MXPA06002668A - Agonista de a-2 no sedante de 1-(2,3-dimetil-fenil)-etil-1, 3-dihidro-imidazol-2-tiona. - Google Patents

Agonista de a-2 no sedante de 1-(2,3-dimetil-fenil)-etil-1, 3-dihidro-imidazol-2-tiona.

Info

Publication number
MXPA06002668A
MXPA06002668A MXPA06002668A MXPA06002668A MXPA06002668A MX PA06002668 A MXPA06002668 A MX PA06002668A MX PA06002668 A MXPA06002668 A MX PA06002668A MX PA06002668 A MXPA06002668 A MX PA06002668A MX PA06002668 A MXPA06002668 A MX PA06002668A
Authority
MX
Mexico
Prior art keywords
alpha
agonist
imizadole
nonsedating
thione
Prior art date
Application number
MXPA06002668A
Other languages
English (en)
Inventor
Todd M Heidelbaugh
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of MXPA06002668A publication Critical patent/MXPA06002668A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invencion proporciona un agonista selectivo de a-2A/a-1A que incluye un compuesto representado por la Estructura 1 o una sal, ester, amida, estereoisomero o mezcla racemica del mismo, farmaceuticamente aceptable. La presente invencion proporciona ademas una composicion farmaceutica que contiene un portador farmaceutico y una cantidad terapeuticamente efectiva de un agonista selectivo de a-2A/ a-1A que incluye un compuesto representado por la Estructura 1 o una sal, ester, amida, estereoisomero o mezcla racemica del mismo, farmaceuticamente aceptable.
MXPA06002668A 2003-09-12 2004-08-20 Agonista de a-2 no sedante de 1-(2,3-dimetil-fenil)-etil-1, 3-dihidro-imidazol-2-tiona. MXPA06002668A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50256203P 2003-09-12 2003-09-12
US10/891,953 US7141597B2 (en) 2003-09-12 2004-07-15 Nonsedating α-2 agonists
PCT/US2004/027134 WO2005034946A1 (en) 2003-09-12 2004-08-20 Nonsedating α-2 agonist 1- (2, 3-dimethyl-phenyl) -ethyl-1, 3-dihydro-imizadole-2-thione

Publications (1)

Publication Number Publication Date
MXPA06002668A true MXPA06002668A (es) 2006-06-06

Family

ID=34278841

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA06002668A MXPA06002668A (es) 2003-09-12 2004-08-20 Agonista de a-2 no sedante de 1-(2,3-dimetil-fenil)-etil-1, 3-dihidro-imidazol-2-tiona.

Country Status (26)

Country Link
US (4) US7141597B2 (es)
EP (2) EP1800679B1 (es)
JP (1) JP4698591B2 (es)
KR (1) KR101145046B1 (es)
CN (1) CN100417379C (es)
AT (2) ATE358479T1 (es)
AU (1) AU2004279332B2 (es)
BR (1) BRPI0413719A (es)
CA (1) CA2537832C (es)
CO (1) CO5680444A2 (es)
CY (1) CY1107608T1 (es)
DE (2) DE602004030051D1 (es)
DK (2) DK1663206T3 (es)
ES (1) ES2285522T3 (es)
HK (2) HK1092704A1 (es)
IL (1) IL173530A (es)
MX (1) MXPA06002668A (es)
NO (1) NO20060667L (es)
NZ (1) NZ545181A (es)
PL (2) PL379561A1 (es)
PT (1) PT1663206E (es)
RU (1) RU2345987C2 (es)
SI (1) SI1663206T1 (es)
TW (1) TWI337999B (es)
WO (1) WO2005034946A1 (es)
ZA (1) ZA200601002B (es)

