ES2148305T3 - Derivados de aminoacidos ciclicos que tienen actividad inhibidora de ace y nep. - Google Patents
Derivados de aminoacidos ciclicos que tienen actividad inhibidora de ace y nep.Info
- Publication number
- ES2148305T3 ES2148305T3 ES94810642T ES94810642T ES2148305T3 ES 2148305 T3 ES2148305 T3 ES 2148305T3 ES 94810642 T ES94810642 T ES 94810642T ES 94810642 T ES94810642 T ES 94810642T ES 2148305 T3 ES2148305 T3 ES 2148305T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- aryl
- cycle
- represents hydrogen
- members
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001413 amino acids Chemical class 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 150000005347 biaryls Chemical class 0.000 abstract 3
- 150000001721 carbon Chemical class 0.000 abstract 3
- -1 CARBOXYL Chemical class 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002019 disulfides Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE DESCRIBEN LOS COMPUESTOS DE LA FORMULA I EN LA QUE R REPRESENTA HIDROGENO, ALQUILO INFERIOR, ALQUILO ARILO INFERIOR HETEROCICLICO O CARBOCICLICO O ALQUILO CICLOALQUILO INFERIOR; R1 REPRESENTA HIDROGENO, ALQUILO INFERIOR, CICLOALQUILO, ARILO CARBOCICLICO O ARILO HETEROCICLICO, O BIARILO; R3 REPRESENTA HIDROGENO O ACILOO; R4 REPRESENTA HIDROGENO, ALQUILO INFERIOR, ARILO HETEROCICLICO O CARBOCICLICO, ALQUILO ARILO INFERIOR CARBOCICLICO O HETEROCICLICO, CICLOALQUILO, ALQUILO CICLOALQUILO INFERIOR, BIARILO O ALQUILO BIARILO INFERIOR; R5 REPRESENTA HIDROGENO O ALQUILO INFERIOR; O R4 Y R5 JUNTO CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS REPRESENTAN CICLOALQUILIDENO O CICLOALQUILIDENO CONDENSADO CON BENCENTO; A JUNTO CON EL ATOMO DE CARBONO AL QUE ESTA UNIDO REPRESENTA UN RADICAL CICLOALQUILIDENO DE 3 A 10 MIEMBROS O CICLOALQUENILIDENO DE 5 A 10 MIEMBROS QUE PUEDE ESTAR SUSTITUIDO POR ALQUILO INFERIOR O ALQUILO ARILO INFERIOR O PUEDE ESTAR FUSIONADO A UN ANILLO DE 5-7 MIEMBROS CARBOCICLICO SATURADO O INSATURADO DE 5-7 MIEMBROS; O A JUNTO CON EL CARBONO AL QUE ESTA UNIDO REPRESENTA OXACICLOALQUILIDENO DE 5 O 6 MIEMBROS, TIACICLOALQUILIDENO O AZACICLOALQUILIDENO OPCIONALMENTE SUSTITUIDO POR ALQUILO INFERIOR O ALQUILO ARILO INFERIOR; O A JUNTO CON EL ATOMO DE CARBONO AL QUE ESTA UNIDO REPRESENTA 2,2NORBORNILIDENO; M ES 0,1,2 O 3; Y COOR2 REPRESENTA CARBOXILO O DERIVADO DE CARBOXILO EN FORMA DE UN ESTER FARMACEUTICAMENTE ACEPTABLE; DERIVADOS DE DISULFURO DERIVADOS DE LOS COMPUESTOS MENCIONADOS EN EL QUE R3 ES HIDROGENO; Y SALES CONSIGUIENTES FARMACEUTICAMENTE ACEPTABLES; COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN LOS MENCIONADOS COMPUESTOS; METODOS DE PREPARACION DE LOS MENCIONADOS COMPUESTOS; INTERMEDIARIOS; Y METODOS PARA TRATAR ENFERMEDADES EN MAMIFEROS QUE RESPONDAN A LA INHIBICION DE ACE Y NEP MEDIANTE LA ADMINISTRACION DE LOS MENCIONADOS COMPUESTOS EN MAMIFEROS QUE NECESITEN DICHO TRATAMIENTO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/153,395 US5432186A (en) | 1993-11-16 | 1993-11-16 | Cyclic amino acid derivatives |
