ES2076393T3 - Analogos de lhrh. - Google Patents
Analogos de lhrh.Info
- Publication number
- ES2076393T3 ES2076393T3 ES91104730T ES91104730T ES2076393T3 ES 2076393 T3 ES2076393 T3 ES 2076393T3 ES 91104730 T ES91104730 T ES 91104730T ES 91104730 T ES91104730 T ES 91104730T ES 2076393 T3 ES2076393 T3 ES 2076393T3
- Authority
- ES
- Spain
- Prior art keywords
- moiety
- methotrexoyl
- trp
- arg
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Luminescent Compositions (AREA)
- Electric Double-Layer Capacitors Or The Like (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Saccharide Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A ANALOGOS LHRR QUE CONTIENEN PORCIONES CITOTOXICAS, TIENEN UNA INFLUENCIA SOBRE LA LIBERALIZACION DE GONADOTROPINAS DE LA PITUITARIA DE MAMIFEROS (POSEE UNA GRAN ACTIVIDAD AGONISTICA O ANTAGONISTICA) Y TIENE UN EFECTO ANTINEOPLASTICO. LOS COMPUESTOS DE ESTA INVENCION ESTAN REPRESENTADOS POR LA FORMULA I: X-R ELEVADO 1-R ELEVADO 2-R ELEVADO 3-SER-R ELEVADO 5-R ELEVADO 6(Q)-LEU-ARG -PRO-R ELEVADO 10-NH SUB 2, EN DONDE R ELEVADO 1 ES PGLN O D-NAL(2), R ELEVADO 2 ES HIS O D-PHE(4CL), R ELEVADO 3 ES TRP, D-TRP O D-PAL(3), R ELEVADO 5 ES TYR O ARG, R ELEVADO 6 ES D-LYS O D-ORM, R ELEVADO 10 ES GLY O D-ALA, X ES HIDROGENO O UN GRUPO ALCANOILO INFERIOR DE 2-5 ATOMOS DE CARBONO, Q ES UNA PORCION CITOTOXICA QUE TIENE LA FORMULA -Q ELEVADO 4 O -A(Q ELEVADO 3) O B(Q ELEVADO 1)SUB 2 O -B(AQ ELEVADO 2)SUB 2, EN DONDE A ES -NH-(CH SUB 2)SUB N-CO -(CH SUB 2)SUB M-CH(NH)-(CH SUB 2)SUB N-CON ES 0 O 1, ESTANDO LA PORCION -CO DE A GRUPO AMINO SOBRE R ELEVADO 6, Y EN EL GRUPO B(AQ ELEVADO 2)SUB 2, LA PORCION DE -CO DE A AMINO SOBRE B, Q ELEVADO 1 ES D O L-MEL, CICLOPROPANOALCANOILO, AZIRIDINA-2-CARBONIL, EPOXIALQUILO O 1,4-NALTOQUINONA-5-OXICARBONIL-ETILO, Q (AL CUADRADO) ES Q ELEVADO 1, ANTRAQUINONIALCOXI O DOXORUBICINILO, Q ELEVADO 3 ES Q (AL CUADRADO) , MITOMICINILO, ESPERAMICINILO O METOTREXOILO, Q ELEVADO 4 ES Q ELEVADO 1 O METOTREZOILO Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS Y METODOS DE UTILIZACION RELACIONADOS CON ESTOS COMPUESTOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50551790A | 1990-04-06 | 1990-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2076393T3 true ES2076393T3 (es) | 1995-11-01 |
Family
ID=24010633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91104730T Expired - Lifetime ES2076393T3 (es) | 1990-04-06 | 1991-03-26 | Analogos de lhrh. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0450461B1 (es) |
| JP (1) | JPH04224600A (es) |
| KR (1) | KR940701270A (es) |
| AT (1) | ATE127476T1 (es) |
| AU (1) | AU638319B2 (es) |
| CA (1) | CA2039908A1 (es) |
| DE (1) | DE69112684T2 (es) |
| DK (1) | DK0450461T3 (es) |
| ES (1) | ES2076393T3 (es) |
| HR (1) | HRP921273A2 (es) |
| HU (1) | HU208159B (es) |
| IE (1) | IE63278B1 (es) |
| MC (1) | MC2265A1 (es) |
| NZ (1) | NZ237705A (es) |
| WO (1) | WO1992022322A1 (es) |
| YU (1) | YU61991A (es) |
| ZA (1) | ZA914552B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6419655B1 (en) | 1998-07-16 | 2002-07-16 | Gonex, Inc. | Method for controlling animal populations utilizing a sterilant projectile |
| US6326467B1 (en) | 1989-02-23 | 2001-12-04 | Colorado State University Research Foundation | Hormone-recombinant toxin compounds and methods for using same |
| US5502035A (en) * | 1993-08-06 | 1996-03-26 | Tap Holdings Inc. | N-terminus modified analogs of LHRH |
| US5413990A (en) * | 1993-08-06 | 1995-05-09 | Tap Pharmaceuticals Inc. | N-terminus modified analogs of LHRH |
| DE4338015A1 (de) * | 1993-11-08 | 1995-05-11 | Asta Medica Ag | Verwendung von D-glucopyranuronsäuren und deren Derivaten zum Einbau in pharmakologisch wirksame Peptide und deren Salze |
| US5677184A (en) * | 1994-04-19 | 1997-10-14 | Takeda Chemical Industries, Ltd. | CHO cells that express human LH-RH receptor |
| US5753206A (en) * | 1995-06-07 | 1998-05-19 | Immunomedics, Inc. | Radiometal-binding analogues of luteinizing hormone releasing hormone |
| US5843903A (en) * | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
| WO2004093807A2 (en) | 2003-04-22 | 2004-11-04 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Somatostatin vectors |
| EP2719392B1 (en) | 2008-06-12 | 2019-07-24 | Ipsen Bioinnovation Limited | Fusion proteins for use in the treatment of acromegaly |
| GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| KR101346262B1 (ko) * | 2013-06-19 | 2014-01-03 | 엘아이지넥스원 주식회사 | 다단 분리형 수중 운동체 및 이의 동작 방법 |
| KR101355886B1 (ko) * | 2013-11-19 | 2014-01-27 | 엘아이지넥스원 주식회사 | 다단 분리형 수중 운동체 및 이의 동작 방법 |
| WO2019030284A1 (en) * | 2017-08-09 | 2019-02-14 | Helmholtz-Zentrum für Infektionsforschung GmbH | NOVEL TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4263279A (en) * | 1975-08-19 | 1981-04-21 | Yeda Research & Development Co. Ltd | Pharmaceutically active compositions containing adriamycin and daunomycin |
| US4894443A (en) * | 1984-02-08 | 1990-01-16 | Cetus Corporation | Toxin conjugates |
| US4677193A (en) * | 1985-02-22 | 1987-06-30 | The Salk Institute For Biological Studies | Peptides containing an aliphatic-aromatic ketone side chain |
| CA1275922C (en) * | 1985-11-28 | 1990-11-06 | Harunobu Amagase | Treatment of cancer |
| US4793986A (en) * | 1987-02-25 | 1988-12-27 | Johnson Matthey, Inc. | Macromolecular platinum antitumor compounds |
| WO1990009799A1 (en) * | 1989-02-23 | 1990-09-07 | Colorado State University Research Foundation | GnRH ANALOGS FOR DESTROYING GONADOTROPHS |
| BR9913040A (pt) * | 1998-08-17 | 2001-05-08 | Thermo Black Clawson Inc | Processos de extrair um licor rico em açúcar e um componente de açúcar a partir de cana-de-açúcar |
-
1991
- 1991-03-26 ES ES91104730T patent/ES2076393T3/es not_active Expired - Lifetime
- 1991-03-26 DE DE69112684T patent/DE69112684T2/de not_active Expired - Fee Related
- 1991-03-26 EP EP91104730A patent/EP0450461B1/en not_active Expired - Lifetime
- 1991-03-26 AT AT91104730T patent/ATE127476T1/de active
- 1991-03-26 DK DK91104730.6T patent/DK0450461T3/da active
- 1991-04-04 YU YU61991A patent/YU61991A/sh unknown
- 1991-04-05 CA CA002039908A patent/CA2039908A1/en not_active Abandoned
- 1991-04-05 IE IE113491A patent/IE63278B1/en not_active IP Right Cessation
- 1991-04-05 JP JP3072936A patent/JPH04224600A/ja active Pending
- 1991-04-05 AU AU74106/91A patent/AU638319B2/en not_active Ceased
- 1991-04-05 HU HU911116A patent/HU208159B/hu not_active IP Right Cessation
- 1991-04-05 NZ NZ237705A patent/NZ237705A/en unknown
- 1991-04-08 MC MC912183A patent/MC2265A1/xx unknown
- 1991-06-14 KR KR1019930703871A patent/KR940701270A/ko not_active Application Discontinuation
- 1991-06-14 ZA ZA914552A patent/ZA914552B/xx unknown
- 1991-06-14 WO PCT/US1991/004264 patent/WO1992022322A1/en active Application Filing
-
1992
- 1992-11-16 HR HRP-619/91A patent/HRP921273A2/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUT57235A (en) | 1991-11-28 |
| WO1992022322A1 (en) | 1992-12-23 |
| EP0450461A3 (en) | 1992-03-11 |
| DE69112684D1 (de) | 1995-10-12 |
| HU208159B (en) | 1993-08-30 |
| CA2039908A1 (en) | 1991-10-07 |
| EP0450461B1 (en) | 1995-09-06 |
| ZA914552B (en) | 1992-06-24 |
| IE63278B1 (en) | 1995-04-05 |
| JPH04224600A (ja) | 1992-08-13 |
| DE69112684T2 (de) | 1996-02-01 |
| IE911134A1 (en) | 1991-10-09 |
| HU911116D0 (en) | 1991-10-28 |
| ATE127476T1 (de) | 1995-09-15 |
| YU61991A (sh) | 1994-04-05 |
| MC2265A1 (fr) | 1993-04-26 |
| KR940701270A (ko) | 1994-05-28 |
| AU7410691A (en) | 1991-10-10 |
| AU638319B2 (en) | 1993-06-24 |
| HRP921273A2 (en) | 1998-06-30 |
| DK0450461T3 (da) | 1995-10-23 |
| EP0450461A2 (en) | 1991-10-09 |
| NZ237705A (en) | 1992-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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