DK0747706T3 - Adduktbeskyttelsesassay - Google Patents

Adduktbeskyttelsesassay

Info

Publication number
DK0747706T3
DK0747706T3 DK96108880T DK96108880T DK0747706T3 DK 0747706 T3 DK0747706 T3 DK 0747706T3 DK 96108880 T DK96108880 T DK 96108880T DK 96108880 T DK96108880 T DK 96108880T DK 0747706 T3 DK0747706 T3 DK 0747706T3
Authority
DK
Denmark
Prior art keywords
signal
label
protection assay
binding partner
adduct protection
Prior art date
Application number
DK96108880T
Other languages
English (en)
Inventor
Norman C Nelson
Michael Becker
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Application granted granted Critical
Publication of DK0747706T3 publication Critical patent/DK0747706T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK96108880T 1995-06-07 1996-06-03 Adduktbeskyttelsesassay DK0747706T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/478,221 US5731148A (en) 1995-06-07 1995-06-07 Adduct protection assay

Publications (1)

Publication Number Publication Date
DK0747706T3 true DK0747706T3 (da) 2003-11-24

Family

ID=23899023

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96108880T DK0747706T3 (da) 1995-06-07 1996-06-03 Adduktbeskyttelsesassay

Country Status (11)

Country Link
US (1) US5731148A (da)
EP (1) EP0747706B1 (da)
JP (1) JP3577085B2 (da)
KR (1) KR19990022460A (da)
AT (1) ATE246807T1 (da)
AU (1) AU703605B2 (da)
CA (1) CA2222556C (da)
DE (1) DE69629333T2 (da)
DK (1) DK0747706T3 (da)
ES (1) ES2203656T3 (da)
WO (1) WO1996041197A1 (da)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US7070925B1 (en) * 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
ES2270467T3 (es) 1996-07-16 2007-04-01 Gen-Probe Incorporated Metodos para detectar y amplificar secuencias de acido nucleico utilizando oligonucleotidos modificados que tienen una tm especifica de la diana mas elevada.
WO1998045420A1 (en) 1997-04-10 1998-10-15 Diagnocure Inc. Pca3, pca3 genes, and methods of use
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
DE69836012T2 (de) 1997-05-02 2007-04-05 Gen-Probe Inc., San Diego Zwei-schritt hybridisierung und einfang von einem polynukleotid
US6180340B1 (en) 1997-10-31 2001-01-30 Gen-Probe Incorporated Extended dynamic range assays
US6361942B1 (en) 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
JP4646404B2 (ja) * 1998-07-02 2011-03-09 ジェン−プローブ・インコーポレーテッド 分子トーチ（ｔｏｒｃｈ）
US5998175A (en) * 1998-07-24 1999-12-07 Lumigen, Inc. Methods of synthesizing and amplifying polynucleotides by ligation of multiple oligomers
JP4772966B2 (ja) 1999-02-12 2011-09-14 ジェン−プローブ・インコーポレーテッド 保護プローブ
ATE456677T1 (de) 1999-07-09 2010-02-15 Gen Probe Inc Hiv-1 detektion mittels nukleinsäureamplifizierung
US6506887B1 (en) * 1999-07-29 2003-01-14 Somalogic, Incorporated Conditional-selex
CA2385477C (en) 1999-09-29 2009-11-03 Diagnocure Inc. Pca3 messenger rna species in benign and malignant prostate tissues
US6506567B2 (en) * 2000-01-31 2003-01-14 Fuji Photo Film Co., Ltd. Water-soluble flourescent intercalator compound
US20010046674A1 (en) * 2000-02-03 2001-11-29 Andrew Ellington Signaling aptamers that transduce molecular recognition to a differential signal
DE60140317D1 (de) * 2000-12-14 2009-12-10 Gen Probe Inc Verfahren und kits zur verbesserung der hybridisierungsraten von polynukleotiden
EP1423522A2 (en) 2001-01-23 2004-06-02 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Hepatitis c virus replicons and replicon enhanced cells
US6780602B2 (en) * 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
WO2003106714A1 (en) 2002-06-14 2003-12-24 Gen-Probe Incorporated Compositions and methods for detecting hepatitis b virus
CA2501946C (en) 2002-10-16 2014-12-23 Gen-Probe Incorporated Compositions and methods for detecting west nile virus
WO2004070056A2 (en) 2003-02-07 2004-08-19 Diagnocure Inc. Method to detect prostate cancer in a sample
US20060257929A1 (en) * 2003-11-12 2006-11-16 Microbiosystems, Limited Partnership Method for the rapid taxonomic identification of pathogenic microorganisms and their toxic proteins
CA2547750C (en) 2003-12-19 2014-04-08 Gen-Probe Incorporated Compositions, methods and kits for detecting the nucleic acids of hiv-1 and hiv-2
EP2806035B1 (en) 2004-02-18 2017-09-13 Chromocell Corporation Methods and materials using signaling probes
US7466908B1 (en) 2004-04-16 2008-12-16 Spartan Bioscience Inc. System for rapid nucleic acid amplification and detection
AU2005262357B2 (en) 2004-07-01 2009-10-29 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
JP4753943B2 (ja) 2004-07-13 2011-08-24 ジェン−プローブ・インコーポレーテッド Ａ型肝炎ウイルス核酸の検出のための組成物及び方法
JP5692954B2 (ja) 2004-09-30 2015-04-01 ジェン−プロウブ インコーポレイテッド Ｈｉｖ−１を検出しそして定量するためのアッセイ
EP1809772B1 (en) 2004-11-09 2013-06-05 Gen-Probe Incorporated Compositions and methods for detecting group a streptococci
CA2491067A1 (en) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
US8124335B2 (en) 2005-05-06 2012-02-28 Gen-Probe Incorporated Compositions and assays to detect influenza virus A and B nucleic acids
US7993853B2 (en) 2005-05-06 2011-08-09 Gen-Probe Incorporated Methods of nucleic acid target capture
CN101611137A (zh) * 2006-11-30 2009-12-23 克罗莫塞尔公司 用于蛋白质生产的最优化的宿主细胞
EP1978111B1 (en) 2007-04-02 2013-03-27 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa
US9458451B2 (en) 2007-06-21 2016-10-04 Gen-Probe Incorporated Multi-channel optical measurement instrument
CA3128538C (en) 2008-04-21 2023-08-08 Gen-Probe Incorporated Method for detecting chikungunya virus
JP5733796B2 (ja) 2008-05-13 2015-06-10 ジェン−プロウブ インコーポレイテッド 標的核酸配列の選択的ハイブリダイゼーションおよび捕捉における使用のため不活化可能型標的捕捉オリゴマー
WO2009158119A2 (en) 2008-05-30 2009-12-30 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of salmonella
US8097412B2 (en) * 2008-07-12 2012-01-17 Biodiagnostics, Inc. DNA-based test for detection of annual and intermediate ryegrass
CA2638458A1 (en) * 2008-07-31 2010-01-31 Spartan Bioscience Inc. Thermal recycling by positioning relative to fixed-temperature source
WO2010068473A1 (en) 2008-11-25 2010-06-17 Gen-Probe Incorporated Compositions and methods for detecting small rnas, and uses thereof
WO2010078374A1 (en) 2008-12-30 2010-07-08 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of listeria
WO2010088496A1 (en) 2009-01-30 2010-08-05 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
US8921039B2 (en) 2009-02-26 2014-12-30 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
CA2802741C (en) 2010-06-30 2020-07-07 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
US9234249B2 (en) 2010-07-12 2016-01-12 Gen-Probe Incorporated Compositions and assays to detect swine H1N1 influenza A virus, seasonal H1 influenza A virus and seasonal H3 influenza A virus nucleic acids
AU2011301804B2 (en) 2010-09-16 2015-07-16 Gen-Probe Incorporated Capture probes immobilizable via L-nucleotide tail
EP3438289A1 (en) 2010-10-04 2019-02-06 Gen-Probe Prodesse, Inc. Compositions, methods and kits to detect adenovirus nucleic acids
CN113215308A (zh) 2011-07-15 2021-08-06 简.探针公司 检测人细小病毒核酸和甲型肝炎病毒核酸的组合物和方法
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
CA2900852A1 (en) 2013-03-15 2014-09-18 Chromocell Corporation Methods and materials using signaling probes
AU2015336079C1 (en) 2014-10-20 2020-12-17 Gen-Probe Incorporated Red blood cell lysis solution
WO2017098321A1 (en) 2015-12-11 2017-06-15 Spartan Bioscience Inc. Tube sealing system and methods for nucleic acid amplification
EP3448998B1 (en) 2016-04-27 2020-06-03 Gen-Probe Incorporated Blood cell lysis reagent
US11976337B2 (en) 2017-03-24 2024-05-07 Gen-Probe Incorporated Methods for detection of influenza in samples
EP4282986A3 (en) 2017-03-24 2024-02-28 Gen-Probe Incorporated Compositions and methods for detecting or quantifying parainfluenza virus
CA3056135C (en) 2017-03-25 2024-02-20 Gen-Probe Incorporated Compositions, methods and kits to detect adenovirus nucleic acids
CN111032209A (zh) 2017-07-10 2020-04-17 简·探针公司 分析系统和方法
CN111094595A (zh) 2017-08-11 2020-05-01 简·探针公司 用于检测金黄色葡萄球菌的组合物和方法
EP3724354A1 (en) 2017-12-15 2020-10-21 Gen-Probe Incorporated Compositions and methods for detecting toxigenic clostridium difficile
US20210071242A1 (en) 2018-01-29 2021-03-11 Gen-Probe Incorporated Analytical systems and methods
GB2597567B (en) 2018-06-13 2022-11-23 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
WO2020014400A1 (en) 2018-07-10 2020-01-16 Gen-Probe Incorporated Methods and systems for detecting and quantifying nucleic acids
WO2020028631A1 (en) 2018-08-01 2020-02-06 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of epstein-barr virus
CA3108105A1 (en) 2018-08-08 2020-02-13 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
EP3841224A1 (en) 2018-08-21 2021-06-30 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
CA3112651A1 (en) 2018-09-27 2020-04-02 Gen-Probe Incorporated Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
WO2020072409A1 (en) 2018-10-01 2020-04-09 Gen-Probe Incorporated Compositions and methods for amplifying or detecting varicella-zoster virus
CA3116895A1 (en) 2018-10-22 2020-04-30 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human polyomavirus bk virus
US20220098647A1 (en) 2019-03-22 2022-03-31 Gen-Probe Incorporated Compositions and Methods for Detecting Group A Streptococcus
CA3176699A1 (en) 2019-05-03 2020-11-12 Gen-Probe Incorporated Receptacle transport system for an analytical system
EP4018004A1 (en) 2019-08-23 2022-06-29 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
EP4025715A1 (en) 2019-09-05 2022-07-13 Gen-Probe Incorporated Detection of chlamydia trachomatis nucleic acid variants
CA3174532A1 (en) 2020-03-04 2021-09-10 Gen-Probe Incorporated Compositions and methods for detecting sars-cov-2 nucleic acid
AU2021365165A1 (en) 2020-10-21 2023-06-15 Gen-Probe Incorporated Fluid container management system
EP4382621A2 (en) 2021-07-27 2024-06-12 Gen-Probe Incorporated Compositions and methods for detecting c. coli and at least one of salmonella, c. jejuni, shigella, and stec
WO2023175434A1 (en) 2022-03-15 2023-09-21 Diagenode S.A. Detection of methylation status of a dna sample
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6515469A (da) * 1965-01-22 1966-07-25
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US4190496A (en) * 1971-05-14 1980-02-26 Syva Company Homogeneous enzyme assay for antibodies
US4199559A (en) * 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4383031A (en) * 1975-04-28 1983-05-10 Miles Laboratories, Inc. Homogeneous chemiluminescent specific binding assay
US4174384A (en) * 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4318707A (en) * 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
CA1185177A (en) * 1981-07-17 1985-04-09 Larry E. Morrison Non-radiative energy transfer immunochemical technique
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
US4668640A (en) * 1981-12-11 1987-05-26 Abbott Laboratories Fluorescence polarization immunoassay utilizing substituted carboxyfluoresceins
GB2112779B (en) * 1981-12-11 1986-10-15 Welsh Nat School Med Aryl acridinium esters as luminescent labelling materials
US4462931A (en) * 1982-06-16 1984-07-31 American Cyanamid Company Enhanced aqueous chemiluminescent systems
US4508642A (en) * 1983-04-21 1985-04-02 World Victor B Method of obtaining greater lifetime duration from chemiluminescent systems
US4816419A (en) * 1983-08-01 1989-03-28 University Of Health Sciences/The Chicago Medical School Fluorescence ligand binding assay using charge-matched dye and solvent components
US4640898A (en) * 1983-08-01 1987-02-03 University Of Health Sciences/The Chicago Medical School Homogeneous fluorescence ligang binding assay based upon preferential alteration of the respective intensities of bound and free label by solvent components
US4582789A (en) * 1984-03-21 1986-04-15 Cetus Corporation Process for labeling nucleic acids using psoralen derivatives
AU580042B2 (en) * 1984-03-22 1988-12-22 Bresatec Limited Non-radioactive biological probes
CA1260372A (en) * 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
US4670379A (en) * 1984-12-19 1987-06-02 E. I. Du Pont De Nemours And Company Polynucleotide hydridization assays employing catalyzed luminescence
DE3568063D1 (en) * 1985-01-10 1989-03-09 Molecular Diagnostics Inc Photochemical method of labelling nucleic acids for detection in hybridization assays
US4655969A (en) * 1985-04-03 1987-04-07 Richter Herbert P Chemiluminescent systems
JP2509574B2 (ja) * 1985-08-15 1996-06-19 アモコ・コーポレーション 標識付けした核酸
JPS6261969A (ja) * 1985-09-06 1987-03-18 アモコ・コーポレーション アクリジニウムエステルの合成法
DE3545398A1 (de) * 1985-12-20 1987-06-25 Boehringer Mannheim Gmbh Verfahren zur steigerung der quanten-ausbeute bei der oxidation von luminol durch peroxide in gegenwart von peroxidase
US4698183A (en) * 1986-02-04 1987-10-06 American Cyanamid Company High light output-short duration chemiluminescent compositions
DE3645292C2 (de) * 1986-08-22 1997-12-11 Hoechst Ag Chemilumineszenzimmunoassays und ein Verfahren zu ihrer Herstellung
US4918192A (en) * 1986-10-06 1990-04-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US5110932A (en) * 1986-10-06 1992-05-05 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
DE3750503T2 (de) * 1986-10-22 1995-02-09 Abbott Lab Chemilumineszierende Acridinium- und Phenantridiniumsalze.
JPS63107898A (ja) * 1986-10-23 1988-05-12 Natl Inst For Res In Inorg Mater プラズマを用いるダイヤモンドの合成法
US4927769A (en) * 1987-07-08 1990-05-22 Ciba Corning Diagnostics Corp. Method for enhancement of chemiluminescence
US5283174A (en) * 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
DE3854029T2 (de) * 1987-09-21 1995-10-26 Gen Probe Inc Homogener Abschirmungstest.
CA1339303C (en) * 1987-09-21 1997-08-19 Lyle John Arnold Jr. Non-nucleotide linking reagents for nucleotide probes
US5185439A (en) * 1987-10-05 1993-02-09 Gen-Probe Incorporated Acridinium ester labelling and purification of nucleotide probes
US4883898A (en) * 1987-12-10 1989-11-28 University Of Chicago Chemiluminescent compounds
NL8703075A (nl) * 1987-12-18 1989-07-17 Nederlanden Staat Acridiniumverbindingen als chemiluminescentie-merkstof.
US5321136A (en) * 1987-12-31 1994-06-14 London Diagnostics, Inc. Peri substituted fused ring chemiluminescent labels and their conjugates, and assays therefrom
US5281712A (en) * 1987-12-31 1994-01-25 London Diagnostics, Inc. Ammonium substituted chemiluminescent labels and their conjugates, and assays therefrom
US5338847A (en) * 1987-12-31 1994-08-16 London Diagnostics, Inc. Hydrolytically stable chemiluminescent labels and their conjugates, and assays therefrom by adduct formation
NZ227506A (en) * 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
DE3844954C2 (de) * 1988-02-20 1998-07-16 Hoechst Ag Spezielle chemilumineszierende Acridinderivate und ihre Verwendung in Lumineszenzimmunoassays
US4950613A (en) * 1988-02-26 1990-08-21 Gen-Probe Incorporated Proteted chemiluminescent labels
AU634716B2 (en) * 1988-08-01 1993-03-04 Ciba Corning Diagnostics Corp. Method for detection of an analyte using acridinium esters and liposomes
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
US5093270A (en) * 1989-05-24 1992-03-03 Ciba Corning Diagnostics Corp. Method for enhancing signal release from liposomes using water-miscible alcohols
GB2233451B (en) * 1989-06-27 1993-09-15 Tropix Inc Chemiluminescence enhancement
JPH0335147A (ja) * 1989-07-03 1991-02-15 Doujin Kagaku Kenkyusho:Kk 化学発光の検出
ES2124231T3 (es) * 1990-10-26 1999-02-01 Genta Inc Procedimiento mejorado para sintesis de oligomeros.
WO1992009580A1 (en) * 1990-11-21 1992-06-11 Beckman Instruments, Inc. Chemiluminescent compounds
EP0492570B1 (en) * 1990-12-24 2001-05-02 Enzo Diagnostics, Inc. Method for detecting a target polynucleotide in a sample using a background reducing reagent and composition and kit comprising such a reagent
JPH0579985A (ja) * 1991-09-24 1993-03-30 Kyoto Daiichi Kagaku:Kk 化学発光増強剤及び増強方法
JPH05255264A (ja) * 1992-03-13 1993-10-05 Sanyo Chem Ind Ltd 標識剤および標識されたリガンドの製法
JPH07506254A (ja) * 1992-05-06 1995-07-13 ジェン−プローブ・インコーポレイテッド ヒトｂ型肝炎ウイルスに対する核酸増幅オリゴヌクレオチドおよびプローブ
JP3248628B2 (ja) * 1992-06-25 2002-01-21 国際試薬株式会社 化学発光性化合物およびこれを用いるアッセイ法
JPH07509245A (ja) * 1992-07-20 1995-10-12 デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 新規化学発光化合物およびその使用方法
JP3207933B2 (ja) * 1992-09-09 2001-09-10 株式会社ヤトロン アクリジニウム誘導体の発光方法及びそれを用いた検査対象物質の検出方法
EP0602524A1 (de) * 1992-12-15 1994-06-22 Hoechst Aktiengesellschaft Chemilumineszenzmarkierte Gensonden und ihre Verwendung in Gensondentesten
JP3584379B2 (ja) * 1993-02-04 2004-11-04 持田製薬株式会社 アクリジニウム化合物およびアクリジニウム化合物複合体
WO1994023069A1 (en) * 1993-03-26 1994-10-13 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
US5491072A (en) * 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
KR960704065A (ko) * 1993-07-19 1996-08-31 다니엘 엘. 캐시앙 올리고뉴클레오티드 스크리닝 검정법(Oligonucleotide Screening Assay)
JPH07330838A (ja) * 1994-06-10 1995-12-19 Nippon Oil & Fats Co Ltd アクリダン基含有高分子および化学発光方法
JP3694044B2 (ja) * 1994-06-22 2005-09-14 株式会社三菱化学ヤトロン アクリジニウム誘導体の発光方法及びその方法を用いた検査対象物質の検出方法
ATE340866T1 (de) * 1994-10-28 2006-10-15 Gen Probe Inc Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen

Also Published As

Publication number Publication date
ES2203656T3 (es) 2004-04-16
KR19990022460A (ko) 1999-03-25
DE69629333T2 (de) 2004-06-24
AU6024496A (en) 1996-12-30
JP2002515118A (ja) 2002-05-21
US5731148A (en) 1998-03-24
WO1996041197A1 (en) 1996-12-19
AU703605B2 (en) 1999-03-25
JP3577085B2 (ja) 2004-10-13
ATE246807T1 (de) 2003-08-15
CA2222556A1 (en) 1996-12-19
DE69629333D1 (de) 2003-09-11
EP0747706A1 (en) 1996-12-11
CA2222556C (en) 2002-06-11
EP0747706B1 (en) 2003-08-06

Similar Documents

Publication Publication Date Title
DE69629333D1 (de) Adduktabschirmungstest
DK0941468T3 (da) Et-trins-hybridimmunochromatografisk udstyr og fremgangsmåde til anvendelse heraf
BR9710836A (pt) Ensaio de analitos usando marcas em partìculas
ATE515693T1 (de) Nachweis einer zielsubstanz in einer probe
EP0805215A3 (en) Diagnostic methods and probes
DE69022578D1 (de) Test für Hepatitis-C.
AU2001289853A1 (en) Multianalyte determination system and methods
ES2148225T3 (es) Reactivos y procedimientos que permiten la deteccion y la cuantificacion de la tiroxina en muestras de fluido.
EP0366448A3 (en) Method of detecting and identifying nucleic acid containing moieties
DE69521104T2 (de) Spezifische Bindungstests und Reagenzien dafür
DK0528525T3 (da) Assaymetoder og sammensætninger til påvisning af serumproteaser, især aktiveret protein C
BRPI0408255A (pt) sistema de processamento de sinal e método
CY1107621T1 (el) Μεθοδος ανιχνευσης αντισωματων σε ενα δειγμα
CA1267088C (en) ANTIBODIES FOR THE DETECTION AND DOSAGE OF ATRAZINE
ES2184260T3 (es) Sistema de ensayo que utiliza particulas magneticas.
FI964003A0 (fi) Kemiallisten analyysien kalibrointimenetelmä
WO2008048698A3 (en) Chemical switches for detecting reactive chemical agents
ES2145746T3 (es) Analisis de deteccion de hepatitis c.
ES2094124T3 (es) Ensayo-inmunologico de anticuerpos contra hiv.
CA2213083A1 (en) Detection of antibody production
ES2101763T3 (es) Acoplamiento de antigenos y anticuerpos a eritrocitos no fijados.
ES2169211T3 (es) Ensayos de proteccion de micelas.
DK0566633T3 (da) Fremgangsmåde til visuelt at påvise tilstedeværelsen af en virus i en klinisk prøve
DE69113298D1 (de) Kalibrierungsmethode von Systemen für Enzymimmuntests.
ATE208041T1 (de) A-protein als diagnostikum für krebs