DE69808895D1 - Leistungssteigerung von bindungsassays mit verwendung mehr als einer markierungsmittel - Google Patents

Leistungssteigerung von bindungsassays mit verwendung mehr als einer markierungsmittel

Info

Publication number
DE69808895D1
DE69808895D1 DE69808895T DE69808895T DE69808895D1 DE 69808895 D1 DE69808895 D1 DE 69808895D1 DE 69808895 T DE69808895 T DE 69808895T DE 69808895 T DE69808895 T DE 69808895T DE 69808895 D1 DE69808895 D1 DE 69808895D1
Authority
DE
Germany
Prior art keywords
binding assays
increased performance
marking agent
analyte
detect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69808895T
Other languages
English (en)
Other versions
DE69808895T2 (de
Inventor
Uri Piran
J Quinn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of DE69808895D1 publication Critical patent/DE69808895D1/de
Publication of DE69808895T2 publication Critical patent/DE69808895T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69808895T 1997-01-31 1998-02-02 Leistungssteigerung von bindungsassays mit verwendung mehr als einer markierungsmittel Expired - Fee Related DE69808895T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/791,591 US6087088A (en) 1997-01-31 1997-01-31 Binding assays using more than one label for determining analyte in the presence of interfering factors
PCT/IB1998/000125 WO1998034109A1 (en) 1997-01-31 1998-02-02 Improving performance of binding assays by use of more than one label

Publications (2)

Publication Number Publication Date
DE69808895D1 true DE69808895D1 (de) 2002-11-28
DE69808895T2 DE69808895T2 (de) 2003-02-27

Family

ID=25154194

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69808895T Expired - Fee Related DE69808895T2 (de) 1997-01-31 1998-02-02 Leistungssteigerung von bindungsassays mit verwendung mehr als einer markierungsmittel

Country Status (8)

Country Link
US (1) US6087088A (de)
EP (1) EP0968422B1 (de)
JP (1) JP2001511890A (de)
AT (1) ATE226727T1 (de)
AU (1) AU5572998A (de)
DE (1) DE69808895T2 (de)
ES (1) ES2186121T3 (de)
WO (1) WO1998034109A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004500569A (ja) * 2000-02-25 2004-01-08 ルミネックス　コーポレイション 多重アッセイ法のための内部標準および内部対照
CA2422856C (en) * 2000-09-25 2012-02-07 Abbott Laboratories Methods and kits for decreasing interferences of assay samples containing plasma or serum in specific binding assays by using a large polycation
US6780602B2 (en) * 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
GB0310270D0 (en) * 2003-05-03 2003-06-11 Univ Edinburgh Biomolecular devices
US7723099B2 (en) 2003-09-10 2010-05-25 Abbott Point Of Care Inc. Immunoassay device with immuno-reference electrode
US20060257929A1 (en) * 2003-11-12 2006-11-16 Microbiosystems, Limited Partnership Method for the rapid taxonomic identification of pathogenic microorganisms and their toxic proteins
WO2006023985A2 (en) * 2004-08-23 2006-03-02 Remote Clinical Solutions, Inc. System and method for modifying a fluid for oral administration
US8445293B2 (en) * 2005-02-09 2013-05-21 Rapid Pathogen Screening, Inc. Method to increase specificity and/or accuracy of lateral flow immunoassays
US8470608B2 (en) * 2008-05-20 2013-06-25 Rapid Pathogen Screening, Inc Combined visual/fluorescence analyte detection test
EP1977242B1 (de) * 2006-01-27 2016-08-03 Becton Dickinson and Company Querfluss-immuntest mit eingekapselter erkennungsmodalität
US8084223B2 (en) * 2009-03-23 2011-12-27 Siemens Healthcare Diagnostics Inc. Detection of false results in assays
CN101864288B (zh) * 2009-04-14 2013-11-13 博阳生物科技（上海）有限公司 游离三碘甲腺原氨酸检测微粒、其制备及应用
ES2735994T3 (es) * 2013-04-11 2019-12-23 Cytocore Inc Método para estimar el riesgo de que la displasia evolucione a cáncer en un sujeto
EP3176580A1 (de) * 2015-12-01 2017-06-07 Roche Diagnostics GmbH Verfahren zur reduzierung von interferenzen in immunoassays

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713347A (en) * 1985-01-14 1987-12-15 Sensor Diagnostics, Inc. Measurement of ligand/anti-ligand interactions using bulk conductance
DE3789430T2 (de) * 1986-06-17 1994-10-27 Baxter Diagnostics Inc Homogenes fluortestverfahren mit abstoss des fluorzenten hintergrundes.
US5380649A (en) * 1987-04-10 1995-01-10 Boehringer Mannheim Gmbh Enzymatic determination of analyte ions in fluids by optimizing measurement levels
GB8800419D0 (en) * 1988-01-08 1988-02-10 Amersham Int Plc Method for measuring free fraction of ligands in biological fluids
DE3900534A1 (de) * 1989-01-10 1990-07-12 Boehringer Mannheim Gmbh Diagnostischer nachweis unter verwendung von chimaeren antikoerpern
JP2683172B2 (ja) * 1991-10-01 1997-11-26 キヤノン株式会社 検体測定方法及び検体測定装置
US5366859A (en) * 1991-10-31 1994-11-22 Mitsubishi Petrochemical Co., Ltd. Radioimmunoassay method
US5723304A (en) * 1992-08-03 1998-03-03 Gec-Marconi Limited Immunological detection using two detectable labels
DE19504198A1 (de) * 1995-02-09 1996-08-14 Behringwerke Ag Kompetitiver Immuntest unter Verwendung komplexierter Analytderivate
US5783453A (en) * 1995-06-29 1998-07-21 Chiron Diagnostics Corporation Non-separation specific binding chemiluminescent assay
ES2270459T3 (es) * 1996-05-01 2007-04-01 Dade Behring Marburg Gmbh Composiciones quimioluminiscentes y su uso en la deteccion de peroxido de hidrogeno.

Also Published As

Publication number Publication date
DE69808895T2 (de) 2003-02-27
ES2186121T3 (es) 2003-05-01
AU5572998A (en) 1998-08-25
EP0968422A1 (de) 2000-01-05
WO1998034109A1 (en) 1998-08-06
ATE226727T1 (de) 2002-11-15
US6087088A (en) 2000-07-11
EP0968422B1 (de) 2002-10-23
JP2001511890A (ja) 2001-08-14

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee