DK0528525T3 - Assaymetoder og sammensætninger til påvisning af serumproteaser, især aktiveret protein C - Google Patents

Assaymetoder og sammensætninger til påvisning af serumproteaser, især aktiveret protein C

Info

Publication number
DK0528525T3
DK0528525T3 DK92306108.9T DK92306108T DK0528525T3 DK 0528525 T3 DK0528525 T3 DK 0528525T3 DK 92306108 T DK92306108 T DK 92306108T DK 0528525 T3 DK0528525 T3 DK 0528525T3
Authority
DK
Denmark
Prior art keywords
compositions
activated protein
assay methods
serum proteases
proteases
Prior art date
Application number
DK92306108.9T
Other languages
English (en)
Inventor
John H Griffin
Andras Gruber
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of DK0528525T3 publication Critical patent/DK0528525T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96461—Protein C (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK92306108.9T 1991-07-03 1992-07-02 Assaymetoder og sammensætninger til påvisning af serumproteaser, især aktiveret protein C DK0528525T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/725,359 US5288612A (en) 1991-07-03 1991-07-03 Assay methods for detecting serum proteases, particularly activated protein C

Publications (1)

Publication Number Publication Date
DK0528525T3 true DK0528525T3 (da) 1998-02-23

Family

ID=24914223

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92306108.9T DK0528525T3 (da) 1991-07-03 1992-07-02 Assaymetoder og sammensætninger til påvisning af serumproteaser, især aktiveret protein C

Country Status (9)

Country Link
US (1) US5288612A (da)
EP (2) EP0595865A4 (da)
AT (1) ATE160876T1 (da)
CA (1) CA2112702C (da)
DE (1) DE69223355T2 (da)
DK (1) DK0528525T3 (da)
ES (1) ES2109982T3 (da)
GR (1) GR3025752T3 (da)
WO (1) WO1993001309A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0592423B1 (en) * 1990-08-06 2000-11-15 Chiron Corporation Methods for the identification of cytokine convertase inhibitors
US6099843A (en) * 1991-02-12 2000-08-08 Heska Corporation Parasitic helminth PLA2 proteins
WO1993009804A1 (en) * 1991-11-18 1993-05-27 The Scripps Research Institute Serine protease derived-polypeptides and anti-peptide antibodies, systems and therapeutic methods for inhibiting coagulation
US6146870A (en) * 1991-12-13 2000-11-14 Heska Corporation Flea protease proteins
US6150125A (en) * 1991-12-13 2000-11-21 Heska Corporation Flea protease proteins and uses thereof
US6156556A (en) * 1991-12-13 2000-12-05 Heska Corporation Flea protease proteins, nucleic acid molecules, and uses thereof
US6210920B1 (en) 1991-12-13 2001-04-03 Heska Corporation Flea protease proteins, nucleic acid molecules, and uses thereof
US6121035A (en) * 1991-12-13 2000-09-19 Heska Corporation Flea aminopeptidase proteins and uses thereof
US5972645A (en) * 1991-12-13 1999-10-26 Heska Corporation Flea serine protease nucleic acid molecules
CA2088222A1 (en) * 1992-10-20 1994-04-21 Nabil G. Seidah Development of research, diagnostic and production tools for pro-hormone convertases
US5416003A (en) * 1993-04-14 1995-05-16 Litmus Concepts, Inc. Reporter enzyme release technology: methods of assaying for the presence of aspartic proteases and other hydrolytic enzyme activities
NL9301134A (nl) * 1993-06-29 1995-01-16 Inst Voor Agrotech Onderzoek Werkwijze voor het detekteren en eventueel kwantificeren van aktiviteit van ten minste één protease-inhibitor in een te analyseren mengsel, alsmede toepassing van de werkwijze voor het bepalen van de (rest)aktiviteit van één (of meer) afzonderlijke (iso)type(s) protease-inhibitor(en) en toepassing van de werkwijze voor het bepalen van de totale (rest)aktiviteit van een mengsel eventueel na een verwerkingsproces zoals een proces ter verwijdering of inaktivatie van protease-inhibitor(en).
DK0633473T3 (da) * 1993-06-30 1999-08-09 Stiftung F R Diagnostische For Måling af den aktiverede partielle thromboplastin-tid (APTT) i en reaktion i et enkelt trin
ATE165168T1 (de) * 1994-03-29 1998-05-15 Lepetit Spa Festphasenimmunoassay zum nachweis von inhibitoren von einem proteolytischen enzym
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
US6214579B1 (en) 1994-10-18 2001-04-10 Heska Corporation Flea leucine aminopeptidase nucleic acid molecules and uses thereof
US5776718A (en) * 1995-03-24 1998-07-07 Arris Pharmaceutical Corporation Reversible protease inhibitors
US6139840A (en) * 1995-10-18 2000-10-31 Heska Corporation Methods of eliciting an antibody response using flea protease proteins and homologs thereof
US6204010B1 (en) 1995-06-07 2001-03-20 Heska Corporation Flea protease proteins, nucleic acid molecules, and uses thereof
IL120704A0 (en) * 1996-04-24 1998-04-05 Heska Corp Flea protease proteins nucleic acid molecules and uses thereof
DE19820328A1 (de) * 1998-05-07 1999-11-11 Roche Diagnostics Gmbh Verfahren und Reagenz zum Nachweis apoptotischer Zellen bzw. einer bei Apoptose aktivierten Protease
EP1082341B1 (en) * 1998-06-01 2010-12-08 Agensys, Inc. Tumor antigen useful in diagnosis and therapy of prostate and colon cancer
US7037667B1 (en) 1998-06-01 2006-05-02 Agensys, Inc. Tumor antigen useful in diagnosis and therapy of prostate and colon cancer
FR2785053A1 (fr) * 1998-10-21 2000-04-28 Centre Nat Rech Scient Procede de detection de l'activite enzymatique de l'enzyme poly(adp-ribose polymerase) et de detection de l'activite inhibitrice ou activatrice d'un inhibiteur ou d'un activateur de cette enzyme
DE10012732A1 (de) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
JP2009527536A (ja) * 2006-02-24 2009-07-30 ノボ ノルディスク ヘルス ケア アーゲー 液体製薬調製物から非金属性タンパク質インヒビターを除去する方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4112064A (en) * 1977-02-22 1978-09-05 Hoffmann-La Roche Inc. Stabilized angiotensin I solutions
US4387166A (en) * 1981-09-15 1983-06-07 Anda Biologicals Immunoassay wherein immune complex forms and ages for at least one hour
GB8327860D0 (en) * 1983-10-18 1983-11-16 Fujisawa Pharmaceutical Co Monoclonal antiprotein c antibody
US5147638A (en) * 1988-12-30 1992-09-15 Oklahoma Medical Research Foundation Inhibition of tumor growth by blockade of the protein C system

Also Published As

Publication number Publication date
ATE160876T1 (de) 1997-12-15
GR3025752T3 (en) 1998-03-31
US5288612A (en) 1994-02-22
CA2112702A1 (en) 1993-01-21
EP0595865A4 (en) 1994-06-22
CA2112702C (en) 2004-06-08
EP0528525A1 (en) 1993-02-24
EP0528525B1 (en) 1997-12-03
AU2317492A (en) 1993-02-11
WO1993001309A1 (en) 1993-01-21
EP0595865A1 (en) 1994-05-11
DE69223355T2 (de) 1998-05-28
ES2109982T3 (es) 1998-02-01
DE69223355D1 (de) 1998-01-15
AU652474B2 (en) 1994-08-25

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