DK1663206T3 - 1-(2,3-dimethyl-phenyl)-ethyl-1,3-dihydro-imizadol-2-thion som ikke-sedativ alpha 2A-agonist - Google Patents
1-(2,3-dimethyl-phenyl)-ethyl-1,3-dihydro-imizadol-2-thion som ikke-sedativ alpha 2A-agonistInfo
- Publication number
- DK1663206T3 DK1663206T3 DK04781753T DK04781753T DK1663206T3 DK 1663206 T3 DK1663206 T3 DK 1663206T3 DK 04781753 T DK04781753 T DK 04781753T DK 04781753 T DK04781753 T DK 04781753T DK 1663206 T3 DK1663206 T3 DK 1663206T3
- Authority
- DK
- Denmark
- Prior art keywords
- agonist
- imizadol
- thione
- sedative
- dihydro
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title abstract 3
- -1 2,3-Dimethyl-phenyl Chemical group 0.000 title 1
- 239000000932 sedative agent Substances 0.000 title 1
- 230000001624 sedative effect Effects 0.000 title 1
- 150000001408 amides Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50256203P | 2003-09-12 | 2003-09-12 | |
| US10/891,953 US7141597B2 (en) | 2003-09-12 | 2004-07-15 | Nonsedating α-2 agonists |
| PCT/US2004/027134 WO2005034946A1 (en) | 2003-09-12 | 2004-08-20 | Nonsedating α-2 agonist 1- (2, 3-dimethyl-phenyl) -ethyl-1, 3-dihydro-imizadole-2-thione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1663206T3 true DK1663206T3 (da) | 2007-07-30 |
Family
ID=34278841
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04781753T DK1663206T3 (da) | 2003-09-12 | 2004-08-20 | 1-(2,3-dimethyl-phenyl)-ethyl-1,3-dihydro-imizadol-2-thion som ikke-sedativ alpha 2A-agonist |
| DK07006921.6T DK1800679T3 (da) | 2003-09-12 | 2004-08-20 | Ikke-sederende A-2 agonist 1-(2,3-dimethyl-phenyl)-ethyl-1,3-dihydro-imidazol-2-thione |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07006921.6T DK1800679T3 (da) | 2003-09-12 | 2004-08-20 | Ikke-sederende A-2 agonist 1-(2,3-dimethyl-phenyl)-ethyl-1,3-dihydro-imidazol-2-thione |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US7141597B2 (da) |
| EP (2) | EP1800679B1 (da) |
| JP (1) | JP4698591B2 (da) |
| KR (1) | KR101145046B1 (da) |
| CN (1) | CN100417379C (da) |
| AT (2) | ATE487477T1 (da) |
| AU (1) | AU2004279332B2 (da) |
| BR (1) | BRPI0413719A (da) |
| CA (1) | CA2537832C (da) |
| CO (1) | CO5680444A2 (da) |
| CY (1) | CY1107608T1 (da) |
| DE (2) | DE602004005720T2 (da) |
| DK (2) | DK1663206T3 (da) |
| ES (1) | ES2285522T3 (da) |
| IL (1) | IL173530A (da) |
| MX (1) | MXPA06002668A (da) |
| NO (1) | NO20060667L (da) |
| NZ (1) | NZ545181A (da) |
| PL (2) | PL1663206T3 (da) |
| PT (1) | PT1663206E (da) |
| RU (1) | RU2345987C2 (da) |
| SI (1) | SI1663206T1 (da) |
| TW (1) | TWI337999B (da) |
| WO (1) | WO2005034946A1 (da) |
| ZA (1) | ZA200601002B (da) |
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| US5869079A (en) * | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
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| WO2002043785A2 (en) | 2000-11-29 | 2002-06-06 | Oculex Pharmaceuticals, Inc. | Intraocular implants for preventing transplant rejection in the eye |
| US7358269B2 (en) * | 2002-05-21 | 2008-04-15 | Allergan, Inc. | 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one |
| US7091232B2 (en) * | 2002-05-21 | 2006-08-15 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7323485B2 (en) * | 2002-05-21 | 2008-01-29 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US20050048099A1 (en) | 2003-01-09 | 2005-03-03 | Allergan, Inc. | Ocular implant made by a double extrusion process |
