Google Patents

Derivados de n-bifenilmetil aminocicloalcancarboxamida con un sustituyente en el metilo, util como antagonistas de bradicinina

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Publication number
ECSP045217A
ECSP045217A EC2004005217A ECSP045217A ECSP045217A EC SP045217 A ECSP045217 A EC SP045217A EC 2004005217 A EC2004005217 A EC 2004005217A EC SP045217 A ECSP045217 A EC SP045217A EC SP045217 A ECSP045217 A EC SP045217A
Authority
EC
Ecuador
Prior art keywords
useful
methyl
derivatives
bradicinina
bifenilmetil
Prior art date
Application number
EC2004005217A
Other languages
English (en)
Inventor
Michael R Wood
Neville J Anthony
Mark G Bock
Dong-Mei Feng
Scott D Kuduk
Dai-Shi Su
Jenny Miu-Chun Wai
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ECSP045217A publication Critical patent/ECSP045217A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Cardiology (AREA)
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  • Communicable Diseases (AREA)
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  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Los derivados N-bifenilo (con sustitución con metilo) de la aminocicloalcancarboxamida son antagonistas o agonistas inversos de la bradicinina B1, útiles en el tratamiento o la prevención de síntomas, tales como dolor e inflamación, asociados con el pasaje de la bradicinina B1.
EC2004005217A 2002-02-08 2004-08-02 Derivados de n-bifenilmetil aminocicloalcancarboxamida con un sustituyente en el metilo, util como antagonistas de bradicinina ECSP045217A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35506202P 2002-02-08 2002-02-08
US41017202P 2002-09-12 2002-09-12

Publications (1)

Publication Number Publication Date
ECSP045217A true ECSP045217A (es) 2004-09-28

Family

ID=27737481

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005217A ECSP045217A (es) 2002-02-08 2004-08-02 Derivados de n-bifenilmetil aminocicloalcancarboxamida con un sustituyente en el metilo, util como antagonistas de bradicinina

Country Status (27)

Country Link
US (2) US6919343B2 (es)
EP (1) EP1501787B1 (es)
JP (1) JP4098249B2 (es)
KR (1) KR20040083440A (es)
CN (1) CN1328247C (es)
AR (1) AR038377A1 (es)
AT (1) ATE309202T1 (es)
AU (1) AU2003216169B2 (es)
BR (1) BR0307508A (es)
CA (1) CA2474373C (es)
DE (1) DE60302240T2 (es)
DK (1) DK1501787T3 (es)
EA (1) EA007297B1 (es)
EC (1) ECSP045217A (es)
ES (1) ES2250899T3 (es)
HR (1) HRP20040677A2 (es)
IS (1) IS7372A (es)
JO (1) JO2356B1 (es)
MA (1) MA27108A1 (es)
MX (1) MXPA04007660A (es)
NO (1) NO20043739L (es)
NZ (1) NZ534062A (es)
PE (1) PE20030986A1 (es)
PL (1) PL371664A1 (es)
RS (1) RS65404A (es)
TW (1) TWI259079B (es)
WO (1) WO2003066577A1 (es)

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PT2401256E (pt) * 2009-02-26 2013-05-13 Boehringer Ingelheim Int Compostos como antagonistas da bradicinina b1
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MA34008B1 (fr) * 2010-02-23 2013-02-01 Boehringer Ingelheim Int Composes en tant qu'antagonistes de la bradykinine b1
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TW202545902A (zh) 2018-10-11 2025-12-01 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑

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