YU61991A - Lhrh analozi - Google Patents

Lhrh analozi

Info

Publication number
YU61991A
YU61991A YU61991A YU61991A YU61991A YU 61991 A YU61991 A YU 61991A YU 61991 A YU61991 A YU 61991A YU 61991 A YU61991 A YU 61991A YU 61991 A YU61991 A YU 61991A
Authority
YU
Yugoslavia
Prior art keywords
moiety
methotrexoyl
trp
arg
group
Prior art date
Application number
YU61991A
Other languages
English (en)
Inventor
V.A. Schally
T. Janaky
A. Juhasz
S. Bajusz
Original Assignee
Andrew, V.S.
Szeged, Tamasjanaky
Juhasz, Atilla
Bayusz, Sandor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Andrew, V.S., Szeged, Tamasjanaky, Juhasz, Atilla, Bayusz, Sandor filed Critical Andrew, V.S.
Priority to HRP-619/91A priority Critical patent/HRP921273A2/xx
Publication of YU61991A publication Critical patent/YU61991A/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Luminescent Compositions (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)

Abstract

LHRH ANALOZI, ovaj pronalazak se bavi sa LHRH analozima koji sadrže citotoksične polovine, imaju uticaja na otpuštanje gonatropina iz pituitarne žlezde kod sisara (poseduju visoku agonističku i antagonističku aktivnost) i imaju antineoplastično delovanje. Jedinjenja ovog pronalaska su pretstavljena Formulom I: X-R1-R2-R3-Ser-R5-R6(Q)-Leu-Arg-Pro-R10-NH2, u kojoj je R1 pGlu, ili D-Nal(2), R2 je His ili D-Fe(4Cl), R3 je Trp, D-Trp ili D-Pal(3), R5 je Tir ili Arg, R6 je D-Liz ili D-Orn, R10 je Gli ili D-Ala, X je vodonik ili niža alkanoil grupa od 2-5 ugljenikova atoma, Q je citotoksična polovina koja ima formulu -Q4 ili -A(Q3) ili -B(Q1)2 ili -B(AQ2)2, gde je A -NH(CH2)n-CO- ili -CO- (CH2)n-CO- gde je n 2-6, B je -NH-CH2-(CH2)m-CO- gde je m O ili 1, n je 0 ili 1, pri čemu je -CO polovina A- i B- vezana za amino grupu na R5, pri čemu je u grupu B(AQ2)2, -CO polovina A- vezana za amino grupu na B, Q1 je D ili L-Mel, ciklopropanalkanoil, aziridin-2-karbonil, epoksialkil ili 1,4-naftokinon-5-oksikarbonil-etil, Q2 je Q1, antrakinonalkiloksi ili doksorubicinil, Q3 je Q2, mitomicinil, esperamicinil ili metatreksoil, Q4 je Q1 ili metotreksoil i farmaceutski prihvatljivim solima istih i postupcima upotrebe koji su u vezi sa ovim jedinjenjima.
YU61991A 1990-04-06 1991-04-04 Lhrh analozi YU61991A (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HRP-619/91A HRP921273A2 (en) 1990-04-06 1992-11-16 Lhrh analogs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50551790A 1990-04-06 1990-04-06

Publications (1)

Publication Number Publication Date
YU61991A true YU61991A (sh) 1994-04-05

Family

ID=24010633

Family Applications (1)

Application Number Title Priority Date Filing Date
YU61991A YU61991A (sh) 1990-04-06 1991-04-04 Lhrh analozi

Country Status (17)

