DK0382213T3 - Biphenylderivat, middel til reparation af eller beskyttelse mod nervecelledegeneration og fremgangsmåde til fremstilling af et phenylderivat, som indgår i dette middel - Google Patents
Biphenylderivat, middel til reparation af eller beskyttelse mod nervecelledegeneration og fremgangsmåde til fremstilling af et phenylderivat, som indgår i dette middelInfo
- Publication number
- DK0382213T3 DK0382213T3 DK90102488.5T DK90102488T DK0382213T3 DK 0382213 T3 DK0382213 T3 DK 0382213T3 DK 90102488 T DK90102488 T DK 90102488T DK 0382213 T3 DK0382213 T3 DK 0382213T3
- Authority
- DK
- Denmark
- Prior art keywords
- agent
- derivative
- repairing
- preparing
- nerve cell
- Prior art date
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D207/26—2-Pyrrolidones
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- C07C35/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a non-condensed ring
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- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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- C07C215/66—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with quaternised amino groups bound to the carbon skeleton
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- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
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- C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2898389 | 1989-02-08 | ||
JP29941589 | 1989-11-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0382213T3 true DK0382213T3 (da) | 1995-07-10 |
Family
ID=26367135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90102488.5T DK0382213T3 (da) | 1989-02-08 | 1990-02-08 | Biphenylderivat, middel til reparation af eller beskyttelse mod nervecelledegeneration og fremgangsmåde til fremstilling af et phenylderivat, som indgår i dette middel |
Country Status (8)
Country | Link |
---|---|
US (1) | US5053548A (da) |
EP (1) | EP0382213B1 (da) |
JP (1) | JPH07103056B2 (da) |
KR (1) | KR900012875A (da) |
CN (1) | CN1029227C (da) |
DE (1) | DE69019185T2 (da) |
DK (1) | DK0382213T3 (da) |
ES (1) | ES2071688T3 (da) |
Families Citing this family (54)
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JP2872800B2 (ja) * | 1990-10-29 | 1999-03-24 | ダイセル化学工業株式会社 | 光学活性ビフェニル誘導体及び光学分割方法 |
DE69414348T2 (de) * | 1993-06-18 | 1999-05-12 | Otsuka Pharmaceutical Co., Ltd., Tokio/Tokyo | Fluorenonderivate, verfahren zu ihrer herstellung sowie wiederherstellungs- und schutzmittel für zentrale und periphere nervendegenerationen |
JP3802581B2 (ja) * | 1995-03-01 | 2006-07-26 | 富山化学工業株式会社 | 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤 |
WO1999000346A1 (en) * | 1997-06-26 | 1999-01-07 | Board Of Regents, The University Of Texas System | Synthesis of dihydrohonokiol compositions |
CO5011067A1 (es) * | 1997-11-03 | 2001-02-28 | Novartis Ag | Derivados de bifenilo como productos farmaceuticos, su pre- paracion y composiciones farmaceuticas que los contienen |
WO1999036380A1 (fr) * | 1998-01-14 | 1999-07-22 | Tsumura & Co. | Agents anxiolytiques contenant des derives de biphenyle comme ingredient actif |
AU2474399A (en) | 1998-01-26 | 1999-08-09 | Mitokor | Mitochondria protecting agents for treating mitochondria associated diseases |
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US6943266B1 (en) * | 1999-10-18 | 2005-09-13 | University Of Connecticut | Bicyclic cannabinoid agonists for the cannabinoid receptor |
US7393842B2 (en) * | 2001-08-31 | 2008-07-01 | University Of Connecticut | Pyrazole analogs acting on cannabinoid receptors |
US6900236B1 (en) | 1999-10-18 | 2005-05-31 | University Of Connecticut | Cannabimimetic indole derivatives |
US8084467B2 (en) * | 1999-10-18 | 2011-12-27 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
DE60033834T2 (de) | 1999-10-18 | 2007-11-15 | The University Of Connecticut, Farmington | Für periphäre cannabinoid-rezeptoren selektive liganden |
US6472436B1 (en) * | 2000-07-17 | 2002-10-29 | The Salk Institute For Biological Studies | Methods for protecting cells from amyloid toxicity and for inhibiting amyloid protein production |
DE10044793A1 (de) * | 2000-09-11 | 2002-04-04 | Bayer Ag | Diphosphine |
JP2002027998A (ja) * | 2000-09-29 | 2002-01-29 | Shionogi & Co Ltd | 神経細胞変性調節活性の測定方法 |
US20030207945A1 (en) * | 2001-12-20 | 2003-11-06 | Harper David Scott | Non-halogenated phenyl substituted phenols, antimicrobial compositions containing the same, and methods of using the same |
JP2004532185A (ja) * | 2001-01-26 | 2004-10-21 | ユニバーシティ オブ コネチカット | 新規なカンナビミメティックリガンド |
DE60237431D1 (de) | 2001-01-29 | 2010-10-07 | Univ Connecticut | Rezeptor-selektive cannabimimetische aminoalkylindole |
JP4312594B2 (ja) * | 2001-07-13 | 2009-08-12 | ユニバーシティ オブ コネチカット | 新規な二環式及び三環式カンナビノイド |
WO2003035005A2 (en) * | 2001-10-26 | 2003-05-01 | University Of Connecticut | Heteroindanes: a new class of potent cannabimimetic ligands |
WO2003057671A1 (fr) * | 2001-12-28 | 2003-07-17 | Takeda Chemical Industries, Ltd. | Compose biaryle et son utilisation |
US20040105906A1 (en) * | 2002-03-22 | 2004-06-03 | Arbiser Jack L. | Antiagionecic, antitumor, chemopreventative agents |
CN1678303A (zh) | 2002-08-23 | 2005-10-05 | 康涅狄格大学 | 具有治疗作用的酮类大麻类 |
US20040087590A1 (en) * | 2002-08-23 | 2004-05-06 | University Of Connecticut | Novel biphenyl and biphenyl-like cannabinoids |
CN1805945A (zh) * | 2003-04-18 | 2006-07-19 | 麦克公司 | 作为钠通道阻滞剂的联芳基取代的噻唑、噁唑和咪唑 |
US7629006B2 (en) * | 2004-09-09 | 2009-12-08 | AZI Company, Ltd | Process for preparing extract from rhus verniciflua and pharmaceutical composition containing the same |
EP1853539A4 (en) * | 2005-02-23 | 2010-04-21 | Jack L Arbiser | HONOKIOL DERIVATIVES TO TREAT PROLIFERATIVE DISEASES |
US7608741B2 (en) * | 2005-05-30 | 2009-10-27 | Korea Institute Of Oriental Medicine | Mass separation method of magnolol from Magnoliae cortex radix |
TWI403320B (zh) | 2005-12-16 | 2013-08-01 | Infinity Discovery Inc | 用於抑制bcl蛋白和結合夥伴間之交互作用的化合物及方法 |
KR100892596B1 (ko) * | 2007-02-12 | 2009-04-09 | 바이오스펙트럼 주식회사 | 바이페닐 다이올 유도체 및 이를 유효성분으로 포함하는조성물 |
KR100926466B1 (ko) * | 2008-09-25 | 2009-11-13 | 주식회사 바이오랜드 | 4-o-메틸호노키올을 함유하는 아밀로이드 관련 질환의 치료 또는 예방용 약제 조성물 |
KR100932962B1 (ko) | 2008-09-25 | 2009-12-21 | 주식회사 바이오랜드 | 4-o-메틸호노키올을 함유하는 아밀로이드 관련 질환의 개선 또는 예방용 기능성 식품조성물 |
WO2010036052A2 (ko) * | 2008-09-25 | 2010-04-01 | 주식회사 바이오랜드 | 4-o-메틸호노키올을 함유하는 아밀로이드 관련 질환의 치료 또는 예방용 조성물 |
EP2423181A1 (en) | 2010-07-28 | 2012-02-29 | Prous Institute For Biomedical Research S.A. | Multitarget substituted biphenyl diol derivatives |