| US20050059664A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Novel methods for identifying improved, non-sedating alpha-2 agonists |
| US20060293359A1 (en) * | 2003-06-25 | 2006-12-28 | Allergan, Inc. | Methods and compositions for the treatment of diabetes |
| US7141597B2 (en) * | 2003-09-12 | 2006-11-28 | Allergan, Inc. | Nonsedating α-2 agonists |
| US7812049B2 (en) * | 2004-01-22 | 2010-10-12 | Vicept Therapeutics, Inc. | Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists |
| US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| BRPI0516950A (pt) | 2004-09-24 | 2008-09-30 | Allergan Inc | 4-(metila cìclica condensada)-imidazol-2-tionas atuando como agonistas adrenérgicos alfa2 |
| MX2007003068A (es) * | 2004-09-24 | 2007-05-21 | Allergan Inc | 4-(fenil-metil y fenil-metil substituido)-imidazol-2tionas como agonistas adrenergicos alfa2 especificos. |
| JP2009500409A (ja) * | 2005-06-29 | 2009-01-08 | アラーガン、インコーポレイテッド | 痛みを処置するためのα２アドレナリン作動剤 |
| US20070203144A1 (en) * | 2006-01-17 | 2007-08-30 | Allergan, Inc. | Use of Memantine and Brimonidine to Attenuate Vitreoretinal Vascular Endothelial Growth Factor (VEGF) Protein Levels in Animals |
| AU2007235002A1 (en) * | 2006-04-07 | 2007-10-18 | Allergan, Inc. | Compositions including relatively water insoluble/unwettable drugs and methods for using same |
| US20070298073A1 (en) * | 2006-06-23 | 2007-12-27 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
| US8802128B2 (en) | 2006-06-23 | 2014-08-12 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
| US20080153874A1 (en) * | 2006-12-22 | 2008-06-26 | Allergan Inc. | Alpha-2b receptor agonist and anticonvulsant compositions for treating chronic pain |
| JP5524047B2 (ja) * | 2007-05-23 | 2014-06-18 | アラーガン インコーポレイテッド | 緑内障および眼圧上昇の治療用環状ラクタム類 |
| DK2160386T3 (da) * | 2007-05-23 | 2012-08-27 | Allergan Inc | Terapeutiske ((phenyl)imidazolyl)methylquinolinylforbindelser |
| US20110028559A1 (en) * | 2007-07-06 | 2011-02-03 | Fang Wenkui K | Substituted fluoroethyl ureas as alpha 2 adrenergic agents |
| RU2491284C2 (ru) * | 2007-08-15 | 2013-08-27 | Аллерган, Инк. | Адренергические соединения |
| CA2696404A1 (en) * | 2007-08-15 | 2009-02-19 | Allergan, Inc. | Therapeutic compounds |
| JP2010536781A (ja) * | 2007-08-15 | 2010-12-02 | アラーガン インコーポレイテッド | 緑内障および疼痛のような症状の治療において有用な複素環系の置換縮合炭素環 |
| WO2009052071A1 (en) * | 2007-10-18 | 2009-04-23 | Allergan, Inc. | Treatment of sensorimotor disorders with 4- ( 1- ( 2, 3 -dimethylphenyl) ethyl) -1h-imidaz0le-2 ( 3h) -thione |
| US20100216857A1 (en) * | 2007-10-18 | 2010-08-26 | Luhrs Lauren M B | Method of treating motor disorders with 4-(1-(2,3-dimethylphenyl)ethyl)-1h-imidazole-2(3h)-thione |
| US8455548B2 (en) * | 2007-10-18 | 2013-06-04 | Allergan, Inc. | Method of treating sensorimotor disorders with alpha-2 adrenergic receptor agonists |
| EP2242748A1 (en) * | 2008-01-11 | 2010-10-27 | Allergan, Inc. | Therapeutic disulfide compounds for treating pain and diabetes |
| US20090263451A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Anti-Inflammatory and/or Analgesic Agents for Treatment of Myofascial Pain |
| US8420114B2 (en) * | 2008-04-18 | 2013-04-16 | Warsaw Orthopedic, Inc. | Alpha and beta adrenergic receptor agonists for treatment of pain and / or inflammation |
| US8956641B2 (en) | 2008-04-18 | 2015-02-17 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of inflammatory diseases |
| USRE48948E1 (en) | 2008-04-18 | 2022-03-01 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable polymer |
| US20090264477A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc., An Indiana Corporation | Beta adrenergic receptor agonists for treatment of pain and/or inflammation |
| US8889173B2 (en) * | 2008-04-18 | 2014-11-18 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of pain and/or inflammation |
| US9072727B2 (en) | 2008-04-18 | 2015-07-07 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of degenerative disc disease |
| CA2752156A1 (en) | 2009-02-13 | 2010-08-19 | Daniel W. Gil | 4-(1-(3-(hydroxymethyl)-2-methylphenyl)ethyl)-1h-imidazole-2(3h)-thione |
| US20100239632A1 (en) | 2009-03-23 | 2010-09-23 | Warsaw Orthopedic, Inc. | Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue |
| US8394800B2 (en) * | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
| US9486500B2 (en) | 2010-01-28 | 2016-11-08 | Warsaw Orthopedic, Inc. | Osteoimplant and methods for making |
| US9050274B2 (en) * | 2010-01-28 | 2015-06-09 | Warsaw Orthopedic, Inc. | Compositions and methods for treating an intervertebral disc using bulking agents or sealing agents |
| US9125902B2 (en) * | 2010-01-28 | 2015-09-08 | Warsaw Orthopedic, Inc. | Methods for treating an intervertebral disc using local analgesics |
| US9060978B2 (en) | 2011-01-24 | 2015-06-23 | Warsaw Orthopedic, Inc. | Method for treating an intervertebral disc disorder by administering a dominant negative tumor necrosis factor antagonist |
| US9592243B2 (en) | 2011-04-25 | 2017-03-14 | Warsaw Orthopedic, Inc. | Medical devices and methods comprising an anabolic agent for treatment of an injury |
| US9511077B2 (en) | 2011-04-25 | 2016-12-06 | Warsaw Orthopedic, Inc. | Medical devices and methods comprising an anabolic agent for wound healing |
| WO2020222188A1 (en) | 2019-05-01 | 2020-11-05 | Clexio Biosciences Ltd. | Methods of treating pruritus |
| CN110894508B (zh) * | 2019-10-31 | 2021-08-06 | 内蒙古大学 | 一种调控白色脂肪棕色化的基因Adra1a的应用 |
| WO2022093767A1 (en) * | 2020-10-26 | 2022-05-05 | Rush University Medical Center | Alpha-2 adrenergic receptor agonists to reduce mortality and improve outcomes in viral respiratory syndromes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS63150266A (ja) * | 1986-12-12 | 1988-06-22 | Mitsui Petrochem Ind Ltd | ベンジルイミダゾ−ル誘導体 |
| US4868197A (en) | 1987-03-20 | 1989-09-19 | Merrell Dow Pharmaceuticals Inc. | Reducing reperfusion injury with 1,3-dihydro-4-methyl-5-(4-methylthio)benzoyl)-2H-imidazol-2-thione |
| ZA881807B (en) | 1987-03-20 | 1988-09-05 | Merrell Dow Pharmaceuticals Inc. | Method for reducing reperfusion injury with imidazol-2-thiones |
| US4798843A (en) | 1987-07-09 | 1989-01-17 | Smithkline Beckman Corporation | 2-mercaproimidazole dopamine-β-hydroxylase inhibitors |
| GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
| FR2706456B1 (fr) * | 1993-06-18 | 1996-06-28 | Rhone Poulenc Agrochimie | Dérivés optiquement actifs de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides. |