| US08/263,859 US5506244A (en) | 1993-11-16 | 1994-06-22 | Cyclic amino acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2148305T3 true ES2148305T3 (es) | 2000-10-16 |
Family
ID=26850506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94810642T Expired - Lifetime ES2148305T3 (es) | 1993-11-16 | 1994-11-07 | Derivados de aminoacidos ciclicos que tienen actividad inhibidora de ace y nep. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5668158A (es) |
| EP (1) | EP0655461B1 (es) |
| JP (1) | JP3647914B2 (es) |
| CN (1) | CN1058019C (es) |
| AT (1) | ATE193706T1 (es) |
| AU (1) | AU687444B2 (es) |
| CA (1) | CA2135711A1 (es) |
| CY (1) | CY2234B1 (es) |
| DE (1) | DE69424846T2 (es) |
| DK (1) | DK0655461T3 (es) |
| ES (1) | ES2148305T3 (es) |
| FI (1) | FI118600B (es) |
| GR (1) | GR3033829T3 (es) |
| HU (1) | HU226300B1 (es) |
| IL (1) | IL111581A (es) |
| NO (1) | NO311224B1 (es) |
| NZ (1) | NZ264913A (es) |
| PH (1) | PH31056A (es) |
| PT (1) | PT655461E (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1273455B (it) * | 1995-01-27 | 1997-07-08 | Zambon Spa | Derivati tiolici ad attivita' inibitrice delle metallopeptidasi |
| JPH08325263A (ja) * | 1995-05-31 | 1996-12-10 | Sumitomo Metal Ind Ltd | 新規２−アミノ−３−フェニルプロピオン酸誘導体 |
| AU7211696A (en) * | 1995-09-27 | 1997-04-17 | Ciba-Geigy Ag | Treatment of chronic progressive renal failure |
| CA2251292A1 (en) * | 1996-04-12 | 1997-10-23 | Bristol-Myers Squibb Company | N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors |
| US6777550B1 (en) | 1996-04-12 | 2004-08-17 | Bristol-Myers Squibb Company | N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors |
| US6423727B1 (en) | 1998-04-23 | 2002-07-23 | Novartis Ag | Certain thiol inhibitors of endothelin-converting enzyme |
| BR9909805A (pt) * | 1998-04-23 | 2000-12-26 | Novartis Ag | Certos inibidores de tiol de enzima de conversão de endotelina |
| US6426354B1 (en) | 1998-04-23 | 2002-07-30 | Novartis Ag | Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme |
| HUP0200662A3 (en) * | 1999-03-29 | 2004-07-28 | Bristol Myers Squibb Company P | Use of composition containing vasopeptidase to treat angina pectoris |
| US6509330B2 (en) | 2000-02-17 | 2003-01-21 | Bristol-Myers Squibb Company | Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors |
| WO2003027091A1 (en) | 2001-09-21 | 2003-04-03 | Novartis Ag | Pyrane derivatives as both ace- and nep- inhibitors |
| CA2473778A1 (en) | 2002-02-08 | 2003-08-14 | Merck & Co., Inc. | N-biphenylmethyl aminocycloalkanecarboxamide derivatives |
| AR038377A1 (es) | 2002-02-08 | 2005-01-12 | Merck & Co Inc | Derivados de n-bifenil-aminocicloalcancarboxamida (con sustitucion con metilo) |
| US7045653B2 (en) | 2002-12-23 | 2006-05-16 | Pfizer, Inc. | Pharmaceuticals |
| WO2008084533A1 (ja) * | 2007-01-10 | 2008-07-17 | Kowa Co., Ltd. | メニエール病治療薬 |
| CN105670160A (zh) * | 2015-10-12 | 2016-06-15 | 陆思烨 | 一种防紫外抗老化电线电缆料及其制备方法 |
| UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093739A (en) * | 1977-06-15 | 1978-06-06 | Mead Johnson & Company | Mercaptoacylamidobenzoyl glycine and mucolytic process |
| GB8820844D0 (en) * | 1988-09-05 | 1988-10-05 | Pfizer Ltd | Therapeutic agents |
| GB9004260D0 (en) * | 1990-02-26 | 1990-04-18 | Pfizer Ltd | Therapeutic agents |
| FR2679564A1 (fr) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
| US5208236A (en) * | 1992-09-23 | 1993-05-04 | Schering Corporation | N-(acylaminomethyl)glutaryl amino acids and use |
-
1994
- 1994-11-07 EP EP94810642A patent/EP0655461B1/en not_active Expired - Lifetime
- 1994-11-07 DK DK94810642T patent/DK0655461T3/da active
- 1994-11-07 DE DE69424846T patent/DE69424846T2/de not_active Expired - Fee Related
- 1994-11-07 AT AT94810642T patent/ATE193706T1/de not_active IP Right Cessation
- 1994-11-07 PT PT94810642T patent/PT655461E/pt unknown
- 1994-11-07 ES ES94810642T patent/ES2148305T3/es not_active Expired - Lifetime
- 1994-11-09 AU AU77729/94A patent/AU687444B2/en not_active Ceased
- 1994-11-10 IL IL11158194A patent/IL111581A/xx not_active IP Right Cessation
- 1994-11-11 PH PH49353A patent/PH31056A/en unknown
- 1994-11-14 FI FI945354A patent/FI118600B/fi not_active IP Right Cessation
- 1994-11-14 NZ NZ264913A patent/NZ264913A/en not_active IP Right Cessation
- 1994-11-14 CA CA002135711A patent/CA2135711A1/en not_active Abandoned
- 1994-11-15 HU HU9403276A patent/HU226300B1/hu not_active IP Right Cessation
- 1994-11-15 JP JP28078594A patent/JP3647914B2/ja not_active Expired - Fee Related
- 1994-11-15 CN CN94118911A patent/CN1058019C/zh not_active Expired - Fee Related
- 1994-11-15 NO NO19944364A patent/NO311224B1/no unknown
-
1996
- 1996-02-14 US US08/601,626 patent/US5668158A/en not_active Expired - Fee Related
-
2000
- 2000-06-30 GR GR20000401530T patent/GR3033829T3/el not_active IP Right Cessation
-
2001
- 2001-09-07 CY CY0100025A patent/CY2234B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI945354A0 (fi) | 1994-11-14 |
| DE69424846D1 (de) | 2000-07-13 |
| US5668158A (en) | 1997-09-16 |
| DE69424846T2 (de) | 2000-11-16 |
| FI945354A7 (fi) | 1995-05-17 |
| ATE193706T1 (de) | 2000-06-15 |
| NO944364L (no) | 1995-05-18 |
| NZ264913A (en) | 1997-02-24 |
| IL111581A (en) | 1999-07-14 |
| PH31056A (en) | 1998-02-03 |
| HUT71423A (en) | 1995-11-28 |
| NO311224B1 (no) | 2001-10-29 |
| CN1107857A (zh) | 1995-09-06 |
| HU9403276D0 (en) | 1995-01-30 |
| HU226300B1 (en) | 2008-08-28 |
| FI118600B (fi) | 2008-01-15 |
| CA2135711A1 (en) | 1995-05-17 |
| IL111581A0 (en) | 1995-01-24 |
| AU7772994A (en) | 1995-05-25 |
| CN1058019C (zh) | 2000-11-01 |
| EP0655461B1 (en) | 2000-06-07 |
| DK0655461T3 (da) | 2000-10-02 |
| AU687444B2 (en) | 1998-02-26 |
| JP3647914B2 (ja) | 2005-05-18 |
| CY2234B1 (en) | 2003-04-18 |
| JPH07196685A (ja) | 1995-08-01 |
| PT655461E (pt) | 2000-11-30 |
| EP0655461A1 (en) | 1995-05-31 |
| GR3033829T3 (en) | 2000-10-31 |
| NO944364D0 (no) | 1994-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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