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ATE306951T1 (de) * 2000-11-29 2005-11-15 Allergan Inc Verhinderung von transplantatabstossung im auge
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US7358269B2 (en) * 2002-05-21 2008-04-15 Allergan, Inc. 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one
US7323485B2 (en) * 2002-05-21 2008-01-29 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US20060293359A1 (en) * 2003-06-25 2006-12-28 Allergan, Inc. Methods and compositions for the treatment of diabetes
US20050059664A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Novel methods for identifying improved, non-sedating alpha-2 agonists
US7141597B2 (en) * 2003-09-12 2006-11-28 Allergan, Inc. Nonsedating α-2 agonists
US7812049B2 (en) * 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
AU2005290075A1 (en) * 2004-09-24 2006-04-06 Allergan, Inc. 4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists
MX2007003094A (es) 2004-09-24 2007-06-07 Allergan Inc 4-(metilo ciclico condensado)-imidazol-2-tionas como agonistas alfa2 adrenergicos.
BRPI0613077A2 (pt) * 2005-06-29 2010-12-21 Allergan Inc agonistas alfa-2 andrenérgicos para o tratamento de dor
US20070203144A1 (en) * 2006-01-17 2007-08-30 Allergan, Inc. Use of Memantine and Brimonidine to Attenuate Vitreoretinal Vascular Endothelial Growth Factor (VEGF) Protein Levels in Animals
WO2007117923A2 (en) * 2006-04-07 2007-10-18 Allergan, Inc. Compositions including relatively water insoluble/unwettable drugs and methods for using same
US20070298073A1 (en) * 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20080153874A1 (en) * 2006-12-22 2008-06-26 Allergan Inc. Alpha-2b receptor agonist and anticonvulsant compositions for treating chronic pain
JP2010528034A (ja) 2007-05-23 2010-08-19 アラーガン、インコーポレイテッド 医薬としての（（フェニル）イミダゾリル）メチルキノリニル化合物
PT2155733E (pt) * 2007-05-23 2013-01-07 Allergan Inc Lactamas cíclicas para o tratamento de glaucoma ou pressão intra-ocular elevada
US20110028559A1 (en) * 2007-07-06 2011-02-03 Fang Wenkui K Substituted fluoroethyl ureas as alpha 2 adrenergic agents
EP2188262A1 (en) * 2007-08-15 2010-05-26 Allergan, Inc. Heterocyclyl substituted fused carbocyles useful in the treatment of conditions such as glaucoma and pain
EP2190835B1 (en) * 2007-08-15 2012-10-03 Allergan, Inc. Adrenergic compounds
AU2008286823A1 (en) * 2007-08-15 2009-02-19 Allergan, Inc. Therapeutic compounds
US20100216857A1 (en) * 2007-10-18 2010-08-26 Luhrs Lauren M B Method of treating motor disorders with 4-(1-(2,3-dimethylphenyl)ethyl)-1h-imidazole-2(3h)-thione
US20110269805A1 (en) * 2007-10-18 2011-11-03 Gil Daniel W Method of treating sensorimotor disorders with 4-(1-(2,3-dimethylphenyl)ethyl)-1h-imidazole-2(3h)-thione
WO2009052073A2 (en) * 2007-10-18 2009-04-23 Allergan, Inc. Method of treating sensorimotor disorders with alpha-2 adrenergic receptor agonists
WO2009089448A1 (en) * 2008-01-11 2009-07-16 Allergan, Inc. Therapeutic disulfide compounds for treating pain and diabetes
US8420114B2 (en) * 2008-04-18 2013-04-16 Warsaw Orthopedic, Inc. Alpha and beta adrenergic receptor agonists for treatment of pain and / or inflammation
US8956641B2 (en) 2008-04-18 2015-02-17 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of inflammatory diseases
US9072727B2 (en) 2008-04-18 2015-07-07 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of degenerative disc disease
US20090263451A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Anti-Inflammatory and/or Analgesic Agents for Treatment of Myofascial Pain
US20090264477A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc., An Indiana Corporation Beta adrenergic receptor agonists for treatment of pain and/or inflammation
US8889173B2 (en) * 2008-04-18 2014-11-18 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of pain and/or inflammation
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
JP2012518005A (ja) 2009-02-13 2012-08-09 アラーガン インコーポレイテッド ４‐（１‐（３‐（ヒドロキシメチル）‐２‐メチルフェニル）エチル）‐１ｈ‐イミダゾール‐２（３ｈ）‐チオン
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Also Published As

Publication number Publication date
EP1663206A1 (en) 2006-06-07
IL173530A (en) 2010-05-31
AU2004279332B2 (en) 2010-10-07
US20050059721A1 (en) 2005-03-17
CY1107608T1 (el) 2013-03-13
ATE487477T1 (de) 2010-11-15
NO20060667L (no) 2006-04-06
US7312238B2 (en) 2007-12-25
KR101145046B1 (ko) 2012-05-21
DE602004005720D1 (de) 2007-05-16
HK1104979A1 (en) 2008-02-01
CN100417379C (zh) 2008-09-10
EP1800679B1 (en) 2010-11-10
ES2285522T3 (es) 2007-11-16
PL379561A1 (pl) 2006-10-16
CA2537832A1 (en) 2005-04-21
AU2004279332A1 (en) 2005-04-21
WO2005034946A1 (en) 2005-04-21
ZA200601002B (en) 2007-04-25
BRPI0413719A (pt) 2006-10-17
US20080176918A1 (en) 2008-07-24
CN1849118A (zh) 2006-10-18
CO5680444A2 (es) 2006-09-29
US20070004790A1 (en) 2007-01-04
DK1663206T3 (da) 2007-07-30
US20110034525A1 (en) 2011-02-10
DE602004005720T2 (de) 2007-12-27
ATE358479T1 (de) 2007-04-15
DK1800679T3 (da) 2011-02-07
PT1663206E (pt) 2007-06-22
EP1800679A2 (en) 2007-06-27
EP1800679A3 (en) 2009-01-21
NZ545181A (en) 2009-07-31
TWI337999B (en) 2011-03-01
DE602004030051D1 (de) 2010-12-23
CA2537832C (en) 2012-01-24
JP4698591B2 (ja) 2011-06-08
PL1663206T3 (pl) 2007-08-31
HK1092704A1 (en) 2007-02-16
US8022226B2 (en) 2011-09-20
RU2006113600A (ru) 2007-11-10
IL173530A0 (en) 2006-07-05
TW200526591A (en) 2005-08-16
JP2007505111A (ja) 2007-03-08
EP1663206B1 (en) 2007-04-04
SI1663206T1 (sl) 2007-06-30
KR20060119970A (ko) 2006-11-24
US7141597B2 (en) 2006-11-28
RU2345987C2 (ru) 2009-02-10

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