PE20060533A1 - Derivados de dicetopiperazina como antagonistas del receptor de oxitocina - Google Patents

Derivados de dicetopiperazina como antagonistas del receptor de oxitocina

Info

Publication number
PE20060533A1
PE20060533A1 PE2005000713A PE2005000713A PE20060533A1 PE 20060533 A1 PE20060533 A1 PE 20060533A1 PE 2005000713 A PE2005000713 A PE 2005000713A PE 2005000713 A PE2005000713 A PE 2005000713A PE 20060533 A1 PE20060533 A1 PE 20060533A1
Authority
PE
Peru
Prior art keywords
methyl
dicetopiperazine
indazol
methylpropyl
oxytocin receptor
Prior art date
Application number
PE2005000713A
Other languages
English (en)
Inventor
Alan David Borthwick
Steven Leslie Sollis
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20060533A1 publication Critical patent/PE20060533A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE DICETOPIPERAZINA DE FORMULA IA, DONDE R1 ES 2-INDANILO; R2 ES 1-METILPROPILO; R3 ES 1-METIL-INDAZOL-5-ILO; R4 ES METILO; R5 ES H O METILO. SON COMPUESTOS PREFERIDOS: (2R)-2-{(3R,6R)-3-(2,3-DIHIDRO-1H-INDEN-2-IL)-6-[(1S)-1-METILPROPIL]-2,5-DIOXO-1-PIPERAZINIL}-N-METIL-2-(1-METIL-1H-INDAZOL-5-IL)ETANAMIDA, (2R)-2-{(3R,6R)-3-(2,3-DIHIDRO-1H-INDEN-2-IL)-6-[(1S)-1-METILPROPIL]-2,5-DIOXO-1-PIPERAZINIL}-N,N-DIMETIL-2-(1-METIL-1H-INDAZOL-5-IL)ETANAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS SELECTIVOS DEL RECEPTOR DE OXITOCINA Y SON UTILES PARA PREVENIR O CONTROLAR EL PARTO PREMATURO
PE2005000713A 2004-06-23 2005-06-22 Derivados de dicetopiperazina como antagonistas del receptor de oxitocina PE20060533A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0414092.7A GB0414092D0 (en) 2004-06-23 2004-06-23 Novel compounds

Publications (1)

Publication Number Publication Date
PE20060533A1 true PE20060533A1 (es) 2006-09-03

Family

ID=32800052

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000713A PE20060533A1 (es) 2004-06-23 2005-06-22 Derivados de dicetopiperazina como antagonistas del receptor de oxitocina

Country Status (18)

Country Link
US (1) US20070208031A1 (es)
EP (1) EP1758893A1 (es)
JP (1) JP2008503535A (es)
CN (1) CN1989130A (es)
AR (1) AR049651A1 (es)
AU (1) AU2005256471A1 (es)
BR (1) BRPI0512359A (es)
CA (1) CA2571529A1 (es)
GB (1) GB0414092D0 (es)
IL (1) IL179912A0 (es)
MA (1) MA28698B1 (es)
MX (1) MXPA06014544A (es)
NO (1) NO20070157L (es)
PE (1) PE20060533A1 (es)
RU (1) RU2007102272A (es)
TW (1) TW200616635A (es)
WO (1) WO2006000400A1 (es)
ZA (1) ZA200610121B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641806B1 (fr) * 1989-01-16 1992-05-07 Diffusion Rech Tech Financ Procede de stabilisation d'une aire de terrain meuble
GB0130677D0 (en) 2001-12-21 2002-02-06 Glaxo Group Ltd Medicaments and novel compounds
GB0314738D0 (en) 2003-06-24 2003-07-30 Glaxo Group Ltd Novel compounds
GB0414100D0 (en) * 2004-06-23 2004-07-28 Glaxo Group Ltd Novel compounds
GB0414093D0 (en) * 2004-06-23 2004-07-28 Glaxo Group Ltd Novel compounds
JP2010535245A (ja) 2007-07-31 2010-11-18 バーンハム インスティテュート フォー メディカル リサーチ キナーゼ阻害剤としての二座化合物
US20100038143A1 (en) * 2008-08-14 2010-02-18 George Alexander Burnett Drill cuttings treatment systems
US8716286B2 (en) 2009-10-30 2014-05-06 Glaxo Group Limited Crystalline forms of (3R, 6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione
CN109305969B (zh) * 2017-07-27 2023-03-10 江苏恒瑞医药股份有限公司 哌嗪-2,5-二酮类衍生物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0130677D0 (en) * 2001-12-21 2002-02-06 Glaxo Group Ltd Medicaments and novel compounds
GB0414100D0 (en) * 2004-06-23 2004-07-28 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
MXPA06014544A (es) 2007-03-12
WO2006000400A1 (en) 2006-01-05
RU2007102272A (ru) 2008-07-27
BRPI0512359A (pt) 2008-03-04
NO20070157L (no) 2007-01-23
MA28698B1 (fr) 2007-06-01
US20070208031A1 (en) 2007-09-06
AR049651A1 (es) 2006-08-23
EP1758893A1 (en) 2007-03-07
CA2571529A1 (en) 2006-01-05
GB0414092D0 (en) 2004-07-28
AU2005256471A1 (en) 2006-01-05
JP2008503535A (ja) 2008-02-07
TW200616635A (en) 2006-06-01
CN1989130A (zh) 2007-06-27
ZA200610121B (en) 2008-08-27
IL179912A0 (en) 2007-05-15

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed