ATE515693T1 - Nachweis einer zielsubstanz in einer probe - Google Patents
Nachweis einer zielsubstanz in einer probeInfo
- Publication number
- ATE515693T1 ATE515693T1 AT99918252T AT99918252T ATE515693T1 AT E515693 T1 ATE515693 T1 AT E515693T1 AT 99918252 T AT99918252 T AT 99918252T AT 99918252 T AT99918252 T AT 99918252T AT E515693 T1 ATE515693 T1 AT E515693T1
- Authority
- AT
- Austria
- Prior art keywords
- target
- electrodes
- sample
- recognition moiety
- conductive
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 239000013076 target substance Substances 0.000 title 1
- 238000003556 assay Methods 0.000 abstract 1
- 229920001940 conductive polymer Polymers 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Detergent Compositions (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12432298A IL124322A (en) | 1998-05-04 | 1998-05-04 | Detection of an entity in a sample |
| PCT/IL1999/000232 WO1999057550A1 (en) | 1998-05-04 | 1999-05-04 | Detection of a target in a sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE515693T1 true ATE515693T1 (de) | 2011-07-15 |
Family
ID=11071451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99918252T ATE515693T1 (de) | 1998-05-04 | 1999-05-04 | Nachweis einer zielsubstanz in einer probe |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20120309106A1 (de) |
| EP (1) | EP1075656B1 (de) |
| JP (1) | JP4618886B2 (de) |
| AT (1) | ATE515693T1 (de) |
| AU (1) | AU3625999A (de) |
| CA (3) | CA2641613C (de) |
| IL (1) | IL124322A (de) |
| WO (1) | WO1999057550A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121312A (en) | 1997-07-14 | 2001-09-13 | Technion Res & Dev Foundation | Microelectronic components, their manufacture and electronic networks containing them |
| IL126776A (en) | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | A method of investing gold |
| CA2367405A1 (en) * | 1999-04-07 | 2000-10-12 | Dennis Michael Connolly | High resolution dna detection methods and devices |
| US7364920B2 (en) | 1999-10-27 | 2008-04-29 | Technion Research And Development Foundation Ltd. | Method for gold deposition |
| DE10113550A1 (de) * | 2001-03-20 | 2002-10-02 | Infineon Technologies Ag | Verfahren zum Erfassen von makromolekularen Biopolymeren mittels einer Elektrodenanordnung |
| EP1417352A4 (de) * | 2001-06-11 | 2006-11-08 | Genorx Inc | Elektronischer nachweis biologischer moleküle mittels dünnschichten |
| US6824974B2 (en) | 2001-06-11 | 2004-11-30 | Genorx, Inc. | Electronic detection of biological molecules using thin layers |
| US20040023253A1 (en) * | 2001-06-11 | 2004-02-05 | Sandeep Kunwar | Device structure for closely spaced electrodes |
| CN100344960C (zh) * | 2001-12-17 | 2007-10-24 | 清华大学 | 刺激动物细胞并记录其生理信号的装置及其生产使用方法 |
| US20030186245A1 (en) * | 2002-03-28 | 2003-10-02 | Roitman Daniel B. | Biomolecular sensors and detection methods utilizing photoinduced charge separation |
| DE10228260A1 (de) * | 2002-06-25 | 2004-01-22 | Bayer Ag | Methode und Vorrichtung zum impedimetrischen Nachweis eines oder mehrerer Analyten in einer Probe |
| US20040166520A1 (en) * | 2003-01-03 | 2004-08-26 | Connolly D. Michael | Identifying items with nucleic acid taggants |
| DE10322912A1 (de) * | 2003-05-21 | 2004-12-16 | Bayer Technology Services Gmbh | Verfahren zum Nachweis von Nukleinsäuren |
| DE10327683A1 (de) * | 2003-06-20 | 2005-01-20 | Bayer Technology Services Gmbh | Verfahren und Vorrichtung zum quantitativen elektrischen Nachweis von Analyten |
| DE10330717A1 (de) * | 2003-07-03 | 2005-02-10 | Friedrich-Schiller-Universität Jena | Vorrichtung und Verfahren zum Nachweis von Analyt |
| US20050079598A1 (en) * | 2003-10-08 | 2005-04-14 | Davis Randall W. | Apparatus and method for identification of biomolecules, in particular nucleic acid sequences, proteins, and antigens and antibodies |
| WO2005045409A1 (ja) * | 2003-11-07 | 2005-05-19 | Osaka Prefecture | 電気抵抗型検出センサおよび検出方法 |
| EP1740951B1 (de) * | 2004-04-29 | 2008-03-05 | Marc Ramael | Verfahren und kit zum nachweis von bestandteilen in einer probe |
| JP4759707B2 (ja) * | 2004-05-28 | 2011-08-31 | ハミダ・フォー・ライフ・ベスローテン・フェンノートシャップ | ナノスケール電子式検出システムおよびその製造方法 |
| JP4873463B2 (ja) * | 2006-06-30 | 2012-02-08 | 独立行政法人産業技術総合研究所 | ナノギャップ電極を有する検出素子及びこれを用いた検出方法 |
| WO2008124706A2 (en) | 2007-04-06 | 2008-10-16 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Devices and methods for target molecule characterization |
| US8968540B2 (en) | 2008-10-06 | 2015-03-03 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Trans-base tunnel reader for sequencing |
| EP2517028B1 (de) * | 2010-02-02 | 2017-12-13 | Arizona Board Of Regents | Gesteuerte tunnelvorrichtung zur sequenzierung von polymeren |
| EP2906720A4 (de) | 2012-10-10 | 2016-06-01 | Univ Arizona | Systeme und vorrichtungen zur molekülerfassung und verfahren zur herstellung davon |
| CN113985017A (zh) | 2016-01-14 | 2022-01-28 | 罗斯韦尔生物技术股份有限公司 | 分子传感器及相关方法 |
| JP7280590B2 (ja) * | 2016-01-28 | 2023-05-24 | ロズウェル バイオテクノロジーズ，インコーポレイテッド | 大スケールの分子電子工学センサアレイを使用する被分析物を測定するための方法および装置 |
| EP3408219B1 (de) | 2016-01-28 | 2022-08-17 | Roswell Biotechnologies, Inc | Massiv parallele dna-sequenzierungsvorrichtung |
| KR20240170584A (ko) | 2016-02-09 | 2024-12-03 | 로스웰 엠이 아이엔씨. | 전자 비표지 dna 및 게놈 시퀀싱 |
| CA3023256A1 (en) * | 2016-05-18 | 2017-11-23 | Integrated Nano-Technologies, Inc. | Method for detection of a pcr product |
| CA3052140A1 (en) | 2017-01-19 | 2018-07-26 | Roswell Biotechnologies, Inc. | Solid state sequencing devices comprising two dimensional layer materials |
| EP3615685B1 (de) | 2017-04-25 | 2025-02-19 | Roswell Biotechnologies, Inc | Enzymatische schaltungen für molekulare sensoren |
| US10508296B2 (en) | 2017-04-25 | 2019-12-17 | Roswell Biotechnologies, Inc. | Enzymatic circuits for molecular sensors |
| EP4023764A3 (de) | 2017-05-09 | 2022-09-21 | Roswell Biotechnologies, Inc. | Bindungssondenschaltungen für molekulare sensoren |
| CN111373049A (zh) | 2017-08-30 | 2020-07-03 | 罗斯威尔生命技术公司 | 用于dna数据存储的进行性酶分子电子传感器 |
| CN111373051A (zh) | 2017-10-10 | 2020-07-03 | 罗斯威尔生命技术公司 | 用于无扩增dna数据存储的方法、装置和系统 |
| WO2019084051A1 (en) * | 2017-10-23 | 2019-05-02 | The General Hospital Corporation | INTEGRATED MICROFLUIDIC ELECTRODE ARRAY SYSTEM FOR ENZYME-RELATED IMMUNO-SORBENT TITRATION FOR INTERVENTION DETECTION OF BIOMARKERS |
| IL278769B2 (en) | 2018-05-17 | 2025-06-01 | Stuart Lindsay | Device, system and method for direct electrical measurement of enzyme activity |
| JP2020041909A (ja) * | 2018-09-11 | 2020-03-19 | 国立大学法人九州大学 | 内分泌攪乱物質等の定量方法及び定量装置 |
| AU2020214334A1 (en) | 2019-01-30 | 2021-08-12 | Arizona Board Of Regents On Behalf Of Arizona State University | Bioelectronic circuits, systems and methods for preparing and using them |
| CN113994013A (zh) | 2019-04-12 | 2022-01-28 | 罗斯威尔生命技术公司 | 用于分子电子学传感器的多环芳族桥 |
| WO2021035221A1 (en) * | 2019-08-22 | 2021-02-25 | Universal Sequencing Technology Corporation | Methods for biomolecular sensing and detection |
| US12146852B2 (en) | 2019-09-06 | 2024-11-19 | Roswell Biotechnologies, Inc. | Methods of fabricating nanoscale structures usable in molecular sensors and other devices |
| AU2021263432A1 (en) * | 2020-04-30 | 2022-12-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for sequencing biopolymers |
| US12385873B2 (en) | 2020-12-25 | 2025-08-12 | Aurangzeb Nafees Nagy | Detection of target nucleic acid molecules |
| US12624389B2 (en) | 2021-06-07 | 2026-05-12 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for sequencing biopolymers |
| JP7555166B1 (ja) * | 2024-07-04 | 2024-09-24 | 株式会社イムノセンス | 電気化学式免疫センサー |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5137827A (en) * | 1986-03-25 | 1992-08-11 | Midwest Research Technologies, Inc. | Diagnostic element for electrical detection of a binding reaction |
| US4794089A (en) * | 1986-03-25 | 1988-12-27 | Midwest Research Microscopy, Inc. | Method for electronic detection of a binding reaction |
| US4995402A (en) * | 1988-10-12 | 1991-02-26 | Thorne, Smith, Astill Technologies, Inc. | Medical droplet whole blood and like monitoring |
| WO1990005300A1 (en) * | 1988-11-10 | 1990-05-17 | Midwest Research Technologies, Inc. | Method for electrical detection of a binding reaction |
| CA2034266A1 (en) * | 1990-02-27 | 1991-08-28 | Paul A. D'orazio | Thick film reagent spreading and reagent immobilization layer |
| IL103674A0 (en) * | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
| US5846708A (en) * | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
| DE69632921T2 (de) * | 1995-12-01 | 2005-07-14 | Innogenetics N.V. | System und verfahren zur bestimmung der impedanz und herstellungsverfahren |
| US6506895B2 (en) * | 1997-08-15 | 2003-01-14 | Surmodics, Inc. | Photoactivatable nucleic acids |
| IL126776A (en) * | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | A method of investing gold |
-
1998
- 1998-05-04 IL IL12432298A patent/IL124322A/en not_active IP Right Cessation
-
1999
- 1999-05-04 AT AT99918252T patent/ATE515693T1/de not_active IP Right Cessation
- 1999-05-04 CA CA2641613A patent/CA2641613C/en not_active Expired - Fee Related
- 1999-05-04 EP EP99918252A patent/EP1075656B1/de not_active Expired - Lifetime
- 1999-05-04 CA CA002331688A patent/CA2331688C/en not_active Expired - Fee Related
- 1999-05-04 WO PCT/IL1999/000232 patent/WO1999057550A1/en not_active Ceased
- 1999-05-04 AU AU36259/99A patent/AU3625999A/en not_active Abandoned
- 1999-05-04 CA CA2820735A patent/CA2820735A1/en not_active Abandoned
- 1999-05-04 JP JP2000547465A patent/JP4618886B2/ja not_active Expired - Fee Related
-
2011
- 2011-08-03 US US13/197,294 patent/US20120309106A1/en not_active Abandoned
-
2016
- 2016-08-08 US US15/231,264 patent/US20170121761A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20170121761A1 (en) | 2017-05-04 |
| WO1999057550A1 (en) | 1999-11-11 |
| JP2002522748A (ja) | 2002-07-23 |
| CA2641613C (en) | 2013-06-25 |
| JP4618886B2 (ja) | 2011-01-26 |
| AU3625999A (en) | 1999-11-23 |
| EP1075656A1 (de) | 2001-02-14 |
| CA2820735A1 (en) | 1999-11-11 |
| CA2331688C (en) | 2008-12-09 |
| EP1075656B1 (de) | 2011-07-06 |
| IL124322A (en) | 2002-05-23 |
| IL124322A0 (en) | 1998-12-06 |
| US20120309106A1 (en) | 2012-12-06 |
| CA2331688A1 (en) | 1999-11-11 |
| CA2641613A1 (en) | 1999-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |