ES2186121T3 - Mejora de los resultados de los dosificados de inmunodeteccion gracias al empleo de varios trazadores. - Google Patents

Mejora de los resultados de los dosificados de inmunodeteccion gracias al empleo de varios trazadores.

Info

Publication number
ES2186121T3
ES2186121T3 ES98900644T ES98900644T ES2186121T3 ES 2186121 T3 ES2186121 T3 ES 2186121T3 ES 98900644 T ES98900644 T ES 98900644T ES 98900644 T ES98900644 T ES 98900644T ES 2186121 T3 ES2186121 T3 ES 2186121T3
Authority
ES
Spain
Prior art keywords
immunodetection
improvement
dosage results
various drawers
analyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98900644T
Other languages
English (en)
Inventor
Uri Piran
John J Quinn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of ES2186121T3 publication Critical patent/ES2186121T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles

Abstract

La invención se refiere a nuevas técnicas de ensayo de inmunodetección desarrolladas con eficiencia y sensibilidad mejoradas mediante la identificación de los factores de interferencia. Esta técnica consiste en una incubación simultánea, de uno o más trazadores, alguno de los cuales se utiliza en primer lugar para detectar analitos, y los otros para detectar sustancias interferentes que se originan en la muestra. Las relaciones matemáticas entre los trazadores permiten hacer correcciones que permiten hacer determinaciones más precisas y sensitivas de la presencia y concentración del analito.
ES98900644T 1997-01-31 1998-02-02 Mejora de los resultados de los dosificados de inmunodeteccion gracias al empleo de varios trazadores. Expired - Lifetime ES2186121T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/791,591 US6087088A (en) 1997-01-31 1997-01-31 Binding assays using more than one label for determining analyte in the presence of interfering factors

Publications (1)

Publication Number Publication Date
ES2186121T3 true ES2186121T3 (es) 2003-05-01

Family

ID=25154194

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98900644T Expired - Lifetime ES2186121T3 (es) 1997-01-31 1998-02-02 Mejora de los resultados de los dosificados de inmunodeteccion gracias al empleo de varios trazadores.

Country Status (8)

Country Link
US (1) US6087088A (es)
EP (1) EP0968422B1 (es)
JP (1) JP2001511890A (es)
AT (1) ATE226727T1 (es)
AU (1) AU5572998A (es)
DE (1) DE69808895T2 (es)
ES (1) ES2186121T3 (es)
WO (1) WO1998034109A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010026920A1 (en) * 2000-02-25 2001-10-04 Mark Chandler Internal standards and controls for multiplexed assay
WO2002027316A2 (en) * 2000-09-25 2002-04-04 Abbott Laboratories Methods and kits for decreasing interferences of assays samples containing plasma or serum in specific binding assays by using a large polycation
US6780602B2 (en) * 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
GB0310270D0 (en) * 2003-05-03 2003-06-11 Univ Edinburgh Biomolecular devices
US7723099B2 (en) * 2003-09-10 2010-05-25 Abbott Point Of Care Inc. Immunoassay device with immuno-reference electrode
US20060257929A1 (en) * 2003-11-12 2006-11-16 Microbiosystems, Limited Partnership Method for the rapid taxonomic identification of pathogenic microorganisms and their toxic proteins
WO2006023985A2 (en) * 2004-08-23 2006-03-02 Remote Clinical Solutions, Inc. System and method for modifying a fluid for oral administration
US8445293B2 (en) * 2005-02-09 2013-05-21 Rapid Pathogen Screening, Inc. Method to increase specificity and/or accuracy of lateral flow immunoassays
US8470608B2 (en) * 2008-05-20 2013-06-25 Rapid Pathogen Screening, Inc Combined visual/fluorescence analyte detection test
US20090155811A1 (en) * 2006-01-27 2009-06-18 Oxonica, Inc. Lateral Flow Immunoassay With Encapsulated Detection Modality
US8084223B2 (en) * 2009-03-23 2011-12-27 Siemens Healthcare Diagnostics Inc. Detection of false results in assays
CN101864288B (zh) * 2009-04-14 2013-11-13 博阳生物科技（上海）有限公司 游离三碘甲腺原氨酸检测微粒、其制备及应用
CN105143882B (zh) * 2013-04-11 2018-10-26 塞托克尔公司 使用细胞学和免疫学的生物学样本评估方法
EP3176580A1 (en) * 2015-12-01 2017-06-07 Roche Diagnostics GmbH Method for reduction of interferences in immunoassays

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713347A (en) * 1985-01-14 1987-12-15 Sensor Diagnostics, Inc. Measurement of ligand/anti-ligand interactions using bulk conductance
EP0272320B1 (en) * 1986-06-17 1994-03-23 Baxter Diagnostics Inc. Homogeneous fluoroassay methods employing fluorescent background rejection
US5380649A (en) * 1987-04-10 1995-01-10 Boehringer Mannheim Gmbh Enzymatic determination of analyte ions in fluids by optimizing measurement levels
GB8800419D0 (en) * 1988-01-08 1988-02-10 Amersham Int Plc Method for measuring free fraction of ligands in biological fluids
DE3900534A1 (de) * 1989-01-10 1990-07-12 Boehringer Mannheim Gmbh Diagnostischer nachweis unter verwendung von chimaeren antikoerpern
JP2683172B2 (ja) * 1991-10-01 1997-11-26 キヤノン株式会社 検体測定方法及び検体測定装置
US5366859A (en) * 1991-10-31 1994-11-22 Mitsubishi Petrochemical Co., Ltd. Radioimmunoassay method
US5723304A (en) * 1992-08-03 1998-03-03 Gec-Marconi Limited Immunological detection using two detectable labels
DE19504198A1 (de) * 1995-02-09 1996-08-14 Behringwerke Ag Kompetitiver Immuntest unter Verwendung komplexierter Analytderivate
US5783453A (en) * 1995-06-29 1998-07-21 Chiron Diagnostics Corporation Non-separation specific binding chemiluminescent assay
ES2270459T3 (es) * 1996-05-01 2007-04-01 Dade Behring Marburg Gmbh Composiciones quimioluminiscentes y su uso en la deteccion de peroxido de hidrogeno.

Also Published As

Publication number Publication date
EP0968422B1 (en) 2002-10-23
US6087088A (en) 2000-07-11
DE69808895T2 (de) 2003-02-27
ATE226727T1 (de) 2002-11-15
JP2001511890A (ja) 2001-08-14
WO1998034109A1 (en) 1998-08-06
AU5572998A (en) 1998-08-25
EP0968422A1 (en) 2000-01-05
DE69808895D1 (de) 2002-11-28

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