ATE556030T1 - Ultrasensitiver nachweis von analyten - Google Patents

Ultrasensitiver nachweis von analyten

Info

Publication number
ATE556030T1
ATE556030T1 AT07812758T AT07812758T ATE556030T1 AT E556030 T1 ATE556030 T1 AT E556030T1 AT 07812758 T AT07812758 T AT 07812758T AT 07812758 T AT07812758 T AT 07812758T AT E556030 T1 ATE556030 T1 AT E556030T1
Authority
AT
Austria
Prior art keywords
analytes
relates
present
ultrasensitive detection
methods
Prior art date
Application number
AT07812758T
Other languages
English (en)
Inventor
Uwe Muller
Phil Lefebvre
Original Assignee
Nanosphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosphere Inc filed Critical Nanosphere Inc
Application granted granted Critical
Publication of ATE556030T1 publication Critical patent/ATE556030T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
AT07812758T 2006-07-10 2007-07-10 Ultrasensitiver nachweis von analyten ATE556030T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81976606P 2006-07-10 2006-07-10
US11/643,033 US20100035243A1 (en) 2006-07-10 2006-12-20 Ultra-sensitive detection of analytes
PCT/US2007/073166 WO2008008785A2 (en) 2006-07-10 2007-07-10 Ultra-sensitive detection of analytes

Publications (1)

Publication Number Publication Date
ATE556030T1 true ATE556030T1 (de) 2012-05-15

Family

ID=38779505

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07812758T ATE556030T1 (de) 2006-07-10 2007-07-10 Ultrasensitiver nachweis von analyten

Country Status (4)

Country Link
US (1) US20100035243A1 (de)
EP (1) EP2038656B1 (de)
AT (1) ATE556030T1 (de)
WO (1) WO2008008785A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT103730A (pt) * 2007-05-04 2008-11-04 Univ Nova De Lisboa Método colorimétrico e estojo de detecção de sequências específicas de ácidos nucleicos através de nanopartículas metálicas funcionalizadas com oligonucleótidos modificados
AU2010242073C1 (en) 2009-04-30 2015-12-24 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
CA2787201A1 (en) 2010-01-14 2011-07-21 University Of Central Florida Research Foundation, Inc. Methods for biomolecule and biomolecule complex (bmc) detection and analysis and the use of such for research and medical diagnosis
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
US9657336B2 (en) * 2011-04-25 2017-05-23 University Of Notre Dame Du Lac Systems and methods for detecting and quantifying a sequence of nucleotides
CA2852665A1 (en) 2011-10-17 2013-04-25 Good Start Genetics, Inc. Analysis methods
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
WO2014138132A2 (en) * 2013-03-04 2014-09-12 Verax Biomedical Incorporated Multi-analyte assay
US8778609B1 (en) 2013-03-14 2014-07-15 Good Start Genetics, Inc. Methods for analyzing nucleic acids
FR3003353B1 (fr) * 2013-03-14 2015-03-06 Horiba Abx Sas Nouvelle methode de dosage en flux d'un objet d'interet
US8847799B1 (en) 2013-06-03 2014-09-30 Good Start Genetics, Inc. Methods and systems for storing sequence read data
EP3058096A1 (de) 2013-10-18 2016-08-24 Good Start Genetics, Inc. Verfahren zur beurteilung eines genomischen bereichs einer person
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
WO2015175530A1 (en) 2014-05-12 2015-11-19 Gore Athurva Methods for detecting aneuploidy
US11408024B2 (en) 2014-09-10 2022-08-09 Molecular Loop Biosciences, Inc. Methods for selectively suppressing non-target sequences
WO2016048829A1 (en) 2014-09-24 2016-03-31 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
EP3271480B8 (de) 2015-01-06 2022-09-28 Molecular Loop Biosciences, Inc. Abtastung auf strukturelle varianten
CN109070083A (zh) * 2016-04-22 2018-12-21 贝克顿迪金森公司 用于阵列产生的高密度沉积
AU2017345814B2 (en) 2016-10-21 2022-07-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Molecular nanotags
CN111344551B (zh) 2017-10-23 2021-07-20 美国政府(由卫生和人类服务部的部长所代表) 光谱散射流式细胞仪的光学配置方法
US20220283083A1 (en) * 2021-03-05 2022-09-08 Sysmex Corporation Method for analyzing test substance, analyzer, training method, analyzer system, and analysis program
WO2023048713A1 (en) * 2021-09-23 2023-03-30 Genomic Testing Cooperative, LCA Compositions and methods for targeted ngs sequencing of cfrna and cftna
CN117723750A (zh) * 2024-02-07 2024-03-19 南昌大学 基于链霉亲和素-生物素反应的动态光散射免疫检测方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650770A (en) * 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
US5665539A (en) * 1991-07-12 1997-09-09 The Regents Of The University Of California Immuno-polymerase chain reaction system for antigen detection
US5635602A (en) * 1993-08-13 1997-06-03 The Regents Of The University Of California Design and synthesis of bispecific DNA-antibody conjugates
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6120666A (en) * 1996-09-26 2000-09-19 Ut-Battelle, Llc Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US7225082B1 (en) * 1999-10-01 2007-05-29 Oxonica, Inc. Colloidal rod particles as nanobar codes
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20020164271A1 (en) * 2001-05-02 2002-11-07 Ho Winston Z. Wavelength-coded bead for bioassay and signature recogniton
US7238472B2 (en) * 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
CA2563510A1 (en) * 2001-07-13 2005-11-17 Nanosphere, Inc. Method for preparing substrates having immobilized molecules and substrates
US6714299B2 (en) * 2001-07-13 2004-03-30 Genicon Sciences Corporation Use of light scattering particles in design, manufacture, and quality control of small volume instruments, devices, and processes

Also Published As

Publication number Publication date
EP2038656B1 (de) 2012-05-02
WO2008008785A3 (en) 2008-08-14
EP2038656A2 (de) 2009-03-25
US20100035243A1 (en) 2010-02-11
WO2008008785A2 (en) 2008-01-17

Similar Documents

Publication Publication Date Title
ATE556030T1 (de) Ultrasensitiver nachweis von analyten
CY1126069T1 (el) Προσδιορισμος για αντισωματα ιου jc
ATE538386T1 (de) Nachweis von krebs anhand von erhöhten bcl-2- konzentrationen
ATE541054T1 (de) Bio-barcode erkennung für zielmoleküle
BRPI0809138B8 (pt) método para detectar a presença ou quantidade de um ou mais analitos em uma amostra biológica
TW200720441A (en) New labelling strategies for the sensitive detection of analytes
DE602005013225D1 (de) Aptamer-nanopartikelkonjugate und verwendungsverfahren zur detektion von zielanalyten
NZ629703A (en) Methods and compositions for detecting multiple analytes with a single signal
MX2009004460A (es) Inmunoensayo de analitos en muestras que contienen anticuerpos anti-analito endogenos.
EP1379693A4 (de) Auf oligonukleotid-modifizierten partikeln basierende bio-strichcodes
EP2340300A4 (de) Verfahren zur erkennung von analyten
ATE466108T1 (de) Optoelektronisches detektionssystem
WO2007005666A3 (en) System and method of analyte detection using differential receptors
ATE431854T1 (de) Auf bio-barcodes beruhender nachweis von zielanalyten
WO2008048371A3 (en) Methods and compositions for highly sensitive analysis of markers and detection of molecules
DK2132339T3 (da) Fremgangsmåde til detektering af en analyt i en biologisk matrix
DE502005005132D1 (de) Verfahren zur erhöhung des dynamischen messbereichs von auf spezifischen bindereaktionen basierenden, insbesondere immunologischen testelementen
WO2007133586A3 (en) Systems and methods for developing diagnostic tests based on biomarker information from legacy clinical sample sets
BRPI0607350A2 (pt) método para detecção da presença ou quantidade de uma proteìna erroneamente duplicada em uma amostra e kit
WO2007133704A3 (en) A non-nucleic acid based biobarcode assay for detection of biological materials
CY1112553T1 (el) Ανοσοπροσδιορισμοι υψηλης ευαισθησιας και κιτια για τον προσδιορισμο πεπτιδιων και πρωτεϊνων βιολογικου ενδιαφεροντος
DE60315715D1 (de) Verwendung von nicotinamide n-methyltransferase zur diagnose von kolorektalem krebs
DK2038430T3 (da) Toll-Like-Receptor-4-dysfunktion og de biologiske anvendelser deraf
WO2007094805A3 (en) Method for electrocatalytic protein detection
BRPI0416270A (pt) método para detectar um analito em uma amostra, e, método e kit para detectar um anticorpo especìfico de uma amostra