KR101492225B1 (ko) * | 2010-10-20 | 2015-03-09 | 주식회사 바이오랜드 | 4-o-메틸호노키올의 합성방법 |
US8962889B2 (en) * | 2010-10-20 | 2015-02-24 | Sumitomo Chemical Company, Limited | Process for producing optically active β-amino aldehyde compound |
JP5676014B2 (ja) * | 2010-12-21 | 2015-02-25 | コルゲート・パーモリブ・カンパニーColgate−Palmolive Company | 抗菌剤としてのハロゲン化ビフェノール |
KR101305524B1 (ko) * | 2011-01-26 | 2013-09-06 | 주식회사 바이오랜드 | 신규한 4-o-메틸호노키올 유도체를 유효성분으로 포함하는 치매 치료용 조성물 |
CN104892374A (zh) * | 2014-03-03 | 2015-09-09 | 北京理工大学 | 一种具有苄醇或苄基甲醚取代基的厚朴酚衍生物 |
MX2018004993A (es) * | 2015-10-23 | 2018-09-12 | Colgate Palmolive Co | Sintesis mejorada de honokiol. |
CN110664795B (zh) * | 2019-09-20 | 2022-12-27 | 广东省禾基生物科技有限公司 | 水溶性组合物及其制备方法与应用 |
CN110615742B (zh) * | 2019-09-20 | 2021-11-19 | 广东省禾基生物科技有限公司 | 厚朴酚衍生物及其制备方法与应用 |
CN110845350B (zh) * | 2019-09-20 | 2021-11-19 | 广东省禾基生物科技有限公司 | 和厚朴酚衍生物及其制备方法与应用 |
CN111039847B (zh) * | 2019-12-05 | 2021-04-16 | 深圳市老年医学研究所 | 厚朴酚衍生物及其制备方法和应用 |
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DE1597617A1 (de) * | 1967-07-20 | 1970-05-21 | Kalle Ag | Zweikomponenten-Diazotypiematerial |
DD122513A1 (da) * | 1972-03-20 | 1976-10-12 | ||
GB1460295A (en) * | 1973-06-01 | 1976-12-31 | Boots Co Ltd | Biphenyls and diphenyl ethers |
JPS5331405B2 (da) * | 1973-09-14 | 1978-09-02 | ||
US4188274A (en) * | 1975-02-26 | 1980-02-12 | Standard Oil Company (Indiana) | Process for trifluoromethylation of aromatic and heterocyclic compounds |
US4174447A (en) * | 1975-02-26 | 1979-11-13 | Standard Oil Company (Indiana) | Process for dimerization, arylation and trifluoromethylation of aromatic and heterocyclic compounds |
US4195154A (en) * | 1977-08-15 | 1980-03-25 | The Dow Chemical Company | Novel 2-amido- or 2-amino-alkyl ethers of polyhydric polyphenols and process for preparing same |
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JPS599528A (ja) * | 1982-07-09 | 1984-01-18 | Canon Inc | トルクセンサ |
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US4599451A (en) * | 1985-05-31 | 1986-07-08 | E. I. Dupont De Nemours And Company | Process for preparing ortho-(alkylthio)phenols |
JPH0637432B2 (ja) * | 1986-11-21 | 1994-05-18 | 株式会社上野製薬応用研究所 | 芳香族アセトキシ化合物の製造方法 |
-
1990
- 1990-02-08 DK DK90102488.5T patent/DK0382213T3/da active
- 1990-02-08 US US07/476,913 patent/US5053548A/en not_active Expired - Fee Related
- 1990-02-08 JP JP2031359A patent/JPH07103056B2/ja not_active Expired - Lifetime
- 1990-02-08 DE DE69019185T patent/DE69019185T2/de not_active Expired - Fee Related
- 1990-02-08 CN CN90100613A patent/CN1029227C/zh not_active Expired - Fee Related
- 1990-02-08 KR KR1019900001614A patent/KR900012875A/ko active IP Right Grant
- 1990-02-08 ES ES90102488T patent/ES2071688T3/es not_active Expired - Lifetime
- 1990-02-08 EP EP90102488A patent/EP0382213B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0382213A3 (en) | 1992-03-18 |
US5053548A (en) | 1991-10-01 |
DE69019185T2 (de) | 1995-10-26 |
ES2071688T3 (es) | 1995-07-01 |
EP0382213A2 (en) | 1990-08-16 |
JPH04154737A (ja) | 1992-05-27 |
KR900012875A (ko) | 1990-09-03 |
CN1044807A (zh) | 1990-08-22 |
EP0382213B1 (en) | 1995-05-10 |
JPH07103056B2 (ja) | 1995-11-08 |
CN1029227C (zh) | 1995-07-05 |
DE69019185D1 (de) | 1995-06-14 |
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