BRPI0512359A - dicetopiperazinas substituìdas como antagonistas da oxitocina - Google Patents

dicetopiperazinas substituìdas como antagonistas da oxitocina

Info

Publication number
BRPI0512359A
BRPI0512359A BRPI0512359-3A BRPI0512359A BRPI0512359A BR PI0512359 A BRPI0512359 A BR PI0512359A BR PI0512359 A BRPI0512359 A BR PI0512359A BR PI0512359 A BRPI0512359 A BR PI0512359A
Authority
BR
Brazil
Prior art keywords
oxytocin antagonists
methyl
antagonists
substituted diketopiperazines
oxytocin
Prior art date
Application number
BRPI0512359-3A
Other languages
English (en)
Inventor
Alan David Borthwick
Steven Leslie Sollis
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BRPI0512359A publication Critical patent/BRPI0512359A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DICETOPIPERAZINAS SUBSTITUìDAS COMO ANTAGONISTAS DA OXITOCINA. Compostos de fórmula (IA) onde R~ 1~ é 2-indanila, R~ 2~ é 1-metilpropila, R~ 3~ é 1-metil-indazol-5-ila, R~ 4~ representa metila e R~ 5~ representa hidrogênio ou metila, e seus derivados farmaceuticamente aceitáveis são descritas, como o são processos para a preparação deles, composições contendo eles e uso deles em medicina, particularmente uso deles como antagonistas da oxitocina.
BRPI0512359-3A 2004-06-23 2005-06-21 dicetopiperazinas substituìdas como antagonistas da oxitocina BRPI0512359A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0414092.7A GB0414092D0 (en) 2004-06-23 2004-06-23 Novel compounds
PCT/EP2005/006761 WO2006000400A1 (en) 2004-06-23 2005-06-21 Substituted diketopiperazines as oxytocin antagonists

Publications (1)

Publication Number Publication Date
BRPI0512359A true BRPI0512359A (pt) 2008-03-04

Family

ID=32800052

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512359-3A BRPI0512359A (pt) 2004-06-23 2005-06-21 dicetopiperazinas substituìdas como antagonistas da oxitocina

Country Status (18)

Country Link
US (1) US20070208031A1 (pt)
EP (1) EP1758893A1 (pt)
JP (1) JP2008503535A (pt)
CN (1) CN1989130A (pt)
AR (1) AR049651A1 (pt)
AU (1) AU2005256471A1 (pt)
BR (1) BRPI0512359A (pt)
CA (1) CA2571529A1 (pt)
GB (1) GB0414092D0 (pt)
IL (1) IL179912A0 (pt)
MA (1) MA28698B1 (pt)
MX (1) MXPA06014544A (pt)
NO (1) NO20070157L (pt)
PE (1) PE20060533A1 (pt)
RU (1) RU2007102272A (pt)
TW (1) TW200616635A (pt)
WO (1) WO2006000400A1 (pt)
ZA (1) ZA200610121B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641806B1 (fr) * 1989-01-16 1992-05-07 Diffusion Rech Tech Financ Procede de stabilisation d'une aire de terrain meuble
GB0130677D0 (en) 2001-12-21 2002-02-06 Glaxo Group Ltd Medicaments and novel compounds
GB0314738D0 (en) 2003-06-24 2003-07-30 Glaxo Group Ltd Novel compounds
GB0414100D0 (en) * 2004-06-23 2004-07-28 Glaxo Group Ltd Novel compounds
GB0414093D0 (en) * 2004-06-23 2004-07-28 Glaxo Group Ltd Novel compounds
JP2010535245A (ja) 2007-07-31 2010-11-18 バーンハム インスティテュート フォー メディカル リサーチ キナーゼ阻害剤としての二座化合物
US20100038143A1 (en) * 2008-08-14 2010-02-18 George Alexander Burnett Drill cuttings treatment systems
US8716286B2 (en) 2009-10-30 2014-05-06 Glaxo Group Limited Crystalline forms of (3R, 6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione
CN109305969B (zh) * 2017-07-27 2023-03-10 江苏恒瑞医药股份有限公司 哌嗪-2,5-二酮类衍生物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0130677D0 (en) * 2001-12-21 2002-02-06 Glaxo Group Ltd Medicaments and novel compounds
GB0414100D0 (en) * 2004-06-23 2004-07-28 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
MXPA06014544A (es) 2007-03-12
WO2006000400A1 (en) 2006-01-05
RU2007102272A (ru) 2008-07-27
NO20070157L (no) 2007-01-23
PE20060533A1 (es) 2006-09-03
MA28698B1 (fr) 2007-06-01
US20070208031A1 (en) 2007-09-06
AR049651A1 (es) 2006-08-23
EP1758893A1 (en) 2007-03-07
CA2571529A1 (en) 2006-01-05
GB0414092D0 (en) 2004-07-28
AU2005256471A1 (en) 2006-01-05
JP2008503535A (ja) 2008-02-07
TW200616635A (en) 2006-06-01
CN1989130A (zh) 2007-06-27
ZA200610121B (en) 2008-08-27
IL179912A0 (en) 2007-05-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.