DK0863917T3 - Målrettede cytotoksiske anthracyclin-analoger - Google Patents

Målrettede cytotoksiske anthracyclin-analoger

Info

Publication number
DK0863917T3
DK0863917T3 DK96938216T DK96938216T DK0863917T3 DK 0863917 T3 DK0863917 T3 DK 0863917T3 DK 96938216 T DK96938216 T DK 96938216T DK 96938216 T DK96938216 T DK 96938216T DK 0863917 T3 DK0863917 T3 DK 0863917T3
Authority
DK
Denmark
Prior art keywords
nitrogen
halo
carbon
och2
excess
Prior art date
Application number
DK96938216T
Other languages
Danish (da)
English (en)
Inventor
V Tulane University Med Andrew
A Tulane University Med Attila
Tulane University Med Ren-Zhi
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24247176&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0863917(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Tulane filed Critical Univ Tulane
Application granted granted Critical
Publication of DK0863917T3 publication Critical patent/DK0863917T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK96938216T 1995-11-27 1996-11-14 Målrettede cytotoksiske anthracyclin-analoger DK0863917T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/562,652 US5843903A (en) 1995-11-27 1995-11-27 Targeted cytotoxic anthracycline analogs
PCT/EP1996/005029 WO1997019954A1 (en) 1995-11-27 1996-11-14 Targeted cytotoxic anthracycline analogs

Publications (1)

Publication Number Publication Date
DK0863917T3 true DK0863917T3 (da) 2004-01-19

Family

ID=24247176

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03010988T DK1384710T3 (da) 1995-11-27 1996-11-14 Syntese af heterocykliske forbindelser indeholdende fem- eller seks-leddede ringe
DK96938216T DK0863917T3 (da) 1995-11-27 1996-11-14 Målrettede cytotoksiske anthracyclin-analoger

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK03010988T DK1384710T3 (da) 1995-11-27 1996-11-14 Syntese af heterocykliske forbindelser indeholdende fem- eller seks-leddede ringe

Country Status (27)

