RU2006113600A - Неседативный а-2-агонист 1-(2,3-диметил-фенил)-этил-1,3-дигидро-имидазол-2-тион - Google Patents

Неседативный а-2-агонист 1-(2,3-диметил-фенил)-этил-1,3-дигидро-имидазол-2-тион Download PDF

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RU2006113600A
RU2006113600A RU2006113600/04A RU2006113600A RU2006113600A RU 2006113600 A RU2006113600 A RU 2006113600A RU 2006113600/04 A RU2006113600/04 A RU 2006113600/04A RU 2006113600 A RU2006113600 A RU 2006113600A RU 2006113600 A RU2006113600 A RU 2006113600A
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selective agonist
agonist
brimonidine
stereoisomer
amide
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RU2345987C2 (ru
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Кен ЧОУ (US)
Кен ЧОУ
Тод М. ХЕЙДЕЛБАУ (US)
Тод М. ХЕЙДЕЛБАУ
Джон Э. ДОНЕЛЛО (US)
Джон Э. ДОНЕЛЛО
Дэниел В. ДЖИЛ (US)
Дэниел В. ДЖИЛ
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Аллерган, Инк. (Us)
Аллерган, Инк.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84Sulfur atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (6)

1. α-2А/α-1А селективный агонист, представляющий собой следующее соединение:
Figure 00000001
или его фармацевтически приемлемую соль, эфир, амид, стереоизомер или рацемическую смесь.
2. α-2А/α-1А селективный агонист по п.1, где указанный селективный агонист обладает α-1А эффективностью, меньшей по сравнению с бримонидином, и соотношением α-1А/α-2А эффективностей, большим по сравнению с бримонидином.
3. α-2А/α-1А селективный агонист по п.1, представляющий собой следующее соединение:
Figure 00000001
4. Фармацевтическая композиция, включающая фармацевтический носитель и терапевтически эффективное количество α-2А/α-1А селективного агониста, который представляет собой следующее соединение:
Figure 00000001
или его фармацевтически приемлемую соль, эфир, амид, стереоизомер или рацемическую смесь.
5. Фармацевтическая композиция по п.4, где указанный селективный агонист обладает α-1А эффективностью, меньшей по сравнению с бримонидином, и соотношением α-1А/α-2А эффективностей, большим по сравнению с бримонидином.
6. Фармацевтическая композиция по п.4, где указанный селективный агонист представляет собой следующее соединение:
Figure 00000001
RU2006113600/04A 2003-09-12 2004-08-20 Неседативный а-2-агонист 1-(2,3-диметилфенил)-этил-1,3-дигидроимидазол-2-тион RU2345987C2 (ru)

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US50256203P 2003-09-12 2003-09-12
US60/502,562 2003-09-12
US10/891,953 2004-07-15
US10/891.953 2004-07-15
US10/891,953 US7141597B2 (en) 2003-09-12 2004-07-15 Nonsedating α-2 agonists

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PL (2) PL379561A1 (ru)
PT (1) PT1663206E (ru)
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SI (1) SI1663206T1 (ru)
TW (1) TWI337999B (ru)
WO (1) WO2005034946A1 (ru)
ZA (1) ZA200601002B (ru)

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CA2537832A1 (en) 2005-04-21
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KR101145046B1 (ko) 2012-05-21
HK1092704A1 (en) 2007-02-16
PT1663206E (pt) 2007-06-22
CY1107608T1 (el) 2013-03-13
IL173530A (en) 2010-05-31
EP1800679A3 (en) 2009-01-21
EP1663206B1 (en) 2007-04-04
BRPI0413719A (pt) 2006-10-17
TWI337999B (en) 2011-03-01
CA2537832C (en) 2012-01-24
US20070004790A1 (en) 2007-01-04
DE602004005720T2 (de) 2007-12-27
RU2345987C2 (ru) 2009-02-10
US8022226B2 (en) 2011-09-20
ATE358479T1 (de) 2007-04-15
DE602004005720D1 (de) 2007-05-16
EP1800679A2 (en) 2007-06-27
CO5680444A2 (es) 2006-09-29
DK1663206T3 (da) 2007-07-30
US20110034525A1 (en) 2011-02-10
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DK1800679T3 (da) 2011-02-07
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JP2007505111A (ja) 2007-03-08
HK1104979A1 (en) 2008-02-01
ES2285522T3 (es) 2007-11-16
KR20060119970A (ko) 2006-11-24
US20050059721A1 (en) 2005-03-17
AU2004279332B2 (en) 2010-10-07
ATE487477T1 (de) 2010-11-15
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SI1663206T1 (sl) 2007-06-30
MXPA06002668A (es) 2006-06-06
EP1663206A1 (en) 2006-06-07
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