ATE226727T1 - Leistungssteigerung von bindungsassays mit verwendung mehr als einer markierungsmittel - Google Patents

Leistungssteigerung von bindungsassays mit verwendung mehr als einer markierungsmittel

Info

Publication number
ATE226727T1
ATE226727T1 AT98900644T AT98900644T ATE226727T1 AT E226727 T1 ATE226727 T1 AT E226727T1 AT 98900644 T AT98900644 T AT 98900644T AT 98900644 T AT98900644 T AT 98900644T AT E226727 T1 ATE226727 T1 AT E226727T1
Authority
AT
Austria
Prior art keywords
binding assay
improving
performance
marking agent
analyte
Prior art date
Application number
AT98900644T
Other languages
English (en)
Inventor
Uri Piran
John J Quinn
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE226727T1 publication Critical patent/ATE226727T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT98900644T 1997-01-31 1998-02-02 Leistungssteigerung von bindungsassays mit verwendung mehr als einer markierungsmittel ATE226727T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/791,591 US6087088A (en) 1997-01-31 1997-01-31 Binding assays using more than one label for determining analyte in the presence of interfering factors
PCT/IB1998/000125 WO1998034109A1 (en) 1997-01-31 1998-02-02 Improving performance of binding assays by use of more than one label

Publications (1)

Publication Number Publication Date
ATE226727T1 true ATE226727T1 (de) 2002-11-15

Family

ID=25154194

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98900644T ATE226727T1 (de) 1997-01-31 1998-02-02 Leistungssteigerung von bindungsassays mit verwendung mehr als einer markierungsmittel

Country Status (8)

Country Link
US (1) US6087088A (de)
EP (1) EP0968422B1 (de)
JP (1) JP2001511890A (de)
AT (1) ATE226727T1 (de)
AU (1) AU5572998A (de)
DE (1) DE69808895T2 (de)
ES (1) ES2186121T3 (de)
WO (1) WO1998034109A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004500569A (ja) * 2000-02-25 2004-01-08 ルミネックス　コーポレイション 多重アッセイ法のための内部標準および内部対照
EP1320753A2 (de) * 2000-09-25 2003-06-25 Abbott Laboratories Verfahren und kits zur reduzierung von störungen in plasma oder serum enthaltenden proben bei spezifische bindungstests unter verwendung eines grossen polycations
US6780602B2 (en) * 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
GB0310270D0 (en) * 2003-05-03 2003-06-11 Univ Edinburgh Biomolecular devices
US7723099B2 (en) * 2003-09-10 2010-05-25 Abbott Point Of Care Inc. Immunoassay device with immuno-reference electrode
US20060257929A1 (en) * 2003-11-12 2006-11-16 Microbiosystems, Limited Partnership Method for the rapid taxonomic identification of pathogenic microorganisms and their toxic proteins
JP2008516641A (ja) * 2004-08-23 2008-05-22 リモート クリニカル ソリューションズ インコーポレイテッド 経口投与するための流体を変更するためのシステム及び方法
US8445293B2 (en) * 2005-02-09 2013-05-21 Rapid Pathogen Screening, Inc. Method to increase specificity and/or accuracy of lateral flow immunoassays
US8470608B2 (en) * 2008-05-20 2013-06-25 Rapid Pathogen Screening, Inc Combined visual/fluorescence analyte detection test
EP1977242B1 (de) * 2006-01-27 2016-08-03 Becton Dickinson and Company Querfluss-immuntest mit eingekapselter erkennungsmodalität
US8084223B2 (en) * 2009-03-23 2011-12-27 Siemens Healthcare Diagnostics Inc. Detection of false results in assays
CN101864288B (zh) * 2009-04-14 2013-11-13 博阳生物科技（上海）有限公司 游离三碘甲腺原氨酸检测微粒、其制备及应用
CN105143882B (zh) * 2013-04-11 2018-10-26 塞托克尔公司 使用细胞学和免疫学的生物学样本评估方法
EP3176580A1 (de) * 2015-12-01 2017-06-07 Roche Diagnostics GmbH Verfahren zur reduzierung von interferenzen in immunoassays