Country Link
US (2) US5843903A (pt)
EP (2) EP0863917B1 (pt)
JP (2) JP3987575B2 (pt)
KR (2) KR100467899B1 (pt)
CN (2) CN1166597C (pt)
AT (2) ATE401305T1 (pt)
AU (1) AU709539B2 (pt)
BR (1) BR9611647B1 (pt)
CA (2) CA2471775C (pt)
CZ (1) CZ297297B6 (pt)
DE (2) DE69637604D1 (pt)
DK (2) DK1384710T3 (pt)
EA (1) EA001372B1 (pt)
ES (2) ES2205067T3 (pt)
HK (2) HK1017363A1 (pt)
HU (1) HU229870B1 (pt)
IL (3) IL134685A (pt)
IS (2) IS2178B (pt)
MX (1) MX9804119A (pt)
NO (2) NO324035B1 (pt)
NZ (1) NZ322054A (pt)
PL (3) PL188786B1 (pt)
PT (2) PT863917E (pt)
SK (2) SK284392B6 (pt)
UA (1) UA67722C2 (pt)
WO (1) WO1997019954A1 (pt)
ZA (1) ZA969709B (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576239B1 (en) 1996-09-10 2003-06-10 The Burnham Institute Angiogenic homing molecules and conjugates derived therefrom
US6180084B1 (en) 1998-08-25 2001-01-30 The Burnham Institute NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same
GB9814527D0 (en) 1998-07-03 1998-09-02 Cyclacel Ltd Delivery system
ES2318906T3 (es) 1998-11-13 2009-05-01 Cyclacel Limited Vectores de transposicion derivados de helice 3 de homeodominio de antennapedia.
FR2786398B1 (fr) * 1998-11-30 2002-12-27 Synt Em Composition pharmaceutique anti-cancereuse et anti-chimioresistance comprenant un agent anticancereux et au moins un peptide
FR2786397B1 (fr) * 1998-11-30 2003-01-10 Synt Em Vecteurs peptidiques de substances a travers la barriere hematoencephalique pour etre utilises dans le diagnostic ou la therapie d'une affection du snc
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6528481B1 (en) 1999-02-16 2003-03-04 The Burnam Institute NG2/HM proteoglycan-binding peptides that home to angiogenic vasculature and related methods
US6380161B1 (en) 1999-06-21 2002-04-30 Inkine Pharmaceutical Company, Inc. Compositions for treating chemotherapy-resistant tumor cells and targeted chemotherapy compositions
JP2003513756A (ja) * 1999-11-12 2003-04-15 アンジオテック ファーマシューティカルズ，インコーポレイテッド 放射性治療と細胞周期インヒビターとの組合せの組成物
ATE344801T1 (de) 1999-12-29 2006-11-15 Immunogen Inc Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung
AU4267700A (en) * 2000-01-13 2001-07-19 Academia Sinica Application of somatostatin analogs to specific delivery of anti-tumor drugs into tumor cells
DE60104552T2 (de) * 2000-04-26 2005-09-01 Biosynthema Inc. An neuropeptide gebundenes rgd (arg-gly-asp)
US7452964B2 (en) 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
KR100420007B1 (ko) * 2001-04-25 2004-03-02 노영쇠 안트라사이클린 유도체 및 이를 포함하는 항암제
KR20040047846A (ko) * 2001-09-21 2004-06-05 더 어드미니스트레이터 오브 더 튜레인 에듀케이셔널 펀드 진단 또는 치료용 소마토스타틴 또는 봄베신 유사체콘쥬게이트 및 이들의 용도
US20050171014A1 (en) * 2002-02-27 2005-08-04 Government Of The United States Of America, Represented By The Secretary, Department Of Health Conjugates of ligand linker and cytotoxic agent and related composition and methods of use
WO2003074551A2 (en) 2002-03-01 2003-09-12 The Administrators Of The Tulane Educational Fund Conjugates of therapeutic or cytotoxic agents and biologically active peptides
US7544767B2 (en) 2002-04-05 2009-06-09 Burnham Institute For Medical Research HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells
KR20050012224A (ko) * 2002-05-21 2005-01-31 다이이찌 산토리 파마 가부시키가이샤 그렐린 함유 의약 조성물
ES2330326T3 (es) 2002-05-24 2009-12-09 Angiotech International Ag Composiciones y metodos para recubrir implantes medicos.
US8313760B2 (en) 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
AU2003275263A1 (en) 2002-09-26 2004-04-19 Angiotech International Ag Perivascular wraps
EP2181704B1 (en) 2002-12-30 2015-05-06 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US20040202666A1 (en) * 2003-01-24 2004-10-14 Immunomedics, Inc. Anti-cancer anthracycline drug-antibody conjugates
US20050043215A1 (en) 2003-02-19 2005-02-24 Tamara Minko Complex drug delivery composition and method for treating cancer
AU2007221964B2 (en) * 2003-04-22 2008-12-11 Ipsen Pharma S.A.S. Peptide vectors
WO2004093807A2 (en) * 2003-04-22 2004-11-04 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatin vectors
US7097993B2 (en) 2003-06-25 2006-08-29 Wisconsin Alumni Research Foundation Method for identifying an agent that modulates type 1 phosphatidylinositol phosphate kinase isoform β661 activity
WO2005086951A2 (en) * 2004-03-10 2005-09-22 Threshold Pharmaceuticals, Inc. Hypoxia-activated anti-cancer agents
US20070060534A1 (en) * 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
EP1900742A1 (en) 2006-09-07 2008-03-19 AEterna Zentaris GmbH Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
JP5340155B2 (ja) * 2006-09-06 2013-11-13 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング 細胞結合分子を有するジソラゾールのコンジュゲート及びそれらの誘導体、新規ジソラゾール誘導体、それらの製法ならびに使用
WO2008100591A2 (en) * 2007-02-14 2008-08-21 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
WO2009099741A1 (en) * 2008-02-01 2009-08-13 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
JP5647971B2 (ja) * 2008-04-11 2015-01-07 天津和美生物技▲術▼有限公司Ｔｉａｎｊｉｎ Ｈｅｍａｙ Ｂｉｏ−Ｔｅｃｈ Ｃｏ．Ｌｔｄ 高活性アントラサイクリン系抗生物質の誘導体、該誘導体の製造及び応用
CN101555264B (zh) * 2008-04-11 2014-09-03 天津和美生物技术有限公司 具有高活性的四环蒽醌类抗生素的衍生物及其制备和应用
BRPI0910810A2 (pt) 2008-07-15 2019-09-24 Genentech Inc conjugados derivados de antraciclina, veículo polimérico, anticorpo, peptídeo ou proteína, veículo t-[cho]m, composições farmacêuticas, métodos de tratamento do câncer ou de distúrbios da proliferação celular, derivado de antraciclina, composto conjugado droga-anticorpo, uso, artigo de manufatura e método de produção de um composto conjugado droga-anticorpo"
CN102325545A (zh) 2009-02-20 2012-01-18 益普生制药股份有限公司 具有神经肽y受体结合化合物的细胞毒性缀合物
CN102050856B (zh) * 2009-11-03 2014-04-30 天津和美生物技术有限公司 具有高活性的表阿霉素的衍生物及其制备和应用
RU2563638C2 (ru) 2010-12-02 2015-09-20 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Способ получения производных морфолинилантрациклина
CN105198966B (zh) * 2014-06-26 2019-06-21 中国人民解放军军事医学科学院毒物药物研究所 GnRH类似物-细胞毒分子缀合物、其制备方法及用途
CA2953371C (en) * 2014-06-30 2021-08-24 Tarveda Therapeutics, Inc. Targeted conjugates and particles and formulations thereof
EP3045540A1 (en) 2015-01-19 2016-07-20 Æterna Zentaris GmbH Enzymatic process for the regioselective manufacturing of N-Fmoc-doxorubicin-14-O-dicarboxylic acid mono esters
CA3001712A1 (en) 2015-10-28 2017-05-04 Tarveda Therapeutics, Inc. Sstr-targeted conjugates and particles and formulations thereof
US10450340B2 (en) 2017-02-16 2019-10-22 Monopar Therapeutics Inc. 3′-deamino-3′-(2″-pyrroline-1″-yl)-5-imino-13-deoxyanthracyclines and methods of preparation
JP7502801B2 (ja) * 2018-11-13 2024-06-19 プロビンシャル・ヘルス・サービシーズ・オーソリティ ガストリン放出ペプチド受容体（ｇｒｐｒ）のインビボイメージングおよびｇｒｐｒ関連障害の治療のための放射性標識ボンベシン由来化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725350A (en) * 1972-04-26 1973-04-03 Commercial Soluents Corp Polymeric substances comprising the reaction product of melamine, aldehyde and oxazolidines
US4299822A (en) * 1980-06-09 1981-11-10 Sidney Farber Cancer Institute, Inc. N-Trifluoroacetyladriamycin-14-O-hemiglutarate and -hemiadipate and therapeutic compositions containing same
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
IL89220A (en) * 1988-02-11 1994-02-27 Bristol Myers Squibb Co Immunoconjugates of anthracycline, their production and pharmaceutical preparations containing them
US5217955A (en) * 1989-09-15 1993-06-08 Biomeasure, Inc. Treatment of cancer with peptide analog of bombesin, grp, litorin or neuromedin
US5304687A (en) * 1989-12-19 1994-04-19 Farmitalia Carlo Erba S.R.L. Morpholinyl derivatives of doxorubicin and process for their preparation
ES2094136T3 (es) * 1989-12-19 1997-01-16 Pharmacia Spa Intermediarios quirales de 1,5-diyodo-2-metoxi o benciloxi.
ES2076393T3 (es) * 1990-04-06 1995-11-01 Univ Tulane Analogos de lhrh.
EP0450480B1 (en) * 1990-04-06 1995-06-21 The Administrators of The Tulane Educational Fund Somatostatin Analogues
JP3169425B2 (ja) * 1992-03-27 2001-05-28 三共株式会社 アジドペンタンサイクリトール
US6214345B1 (en) * 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates

Also Published As

Publication number Publication date
BR9611647A (pt) 1999-02-23
CA2238574A1 (en) 1997-06-05
EP1384710A1 (en) 2004-01-28
PL188786B1 (pl) 2005-04-29
PT863917E (pt) 2004-02-27
NO324035B1 (no) 2007-07-30
DE69630233T2 (de) 2004-08-05
KR100467899B1 (ko) 2005-01-24
MX9804119A (es) 1998-09-30
BR9611647B1 (pt) 2010-03-09
CA2471775A1 (en) 1997-06-05
NO982252L (no) 1998-05-15
IS4734A (is) 1998-05-05
NO982252D0 (no) 1998-05-15
SK284392B6 (sk) 2005-03-04
PL191781B1 (pl) 2006-07-31
KR100445754B1 (ko) 2004-12-08
ES2205067T3 (es) 2004-05-01
AU709539B2 (en) 1999-09-02
HK1052920A1 (en) 2003-10-03
DE69630233D1 (de) 2003-11-06
IS8567A (is) 2006-11-09
EA199800492A1 (ru) 1998-12-24
CN1202903A (zh) 1998-12-23
US5843903A (en) 1998-12-01
IL134685A0 (en) 2001-04-30
CN1166597C (zh) 2004-09-15
NZ322054A (en) 1999-04-29
JP2007045845A (ja) 2007-02-22
CN1405127A (zh) 2003-03-26
DE69637604D1 (de) 2008-08-28
WO1997019954A1 (en) 1997-06-05
US6184374B1 (en) 2001-02-06
ATE251179T1 (de) 2003-10-15
ZA969709B (en) 1997-08-25
IS2178B (is) 2006-12-15
KR20040037176A (ko) 2004-05-04
IL119691A0 (en) 1997-02-18
CA2471775C (en) 2008-01-29
CZ135798A3 (cs) 1998-10-14
HK1017363A1 (en) 1999-11-19
IS2634B (is) 2010-06-15
CZ297297B6 (cs) 2006-11-15
IL119691A (en) 2002-02-10
EP1384710B1 (en) 2008-07-16
EP0863917B1 (en) 2003-10-01
PT1384710E (pt) 2008-10-08
IL134685A (en) 2002-12-01
JP4778405B2 (ja) 2011-09-21
SK62898A3 (en) 1999-06-11
JP3987575B2 (ja) 2007-10-10
JP2000502055A (ja) 2000-02-22
SK284672B6 (sk) 2005-08-04
HK1052920B (zh) 2005-03-04
DK1384710T3 (da) 2008-11-17
PL187230B1 (pl) 2004-06-30
KR19990071672A (ko) 1999-09-27
EA001372B1 (ru) 2001-02-26
UA67722C2 (en) 2004-07-15
PL326865A1 (en) 1998-10-26
CA2238574C (en) 2004-10-19
ES2310222T3 (es) 2009-01-01
HU229870B1 (en) 2014-10-28
EP0863917A1 (en) 1998-09-16
CN1137136C (zh) 2004-02-04
ATE401305T1 (de) 2008-08-15
HUP9903771A3 (en) 2000-07-28
HUP9903771A2 (hu) 2000-02-28
AU7572296A (en) 1997-06-19
NO20051111L (no) 2005-03-01

Similar Documents

Publication Publication Date Title
DK0863917T3 (da) Målrettede cytotoksiske anthracyclin-analoger
SE9301911D0 (sv) New peptide derivatives
BR9813835A (pt) Composto, composição farmacêutica e método de tratamento ou prevenção de uma desordem tromboembólica
BR9917080A (pt) Composto, composição farmacêutica, uso do composto e método de tratamento ou prevenção de uma disfunção tromboembólica
NZ302072A (en) 1,3-diamino propyl stereomeric derivatives and organic acid and inorganic salts of their amine intermediates in the preparation of retroviral protease inhibitors
AR003137A1 (es) Una composicion farmaceutica para tratar la leucemia
MX9606494A (es) Compuestos organicos.
DK0941975T3 (da) Injiceringscement indeholdende korrosionshæmmere
MX9303587A (es) Producto para el cuidado de lentes de contacto, para lentes de contacto duros o blandos.
TW333533B (en) Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
EA199800289A1 (ru) Производные пептидов
ATE228359T1 (de) Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
AR015458A1 (es) Compuestos de tetrahidrofurano, y composicion farmaceutica que lo contiene.
TH13531EX (th) สารต่อต้านเชื้อราชนิดไซคลิค เพพไทด์ และกรรมวิธีเตรียมสารเหล่านั้น
EP1210948A4 (en) DRUGS FOR NERVOUS DISEASES
DK0674649T3 (da) Antiparasitiske midler
YU58300A (sh) Postupak za dobijanje 3-aminoalkohola
ATE221897T1 (de) Inhibitoren der blutplättchen-aggregation, die c- terminale aminosäurereste mit aminergen seitenketten enthalten