DK1234031T3 - B7-h1, et hidtil ukendt immunregulerende molekyle - Google Patents
B7-h1, et hidtil ukendt immunregulerende molekyle Download PDFInfo
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- DK1234031T3 DK1234031T3 DK00983821.0T DK00983821T DK1234031T3 DK 1234031 T3 DK1234031 T3 DK 1234031T3 DK 00983821 T DK00983821 T DK 00983821T DK 1234031 T3 DK1234031 T3 DK 1234031T3
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/524—CH2 domain
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- C07K2317/526—CH3 domain
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70532—B7 molecules, e.g. CD80, CD86
Claims (26)
1. Isoleret polypeptid, hvor polypeptidet består af aminosyrerest 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 eller 32 til aminosyrerest 290 af SEQ ID NO: 1 eller SEQ ID NO: 3.
2. Polypeptid ifølge krav 1 til anvendelse som et medikament.
3. Polypeptid til anvendelse ifølge krav 2, hvor medikamentet er et medikament til administration til et pattedyr, især et pattedyr, som mistænkes for at have en immundefektsygdom, en inflammatorisk tilstand eller en autoimmunsygdom.
4. Nukleinsyre, der koder for polypeptidet ifølge krav 1, hvor nukleinsyren er til anvendelse som et medikament.
5. Rekombinant celle, som er en dattercelle af en celle opnået fra et pattedyr, der er blevet transficeret eller transformeret ex vivo med en nukleinsyre, der koder for polypeptidet ifølge krav 1, således at cellen udtrykker polypeptidet, til anvendelse som et medikament, hvor cellen opnået fra pattedyret ikke er en human embryocelle, og hvor transfektionen eller transformationen med nukleinsyren ikke er en proces til modificering af den genetiske identitet af kimlinjen hos et menneske.
6. Rekombinant celle, som er en dattercelle af en celle opnået fra et pattedyr, der er blevet transficeret eller transformeret ex vivo med et DNA, der omfatter en polypeptidkodende nukleinsyre, hvor nukleinsyren under stringente betingelser hybridiserer til komplementet af en nukleinsyre, der koder for et polypeptid, der omfatter aminosyrer med sekvensen ifølge SEQ ID NO: 1 eller SEQ ID NO: 3, hvor cellen udtrykker polypeptidet, der kodes af nukleinsyren, og hvor den rekombinante celle er til anvendelse som et medikament til behandling af en immundefektsygdom, en inflammatorisk tilstand eller en autoimmunsygdom hos pattedyret, hvor cellen opnået fra pattedyret ikke er en human embryocelle, og hvor transfektionen eller transformationen med nukleinsyren ikke er en proces til modificering af den genetiske identitet af kimlinjen hos et menneske.
7. Rekombinant celle til anvendelse ifølge krav 5 eller 6, hvor cellen er en antigenpræsenterende celle (APC), og cellen udtrykker polypeptidet på dens overflade.
8. Rekombinant celle til anvendelse ifølge krav 7, hvor APC'en er en APC, der er pulseret med et antigen eller et antigent peptid.
9. Isoleret polypeptid, der kodes af et DNA, der omfatter: en polypeptidkodende nukleinsyre, hvor nukleinsyren under stringente betingelser hybridiserer til komplementet af en nukleinsyre, der koder for et polypeptid, der omfatter aminosyrer med sekvensen ifølge SEQ NO: 1 eller SEQ NO: 3, hvor det isolerede polypeptid er til anvendelse som et medikament til administration til et pattedyr, som mistænkes for at have en inflammatorisk tilstand.
10. In vitro-fremgangsmåde til etablering af kontakt med en T-celle, hvilken fremgangsmåde omfatter dyrkning af T-cellen in vitro med polypeptidet ifølge krav 1.
11. Fremgangsmåde til identificering af en forbindelse, der hæmmer et immunrespons, hvilken fremgangsmåde omfatter: (a) tilvejebringelse af en testforbindelse; (b) dyrkning af forbindelsen sammen med et isoleret polypeptid, en T-celle og et molekyle, der leverer et aktiveringssignal til en T-celle; og (c) bestemmelse af, om testforbindelsen hæmmer T-cellens respons på molekylet som indikation af, at testforbindelsen hæmmer et immunrespons, hvor det isolerede polypeptid kodes af et DNA, der omfatter: en polypeptidkodende nukleinsyre, hvilken nukleinsyren under stringente betingelser hybridiserer til komplementet af en nukleinsyre, der koder for et polypeptid, der omfatter aminosyrer med sekvensen ifølge SEQ NO: 1 eller SEQ NO: 3.
12. Fremgangsmåde ifølge krav 11, hvor molekylet er et antistof, der binder til en T-cellereceptor eller et CD3-polypeptid, eller hvor molekylet er et alloantigen eller et antigent peptid, der er bundet til et MHC (major histocompatibility complex)-molekyle på overfladen af en antigenpræsenterende celle (APC) , især en APC, der er transficeret eller transformeret med en nukleinsyre, der koder for polypeptidet, og polypeptidet udtrykkes på overfladen af APC'en.
13. Fremgangsmåde til identificering af en forbindelse, der forstærker et immunrespons, hvilken fremgangsmåde omfatter: (a) tilvejebringelse af en testforbindelse; (b) dyrkning af forbindelsen sammen med et isoleret polypeptid, en T-celle og et molekyle, der leverer et aktiveringssignal til en T-celle; og (c) bestemmelse af, om testforbindelsen forstærker T-cellens respons på molekyle som indikation af, at testforbindelsen forstærker et immunrespons, hvor det isolerede polypeptid kodes af et DNA, der omfatter: en polypeptidkodende nukleinsyre, hvilken nukleinsyre under stringente betingelser hybridiserer til komplementet af en nukleinsyre, der koder for et polypeptid, der omfatter aminosyrer med sekvensen ifølge SEQ NO: 1 eller SEQ NO: 3.
14. Fremgangsmåde ifølge krav 13, hvor molekylet er et antistof, der binder til en T-cellereceptor eller et CD3-polypeptid, eller hvor molekylet er et alloantigen eller et antigent peptid, der er bundet til et MHC-molekyle på overfladen af en APC, især en APC, der er transficeret eller transformeret med en nukleinsyre, der koder for polypeptidet, og polypeptidet udtrykkes på overfladen af APC'en.
15. Antistof, der binder til et polypeptid, der består af aminosyrerest 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 eller 32 til aminosyrerest 290 af SEQ ID NO: 1 eller SEQ ID NO: 3.
16. B7-Hl-molekyle til anvendelse til behandling af en inflammatorisk tilstand, rheumatoid arthritis (RA), multipel sklerose (MS) eller insulinafhængig diabetes mellitus (IDDM), hvor B7-Hl-molekylerne er polypeptider, der kodes af et DNA, der indbefatter en nukleinsyre, der (i) koder for et polypeptid med evnen til at co-stimulere en T-celle og (11) under stringente betingelser hybridiserer til komplementet af en nukleinsyre, der koder for et polypeptid, der omfatter aminosyrer med sekvensen ifølge SEQ ID NO: 1 eller SEQ ID NO: 3, eller polypeptider, der omfatter aminosyrer med sekvensen af aminosyrerest 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 eller 32 til aminosyrerest 290 af SEQ ID NO: 1 eller SEQ ID NO: 3, eller polypeptider, der omfatter aminosyrer med sekvensen ifølge SEQ ID NO: 1 eller SEQ ID NO: 3 eller den ene eller den anden af disse aminosyrer, som kun afviger ved en eller flere konservative substitutioner, eller funktionelle fragmenter af et hvilket som helst af disse polypeptider, hvor et funktionelt fragment af et polypeptid er et fragment af polypeptidet, der er kortere end polypeptidets fulde længde og har evnen til at co-stimulere en T-celle, eller fusionsproteiner, der indeholder et første domæne og mindst ét yderligere domæne, hvor det første domæne er et hvilket som helst af polypeptiderne eller de funktionelle fragmenter, eller et hvilket som helst af polypeptiderne og de funktionelle fragmenter, der er modificeret ved tilføjelse i den amino-og/eller carboxylterminale ende af et blokeringsmiddel til fremme af overlevelse af det relevante polypeptid in vivo, eller et hvilket som helst af polypeptiderne og de funktionelle fragmenter, der er kovalent eller ikke-kovalent bundet til farmaceutisk acceptable bæreproteiner.
17. B7-Hl-molekyler til anvendelse ifølge krav 16, hvor den inflammatoriske tilstand er en inflammatorisk tilstand, der er induceret af et smitstof.
18. Fremgangsmåde til co-stimulering af en T-celle, der omfatter etablering af kontakt af en kombination, der omfatter et B7-Hl-polypeptid og (a) et antistof, der binder til en T-cellereceptor (TCR), eller (b) et polypeptid af CD3- komplekset, der er fysisk forbundet med TCR'en, med en CD4+-T-celle eller en CD8+-T-celle in vitro, eller etablering af kontakt af en kombination, der omfatter et B7-Hl-polypeptid og et MHC-alloantigen, med en CD8+-T-celle in vitro, hvor B7-H1-polypeptidet er et polypeptid, der kodes af et DNA, der omfatter en nukleinsyre med en sekvens, der (i) koder for et polypeptid med evnen til at co-stimulere en T-celle og (11) under stringente betingelser hybridiserer til komplementet af en nukleinsyre, der koder for et polypeptid, der omfatter aminosyrer med sekvensen ifølge SEQ ID NO: 1 eller SEQ ID NO: 3, eller et polypeptid, der omfatter aminosyrer med sekvensen af aminosyrerest 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 eller 32 til aminosyrerest 290 af SEQ ID NO: 1 eller SEQ ID NO: 3, eller et polypeptid, der omfatter aminosyrer med sekvensen ifølge SEQ ID NO: 1 eller SEQ ID NO: 3 eller den ene eller den anden af disse aminosyrer, som kun afviger ved en eller flere konservative substitutioner, eller et funktionelt fragment af et hvilket som helst af disse polypeptider, hvor et funktionelt fragment af et polypeptid er et fragment af polypeptidet, der er kortere end polypeptidets fulde længde og har evnen til at co-stimulere en T-celle, eller et fusionsprotein, der indeholder et første domæne og mindst ét yderligere domæne, hvor det første domæne er et hvilket som helst af polypeptiderne eller det funktionelle fragment, eller et hvilket som helst af polypeptiderne eller det funktionelle fragment, der er modificeret ved tilføjelse i den amino-og/eller carboxylterminale ende af et blokeringsmiddel til fremme af overlevelse af det relevante polypeptid in vivo, eller et hvilket som helst af polypeptiderne eller det funktionelle fragment, der er kovalent eller ikke-kovalent bundet til et farmaceutisk acceptabelt bæreprotein.
19. Fremgangsmåde ifølge krav 18, hvor antistoffet binder til et polypeptid af CD3-komplekset, der er fysisk forbundet TCR'en.
20. Fremgangsmåde til co-stimulering af en T-celle, der omfatter etablering af kontakt af en kombination, der omfatter et B7-Hl-polypeptid og (a) et MHC-alloantigen eller (b) et antistof, der binder til en T-cellereceptor (TCR), eller (c) et polypeptid af CD3-komplekset, der er fysisk forbundet med TCR'en, med T-cellen in vitro, hvor B7-Hl-polypeptidet er bundet til bunden af en dyrkningsbeholder, især en brønd på en plastikmikrotiterplade, og hvor B7-Hl-polypeptidet er et polypeptid, der kodes af et DNA, der omfatter en nukleinsyre med en sekvens, der (i) koder for et polypeptid med evnen til at co-stimulere en T-celle og (ii) under stringente betingelser hybridiserer til komplementet af en nukleinsyre, der koder for et polypeptid, der omfatter aminosyrer med sekvensen ifølge SEQ ID NO: 1 eller SEQ ID NO: 3, eller et polypeptid, der omfatter aminosyrer med sekvensen af aminosyrerest 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 eller 32 til aminosyrerest 290 af SEQ ID NO: 1 eller SEQ ID NO: 3, eller et polypeptid, der omfatter aminosyrer med sekvensen ifølge SEQ ID NO: 1 eller SEQ ID NO: 3 eller den ene eller den anden af disse aminosyrer, som kun afviger ved en eller flere konservative substitutioner, eller et funktionelt fragment af et hvilket som helst af disse polypeptider, hvor et funktionelt fragment af et polypeptid er et fragment af polypeptidet, der er kortere end polypeptidets fulde længde og har evnen til at co-stimulere en T-celle, eller et fusionsprotein, der indeholder et første domæne og mindst ét yderligere domæne, hvor det første domæne er et hvilket som helst af polypeptiderne eller det funktionelle fragment, eller et hvilket som helst af polypeptiderne eller det funktionelle fragment, der er modificeret ved tilføjelse i den amino-og/eller carboxylterminale ende af et blokeringsmiddel til fremme af overlevelse af det relevante polypeptid in vivo, eller et hvilket som helst af polypeptiderne eller det funktionelle fragment, der er kovalent eller ikke-kovalent bundet til et farmaceutisk acceptabelt bæreprotein.
21. Fremgangsmåde ifølge krav 20, hvor antistoffet binder til et polypeptid af CD3-komplekset, der er fysisk forbundet med TOR'en.
22. Anvendelse af en opløsning eller en fast understøtning, der omfatter et B7-Hl-polypeptid eller -polypeptidfragment og et molekyle, der leverer et aktiveringssignal til en T-celle, til ex vivo-behandling af mononukleære celler fra perifert blod (PBMC), hvor B7-Hl-polypeptidet er et polypeptid, der kodes af et DNA, der omfatter en nukleinsyre med en sekvens, der (i) koder for et polypeptid med evnen til at co-stimulere en T-celle og (ii) under stringente betingelser hybridiserer til komplementet af en nukleinsyre, der koder for et polypeptid, der omfatter aminosyrer med sekvensen ifølge SEQ ID NO: 1 eller SEQ ID NO: 3, eller et polypeptid, der omfatter aminosyrer med sekvensen af aminosyrerest 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 eller 32 til aminosyrerest 290 af SEQ ID NO: 1 eller SEQ ID NO: 3, eller et polypeptid, der omfatter aminosyrer med sekvensen ifølge SEQ ID NO: 1 eller SEQ ID NO: 3 eller den ene eller den anden af disse aminosyrer, som kun afviger ved en eller flere konservative substitutioner, eller et funktionelt fragment af et hvilket som helst af disse polypeptider, hvor et funktionelt fragment af et polypeptid er et fragment af polypeptidet, der er kortere end polypeptidets fulde længde og har evnen til at co-stimulere en T-celle, eller et fusionsprotein, der indeholder et første domæne og mindst ét yderligere domæne, hvor det første domæne er et hvilket som helst af polypeptiderne eller det funktionelle fragment, eller et hvilket som helst af polypeptiderne eller det funktionelle fragment, der er modificeret ved tilføjelse i den amino-og/eller carboxylterminale ende af et blokeringsmiddel til fremme af overlevelse af det relevante polypeptid in vivo, eller et hvilket som helst af polypeptiderne eller det funktionelle fragment, der er kovalent eller ikke-kovalent bundet til et farmaceutisk acceptabelt bæreprotein.
23. Anvendelse ifølge krav 22, hvor aktiveringssignalet leveres til T-cellen via den antigenspecifikke T-cellereceptor (TCR).
24. Anvendelse ifølge krav 22 eller 23, hvor molekylet er et antistof, der binder til TCR'en eller til et polypeptid af CD3-komplekset, der er fysisk forbundet med TCR'en på Τ'-celleoverfladen, et alloantigen eller et antigent peptid, der er bundet til et MHC-molekyle.
25. Fusionsprotein, der omfatter det ekstracellulære domæne af human B7-H1, som er fusioneret med Fc-delen af muse-IgG2a (hB7-HHg) , hvor B7-H1 er et polypeptid, der kodes af et DNA, der omfatter en nukleinsyre med en sekvens, der (i) koder for et polypeptid med evnen til at co-stimulere en T-celle og (i i) under stringente betingelser hybridiserer til komplementet af en nukleinsyre, der koder for et polypeptid, der omfatter aminosyrer med sekvensen ifølge SEQ ID NO: 1, eller et polypeptid, der omfatter aminosyrer med sekvensen af aminosyrerest 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 eller 32 til aminosyrerest 290 af SEQ ID NO: 1, eller et polypeptid, der omfatter aminosyrer med sekvensen ifølge SEQ ID NO: 1 eller omfatter aminosyrer med sekvensen ifølge SEQ ID NO: 1, som kun afviger ved en eller flere konservative substitutioner, eller et funktionelt fragment af et hvilket som helst af disse polypeptider, hvor et funktionelt fragment af et polypeptid er et fragment af polypeptidet, der er kortere end polypeptidets fulde længde og har evnen til at co-stimulere en T-celle, eller et fusionsprotein, der indeholder et første domæne og mindst ét yderligere domæne, hvor det første domæne er et hvilket som helst af polypeptiderne eller det funktionelle fragment, eller et hvilket som helst af polypeptiderne eller det funktionelle fragment, der er modificeret ved tilføjelse i den amino-og/eller carboxylterminale ende af et blokeringsmiddel til fremme af overlevelse af det relevante polypeptid in vivo, eller et hvilket som helst af polypeptiderne eller det funktionelle fragment, der er kovalent eller ikke-kovalent bundet til et farmaceutisk acceptabelt bæreprotein.
26. Fremgangsmåde til hæmning af en co-stimulerende virkning af human B7-H1 på T-celler, hvor T-cellerne bringes i kontakt med antistoffer, der binder specifikt til et polypeptid med sekvensen ifølge SEQ ID NO: 1 in vitro, hvor den co-stimulerende virkning af B7-H1 på T-cellerne omfatter forstærkning af et effektorrespons, et hjælperespons eller et suppressivt respons af T-cellerne.