| EP0758323A1 (en) | 1994-05-02 | 1997-02-19 | Zeneca Limited | Herbicidal hydroxybenzyl-substituted heteroaryl compounds and derivatives thereof |
| BR9813381A (pt) * | 1997-12-04 | 2000-10-03 | Allergan Sales Inc | "derivados de imidazol substituìdo possuindo atividade semelhante a agonista em receptores adrenérgicos alfa 2b ou 2b/2c" |
| AR015744A1 (es) * | 1998-04-01 | 2001-05-16 | Orion Corp | Uso de dexmedetomidina para sedacion en terapia intensiva |
| US7091232B2 (en) * | 2002-05-21 | 2006-08-15 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7141597B2 (en) * | 2003-09-12 | 2006-11-28 | Allergan, Inc. | Nonsedating α-2 agonists |
-
2004
- 2004-07-15 US US10/891,953 patent/US7141597B2/en not_active Expired - Fee Related
- 2004-08-20 NZ NZ545181A patent/NZ545181A/en not_active IP Right Cessation
- 2004-08-20 KR KR1020067005031A patent/KR101145046B1/ko not_active Expired - Fee Related
- 2004-08-20 PT PT04781753T patent/PT1663206E/pt unknown
- 2004-08-20 EP EP07006921A patent/EP1800679B1/en not_active Expired - Lifetime
- 2004-08-20 EP EP04781753A patent/EP1663206B1/en not_active Expired - Lifetime
- 2004-08-20 CN CNB2004800262738A patent/CN100417379C/zh not_active Expired - Fee Related
- 2004-08-20 PL PL04781753T patent/PL1663206T3/pl unknown
- 2004-08-20 DK DK04781753T patent/DK1663206T3/da active
- 2004-08-20 ES ES04781753T patent/ES2285522T3/es not_active Expired - Lifetime
- 2004-08-20 RU RU2006113600/04A patent/RU2345987C2/ru not_active IP Right Cessation
- 2004-08-20 CA CA2537832A patent/CA2537832C/en not_active Expired - Fee Related
- 2004-08-20 DE DE602004005720T patent/DE602004005720T2/de not_active Expired - Lifetime
- 2004-08-20 SI SI200430257T patent/SI1663206T1/sl unknown
- 2004-08-20 AT AT07006921T patent/ATE487477T1/de not_active IP Right Cessation
- 2004-08-20 JP JP2006526107A patent/JP4698591B2/ja not_active Expired - Fee Related
- 2004-08-20 BR BRPI0413719-1A patent/BRPI0413719A/pt not_active IP Right Cessation
- 2004-08-20 AT AT04781753T patent/ATE358479T1/de active
- 2004-08-20 DE DE602004030051T patent/DE602004030051D1/de not_active Expired - Lifetime
- 2004-08-20 AU AU2004279332A patent/AU2004279332B2/en not_active Ceased
- 2004-08-20 MX MXPA06002668A patent/MXPA06002668A/es active IP Right Grant
- 2004-08-20 WO PCT/US2004/027134 patent/WO2005034946A1/en not_active Ceased
- 2004-08-20 DK DK07006921.6T patent/DK1800679T3/da active
- 2004-08-20 PL PL379561A patent/PL379561A1/pl unknown
- 2004-09-10 TW TW093127519A patent/TWI337999B/zh not_active IP Right Cessation
-
2006
- 2006-02-03 ZA ZA200601002A patent/ZA200601002B/en unknown
- 2006-02-05 IL IL173530A patent/IL173530A/en active IP Right Grant
- 2006-02-10 NO NO20060667A patent/NO20060667L/no not_active Application Discontinuation
- 2006-02-21 CO CO06017219A patent/CO5680444A2/es unknown
- 2006-07-20 US US11/458,731 patent/US7312238B2/en not_active Expired - Lifetime
-
2007
- 2007-06-21 CY CY20071100823T patent/CY1107608T1/el unknown
- 2007-12-18 US US11/959,356 patent/US20080176918A1/en not_active Abandoned
-
2010
- 2010-09-09 US US12/878,593 patent/US8022226B2/en not_active Expired - Lifetime
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