Country Link
EP (1) EP0450461B1 (sh)
JP (1) JPH04224600A (sh)
KR (1) KR940701270A (sh)
AT (1) ATE127476T1 (sh)
AU (1) AU638319B2 (sh)
CA (1) CA2039908A1 (sh)
DE (1) DE69112684T2 (sh)
DK (1) DK0450461T3 (sh)
ES (1) ES2076393T3 (sh)
HR (1) HRP921273A2 (sh)
HU (1) HU208159B (sh)
IE (1) IE63278B1 (sh)
MC (1) MC2265A1 (sh)
NZ (1) NZ237705A (sh)
WO (1) WO1992022322A1 (sh)
YU (1) YU61991A (sh)
ZA (1) ZA914552B (sh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6419655B1 (en) 1998-07-16 2002-07-16 Gonex, Inc. Method for controlling animal populations utilizing a sterilant projectile
US6326467B1 (en) 1989-02-23 2001-12-04 Colorado State University Research Foundation Hormone-recombinant toxin compounds and methods for using same
US5502035A (en) * 1993-08-06 1996-03-26 Tap Holdings Inc. N-terminus modified analogs of LHRH
US5413990A (en) * 1993-08-06 1995-05-09 Tap Pharmaceuticals Inc. N-terminus modified analogs of LHRH
DE4338015A1 (de) * 1993-11-08 1995-05-11 Asta Medica Ag Verwendung von D-glucopyranuronsäuren und deren Derivaten zum Einbau in pharmakologisch wirksame Peptide und deren Salze
US5677184A (en) * 1994-04-19 1997-10-14 Takeda Chemical Industries, Ltd. CHO cells that express human LH-RH receptor
US5753206A (en) * 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
WO2004093807A2 (en) 2003-04-22 2004-11-04 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatin vectors
EP2719392B1 (en) 2008-06-12 2019-07-24 Ipsen Bioinnovation Limited Fusion proteins for use in the treatment of acromegaly
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
KR101346262B1 (ko) * 2013-06-19 2014-01-03 엘아이지넥스원 주식회사 다단 분리형 수중 운동체 및 이의 동작 방법
KR101355886B1 (ko) * 2013-11-19 2014-01-27 엘아이지넥스원 주식회사 다단 분리형 수중 운동체 및 이의 동작 방법
WO2019030284A1 (en) * 2017-08-09 2019-02-14 Helmholtz-Zentrum für Infektionsforschung GmbH NOVEL TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4263279A (en) * 1975-08-19 1981-04-21 Yeda Research & Development Co. Ltd Pharmaceutically active compositions containing adriamycin and daunomycin
US4894443A (en) * 1984-02-08 1990-01-16 Cetus Corporation Toxin conjugates
US4677193A (en) * 1985-02-22 1987-06-30 The Salk Institute For Biological Studies Peptides containing an aliphatic-aromatic ketone side chain
CA1275922C (en) * 1985-11-28 1990-11-06 Harunobu Amagase Treatment of cancer
US4793986A (en) * 1987-02-25 1988-12-27 Johnson Matthey, Inc. Macromolecular platinum antitumor compounds
WO1990009799A1 (en) * 1989-02-23 1990-09-07 Colorado State University Research Foundation GnRH ANALOGS FOR DESTROYING GONADOTROPHS
BR9913040A (pt) * 1998-08-17 2001-05-08 Thermo Black Clawson Inc Processos de extrair um licor rico em açúcar e um componente de açúcar a partir de cana-de-açúcar

Also Published As

Publication number Publication date
HUT57235A (en) 1991-11-28
WO1992022322A1 (en) 1992-12-23
EP0450461A3 (en) 1992-03-11
DE69112684D1 (de) 1995-10-12
HU208159B (en) 1993-08-30
CA2039908A1 (en) 1991-10-07
EP0450461B1 (en) 1995-09-06
ZA914552B (en) 1992-06-24
IE63278B1 (en) 1995-04-05
JPH04224600A (ja) 1992-08-13
DE69112684T2 (de) 1996-02-01
IE911134A1 (en) 1991-10-09
HU911116D0 (en) 1991-10-28
ATE127476T1 (de) 1995-09-15
MC2265A1 (fr) 1993-04-26
KR940701270A (ko) 1994-05-28
AU7410691A (en) 1991-10-10
AU638319B2 (en) 1993-06-24
ES2076393T3 (es) 1995-11-01
HRP921273A2 (en) 1998-06-30
DK0450461T3 (da) 1995-10-23
EP0450461A2 (en) 1991-10-09
NZ237705A (en) 1992-11-25

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