JPS5732238A - Biphenyl derivative - Google Patents

Biphenyl derivative

Info

Publication number
JPS5732238A
JPS5732238A JP10849880A JP10849880A JPS5732238A JP S5732238 A JPS5732238 A JP S5732238A JP 10849880 A JP10849880 A JP 10849880A JP 10849880 A JP10849880 A JP 10849880A JP S5732238 A JPS5732238 A JP S5732238A
Authority
JP
Japan
Prior art keywords
formula
inflammatory
halogen
lower alkyl
lower alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10849880A
Other languages
Japanese (ja)
Inventor
Kanji Noda
Akira Nakagawa
Satoru Miyata
Toshitaka Inoue
Hiroyuki Ide
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Priority to JP10849880A priority Critical patent/JPS5732238A/en
Publication of JPS5732238A publication Critical patent/JPS5732238A/en
Pending legal-status Critical Current

Links

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:Biphenyl derivatives of formula I (R1 is -CHO, -CH2CH=CH2- CH2OH, -CH2CN; R2 is H, lower alkyl, allyl; X and Y are H, halogen, trifluoromethyl, lower alkoxy, lower alkyl).
EXAMPLE: 2-Methoxy-3-phenylbenzylalcohol.
USE: Intermediate of biphenylylacetic acid derivatives that have pharmacological activities such as remarkable anti-inflammatory, analgesic and antipyretic activities and are used as an anti-inflammatory.
PREPARATION: For example, a biphenylcarboxylic derivative of formula II (R3 is hydroxyl, lower alkoxy, halogen) is reduced with a reducing reagent such as vitride [sodium bis(2-methoxyethoxy)aluminum hydride] in an organic solvent such as tetrahydrofuran to give the compound of formula I where R1 is -CH2OH.
COPYRIGHT: (C)1982,JPO&Japio
JP10849880A 1980-08-06 1980-08-06 Biphenyl derivative Pending JPS5732238A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10849880A JPS5732238A (en) 1980-08-06 1980-08-06 Biphenyl derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10849880A JPS5732238A (en) 1980-08-06 1980-08-06 Biphenyl derivative

Publications (1)

Publication Number Publication Date
JPS5732238A true JPS5732238A (en) 1982-02-20

Family

ID=14486292

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10849880A Pending JPS5732238A (en) 1980-08-06 1980-08-06 Biphenyl derivative

Country Status (1)

Country Link
JP (1) JPS5732238A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382213A2 (en) * 1989-02-08 1990-08-16 Otsuka Pharmaceutical Co., Ltd. Biphenyl derivative, nerve cell degeneration repairing or protecting agent and process for preparing a phenyl derivative contained in the agent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382213A2 (en) * 1989-02-08 1990-08-16 Otsuka Pharmaceutical Co., Ltd. Biphenyl derivative, nerve cell degeneration repairing or protecting agent and process for preparing a phenyl derivative contained in the agent

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