SI1663206T1 - 1-(2,3-dimetil-fenil)-etil-1,3-dihidroimidazol-2-tion kot nesedativni agonist alfa 2A - Google Patents

1-(2,3-dimetil-fenil)-etil-1,3-dihidroimidazol-2-tion kot nesedativni agonist alfa 2A

Info

Publication number
SI1663206T1
SI1663206T1 SI200430257T SI200430257T SI1663206T1 SI 1663206 T1 SI1663206 T1 SI 1663206T1 SI 200430257 T SI200430257 T SI 200430257T SI 200430257 T SI200430257 T SI 200430257T SI 1663206 T1 SI1663206 T1 SI 1663206T1
Authority
SI
Slovenia
Prior art keywords
agonist
thione
dihydro
imidazole
dimethyl
Prior art date
Application number
SI200430257T
Other languages
English (en)
Inventor
Ken Chow
Todd M Heidelbaugh
John E Donello
Daniel W Gil
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of SI1663206T1 publication Critical patent/SI1663206T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI200430257T 2003-09-12 2004-08-20 1-(2,3-dimetil-fenil)-etil-1,3-dihidroimidazol-2-tion kot nesedativni agonist alfa 2A SI1663206T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50256203P 2003-09-12 2003-09-12
US10/891,953 US7141597B2 (en) 2003-09-12 2004-07-15 Nonsedating α-2 agonists
EP04781753A EP1663206B1 (en) 2003-09-12 2004-08-20 1-(2,3-dimethyl-phenyl)-ethyl-1,3-dihydro-imidazole-2-thione as non-sedating alpha 2a agonist
PCT/US2004/027134 WO2005034946A1 (en) 2003-09-12 2004-08-20 Nonsedating α-2 agonist 1- (2, 3-dimethyl-phenyl) -ethyl-1, 3-dihydro-imizadole-2-thione

Publications (1)

Publication Number Publication Date
SI1663206T1 true SI1663206T1 (sl) 2007-06-30

Family

ID=34278841

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200430257T SI1663206T1 (sl) 2003-09-12 2004-08-20 1-(2,3-dimetil-fenil)-etil-1,3-dihidroimidazol-2-tion kot nesedativni agonist alfa 2A

Country Status (25)

Country Link
US (4) US7141597B2 (sl)
EP (2) EP1800679B1 (sl)
JP (1) JP4698591B2 (sl)
KR (1) KR101145046B1 (sl)
CN (1) CN100417379C (sl)
AT (2) ATE487477T1 (sl)
AU (1) AU2004279332B2 (sl)
BR (1) BRPI0413719A (sl)
CA (1) CA2537832C (sl)
CO (1) CO5680444A2 (sl)
CY (1) CY1107608T1 (sl)
DE (2) DE602004005720T2 (sl)
DK (2) DK1663206T3 (sl)
ES (1) ES2285522T3 (sl)
IL (1) IL173530A (sl)
MX (1) MXPA06002668A (sl)
NO (1) NO20060667L (sl)
NZ (1) NZ545181A (sl)
PL (2) PL1663206T3 (sl)
PT (1) PT1663206E (sl)
RU (1) RU2345987C2 (sl)
SI (1) SI1663206T1 (sl)
TW (1) TWI337999B (sl)
WO (1) WO2005034946A1 (sl)
ZA (1) ZA200601002B (sl)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
WO2002043785A2 (en) 2000-11-29 2002-06-06 Oculex Pharmaceuticals, Inc. Intraocular implants for preventing transplant rejection in the eye
US7358269B2 (en) * 2002-05-21 2008-04-15 Allergan, Inc. 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one
US7091232B2 (en) * 2002-05-21 2006-08-15 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US7323485B2 (en) * 2002-05-21 2008-01-29 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US20050059664A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Novel methods for identifying improved, non-sedating alpha-2 agonists
US20060293359A1 (en) * 2003-06-25 2006-12-28 Allergan, Inc. Methods and compositions for the treatment of diabetes
US7141597B2 (en) * 2003-09-12 2006-11-28 Allergan, Inc. Nonsedating α-2 agonists
US7812049B2 (en) * 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
BRPI0516950A (pt) 2004-09-24 2008-09-30 Allergan Inc 4-(metila cìclica condensada)-imidazol-2-tionas atuando como agonistas adrenérgicos alfa2
MX2007003068A (es) * 2004-09-24 2007-05-21 Allergan Inc 4-(fenil-metil y fenil-metil substituido)-imidazol-2tionas como agonistas adrenergicos alfa2 especificos.
JP2009500409A (ja) * 2005-06-29 2009-01-08 アラーガン、インコーポレイテッド 痛みを処置するためのα２アドレナリン作動剤
US20070203144A1 (en) * 2006-01-17 2007-08-30 Allergan, Inc. Use of Memantine and Brimonidine to Attenuate Vitreoretinal Vascular Endothelial Growth Factor (VEGF) Protein Levels in Animals
AU2007235002A1 (en) * 2006-04-07 2007-10-18 Allergan, Inc. Compositions including relatively water insoluble/unwettable drugs and methods for using same
US20070298073A1 (en) * 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20080153874A1 (en) * 2006-12-22 2008-06-26 Allergan Inc. Alpha-2b receptor agonist and anticonvulsant compositions for treating chronic pain
JP5524047B2 (ja) * 2007-05-23 2014-06-18 アラーガン インコーポレイテッド 緑内障および眼圧上昇の治療用環状ラクタム類
DK2160386T3 (da) * 2007-05-23 2012-08-27 Allergan Inc Terapeutiske ((phenyl)imidazolyl)methylquinolinylforbindelser
US20110028559A1 (en) * 2007-07-06 2011-02-03 Fang Wenkui K Substituted fluoroethyl ureas as alpha 2 adrenergic agents
RU2491284C2 (ru) * 2007-08-15 2013-08-27 Аллерган, Инк. Адренергические соединения
CA2696404A1 (en) * 2007-08-15 2009-02-19 Allergan, Inc. Therapeutic compounds
JP2010536781A (ja) * 2007-08-15 2010-12-02 アラーガン インコーポレイテッド 緑内障および疼痛のような症状の治療において有用な複素環系の置換縮合炭素環
WO2009052071A1 (en) * 2007-10-18 2009-04-23 Allergan, Inc. Treatment of sensorimotor disorders with 4- ( 1- ( 2, 3 -dimethylphenyl) ethyl) -1h-imidaz0le-2 ( 3h) -thione
US20100216857A1 (en) * 2007-10-18 2010-08-26 Luhrs Lauren M B Method of treating motor disorders with 4-(1-(2,3-dimethylphenyl)ethyl)-1h-imidazole-2(3h)-thione
US8455548B2 (en) * 2007-10-18 2013-06-04 Allergan, Inc. Method of treating sensorimotor disorders with alpha-2 adrenergic receptor agonists
EP2242748A1 (en) * 2008-01-11 2010-10-27 Allergan, Inc. Therapeutic disulfide compounds for treating pain and diabetes
US20090263451A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Anti-Inflammatory and/or Analgesic Agents for Treatment of Myofascial Pain
US8420114B2 (en) * 2008-04-18 2013-04-16 Warsaw Orthopedic, Inc. Alpha and beta adrenergic receptor agonists for treatment of pain and / or inflammation
US8956641B2 (en) 2008-04-18 2015-02-17 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of inflammatory diseases
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US20090264477A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc., An Indiana Corporation Beta adrenergic receptor agonists for treatment of pain and/or inflammation
US8889173B2 (en) * 2008-04-18 2014-11-18 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of pain and/or inflammation
US9072727B2 (en) 2008-04-18 2015-07-07 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of degenerative disc disease
CA2752156A1 (en) 2009-02-13 2010-08-19 Daniel W. Gil 4-(1-(3-(hydroxymethyl)-2-methylphenyl)ethyl)-1h-imidazole-2(3h)-thione
US20100239632A1 (en) 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
US8394800B2 (en) * 2009-11-19 2013-03-12 Galderma Laboratories, L.P. Method for treating psoriasis
US9486500B2 (en) 2010-01-28 2016-11-08 Warsaw Orthopedic, Inc. Osteoimplant and methods for making
US9050274B2 (en) * 2010-01-28 2015-06-09 Warsaw Orthopedic, Inc. Compositions and methods for treating an intervertebral disc using bulking agents or sealing agents
US9125902B2 (en) * 2010-01-28 2015-09-08 Warsaw Orthopedic, Inc. Methods for treating an intervertebral disc using local analgesics
US9060978B2 (en) 2011-01-24 2015-06-23 Warsaw Orthopedic, Inc. Method for treating an intervertebral disc disorder by administering a dominant negative tumor necrosis factor antagonist
US9592243B2 (en) 2011-04-25 2017-03-14 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for treatment of an injury
US9511077B2 (en) 2011-04-25 2016-12-06 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for wound healing
WO2020222188A1 (en) 2019-05-01 2020-11-05 Clexio Biosciences Ltd. Methods of treating pruritus
CN110894508B (zh) * 2019-10-31 2021-08-06 内蒙古大学 一种调控白色脂肪棕色化的基因Adra1a的应用
WO2022093767A1 (en) * 2020-10-26 2022-05-05 Rush University Medical Center Alpha-2 adrenergic receptor agonists to reduce mortality and improve outcomes in viral respiratory syndromes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63150266A (ja) * 1986-12-12 1988-06-22 Mitsui Petrochem Ind Ltd ベンジルイミダゾ−ル誘導体
US4868197A (en) 1987-03-20 1989-09-19 Merrell Dow Pharmaceuticals Inc. Reducing reperfusion injury with 1,3-dihydro-4-methyl-5-(4-methylthio)benzoyl)-2H-imidazol-2-thione
ZA881807B (en) 1987-03-20 1988-09-05 Merrell Dow Pharmaceuticals Inc. Method for reducing reperfusion injury with imidazol-2-thiones
US4798843A (en) 1987-07-09 1989-01-17 Smithkline Beckman Corporation 2-mercaproimidazole dopamine-β-hydroxylase inhibitors
GB2206880B (en) * 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
FR2706456B1 (fr) * 1993-06-18 1996-06-28 Rhone Poulenc Agrochimie Dérivés optiquement actifs de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides.
EP0758323A1 (en) 1994-05-02 1997-02-19 Zeneca Limited Herbicidal hydroxybenzyl-substituted heteroaryl compounds and derivatives thereof
BR9813381A (pt) * 1997-12-04 2000-10-03 Allergan Sales Inc "derivados de imidazol substituìdo possuindo atividade semelhante a agonista em receptores adrenérgicos alfa 2b ou 2b/2c"
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
US7091232B2 (en) * 2002-05-21 2006-08-15 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US7141597B2 (en) * 2003-09-12 2006-11-28 Allergan, Inc. Nonsedating α-2 agonists

Also Published As

Publication number Publication date
EP1800679A3 (en) 2009-01-21
CN100417379C (zh) 2008-09-10
BRPI0413719A (pt) 2006-10-17
US8022226B2 (en) 2011-09-20
PT1663206E (pt) 2007-06-22
US7141597B2 (en) 2006-11-28
DK1800679T3 (da) 2011-02-07
US20070004790A1 (en) 2007-01-04
JP2007505111A (ja) 2007-03-08
AU2004279332A1 (en) 2005-04-21
RU2006113600A (ru) 2007-11-10
CA2537832A1 (en) 2005-04-21
EP1800679B1 (en) 2010-11-10
MXPA06002668A (es) 2006-06-06
US20080176918A1 (en) 2008-07-24
CN1849118A (zh) 2006-10-18
KR101145046B1 (ko) 2012-05-21
EP1800679A2 (en) 2007-06-27
ATE487477T1 (de) 2010-11-15
DE602004030051D1 (de) 2010-12-23
TW200526591A (en) 2005-08-16
US20110034525A1 (en) 2011-02-10
PL1663206T3 (pl) 2007-08-31
US7312238B2 (en) 2007-12-25
CO5680444A2 (es) 2006-09-29
NZ545181A (en) 2009-07-31
CA2537832C (en) 2012-01-24
EP1663206A1 (en) 2006-06-07
AU2004279332B2 (en) 2010-10-07
IL173530A0 (en) 2006-07-05
TWI337999B (en) 2011-03-01
EP1663206B1 (en) 2007-04-04
IL173530A (en) 2010-05-31
DE602004005720D1 (de) 2007-05-16
ATE358479T1 (de) 2007-04-15
WO2005034946A1 (en) 2005-04-21
US20050059721A1 (en) 2005-03-17
ZA200601002B (en) 2007-04-25
HK1104979A1 (en) 2008-02-01
NO20060667L (no) 2006-04-06
KR20060119970A (ko) 2006-11-24
JP4698591B2 (ja) 2011-06-08
CY1107608T1 (el) 2013-03-13
RU2345987C2 (ru) 2009-02-10
PL379561A1 (pl) 2006-10-16
DK1663206T3 (da) 2007-07-30
ES2285522T3 (es) 2007-11-16
DE602004005720T2 (de) 2007-12-27
HK1092704A1 (en) 2007-02-16

Similar Documents

Publication Publication Date Title
PL1663206T3 (pl) 1-(2,3-dimetylo-fenylo)-etylo-1,3-dihydro-imidazolo-2-tion jako alfa 2A agonista bez działania uspokajającego
ATE406360T1 (de) Antagonisten der opioidrezeptoren
IL163911A0 (en) Naltrexone hydrochloride compositions
WO2004000808A3 (en) N-substituted piperidine derivatives as serotonin receptor agents
HUP0302226A3 (en) Substituted pyrrolopyridinone dervatives useful as phosphodiesterse inhibitors, their intermediates and pharmaceutical compositions containing the compounds
WO2004014384A3 (en) Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors
AU2003239389A1 (en) Opioid receptor antagonists
YU41199A (sh) Hinoksalindioni
SE0200919D0 (sv) Chemical compounds
AU2003250471A8 (en) Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors
WO2004112704A3 (en) Substituted piperidine compounds and methods of their use
AU2003205570A1 (en) Combination of mtp inhibitors or apob secretion inhibitors with fibrates for use as drugs
PL350568A1 (en) N-(2-phenyl-4-aminobutyl)-1-naphtamides as antagonists of neurokinin 1 receptors
IL172542A0 (en) 2-hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide
MY139228A (en) Imidazolinylmethyl aralkylsulfonamides
IL166730A0 (en) N-(3-methoxy-5-methylpyrazin-2-yl)-2-(4-Ä1,3,4-oxadiazol-2-ylÜphenyl)pyridine-3-sulphonamide as an anticancer agent
PL1636217T3 (pl) 1-Imidazobenzotiazole jako ligandy receptora adenozynowego
MXPA05011476A (es) Imidazolin-2-il-aminofenil-amidas como antagonistas de prostaglandina i2.
DE69827614D1 (de) Chinoxalindionen
UA81664C2 (ru) Производные дифенилмочевины и их применение, как блокаторов хлоридных каналов
TW200505468A (en) Agent for improving hepato-bililary dysfunction
AU2003284772A1 (en) PHARMACEUTICAL COMPOSITION FOR CONTROLING THE STABILITY OF HIF-1Alpha
ITVR20020030A1 (it) Miscela per polvere di saldatura, nonché procedimento per l'impiego di detta miscela.