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US09/451,291 US6803192B1 (en) | 1999-11-30 | 1999-11-30 | B7-H1, a novel immunoregulatory molecule |
US64910800A | 2000-08-28 | 2000-08-28 | |
PCT/US2000/032583 WO2001039722A2 (en) | 1999-11-30 | 2000-11-30 | B7-h1, a novel immunoregulatory molecule |
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Families Citing this family (222)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL148021A0 (en) * | 1999-08-23 | 2002-09-12 | Dana Farber Cancer Inst Inc | Novel b7-4 molecules and uses therefor |
PT1210428E (pt) | 1999-08-23 | 2015-07-21 | Genetics Inst Llc | Pd-1, um recetor para b7-4 e suas utilizações |
CA2392477A1 (en) | 1999-11-30 | 2001-06-07 | Mayo Foundation For Medical Education And Research | B7-h1, a novel immunoregulatory molecule |
AU2001275285A1 (en) | 2000-06-06 | 2001-12-17 | Bristol-Myers Squibb Company | B7-related nucleic acids and polypeptides and their uses for immunomodulation |
US20030031675A1 (en) | 2000-06-06 | 2003-02-13 | Mikesell Glen E. | B7-related nucleic acids and polypeptides useful for immunomodulation |
AU7309601A (en) | 2000-06-28 | 2002-01-08 | Genetics Inst | Pd-l2 molecules: novel pd-1 ligands and uses therefor |
US7794710B2 (en) * | 2001-04-20 | 2010-09-14 | Mayo Foundation For Medical Education And Research | Methods of enhancing T cell responsiveness |
EP1456652A4 (en) * | 2001-11-13 | 2005-11-02 | Dana Farber Cancer Inst Inc | IMMUNOCELL ACTIVATION MODULATING SUBSTANCES AND USE METHOD THEREFOR |
JP4409430B2 (ja) | 2002-07-03 | 2010-02-03 | 小野薬品工業株式会社 | 免疫賦活組成物 |
WO2004060911A2 (en) | 2002-12-30 | 2004-07-22 | Amgen Inc. | Combination therapy with co-stimulatory factors |
MX2007004176A (es) | 2004-10-06 | 2007-06-15 | Mayo Foundation | B7-h1 y metodos de diagnosis, prognosis, y tratamiento de cancer. |
CN109485727A (zh) | 2005-05-09 | 2019-03-19 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
BRPI0611766A2 (pt) | 2005-06-08 | 2011-12-20 | Dana Farber Cancer Inst Inc | métodos e composições para o tratamento de infecções persistentes e cáncer por inibição da rota de morte celular programada |
DK1907424T3 (da) | 2005-07-01 | 2015-11-09 | Squibb & Sons Llc | Humane monoklonale antistoffer mod programmeret dødsligand 1 (pd-l1) |
US8216996B2 (en) | 2006-03-03 | 2012-07-10 | Ono Pharmaceutical Co., Ltd. | Multimer of extracellular domain of cell surface functional molecule |
WO2007124361A2 (en) * | 2006-04-20 | 2007-11-01 | Mayo Foundation For Medical Education And Research | Soluble b7-h1 |
WO2010063011A2 (en) | 2008-11-28 | 2010-06-03 | Emory University | Methods for the treatment of infections and tumors |
BRPI0917592B1 (pt) | 2008-12-09 | 2021-08-17 | Genentech, Inc | Anticorpo anti-pd-l1, composição, artigos manufaturados e usos de uma composição |
US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
US9783578B2 (en) | 2010-06-25 | 2017-10-10 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
KR101970025B1 (ko) | 2011-04-20 | 2019-04-17 | 메디뮨 엘엘씨 | B7-h1 및 pd-1과 결합하는 항체 및 다른 분자들 |
US9096642B2 (en) | 2011-06-08 | 2015-08-04 | Aurigene Discovery Technologies Limited | Therapeutic compounds for immunomodulation |
EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
HUE052198T2 (hu) | 2011-07-21 | 2021-04-28 | Sumitomo Dainippon Pharma Oncology Inc | Heterociklusos protein kináz inhibitorok |
WO2013173223A1 (en) | 2012-05-15 | 2013-11-21 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
US9302005B2 (en) | 2013-03-14 | 2016-04-05 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
KR102158924B1 (ko) | 2013-03-15 | 2020-09-22 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
WO2014194293A1 (en) | 2013-05-30 | 2014-12-04 | Amplimmune, Inc. | Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof |
EP3178849B1 (en) | 2013-09-20 | 2019-03-20 | Bristol-Myers Squibb Company | Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors |
EP3757130A1 (en) | 2013-09-26 | 2020-12-30 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
US10259875B2 (en) | 2013-10-01 | 2019-04-16 | Mayo Foundation For Medical Education And Research | Methods for treating cancer in patients with elevated levels of BIM |
DE202014010499U1 (de) | 2013-12-17 | 2015-10-20 | Kymab Limited | Targeting von humaner PCSK9 zur Cholesterinbehandlung |
US20160340407A1 (en) * | 2014-01-14 | 2016-11-24 | Dana-Farber Camcer Institute, Inc. | Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms |
HUE057917T2 (hu) | 2014-01-15 | 2022-06-28 | Kadmon Corp Llc | Immunmodulátor szerek |
TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
WO2015179654A1 (en) | 2014-05-22 | 2015-11-26 | Mayo Foundation For Medical Education And Research | Distinguishing antagonistic and agonistic anti b7-h1 antibodies |
WO2015181342A1 (en) | 2014-05-29 | 2015-12-03 | Spring Bioscience Corporation | Pd-l1 antibodies and uses thereof |
EP3151921B1 (en) | 2014-06-06 | 2019-08-28 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof |
TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
JP7032929B2 (ja) | 2014-07-11 | 2022-03-09 | ヴェンタナ メディカル システムズ, インク. | 抗pd-l1抗体及びその診断上の使用 |
WO2016014148A1 (en) | 2014-07-23 | 2016-01-28 | Mayo Foundation For Medical Education And Research | Targeting dna-pkcs and b7-h1 to treat cancer |
EP3191097B1 (en) | 2014-09-13 | 2019-10-23 | Novartis AG | Combination therapies |
MX2017004810A (es) | 2014-10-14 | 2017-10-16 | Novartis Ag | Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas. |
TWI758928B (zh) | 2014-11-21 | 2022-03-21 | 美商必治妥美雅史谷比公司 | 抗cd73抗體及其用途 |
HUE052526T2 (hu) | 2014-11-21 | 2021-05-28 | Bristol Myers Squibb Co | Antitestek, amelyek tartalmaznak módosított nehéz konstans régiókat |
US10975442B2 (en) | 2014-12-19 | 2021-04-13 | Massachusetts Institute Of Technology | Molecular biomarkers for cancer immunotherapy |
CA2971732A1 (en) | 2014-12-23 | 2016-06-30 | Bristol-Myers Squibb Company | Antibodies to tigit |
WO2016124558A1 (en) | 2015-02-03 | 2016-08-11 | Ventana Medical Systems, Inc. | Histochemical assay for evaluating expression of programmed death ligand 1 (pd-l1) |
MA41460A (fr) | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | Agents de liaison à la tnfrsf et leurs utilisations |
US10983128B2 (en) | 2015-02-05 | 2021-04-20 | Bristol-Myers Squibb Company | CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy |
CN107530341B (zh) | 2015-03-06 | 2021-10-01 | 大连万春布林医药有限公司 | 治疗与ras突变相关的癌症的方法 |
RU2728796C2 (ru) | 2015-03-06 | 2020-07-31 | Бейондспринг Фармасьютикалс, Инк. | Способ лечения опухоли головного мозга |
IL292449B2 (en) | 2015-03-13 | 2024-02-01 | Cytomx Therapeutics Inc | Nucleic acids encoding antibodies against PDL1 and methods for their preparation |
US11060150B2 (en) | 2015-03-17 | 2021-07-13 | Mayo Foundation For Medical Education And Research | Methods and materials for assessing and treating cancer |
LT3303396T (lt) | 2015-05-29 | 2023-01-10 | Bristol-Myers Squibb Company | Antikūnai prieš ox40 ir jų panaudojimo būdai |
CN113603784A (zh) | 2015-05-29 | 2021-11-05 | 艾吉纳斯公司 | 抗-ctla-4抗体及其使用方法 |
TW201709929A (zh) | 2015-06-12 | 2017-03-16 | 宏觀基因股份有限公司 | 治療癌症的聯合療法 |
EA201890162A1 (ru) | 2015-06-29 | 2018-07-31 | Бристол-Маерс Сквибб Компани | Антитела к cd40 с повышенной агонистической активностью |
SG10202108194XA (en) | 2015-07-13 | 2021-09-29 | Beyondspring Pharmaceuticals Inc | Plinabulin compositions |
KR20180040138A (ko) | 2015-07-13 | 2018-04-19 | 싸이톰스 테라퓨틱스, 인크. | 항pd-1 항체, 활성화 가능한 항pd-1 항체, 및 이들의 사용 방법 |
US10682390B2 (en) | 2015-07-16 | 2020-06-16 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
MD3456346T2 (ro) | 2015-07-30 | 2021-11-30 | Macrogenics Inc | Molecule de legare la PD-1 și LAG-3 și metode de utilizare a acestora |
AR105654A1 (es) | 2015-08-24 | 2017-10-25 | Lilly Co Eli | Anticuerpos pd-l1 (ligando 1 de muerte celular programada) |
RU2731202C2 (ru) | 2015-10-08 | 2020-08-31 | Макродженикс, Инк. | Комбинированная терапия для лечения рака |
CN108135934A (zh) | 2015-10-19 | 2018-06-08 | 永恒生物科技股份有限公司 | 通过组合疗法治疗实体或淋巴肿瘤的方法 |
WO2017075045A2 (en) | 2015-10-30 | 2017-05-04 | Mayo Foundation For Medical Education And Research | Antibodies to b7-h1 |
CN109608544B (zh) | 2015-11-17 | 2022-09-16 | 苏州盛迪亚生物医药有限公司 | Pd-l1抗体、其抗原结合片段及其医药用途 |
AU2016356780A1 (en) | 2015-11-19 | 2018-06-28 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof |
UA125611C2 (uk) | 2015-12-14 | 2022-05-04 | Макродженікс, Інк. | Біспецифічні молекули, що мають імунореактивність відносно pd-1 і ctla-4, і способи їх застосування |
IL259988B2 (en) | 2015-12-15 | 2023-02-01 | Oncoimmune Inc | Chimeric and humanized monoclonal antibodies against ctla-4 and uses thereof |
CA3013467A1 (en) | 2016-02-08 | 2017-08-17 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
US20190284293A1 (en) | 2016-03-04 | 2019-09-19 | Bristol-Myers Squibb Company | Combination therapy with anti-cd73 antibodies |
US11497781B2 (en) | 2016-03-10 | 2022-11-15 | Cg Oncology, Inc. | Methods of treating bladder cancer by combination therapy comprising the oncolytic adenovirus CG0070 and an immune checkpoint inhibitor |
SG11201808821WA (en) | 2016-04-18 | 2018-11-29 | Celldex Therapeutics Inc | Agonistic antibodies that bind human cd40 and uses thereof |
WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
TWI822521B (zh) | 2016-05-13 | 2023-11-11 | 美商再生元醫藥公司 | 藉由投予pd-1抑制劑治療皮膚癌之方法 |
TWI781934B (zh) | 2016-05-27 | 2022-11-01 | 美商艾吉納斯公司 | 抗-tim-3抗體及其使用方法 |
WO2017210335A1 (en) | 2016-06-01 | 2017-12-07 | Bristol-Myers Squibb Company | Imaging methods using 18f-radiolabeled biologics |
ES2965957T3 (es) | 2016-06-02 | 2024-04-17 | Ultimovacs Asa | Una vacuna junto con un inhibidor del punto de control inmunitario para usar en el tratamiento del cáncer |
BR112018074990A2 (pt) | 2016-06-06 | 2019-03-12 | Beyondspring Pharmaceuticals, Inc. | composição, usos e método para reduzir neutropenia |
CN109715196A (zh) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | 用于促进免疫细胞功能的组合物和方法 |
CN117683135A (zh) | 2016-07-14 | 2024-03-12 | 百时美施贵宝公司 | 针对tim3的抗体及其用途 |
WO2018057825A1 (en) * | 2016-09-23 | 2018-03-29 | The Curators Of The University Of Missouri | Antigen-specific immune modulation |
TW202246349A (zh) | 2016-10-11 | 2022-12-01 | 美商艾吉納斯公司 | 抗lag-3抗體及其使用方法 |
WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
BR112019011582A2 (pt) | 2016-12-07 | 2019-10-22 | Agenus Inc. | anticorpos e métodos de utilização dos mesmos |
MD3551660T2 (ro) | 2016-12-07 | 2024-03-31 | Agenus Inc | Anticorpi anti-CTLA-4 și procedee de utilizare a acestora |
AU2017378226A1 (en) | 2016-12-14 | 2019-06-20 | Janssen Biotech, Inc. | CD8A-binding fibronectin type III domains |
US10611823B2 (en) | 2016-12-14 | 2020-04-07 | Hanssen Biotech, Inc | CD137 binding fibronectin type III domains |
US10597438B2 (en) | 2016-12-14 | 2020-03-24 | Janssen Biotech, Inc. | PD-L1 binding fibronectin type III domains |
US11633393B2 (en) | 2017-01-06 | 2023-04-25 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
JP2020503883A (ja) | 2017-01-13 | 2020-02-06 | アジェナス インコーポレイテッド | Ny−eso−1に結合するt細胞受容体およびその使用方法 |
EP3576733A4 (en) | 2017-02-01 | 2020-11-25 | Beyondspring Pharmaceuticals, Inc. | METHOD OF REDUCING NEUTROPENIA |
BR112019017628A2 (pt) | 2017-02-24 | 2020-07-07 | Macrogenics, Inc. | molécula de ligação a cd137 x ta, composições farmacêuticas, uso da molécula de ligação a cd137 x ta, molécula de ligação a cd137, uso da molécula de ligação a cd137, molécula de ligação a her2/neu, uso da molécula de ligação a her2/neu, e uso de uma composição |
US11603407B2 (en) | 2017-04-06 | 2023-03-14 | Regeneron Pharmaceuticals, Inc. | Stable antibody formulation |
TW201841942A (zh) | 2017-04-13 | 2018-12-01 | 美商艾吉納斯公司 | 抗cd137抗體及其使用方法 |
WO2018200430A1 (en) | 2017-04-26 | 2018-11-01 | Bristol-Myers Squibb Company | Methods of antibody production that minimize disulfide bond reduction |
AR111651A1 (es) | 2017-04-28 | 2019-08-07 | Novartis Ag | Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación |
RS64576B1 (sr) | 2017-05-01 | 2023-10-31 | Agenus Inc | Anti-tigit antitela i postupci njihove primene |
KR20200013241A (ko) | 2017-05-25 | 2020-02-06 | 브리스톨-마이어스 스큅 컴퍼니 | 변형된 중쇄 불변 영역을 포함하는 항체 |
EP3630842A2 (en) | 2017-05-30 | 2020-04-08 | Bristol-Myers Squibb Company | Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent |
US11723975B2 (en) | 2017-05-30 | 2023-08-15 | Bristol-Myers Squibb Company | Compositions comprising an anti-LAG-3 antibody or an anti-LAG-3 antibody and an anti-PD-1 or anti-PD-L1 antibody |
CN110720039A (zh) | 2017-05-30 | 2020-01-21 | 百时美施贵宝公司 | Lag-3阳性肿瘤的治疗 |
AU2018278327B2 (en) | 2017-06-01 | 2023-03-16 | Cytomx Therapeutics, Inc. | Activatable anti-pdl1 antibodies and methods of use thereof |
WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
WO2018235056A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | IL-1BETA BINDING ANTIBODIES FOR USE IN THE TREATMENT OF CANCER |
US20200172628A1 (en) | 2017-06-22 | 2020-06-04 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
CN110785187B (zh) | 2017-06-22 | 2024-04-05 | 诺华股份有限公司 | 针对cd73的抗体分子及其用途 |
US20190048072A1 (en) | 2017-06-22 | 2019-02-14 | Novartis Ag | USE OF IL-1beta BINDING ANTIBODIES |
JP2020525483A (ja) | 2017-06-27 | 2020-08-27 | ノバルティス アーゲー | 抗tim−3抗体のための投与レジメンおよびその使用 |
US11560425B2 (en) | 2017-06-27 | 2023-01-24 | Neuracle Science Co., Ltd. | Use of anti-FAM19A5 antibodies for treating cancers |
AU2018302283A1 (en) | 2017-07-20 | 2020-02-06 | Novartis Ag | Dosage regimens of anti-LAG-3 antibodies and uses thereof |
SG11202001319QA (en) | 2017-09-04 | 2020-03-30 | Agenus Inc | T cell receptors that bind to mixed lineage leukemia (mll)-specific phosphopeptides and methods of use thereof |
US11497756B2 (en) | 2017-09-12 | 2022-11-15 | Sumitomo Pharma Oncology, Inc. | Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib |
WO2019075090A1 (en) | 2017-10-10 | 2019-04-18 | Tilos Therapeutics, Inc. | ANTI-LAP ANTIBODIES AND USES THEREOF |
US20210040205A1 (en) | 2017-10-25 | 2021-02-11 | Novartis Ag | Antibodies targeting cd32b and methods of use thereof |
JP2021501801A (ja) | 2017-11-01 | 2021-01-21 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 癌の処置に用いるための免疫刺激アゴニスト抗体 |
WO2019133747A1 (en) | 2017-12-27 | 2019-07-04 | Bristol-Myers Squibb Company | Anti-cd40 antibodies and uses thereof |
EP3737408A1 (en) | 2018-01-08 | 2020-11-18 | Novartis AG | Immune-enhancing rnas for combination with chimeric antigen receptor therapy |
BR112020013475A2 (pt) | 2018-01-10 | 2020-12-08 | Jiangsu Hengrui Medicine Co., Ltd. | Anticorpo de pd-l1, fragmento de ligação ao antígeno do mesmo, e uso farmacêutico do mesmo |
KR20200108870A (ko) | 2018-01-12 | 2020-09-21 | 브리스톨-마이어스 스큅 컴퍼니 | Tim3에 대한 항체 및 그의 용도 |
WO2019144126A1 (en) | 2018-01-22 | 2019-07-25 | Pascal Biosciences Inc. | Cannabinoids and derivatives for promoting immunogenicity of tumor and infected cells |
WO2019147615A1 (en) | 2018-01-24 | 2019-08-01 | Beyondspring Pharmaceuticals, Inc. | Composition and method for reducing thrombocytopenia via the administration of plinabulin |
WO2019152660A1 (en) | 2018-01-31 | 2019-08-08 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
WO2019157124A1 (en) | 2018-02-08 | 2019-08-15 | Bristol-Myers Squibb Company | Combination of a tetanus toxoid, anti-ox40 antibody and/or anti-pd-1 antibody to treat tumors |
WO2019160956A1 (en) | 2018-02-13 | 2019-08-22 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
CA3092470A1 (en) | 2018-02-27 | 2019-09-06 | Incyte Corporation | Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors |
CA3092589A1 (en) | 2018-03-21 | 2019-09-26 | Five Prime Therapeutics, Inc. | Antibodies binding to vista at acidic ph |
US20210147547A1 (en) | 2018-04-13 | 2021-05-20 | Novartis Ag | Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof |
AU2019256383A1 (en) | 2018-04-17 | 2020-11-26 | Celldex Therapeutics, Inc. | Anti-CD27 and anti-PD-L1 antibodies and bispecific constructs |
CA3096909A1 (en) | 2018-04-26 | 2019-10-31 | Agenus Inc. | Heat shock protein-binding peptide compositions and methods of use thereof |
JP7391046B2 (ja) | 2018-05-18 | 2023-12-04 | インサイト・コーポレイション | A2a/a2b阻害剤としての縮合ピリミジン誘導体 |
TW202015726A (zh) | 2018-05-30 | 2020-05-01 | 瑞士商諾華公司 | Entpd2抗體、組合療法、及使用該等抗體和組合療法之方法 |
WO2019232244A2 (en) | 2018-05-31 | 2019-12-05 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
EP3802611A2 (en) | 2018-06-01 | 2021-04-14 | Novartis AG | Binding molecules against bcma and uses thereof |
CA3104467A1 (en) | 2018-06-20 | 2019-12-26 | Incyte Corporation | Anti-pd-1 antibodies and uses thereof |
JP7411627B2 (ja) | 2018-07-09 | 2024-01-11 | ファイヴ プライム セラピューティクス インク | Ilt4と結合する抗体 |
AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
IL278951B (en) | 2018-07-10 | 2022-08-01 | Novartis Ag | History of 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-6,2-dione and their use in the treatment of ikzf2-dependent diseases |
MX2021000213A (es) | 2018-07-11 | 2021-03-25 | Five Prime Therapeutics Inc | Anticuerpos de union al supresor de activacion de linfocitos t que contiene inmunoglobulina con dominio v (vista) a ph acidico. |
US20210277135A1 (en) | 2018-07-13 | 2021-09-09 | Bristol-Myers Squibb Company | Ox-40 agonist, pd-1 pathway inhibitor and ctla-4 inhibitor combination for use in a method of treating a cancer or a solid tumor |
BR112021000727A2 (pt) | 2018-07-20 | 2021-04-13 | Surface Oncology, Inc. | Composições anti-cd112r e métodos |
SG11202100693UA (en) | 2018-07-26 | 2021-02-25 | Bristol Myers Squibb Co | Lag-3 combination therapy for the treatment of cancer |
US11130802B2 (en) | 2018-10-10 | 2021-09-28 | Tilos Therapeutics, Inc. | Anti-lap antibody variants |
WO2020081493A1 (en) | 2018-10-16 | 2020-04-23 | Molecular Templates, Inc. | Pd-l1 binding proteins |
WO2020089811A1 (en) | 2018-10-31 | 2020-05-07 | Novartis Ag | Dc-sign antibody drug conjugates |
SG11202104864QA (en) | 2018-11-13 | 2021-06-29 | Compass Therapeutics Llc | Multispecific binding constructs against checkpoint molecules and uses thereof |
US20220008515A1 (en) | 2018-11-16 | 2022-01-13 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of il-7 protein and an immune checkpoint inhibitor |
EP3887397A1 (en) | 2018-11-28 | 2021-10-06 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
CN113490499A (zh) | 2018-12-04 | 2021-10-08 | 大日本住友制药肿瘤公司 | 用作治疗癌症的活性剂的cdk9抑制剂及其多晶型物 |
MX2021007392A (es) | 2018-12-20 | 2021-08-24 | Novartis Ag | Regimen de dosificacion y combinacion farmaceutica que comprende derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona. |
WO2020128637A1 (en) | 2018-12-21 | 2020-06-25 | Novartis Ag | Use of il-1 binding antibodies in the treatment of a msi-h cancer |
SG11202104699TA (en) | 2018-12-21 | 2021-07-29 | Novartis Ag | Use of il-1 beta antibodies in the treatment or prevention of myelodysplastic syndrome |
JP2022514087A (ja) | 2018-12-21 | 2022-02-09 | ノバルティス アーゲー | IL-1β結合抗体の使用 |
AU2019408408A1 (en) | 2018-12-21 | 2021-06-03 | Valerio Therapeutics | New conjugated nucleic acid molecules and their uses |
US20220025036A1 (en) | 2018-12-21 | 2022-01-27 | Novartis Ag | Use of il-1beta binding antibodies |
TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
US20220098304A1 (en) | 2019-02-03 | 2022-03-31 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-pd-1 antibody, antigen-binding fragment thereof and pharmaceutical use thereof |
JP2022520361A (ja) | 2019-02-12 | 2022-03-30 | スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド | 複素環式タンパク質キナーゼ阻害剤を含む製剤 |
US20220107320A1 (en) | 2019-02-15 | 2022-04-07 | Incelldx, Inc. | Assaying Bladder-Associated Samples, Identifying and Treating Bladder-Associated Neoplasia, and Kits for Use Therein |
KR20210129672A (ko) | 2019-02-15 | 2021-10-28 | 노파르티스 아게 | 치환된 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체 및 이의 용도 |
JP2022520811A (ja) | 2019-02-15 | 2022-04-01 | ノバルティス アーゲー | 3-(1-オキソ-5-(ピペリジン-4-イル)イソインドリン-2-イル)ピペリジン-2,6-ジオン誘導体及びその使用 |
WO2020191326A1 (en) | 2019-03-20 | 2020-09-24 | Sumitomo Dainippon Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (aml) with venetoclax failure |
AU2020245437A1 (en) | 2019-03-22 | 2021-09-30 | Sumitomo Pharma Oncology, Inc. | Compositions comprising PKM2 modulators and methods of treatment using the same |
CA3145864A1 (en) | 2019-07-03 | 2021-01-07 | Sumitomo Dainippon Pharma Oncology, Inc. | Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof |
WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
JP2022545741A (ja) | 2019-08-30 | 2022-10-28 | アジェナス インコーポレイテッド | 抗cd96抗体およびその使用方法 |
TW202124446A (zh) | 2019-09-18 | 2021-07-01 | 瑞士商諾華公司 | 與entpd2抗體之組合療法 |
WO2021055816A1 (en) | 2019-09-18 | 2021-03-25 | Molecular Templates, Inc. | Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds |
CN114423793A (zh) | 2019-09-18 | 2022-04-29 | 分子模板公司 | 包含志贺菌毒素a亚基支架的pd-l1结合分子 |
US20220348651A1 (en) | 2019-09-18 | 2022-11-03 | Novartis Ag | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
JP2022548292A (ja) | 2019-09-19 | 2022-11-17 | ブリストル-マイヤーズ スクイブ カンパニー | 酸性pHでVISTAと結合する抗体 |
US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
US11628222B2 (en) | 2019-10-14 | 2023-04-18 | Aro Biotherapeutics Company | CD71 binding fibronectin type III domains |
TW202128191A (zh) | 2019-10-21 | 2021-08-01 | 瑞士商諾華公司 | Tim-3抑制劑及其用途 |
CN114786679A (zh) | 2019-10-21 | 2022-07-22 | 诺华股份有限公司 | 具有维奈托克和tim-3抑制剂的组合疗法 |
US20220395553A1 (en) | 2019-11-14 | 2022-12-15 | Cohbar, Inc. | Cxcr4 antagonist peptides |
WO2021102343A1 (en) | 2019-11-22 | 2021-05-27 | Sumitomo Dainippon Pharma Oncology, Inc. | Solid dose pharmaceutical composition |
EP4070113A4 (en) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS |
WO2021123902A1 (en) | 2019-12-20 | 2021-06-24 | Novartis Ag | Combination of anti tim-3 antibody mbg453 and anti tgf-beta antibody nis793, with or without decitabine or the anti pd-1 antibody spartalizumab, for treating myelofibrosis and myelodysplastic syndrome |
TW202135824A (zh) | 2020-01-03 | 2021-10-01 | 美商英塞特公司 | 包含a2a/a2b及pd-1/pd-l1抑制劑之組合療法 |
IL293752A (en) | 2020-01-17 | 2022-08-01 | Novartis Ag | A combination containing a tim-3 inhibitor and a substance that causes hypomethylation for use in the treatment of myeloplastic syndrome or chronic myelomonocytic leukemia |
CA3161513A1 (en) | 2020-01-28 | 2021-08-05 | Irwin DAVIDSON | Antisense oligonucleotide targeting linc00518 for treating melanoma |
KR20220133996A (ko) | 2020-01-30 | 2022-10-05 | 오엔에이 테라퓨틱스 에스.엘. | 암 및 암 전이를 치료하기 위한 병용 요법 |
CA3174442A1 (en) | 2020-03-06 | 2021-09-10 | ONA Therapeutics S.L. | Anti-cd36 antibodies and their use to treat cancer |
KR20220151189A (ko) | 2020-03-09 | 2022-11-14 | 브리스톨-마이어스 스큅 컴퍼니 | 증진된 효능제 활성을 갖는 cd40에 대한 항체 |
EP4132971A1 (en) | 2020-04-09 | 2023-02-15 | Merck Sharp & Dohme LLC | Affinity matured anti-lap antibodies and uses thereof |
US20230192867A1 (en) | 2020-05-15 | 2023-06-22 | Bristol-Myers Squibb Company | Antibodies to garp |
TW202214857A (zh) | 2020-06-19 | 2022-04-16 | 法商昂席歐公司 | 新型結合核酸分子及其用途 |
JP2023531676A (ja) | 2020-06-23 | 2023-07-25 | ノバルティス アーゲー | 3-(1-オキソイソインドリン-2-イル)ピぺリジン-2,6-ジオン誘導体を含む投与レジメン |
EP4178611A1 (en) | 2020-07-07 | 2023-05-17 | BioNTech SE | Therapeutic rna for hpv-positive cancer |
JP2023536164A (ja) | 2020-08-03 | 2023-08-23 | ノバルティス アーゲー | ヘテロアリール置換3-(1-オキソイソインドリン-2-イル)ピペリジン-2,6-ジオン誘導体及びその使用 |
JP2023537412A (ja) | 2020-08-13 | 2023-08-31 | ブリストル-マイヤーズ スクイブ カンパニー | 目的の細胞を標的とするためのil-2の向け直し方法 |
EP4240491A1 (en) | 2020-11-06 | 2023-09-13 | Novartis AG | Cd19 binding molecules and uses thereof |
TW202237119A (zh) | 2020-12-10 | 2022-10-01 | 美商住友製藥腫瘤公司 | Alk﹘5抑制劑和彼之用途 |
TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性rna |
WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
WO2022147092A1 (en) | 2020-12-29 | 2022-07-07 | Incyte Corporation | Combination therapy comprising a2a/a2b inhibitors, pd-1/pd-l1 inhibitors, and anti-cd73 antibodies |
EP4284510A1 (en) | 2021-01-29 | 2023-12-06 | Novartis AG | Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof |
TW202241508A (zh) | 2021-01-29 | 2022-11-01 | 美商艾歐凡斯生物治療公司 | 細胞介素相關之腫瘤浸潤性淋巴球組合物及方法 |
JP2024511373A (ja) | 2021-03-18 | 2024-03-13 | ノバルティス アーゲー | がんのためのバイオマーカーおよびその使用 |
TW202304506A (zh) | 2021-03-25 | 2023-02-01 | 日商安斯泰來製藥公司 | 涉及抗claudin 18.2抗體的組合治療以治療癌症 |
TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
TW202309022A (zh) | 2021-04-13 | 2023-03-01 | 美商努法倫特公司 | 用於治療具egfr突變之癌症之胺基取代雜環 |
AR125874A1 (es) | 2021-05-18 | 2023-08-23 | Novartis Ag | Terapias de combinación |
AU2022312698A1 (en) | 2021-07-13 | 2024-01-25 | BioNTech SE | Multispecific binding agents against cd40 and cd137 in combination therapy for cancer |
CA3226281A1 (en) | 2021-07-30 | 2023-02-02 | ONA Therapeutics S.L. | Anti-cd36 antibodies and their use to treat cancer |
WO2023051926A1 (en) | 2021-09-30 | 2023-04-06 | BioNTech SE | Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists |
TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
WO2023077034A1 (en) | 2021-10-28 | 2023-05-04 | Lyell Immunopharma, Inc. | Methods for culturing immune cells |
WO2023083439A1 (en) | 2021-11-09 | 2023-05-19 | BioNTech SE | Tlr7 agonist and combinations for cancer treatment |
WO2023111203A1 (en) | 2021-12-16 | 2023-06-22 | Onxeo | New conjugated nucleic acid molecules and their uses |
WO2023130081A1 (en) | 2021-12-30 | 2023-07-06 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of il-7 protein and vegf antagonist |
WO2023147488A1 (en) | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Cytokine associated tumor infiltrating lymphocytes compositions and methods |
WO2023170606A1 (en) | 2022-03-08 | 2023-09-14 | Alentis Therapeutics Ag | Use of anti-claudin-1 antibodies to increase t cell availability |
WO2023174210A1 (en) | 2022-03-14 | 2023-09-21 | Laekna Limited | Combination treatment for cancer |
WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
Family Cites Families (154)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
US4272398A (en) | 1978-08-17 | 1981-06-09 | The United States Of America As Represented By The Secretary Of Agriculture | Microencapsulation process |
US4257774A (en) | 1979-07-16 | 1981-03-24 | Meloy Laboratories, Inc. | Intercalation inhibition assay for compounds that interact with DNA or RNA |
US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
US5155020A (en) | 1989-03-08 | 1992-10-13 | Health Research Inc. | Recombinant poxvirus host range selection system |
EP0088994B1 (en) | 1982-03-15 | 1991-06-19 | Schering Corporation | Hybrid dna, binding composition prepared thereby and processes therefor |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4650764A (en) | 1983-04-12 | 1987-03-17 | Wisconsin Alumni Research Foundation | Helper cell |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
AU610083B2 (en) | 1986-08-18 | 1991-05-16 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
US4980289A (en) | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
US4861627A (en) | 1987-05-01 | 1989-08-29 | Massachusetts Institute Of Technology | Preparation of multiwall polymeric microcapsules |
US5254678A (en) | 1987-12-15 | 1993-10-19 | Gene Shears Pty. Limited | Ribozymes |
EP0325224B1 (en) | 1988-01-22 | 1996-07-31 | ZymoGenetics, Inc. | Methods of producing secreted receptor analogs |
US5750375A (en) | 1988-01-22 | 1998-05-12 | Zymogenetics, Inc. | Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions |
US5567584A (en) | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
US6018026A (en) | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
US5750666A (en) | 1988-05-26 | 1998-05-12 | Competitve Technologies, Inc. | Polynucleotide phosphorodithioate compounds |
US6303121B1 (en) | 1992-07-30 | 2001-10-16 | Advanced Research And Technology | Method of using human receptor protein 4-1BB |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5124263A (en) | 1989-01-12 | 1992-06-23 | Wisconsin Alumni Research Foundation | Recombination resistant retroviral helper cell and products produced thereby |
US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
US5225336A (en) | 1989-03-08 | 1993-07-06 | Health Research Incorporated | Recombinant poxvirus host range selection system |
US5175099A (en) | 1989-05-17 | 1992-12-29 | Research Corporation Technologies, Inc. | Retrovirus-mediated secretion of recombinant products |
US5240846A (en) | 1989-08-22 | 1993-08-31 | The Regents Of The University Of Michigan | Gene therapy vector for cystic fibrosis |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
ATE149841T1 (de) | 1990-01-26 | 1997-03-15 | Immunomedics Inc | Impfstoffe gegen krebs und infektionskrankheiten |
US5204243A (en) | 1990-02-14 | 1993-04-20 | Health Research Incorporated | Recombinant poxvirus internal cores |
US5214136A (en) | 1990-02-20 | 1993-05-25 | Gilead Sciences, Inc. | Anthraquinone-derivatives oligonucleotides |
US5580756A (en) * | 1990-03-26 | 1996-12-03 | Bristol-Myers Squibb Co. | B7Ig fusion protein |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
CA2086325C (en) | 1990-07-02 | 2010-10-05 | Peter S. Linsley | Ligand for cd28 receptor on b cells and methods |
CA2109602C (en) | 1990-07-10 | 2002-10-01 | Gregory P. Winter | Methods for producing members of specific binding pairs |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5218105A (en) | 1990-07-27 | 1993-06-08 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
WO1992005186A1 (en) | 1990-09-20 | 1992-04-02 | Gilead Sciences | Modified internucleoside linkages |
US5296347A (en) | 1991-02-08 | 1994-03-22 | Ciba Corning Diagnostics Corp. | Bridge immunoassay |
CA2082951C (en) | 1991-03-15 | 1999-12-21 | Robert M. Platz | Pulmonary administration of granulocyte colony stimulating factor |
KR0163798B1 (ko) | 1991-07-03 | 1999-01-15 | 나가따 마사오 | 열가성 폴리우레탄 탄성체, 그의 제조 방법, 그의 제조 장치 및 그로부터 제조한 탄성 섬유 |
US7211259B1 (en) | 1993-05-07 | 2007-05-01 | Immunex Corporation | 4-1BB polypeptides and DNA encoding 4-1BB polypeptides |
WO1994026290A1 (en) | 1993-05-07 | 1994-11-24 | Immunex Corporation | Cytokine designated 4-1bb ligand and human receptor that binds thereto |
US5858776A (en) * | 1993-11-03 | 1999-01-12 | Repligen Corporation | Tumor cells with increased immunogenicity and uses therefor |
US5942607A (en) | 1993-07-26 | 1999-08-24 | Dana-Farber Cancer Institute | B7-2: a CTLA4/CD28 ligand |
US5861310A (en) | 1993-11-03 | 1999-01-19 | Dana-Farber Cancer Institute | Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor |
US5426426A (en) | 1993-08-16 | 1995-06-20 | Motorola, Inc. | Tokens for use in data communications systems |
DE69435171D1 (de) | 1993-09-14 | 2009-01-08 | Pharmexa Inc | Pan dr-bindeproteinen zur erhöhung der immunantwort |
CA2172165C (en) | 1993-09-16 | 2003-12-02 | Byoung S. Kwon | Human receptor h4-1bb |
US5451569A (en) | 1994-04-19 | 1995-09-19 | Hong Kong University Of Science And Technology R & D Corporation Limited | Pulmonary drug delivery system |
US5972703A (en) | 1994-08-12 | 1999-10-26 | The Regents Of The University Of Michigan | Bone precursor cells: compositions and methods |
AU5369996A (en) | 1995-03-23 | 1996-10-08 | Indiana University Foundation | Monoclonal antibody against human receptor protein 4-1bb and methods of its use for treatment of diseases |
PT766745E (pt) | 1995-04-08 | 2003-02-28 | Lg Chemical Ltd | ANTICORPO MONOCLONAL ESPECíFICO PARA 4-1BB HUMANO E LINHA CELULAR PARA PRODUCAO DO MESMO |
US5675848A (en) | 1995-10-18 | 1997-10-14 | Mallinckrodt Medical, Inc. | Inflatable blanket having perforations of different sizes |
EP0859959B1 (en) | 1995-11-10 | 2003-08-06 | ELAN CORPORATION, Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
EP0871747A1 (en) | 1996-01-02 | 1998-10-21 | Chiron Viagene, Inc. | Immunostimulation mediated by gene-modified dendritic cells |
US5874240A (en) | 1996-03-15 | 1999-02-23 | Human Genome Sciences, Inc. | Human 4-1BB receptor splicing variant |
DE69718268D1 (de) | 1996-10-03 | 2003-02-13 | Canon Kk | Verfahren zur Detektion von Zielnukleinsäure, Verfahren zu ihrer Quantifizierung und Pyrylium-Verbindungen zur Chemilumineszenz-Analyse |
NZ334691A (en) | 1996-10-11 | 2000-12-22 | Bristol Myers Squibb Co | Compositions of anti-4-1BB antibody effective for immunomodulation and treatment of T-cell autoimmune disease |
KR100645448B1 (ko) | 1996-11-20 | 2006-11-13 | 예일 유니버시티 | 세포 아폽토시스를 저해하는 설바이빈 단백질 및 이를 조절하는 방법 |
AUPO390396A0 (en) | 1996-11-29 | 1996-12-19 | Csl Limited | Novel promiscuous T helper cell epitopes |
WO1998033914A1 (en) | 1997-01-31 | 1998-08-06 | University Of Rochester | Chimeric antibody fusion proteins for the recruitment and stimulation of an antitumor immune response |
WO1998036096A1 (en) | 1997-02-14 | 1998-08-20 | E.I. Du Pont De Nemours And Company | Detection of double-stranded dna in a homogeneous solution |
US7368531B2 (en) * | 1997-03-07 | 2008-05-06 | Human Genome Sciences, Inc. | Human secreted proteins |
WO2001034768A2 (en) | 1999-11-09 | 2001-05-17 | Human Genome Sciences, Inc. | 15 human secreted proteins |
US20070224663A1 (en) | 1997-03-07 | 2007-09-27 | Human Genome Sciences, Inc. | Human Secreted Proteins |
US7411051B2 (en) * | 1997-03-07 | 2008-08-12 | Human Genome Sciences, Inc. | Antibodies to HDPPA04 polypeptide |
US20060223088A1 (en) | 1997-03-07 | 2006-10-05 | Rosen Craig A | Human secreted proteins |
ATE321859T1 (de) | 1998-06-10 | 2006-04-15 | Us Gov Health & Human Serv | B2microglobulin fusionsproteine und varianten mit hoher affinität |
KR20000034847A (ko) | 1998-11-17 | 2000-06-26 | 성재갑 | 인간 4-1비비 분자에 대한 인간화 항체 및 이를 포함하는 약학조성물 |
US6734172B2 (en) | 1998-11-18 | 2004-05-11 | Pacific Northwest Research Institute | Surface receptor antigen vaccines |
US20080213778A1 (en) * | 1998-12-30 | 2008-09-04 | Millennium Pharmaceuticals, Inc. | Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses |
US7041474B2 (en) | 1998-12-30 | 2006-05-09 | Millennium Pharmaceuticals, Inc. | Nucleic acid encoding human tango 509 |
AU3209300A (en) | 1999-01-15 | 2000-08-01 | Mount Sinai School Of Medicine Of The City University Of New York, The | Combination therapy of cancer by the activation of co-stimulatory molecules expressed by immune cells and cytokines |
AU3899700A (en) | 1999-03-17 | 2000-10-04 | Alphagene, Inc. | Secreted proteins and polynucleotides encoding them |
DE60039353D1 (de) | 1999-04-02 | 2008-08-14 | Corixa Corp | Verbindungen und verfahren für therapie und diagnose von lungenkrebs |
CA2378403A1 (en) | 1999-07-26 | 2001-02-01 | Genentech, Inc. | Novel polynucleotides and method for the use thereof |
EP1074617A3 (en) | 1999-07-29 | 2004-04-21 | Research Association for Biotechnology | Primers for synthesising full-length cDNA and their use |
US6423885B1 (en) | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
PT1210428E (pt) * | 1999-08-23 | 2015-07-21 | Genetics Inst Llc | Pd-1, um recetor para b7-4 e suas utilizações |
IL148021A0 (en) | 1999-08-23 | 2002-09-12 | Dana Farber Cancer Inst Inc | Novel b7-4 molecules and uses therefor |
EP1218411A4 (en) | 1999-09-20 | 2004-09-01 | Millennium Pharm Inc | SECRETED PROTEINS AND THEIR USES |
US6803192B1 (en) * | 1999-11-30 | 2004-10-12 | Mayo Foundation For Medical Education And Research | B7-H1, a novel immunoregulatory molecule |
CA2392477A1 (en) | 1999-11-30 | 2001-06-07 | Mayo Foundation For Medical Education And Research | B7-h1, a novel immunoregulatory molecule |
US7029365B2 (en) * | 2000-02-17 | 2006-04-18 | Applied Materials Inc. | Pad assembly for electrochemical mechanical processing |
WO2001062905A2 (en) | 2000-02-25 | 2001-08-30 | Immunex Corporation | Integrin antagonists |
AU4592601A (en) | 2000-03-21 | 2001-10-03 | Millennium Predictive Medicine | Novel genes, compositions, kits, and method for identification, assessment, prevention, and therapy of ovarian cancer |
CA2747325A1 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
US20030031675A1 (en) * | 2000-06-06 | 2003-02-13 | Mikesell Glen E. | B7-related nucleic acids and polypeptides useful for immunomodulation |
AU2001275285A1 (en) * | 2000-06-06 | 2001-12-17 | Bristol-Myers Squibb Company | B7-related nucleic acids and polypeptides and their uses for immunomodulation |
AU7309601A (en) | 2000-06-28 | 2002-01-08 | Genetics Inst | Pd-l2 molecules: novel pd-1 ligands and uses therefor |
AU2001271714A1 (en) | 2000-06-30 | 2002-01-14 | Human Genome Sciences, Inc. | B7-like polynucleotides, polypeptides, and antibodies |
ES2272500T3 (es) | 2000-07-05 | 2007-05-01 | Vogue Pool Products | Estructura de soporte para una piscina fuera de suelo. |
US6635750B1 (en) | 2000-07-20 | 2003-10-21 | Millennium Pharmaceuticals, Inc. | B7-H2 nucleic acids, members of the B7 family |
AU2001283507A1 (en) * | 2000-07-27 | 2002-02-13 | Mayo Foundation For Medical Education And Research | B7-h3 and b7-h4, novel immunoregulatory molecules |
CA2422215A1 (en) * | 2000-09-20 | 2002-03-28 | Amgen Inc. | B7-like molecules and uses thereof |
AU2002232447A1 (en) | 2000-11-02 | 2002-05-15 | Immunex Corporation | Method of enhancing lymphocyte-mediated immune responses |
US20040209263A1 (en) | 2000-12-07 | 2004-10-21 | Clawson Gary A. | Selection of catalytic nucleic acids targeted to infectious agents |
CA2433313A1 (en) | 2000-12-19 | 2002-07-25 | Curagen Corporation | Polypetides and nucleic acids encoding same |
US20030180309A1 (en) | 2001-01-08 | 2003-09-25 | Baum Peter R. | Human B7 polypeptides |
US6743619B1 (en) | 2001-01-30 | 2004-06-01 | Nuvelo | Nucleic acids and polypeptides |
WO2003008583A2 (en) | 2001-03-02 | 2003-01-30 | Sagres Discovery | Novel compositions and methods for cancer |
AR036993A1 (es) | 2001-04-02 | 2004-10-20 | Wyeth Corp | Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas |
CA2442066C (en) * | 2001-04-02 | 2005-11-01 | Wyeth | Pd-1, a receptor for b7-4, and uses therefor |
US20060084794A1 (en) | 2001-04-12 | 2006-04-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7794710B2 (en) | 2001-04-20 | 2010-09-14 | Mayo Foundation For Medical Education And Research | Methods of enhancing T cell responsiveness |
WO2003006632A2 (en) | 2001-07-12 | 2003-01-23 | Canvac | Methods and compisitions for activation human t cells in vitro |
EP1434596B1 (en) | 2001-10-09 | 2009-07-08 | Mayo Foundation For Medical Education And Research | Enhancement of immune responses by agonist 4-1bb-antibodies |
AU2002337920A1 (en) | 2001-10-19 | 2003-04-28 | Zymogenetics, Inc. | Dimerized growth factor and materials and methods for producing it |
EP1456652A4 (en) | 2001-11-13 | 2005-11-02 | Dana Farber Cancer Inst Inc | IMMUNOCELL ACTIVATION MODULATING SUBSTANCES AND USE METHOD THEREFOR |
US7164500B2 (en) | 2002-01-29 | 2007-01-16 | Hewlett-Packard Development Company, L.P. | Method and apparatus for the automatic generation of image capture device control marks |
JP4409430B2 (ja) | 2002-07-03 | 2010-02-03 | 小野薬品工業株式会社 | 免疫賦活組成物 |
CN1688603A (zh) | 2002-07-15 | 2005-10-26 | 马约医学教育与研究基金会 | 使用4-1bb结合剂的治疗和预防 |
US7769423B2 (en) | 2002-09-11 | 2010-08-03 | Duke University | MRI imageable liposomes for the evaluation of treatment efficacy, thermal distribution, and demonstration of dose painting |
US7432351B1 (en) | 2002-10-04 | 2008-10-07 | Mayo Foundation For Medical Education And Research | B7-H1 variants |
US7449300B2 (en) * | 2002-11-21 | 2008-11-11 | Mayo Foundation For Medical Education And Research | Detection of antibodies specific for B7-H1 in subjects with diseases or pathological conditions mediated by activated T cells |
JP4532409B2 (ja) | 2003-01-23 | 2010-08-25 | 小野薬品工業株式会社 | ヒトpd−1に対し特異性を有する物質 |
WO2004077060A2 (en) | 2003-02-27 | 2004-09-10 | Mount Sinai Hospital | Assay for detection of renal cell carcinoma |
KR100518346B1 (ko) * | 2003-12-01 | 2005-09-29 | 현대모비스 주식회사 | 스티어링 기어 일체형 프레임 구조 |
US7381794B2 (en) | 2004-03-08 | 2008-06-03 | Zymogenetics, Inc. | Dimeric fusion proteins and materials and methods for producing them |
MX2007004176A (es) * | 2004-10-06 | 2007-06-15 | Mayo Foundation | B7-h1 y metodos de diagnosis, prognosis, y tratamiento de cancer. |
EP1814568A4 (en) | 2004-10-29 | 2009-08-12 | Univ Southern California | ANTI-CANCER POLYIMMUNOTHERAPY IN WHICH CO-STIMULATING MOLECULES ARE USED |
BRPI0611766A2 (pt) | 2005-06-08 | 2011-12-20 | Dana Farber Cancer Inst Inc | métodos e composições para o tratamento de infecções persistentes e cáncer por inibição da rota de morte celular programada |
US20070231344A1 (en) | 2005-10-28 | 2007-10-04 | The Brigham And Women's Hospital, Inc. | Conjugate vaccines for non-proteinaceous antigens |
US20090215084A1 (en) * | 2006-01-05 | 2009-08-27 | Mayo Foundation For Medical Education And Research | B7-h1 and b7-h4 in cancer |
US20100015642A1 (en) | 2006-01-05 | 2010-01-21 | Kwon Eugene D | B7-h1 and survivin in cancer |
US8216996B2 (en) | 2006-03-03 | 2012-07-10 | Ono Pharmaceutical Co., Ltd. | Multimer of extracellular domain of cell surface functional molecule |
WO2007124361A2 (en) | 2006-04-20 | 2007-11-01 | Mayo Foundation For Medical Education And Research | Soluble b7-h1 |
WO2008037080A1 (en) | 2006-09-29 | 2008-04-03 | Universite De Montreal | Methods and compositions for immune response modulation and uses thereof |
CA3045637A1 (en) | 2006-12-27 | 2008-07-10 | Emory University | Compositions and methods for the treatment of infections and tumors |
EP2514762B1 (en) | 2007-07-13 | 2015-04-08 | The Johns Hopkins University | B7-DC variants |
AU2008287063B2 (en) | 2007-08-09 | 2013-10-24 | Genzyme Corporation | Method of treating autoimmune disease with mesenchymal stem cells |
WO2009111315A2 (en) | 2008-02-29 | 2009-09-11 | Mayo Foundation For Medical Education And Research | Methods for reducing granulomatous inflammation |
WO2009114110A1 (en) | 2008-03-08 | 2009-09-17 | Immungene, Inc. | Engineered fusion molecules immunotherapy in cancer and inflammatory diseases |
US20110223188A1 (en) | 2008-08-25 | 2011-09-15 | Solomon Langermann | Targeted costimulatory polypeptides and methods of use to treat cancer |
PE20110435A1 (es) | 2008-08-25 | 2011-07-20 | Amplimmune Inc | Composiciones antagonistas del pd-1 |
IT1395574B1 (it) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | Dispositivo di erogazione |
WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
-
2000
- 2000-11-30 CA CA002392477A patent/CA2392477A1/en not_active Abandoned
- 2000-11-30 AU AU20530/01A patent/AU784634B2/en not_active Expired
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- 2000-11-30 ES ES00983821.0T patent/ES2629683T3/es not_active Expired - Lifetime
- 2000-11-30 EP EP17159364.3A patent/EP3225632B1/en not_active Expired - Lifetime
- 2000-11-30 PT PT983821T patent/PT1234031T/pt unknown
- 2000-11-30 DK DK00983821.0T patent/DK1234031T3/da active
- 2000-11-30 WO PCT/US2000/032583 patent/WO2001039722A2/en active Application Filing
- 2000-11-30 EP EP00983821.0A patent/EP1234031B2/en not_active Expired - Lifetime
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2008
- 2008-12-31 US US12/347,492 patent/US9062112B2/en not_active Expired - Fee Related
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2009
- 2009-04-09 US US12/421,310 patent/US8981063B2/en not_active Expired - Fee Related
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2011
- 2011-10-25 US US13/280,779 patent/US8460927B2/en not_active Expired - Fee Related
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2013
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2015
- 2015-02-09 US US14/617,500 patent/US20150232533A1/en not_active Abandoned
- 2015-09-03 US US14/845,020 patent/US20160096890A1/en not_active Abandoned
- 2015-09-03 US US14/844,914 patent/US20160096889A1/en not_active Abandoned
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2017
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US20160096890A1 (en) | 2016-04-07 |
US20130330329A1 (en) | 2013-12-12 |
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EP1234031B1 (en) | 2017-03-15 |
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US20090317368A1 (en) | 2009-12-24 |
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US20120064626A1 (en) | 2012-03-15 |
US20180201684A1 (en) | 2018-07-19 |
AU2053001A (en) | 2001-06-12 |
WO2001039722A2 (en) | 2001-06-07 |
EP3225632A1 (en) | 2017-10-04 |
WO2001039722A3 (en) | 2002-02-21 |
EP1234031A4 (en) | 2004-04-07 |
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