DK0848704T3 - Krystallinsk form III af hemi-calciumsaltet (atorvastatin) af [R-(R*,R*)]-2-(4-fluorphenyl)-beta-delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carboxyl]-1H-pyrrol-1-heptansyre - Google Patents

Krystallinsk form III af hemi-calciumsaltet (atorvastatin) af [R-(R*,R*)]-2-(4-fluorphenyl)-beta-delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carboxyl]-1H-pyrrol-1-heptansyre

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Publication number
DK0848704T3
DK0848704T3 DK96924367T DK96924367T DK0848704T3 DK 0848704 T3 DK0848704 T3 DK 0848704T3 DK 96924367 T DK96924367 T DK 96924367T DK 96924367 T DK96924367 T DK 96924367T DK 0848704 T3 DK0848704 T3 DK 0848704T3
Authority
DK
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Prior art keywords
phenylamino
methylethyl
fluorophenyl
pyrrole
dihydroxy
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DK96924367T
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Danish (da)
English (en)
Inventor
T Mckenzie Ann
Original Assignee
Warner Lambert Co
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21696105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0848704(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
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Publication of DK0848704T3 publication Critical patent/DK0848704T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
DK96924367T 1995-07-17 1996-07-08 Krystallinsk form III af hemi-calciumsaltet (atorvastatin) af [R-(R*,R*)]-2-(4-fluorphenyl)-beta-delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carboxyl]-1H-pyrrol-1-heptansyre DK0848704T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US145495P 1995-07-17 1995-07-17
PCT/US1996/011367 WO1997003958A1 (en) 1995-07-17 1996-07-08 Form iii crystalline (r-(r*,r*)-2-(4-fluorophenyl)-beta-delta-dihydroxy-5-(1-methyl-ethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)

Publications (1)

Publication Number Publication Date
DK0848704T3 true DK0848704T3 (da) 2002-02-04

Family

ID=21696105

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96924367T DK0848704T3 (da) 1995-07-17 1996-07-08 Krystallinsk form III af hemi-calciumsaltet (atorvastatin) af [R-(R*,R*)]-2-(4-fluorphenyl)-beta-delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carboxyl]-1H-pyrrol-1-heptansyre

Country Status (33)

Country Link
US (1) US6121461A (et)
JP (1) JP3296563B2 (et)
KR (1) KR100431039B1 (et)
CN (1) CN1081632C (et)
AT (1) ATE207465T1 (et)
AU (1) AU725368B2 (et)
BG (1) BG63629B1 (et)
BR (1) BR9610567A (et)
CA (1) CA2220458C (et)
CO (1) CO4700442A1 (et)
CZ (1) CZ294109B6 (et)
DK (1) DK0848704T3 (et)
EA (1) EA000505B1 (et)
EE (1) EE03607B1 (et)
ES (1) ES2166456T3 (et)
GE (1) GEP20002028B (et)
HK (1) HK1018053A1 (et)
HR (1) HRP960313B1 (et)
HU (1) HU223598B1 (et)
ID (1) ID16158A (et)
IL (3) IL122162A (et)
MX (1) MX9708857A (et)
MY (1) MY118398A (et)
NO (1) NO309899B1 (et)
NZ (1) NZ312906A (et)
PE (1) PE1798A1 (et)
PL (1) PL192244B1 (et)
RO (1) RO120068B1 (et)
SK (1) SK284201B6 (et)
TW (1) TW401399B (et)
UA (1) UA44796C2 (et)
WO (1) WO1997003958A1 (et)
ZA (1) ZA966045B (et)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
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US6569461B1 (en) 1999-03-08 2003-05-27 Merck & Co., Inc. Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors
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SI20425A (sl) 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
IL149087A0 (en) 1999-12-17 2002-11-10 Warner Lambert Res & Dev Ie A factory scale process for producing crystalline atorvastatin trihydrate hemi calcium
ATE320415T1 (de) 1999-12-17 2006-04-15 Pfizer Science & Tech Ltd Verfahren zur herstellung von kristallin atorvastin kalcium
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US7074818B2 (en) 2001-07-30 2006-07-11 Dr. Reddy's Laboratories Limited Crystalline forms VI and VII of Atorvastatin calcium
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US20060020137A1 (en) * 2001-11-29 2006-01-26 Limor Tessler Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
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MXPA04007995A (es) * 2002-02-19 2004-11-26 Teva Pharma Desolvatacion de solvatos de hemicalcio de atorvastatina.
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KR20120011249A (ko) 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
CN102424663B (zh) * 2010-12-03 2013-08-14 天津滨江药物研发有限公司 一种阿托伐他汀氨基酸盐及其制备方法
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CN103483238B (zh) * 2013-08-20 2014-12-31 蚌埠丰原医药科技发展有限公司 阿托伐他汀钙三水合物的制备方法
CN106432033B (zh) * 2016-10-21 2018-07-27 江苏阿尔法药业有限公司 一种无定形阿托伐他汀钙的制备方法
KR101723783B1 (ko) 2017-02-24 2017-04-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법

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Publication number Publication date
ZA966045B (en) 1997-02-04
HUP9901687A3 (en) 2000-04-28
ES2166456T3 (es) 2002-04-16
NO980208D0 (no) 1998-01-16
HRP960313B1 (en) 2002-08-31
SK284201B6 (sk) 2004-10-05
KR100431039B1 (ko) 2004-08-25
CN1190957A (zh) 1998-08-19
EE03607B1 (et) 2002-02-15
IL128863A0 (en) 2000-01-31
IL177378A0 (en) 2006-12-10
HUP9901687A2 (hu) 1999-10-28
BG63629B1 (bg) 2002-07-31
AU6484196A (en) 1997-02-18
PL324532A1 (en) 1998-06-08
JPH11509229A (ja) 1999-08-17
PE1798A1 (es) 1998-03-04
WO1997003958A1 (en) 1997-02-06
SK5998A3 (en) 1998-05-06
AU725368B2 (en) 2000-10-12
IL122162A0 (en) 1998-04-05
RO120068B1 (ro) 2005-08-30
CO4700442A1 (es) 1998-12-29
EA000505B1 (ru) 1999-10-28
CZ12398A3 (cs) 1998-06-17
TW401399B (en) 2000-08-11
CA2220458C (en) 2002-09-24
HK1018053A1 (en) 1999-12-10
JP3296563B2 (ja) 2002-07-02
EA199800129A1 (ru) 1998-08-27
US6121461A (en) 2000-09-19
PL192244B1 (pl) 2006-09-29
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