PL1663206T3 - 1-(2,3-dimetylo-fenylo)-etylo-1,3-dihydro-imidazolo-2-tion jako alfa 2A agonista bez działania uspokajającego - Google Patents

1-(2,3-dimetylo-fenylo)-etylo-1,3-dihydro-imidazolo-2-tion jako alfa 2A agonista bez działania uspokajającego

Info

Publication number
PL1663206T3
PL1663206T3 PL04781753T PL04781753T PL1663206T3 PL 1663206 T3 PL1663206 T3 PL 1663206T3 PL 04781753 T PL04781753 T PL 04781753T PL 04781753 T PL04781753 T PL 04781753T PL 1663206 T3 PL1663206 T3 PL 1663206T3
Authority
PL
Poland
Prior art keywords
agonist
thione
dihydro
imidazole
dimethyl
Prior art date
Application number
PL04781753T
Other languages
English (en)
Inventor
Ken Chow
Todd M Heidelbaugh
John E Donello
Daniel W Gil
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of PL1663206T3 publication Critical patent/PL1663206T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL04781753T 2003-09-12 2004-08-20 1-(2,3-dimetylo-fenylo)-etylo-1,3-dihydro-imidazolo-2-tion jako alfa 2A agonista bez działania uspokajającego PL1663206T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50256203P 2003-09-12 2003-09-12
US10/891,953 US7141597B2 (en) 2003-09-12 2004-07-15 Nonsedating α-2 agonists
EP04781753A EP1663206B1 (en) 2003-09-12 2004-08-20 1-(2,3-dimethyl-phenyl)-ethyl-1,3-dihydro-imidazole-2-thione as non-sedating alpha 2a agonist
PCT/US2004/027134 WO2005034946A1 (en) 2003-09-12 2004-08-20 Nonsedating α-2 agonist 1- (2, 3-dimethyl-phenyl) -ethyl-1, 3-dihydro-imizadole-2-thione

Publications (1)

Publication Number Publication Date
PL1663206T3 true PL1663206T3 (pl) 2007-08-31

Family

ID=34278841

Family Applications (2)

Application Number Title Priority Date Filing Date
PL04781753T PL1663206T3 (pl) 2003-09-12 2004-08-20 1-(2,3-dimetylo-fenylo)-etylo-1,3-dihydro-imidazolo-2-tion jako alfa 2A agonista bez działania uspokajającego
PL379561A PL379561A1 (pl) 2003-09-12 2004-08-20 Niesedatywny agonista Ó-2, 1-(2, 3-dimetylo-fenylo)-etylo-1, 3-dihydro-imidazolo-2-tion

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL379561A PL379561A1 (pl) 2003-09-12 2004-08-20 Niesedatywny agonista Ó-2, 1-(2, 3-dimetylo-fenylo)-etylo-1, 3-dihydro-imidazolo-2-tion

Country Status (25)

Country Link
US (4) US7141597B2 (pl)
EP (2) EP1800679B1 (pl)
JP (1) JP4698591B2 (pl)
KR (1) KR101145046B1 (pl)
CN (1) CN100417379C (pl)
AT (2) ATE487477T1 (pl)
AU (1) AU2004279332B2 (pl)
BR (1) BRPI0413719A (pl)
CA (1) CA2537832C (pl)
CO (1) CO5680444A2 (pl)
CY (1) CY1107608T1 (pl)
DE (2) DE602004005720T2 (pl)
DK (2) DK1800679T3 (pl)
ES (1) ES2285522T3 (pl)
IL (1) IL173530A (pl)
MX (1) MXPA06002668A (pl)
NO (1) NO20060667L (pl)
NZ (1) NZ545181A (pl)
PL (2) PL1663206T3 (pl)
PT (1) PT1663206E (pl)
RU (1) RU2345987C2 (pl)
SI (1) SI1663206T1 (pl)
TW (1) TWI337999B (pl)
WO (1) WO2005034946A1 (pl)
ZA (1) ZA200601002B (pl)

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US7358269B2 (en) * 2002-05-21 2008-04-15 Allergan, Inc. 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one
US7323485B2 (en) * 2002-05-21 2008-01-29 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US7141597B2 (en) * 2003-09-12 2006-11-28 Allergan, Inc. Nonsedating α-2 agonists
US20050059664A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Novel methods for identifying improved, non-sedating alpha-2 agonists
US20060293359A1 (en) * 2003-06-25 2006-12-28 Allergan, Inc. Methods and compositions for the treatment of diabetes
US7812049B2 (en) * 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
AU2005289998A1 (en) * 2004-09-24 2006-04-06 Allergan, Inc. 4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
WO2006036480A1 (en) * 2004-09-24 2006-04-06 Allergan, Inc. 4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists
AU2006266397A1 (en) * 2005-06-29 2007-01-11 Allergan, Inc. Alpha-2 adrenergic agonists for the treatment of pain
US20070203144A1 (en) * 2006-01-17 2007-08-30 Allergan, Inc. Use of Memantine and Brimonidine to Attenuate Vitreoretinal Vascular Endothelial Growth Factor (VEGF) Protein Levels in Animals
BRPI0710674A2 (pt) * 2006-04-07 2011-08-23 Allergan Inc composições incluindo fármacos relativamente insolúveis em água/não umectáveis e métodos para usar as mesmas
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20070298073A1 (en) * 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20080153874A1 (en) * 2006-12-22 2008-06-26 Allergan Inc. Alpha-2b receptor agonist and anticonvulsant compositions for treating chronic pain
AU2008256928A1 (en) * 2007-05-23 2008-12-04 Allergan, Inc. Therapeutic ((phenyl)imidazolyl)methylquinolinyl compounds
DK2155733T3 (da) * 2007-05-23 2012-10-29 Allergan Inc Cykliske lactamer til behandling af glaukom eller forhøjet intraokulært tryk
US20110028559A1 (en) * 2007-07-06 2011-02-03 Fang Wenkui K Substituted fluoroethyl ureas as alpha 2 adrenergic agents
WO2009023758A1 (en) * 2007-08-15 2009-02-19 Allergan, Inc. Heterocyclyl substituted fused carbocyles useful in the treatment of conditions such as glaucoma and pain
ES2396269T3 (es) * 2007-08-15 2013-02-20 Allergan, Inc. Compuestos adrenérgicos
CN101855213B (zh) * 2007-08-15 2014-09-10 阿勒根公司 治疗性化合物
WO2009052071A1 (en) * 2007-10-18 2009-04-23 Allergan, Inc. Treatment of sensorimotor disorders with 4- ( 1- ( 2, 3 -dimethylphenyl) ethyl) -1h-imidaz0le-2 ( 3h) -thione
WO2009052072A1 (en) * 2007-10-18 2009-04-23 Allergan, Inc. Treating motor disorders with 4-(1-(2,3-dimethylphenyl)ethyl)-1h-imidazole-2(3h)-thione
WO2009052073A2 (en) * 2007-10-18 2009-04-23 Allergan, Inc. Method of treating sensorimotor disorders with alpha-2 adrenergic receptor agonists
EP2242748A1 (en) * 2008-01-11 2010-10-27 Allergan, Inc. Therapeutic disulfide compounds for treating pain and diabetes
US8889173B2 (en) * 2008-04-18 2014-11-18 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of pain and/or inflammation
US20090263451A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Anti-Inflammatory and/or Analgesic Agents for Treatment of Myofascial Pain
US8956641B2 (en) 2008-04-18 2015-02-17 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of inflammatory diseases
US20090264477A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc., An Indiana Corporation Beta adrenergic receptor agonists for treatment of pain and/or inflammation
US9072727B2 (en) 2008-04-18 2015-07-07 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of degenerative disc disease
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US8420114B2 (en) * 2008-04-18 2013-04-16 Warsaw Orthopedic, Inc. Alpha and beta adrenergic receptor agonists for treatment of pain and / or inflammation
EP2396305A1 (en) 2009-02-13 2011-12-21 Allergan, Inc. 4-(1-(3-(hydroxymethyl)-2-methylphenyl)ethyl)-1h-imidazole-2(3h)-thione
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Also Published As

Publication number Publication date
US7141597B2 (en) 2006-11-28
EP1800679B1 (en) 2010-11-10
US7312238B2 (en) 2007-12-25
CY1107608T1 (el) 2013-03-13
BRPI0413719A (pt) 2006-10-17
AU2004279332A1 (en) 2005-04-21
EP1800679A3 (en) 2009-01-21
US20110034525A1 (en) 2011-02-10
CA2537832C (en) 2012-01-24
US8022226B2 (en) 2011-09-20
CN1849118A (zh) 2006-10-18
JP2007505111A (ja) 2007-03-08
EP1663206A1 (en) 2006-06-07
IL173530A0 (en) 2006-07-05
DE602004030051D1 (de) 2010-12-23
CO5680444A2 (es) 2006-09-29
AU2004279332B2 (en) 2010-10-07
KR20060119970A (ko) 2006-11-24
SI1663206T1 (sl) 2007-06-30
CA2537832A1 (en) 2005-04-21
US20070004790A1 (en) 2007-01-04
ATE487477T1 (de) 2010-11-15
EP1800679A2 (en) 2007-06-27
KR101145046B1 (ko) 2012-05-21
RU2006113600A (ru) 2007-11-10
ZA200601002B (en) 2007-04-25
RU2345987C2 (ru) 2009-02-10
EP1663206B1 (en) 2007-04-04
DE602004005720D1 (de) 2007-05-16
HK1092704A1 (en) 2007-02-16
MXPA06002668A (es) 2006-06-06
US20050059721A1 (en) 2005-03-17
DE602004005720T2 (de) 2007-12-27
DK1663206T3 (da) 2007-07-30
TWI337999B (en) 2011-03-01
NO20060667L (no) 2006-04-06
WO2005034946A1 (en) 2005-04-21
US20080176918A1 (en) 2008-07-24
ATE358479T1 (de) 2007-04-15
HK1104979A1 (en) 2008-02-01
CN100417379C (zh) 2008-09-10
TW200526591A (en) 2005-08-16
IL173530A (en) 2010-05-31
JP4698591B2 (ja) 2011-06-08
PL379561A1 (pl) 2006-10-16
NZ545181A (en) 2009-07-31
PT1663206E (pt) 2007-06-22
ES2285522T3 (es) 2007-11-16
DK1800679T3 (da) 2011-02-07

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