MX2018004993A - Sintesis mejorada de honokiol. - Google Patents

Sintesis mejorada de honokiol.

Info

Publication number
MX2018004993A
MX2018004993A MX2018004993A MX2018004993A MX2018004993A MX 2018004993 A MX2018004993 A MX 2018004993A MX 2018004993 A MX2018004993 A MX 2018004993A MX 2018004993 A MX2018004993 A MX 2018004993A MX 2018004993 A MX2018004993 A MX 2018004993A
Authority
MX
Mexico
Prior art keywords
honokiol
biphenyl
diol
dimethyl
improved synthesis
Prior art date
Application number
MX2018004993A
Other languages
English (en)
Inventor
Jaracz Stanislav
Kozlowski Marisa
Eun Lee Young
Min Kim Sun
Original Assignee
Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Publication of MX2018004993A publication Critical patent/MX2018004993A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon unsaturated bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/09—Preparation of ethers by dehydration of compounds containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/24—Preparation of ethers by reactions not forming ether-oxygen bonds by elimination of halogens, e.g. elimination of HCl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
    • C07C43/2055—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring containing more than one ether bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

En la presente solicitud se describen métodos mejorados para la síntesis de honokiol, así como métodos para la síntesis de 3,3'-di-ter-butil-5,5'-dimetil-[1,1'-bifenil]-2,4'-diol, 3',5-dimetil-[1,1'-bifenil]-2,4'-diol, y 2,4'-dimetoxi-3',5-dimeti l-1,1'-bifenilo, 3,3',5,5'-tetra-ter-butil-[1,1'-bifenil]-2,4'-dio l, y ciertos bisfenoles tetrasustituidos, y usos para los mismos.
MX2018004993A 2015-10-23 2016-10-21 Sintesis mejorada de honokiol. MX2018004993A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562245490P 2015-10-23 2015-10-23
US201662316291P 2016-03-31 2016-03-31
PCT/US2016/058258 WO2017070568A1 (en) 2015-10-23 2016-10-21 Improved synthesis of honokiol

Publications (1)

Publication Number Publication Date
MX2018004993A true MX2018004993A (es) 2018-09-12

Family

ID=58558108

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018004993A MX2018004993A (es) 2015-10-23 2016-10-21 Sintesis mejorada de honokiol.

Country Status (10)

Country Link
US (1) US10053406B2 (es)
EP (1) EP3364957B1 (es)
CN (1) CN108430463B (es)
AU (1) AU2016340992B2 (es)
BR (1) BR112018008261B1 (es)
HK (1) HK1258143A1 (es)
IL (1) IL258408B (es)
MX (1) MX2018004993A (es)
RU (1) RU2727202C2 (es)
WO (1) WO2017070568A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10053406B2 (en) 2015-10-23 2018-08-21 Colgate-Palmolive Company Synthesis of honokiol
WO2020083737A1 (en) * 2018-10-24 2020-04-30 Unilever N.V. A topical composition
CN113717683B (zh) * 2021-09-27 2023-05-09 武汉纺织大学 一种光固化水下生物基抗菌胶粘剂及其制备方法
CN116082111B (zh) * 2023-01-18 2024-04-26 四川大学 一种合成1,1,2-三芳基乙烷的方法
CN118146072A (zh) * 2024-05-09 2024-06-07 成都金瑞基业生物科技有限公司 一种和厚朴酚及其中间体的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3247262A (en) * 1961-11-17 1966-04-19 Dow Chemical Co Process for making polyphenols
CN1029227C (zh) * 1989-02-08 1995-07-05 大制药株式会社 苯衍生物的制备方法
JPH0674227B2 (ja) * 1989-10-06 1994-09-21 本州化学工業株式会社 ｐ，ｐ′―ビフェノールの製造方法
AU8168998A (en) 1997-06-26 1999-01-19 Board Of Regents, The University Of Texas System Synthesis of dihydrohonokiol compositions
AU2589900A (en) 1998-12-31 2000-07-24 Board Of Regents, The University Of Texas System Synthesis of dihydrohonokiol compositions
US8425881B2 (en) * 2005-03-18 2013-04-23 Colgate-Palmolive Company Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods
EP1710237A1 (en) 2005-04-08 2006-10-11 Bayer CropScience S.A. New heterocyclylethylbenzamide derivatives
KR100892596B1 (ko) 2007-02-12 2009-04-09 바이오스펙트럼 주식회사 바이페닐 다이올 유도체 및 이를 유효성분으로 포함하는조성물
ES2661462T3 (es) 2007-05-03 2018-04-02 Jack L. Arbiser Análogos de honokiol y su uso en el tratamiento de cánceres
MY162466A (en) * 2010-02-25 2017-06-15 Colgate Palmolive Co Synthesis of magnolol and its analogue compounds
ITMI20120661A1 (it) 2012-04-20 2013-10-21 Giellepi S P A Composizione per il trattamento delle neuropatie
US10053406B2 (en) 2015-10-23 2018-08-21 Colgate-Palmolive Company Synthesis of honokiol

Also Published As

Publication number Publication date
IL258408B (en) 2021-04-29
BR112018008261A2 (pt) 2018-10-23
US10053406B2 (en) 2018-08-21
RU2018118785A3 (es) 2020-02-14
HK1258143A1 (zh) 2019-11-08
RU2727202C2 (ru) 2020-07-21
AU2016340992B2 (en) 2020-10-08
RU2018118785A (ru) 2019-11-26
AU2016340992A1 (en) 2018-04-26
EP3364957A4 (en) 2019-06-26
CN108430463A (zh) 2018-08-21
BR112018008261B1 (pt) 2024-01-02
EP3364957A1 (en) 2018-08-29
US20170113989A1 (en) 2017-04-27
EP3364957B1 (en) 2020-12-09
WO2017070568A1 (en) 2017-04-27
IL258408A (en) 2018-06-28
CN108430463B (zh) 2021-01-29

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