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713347A (en) * 1985-01-14 1987-12-15 Sensor Diagnostics, Inc. Measurement of ligand/anti-ligand interactions using bulk conductance
JP2802921B2 (ja) * 1986-06-17 1998-09-24 マイクロスキャン、インコーポレイテッド 蛍光バックグラウンド消去および水溶性希土類金属キレートフルオロフォルを使用する均質蛍光アッセイ
US5409814A (en) * 1987-04-10 1995-04-25 Boehringer Mannheim Gmbh Determination of ions in fluids
GB8800419D0 (en) * 1988-01-08 1988-02-10 Amersham Int Plc Method for measuring free fraction of ligands in biological fluids
DE3900534A1 (de) * 1989-01-10 1990-07-12 Boehringer Mannheim Gmbh Diagnostischer nachweis unter verwendung von chimaeren antikoerpern
JP2683172B2 (ja) * 1991-10-01 1997-11-26 キヤノン株式会社 検体測定方法及び検体測定装置
US5366859A (en) * 1991-10-31 1994-11-22 Mitsubishi Petrochemical Co., Ltd. Radioimmunoassay method
WO1994003811A1 (en) * 1992-08-03 1994-02-17 Gec-Marconi Limited Immunological detection using two detectable labels
DE19504198A1 (de) * 1995-02-09 1996-08-14 Behringwerke Ag Kompetitiver Immuntest unter Verwendung komplexierter Analytderivate
US5783453A (en) * 1995-06-29 1998-07-21 Chiron Diagnostics Corporation Non-separation specific binding chemiluminescent assay
DE69736382T2 (de) * 1996-05-01 2007-08-09 Dade Behring Marburg Gmbh Chemilumineszente zusammensetungen und ihre verwendung zum nachweis von wasserstoffperoxid

Also Published As

Publication number Publication date
JP2001511890A (ja) 2001-08-14
ES2186121T3 (es) 2003-05-01
WO1998034109A1 (en) 1998-08-06
US6087088A (en) 2000-07-11
DE69808895T2 (de) 2003-02-27
AU5572998A (en) 1998-08-25
EP0968422B1 (de) 2002-10-23
EP0968422A1 (de) 2000-01-05
DE69808895D1 (de) 2002-11-28

Similar Documents

Publication Publication Date Title
FI890526A0 (fi) Analyyttikonsentraation määritys käyttäen kahta leimausainetta
ATE226727T1 (de) Leistungssteigerung von bindungsassays mit verwendung mehr als einer markierungsmittel
ATE371189T1 (de) Liganden-bindetest und kit mit einer abtrennzone für störende probenkomponenten
NZ306051A (en) Testing using electrochemiluminescence
ATE515693T1 (de) Nachweis einer zielsubstanz in einer probe
DE69330067D1 (de) Analytische testvorrichtung einschliesslich negativ- und positivkontrolle
DK1111386T3 (da) Teststrimmel til bestemmelse af en analyt i en flydende pröve
ES2054617T3 (es) Nuevo metodo para la deteccion y/o determinacion cuantitativa de agentes ligantes especificos y sus correspondientes sustancias ligables.
ATE127921T1 (de) Liganden-rezeptor-assays unter verwendung eines schwellenwertes.
ATE412050T1 (de) Fluoreszenzprotein-sensoren zur erkennung von analyten
ATE186599T1 (de) Verfahren für nicht-kompetitive bindungsassays
CA2426479A1 (en) Dye pair for fluorescence resonance energy transfer (fret) measurements
DE50109428D1 (de) Nachweisverfahren, in welchem der High-Dose-Hook-Effekt vermieden, verringert oder nachgewiesen wird
ATE461450T1 (de) Verwendung von kontrollflächen zur detektion von störproben in einem nachweisverfahren
ATE449963T1 (de) Immunoassays unter verwendung von sers (surface enhanced raman scattering)
DK1513878T3 (da) Sammensætninger og fremgangsmåder til analyse af Apo B48 og Apo B100
DE69214906D1 (de) Homogene Immunotests unter Verwendung von Enzym-Inhibitoren
DE69736336D1 (de) Verfahren zur messung von blutersatzstoffen
ATE333510T1 (de) Enzymatische messung von mycophenolsäure
EP1293780A3 (de) Spezifisches Bindungsanalyseverfahren
ATE232981T1 (de) Differenziertes timingsverfahren zum nachweiss multiple analyte in eine testprobe
ATE354090T1 (de) Verfahren zum bestimmen von crp mit hilfe von phosphorylcholin
ES2184109T3 (es) Determinacion de analitos mediando utilizacion de dos marcaciones.
DE50006325D1 (de) Verfahren zum nachweis von analyten in einer messprobe sowie messträger hierfür
DE59910326D1 (de) Verwendung derivatisierter Reagenzien in Chemilumineszenz- und Elektrochemilumineszenz-Nachweisverfahren

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties