DK1379239T3 - N(2-aryl-ethyl)-benzyl-aminer som antagonister af 5 HT6 receptoren - Google Patents

N(2-aryl-ethyl)-benzyl-aminer som antagonister af 5 HT6 receptoren

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Publication number
DK1379239T3
DK1379239T3 DK02731094T DK02731094T DK1379239T3 DK 1379239 T3 DK1379239 T3 DK 1379239T3 DK 02731094 T DK02731094 T DK 02731094T DK 02731094 T DK02731094 T DK 02731094T DK 1379239 T3 DK1379239 T3 DK 1379239T3
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DK
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Prior art keywords
antagonists
receptor
benzylamines
aryl
ethyl
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DK02731094T
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Danish (da)
English (en)
Inventor
Zhaogen Chen
Michael Philip Cohen
Matthew Joseph Fisher
Bruno Prestwick Giethlen
James Ronald Gillig
Jefferson Ray Mccowan
Shawn Christopher Miller
John Mehnert Schaus
Original Assignee
Lilly Co Eli
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Publication of DK1379239T3 publication Critical patent/DK1379239T3/da

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
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    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
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    • C07D209/04—Indoles; Hydrogenated indoles
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WO2002078693A3 (en) 2002-12-05
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SK12052003A3 (sk) 2004-09-08
KR100894189B1 (ko) 2009-04-22
BR0208179A (pt) 2004-03-02
HK1061649A1 (en) 2004-09-30
PT1859798E (pt) 2016-03-31
US8044090B2 (en) 2011-10-25
HUP0303651A2 (hu) 2004-03-01
HRP20030771A2 (en) 2005-08-31
HU230322B1 (hu) 2016-01-28
IL157651A (en) 2010-02-17
EA007493B1 (ru) 2006-10-27
CZ20032614A3 (en) 2004-03-17
IL185871A0 (en) 2008-01-06
PL220721B1 (pl) 2015-12-31
CZ305838B6 (cs) 2016-04-06
CA2442114C (en) 2011-06-21
NO20034289L (no) 2003-11-28
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AU2002303094B2 (en) 2006-11-23
ZA200306795B (en) 2005-02-23
ES2566056T3 (es) 2016-04-08
DE60222396T2 (de) 2008-05-15
CY1110362T1 (el) 2015-04-29
HUP0303651A3 (en) 2004-08-30
JP2004532209A (ja) 2004-10-21
DE60222396D1 (de) 2007-10-25
CA2442114A1 (en) 2002-10-10
ATE372768T1 (de) 2007-09-15
SK287463B6 (sk) 2010-10-07
SI1859798T1 (sl) 2016-07-29
US20060009511A9 (en) 2006-01-12
NO20034289D0 (no) 2003-09-25
HRP20030771B1 (en) 2008-10-31
IL157651A0 (en) 2004-03-28
MXPA03008726A (es) 2003-12-12
DK1859798T3 (en) 2016-03-21
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ES2292758T3 (es) 2008-03-16
WO2002078693A2 (en) 2002-10-10
EA200301073A1 (ru) 2004-02-26
US20040132800A1 (en) 2004-07-08
EP1379239B1 (en) 2007-09-12
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US20090306110A1 (en) 2009-12-10

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