JPS5732238A - Biphenyl derivative - Google Patents
Biphenyl derivativeInfo
- Publication number
- JPS5732238A JPS5732238A JP10849880A JP10849880A JPS5732238A JP S5732238 A JPS5732238 A JP S5732238A JP 10849880 A JP10849880 A JP 10849880A JP 10849880 A JP10849880 A JP 10849880A JP S5732238 A JPS5732238 A JP S5732238A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- inflammatory
- halogen
- lower alkyl
- lower alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:Biphenyl derivatives of formula I (R1 is -CHO, -CH2CH=CH2- CH2OH, -CH2CN; R2 is H, lower alkyl, allyl; X and Y are H, halogen, trifluoromethyl, lower alkoxy, lower alkyl).
EXAMPLE: 2-Methoxy-3-phenylbenzylalcohol.
USE: Intermediate of biphenylylacetic acid derivatives that have pharmacological activities such as remarkable anti-inflammatory, analgesic and antipyretic activities and are used as an anti-inflammatory.
PREPARATION: For example, a biphenylcarboxylic derivative of formula II (R3 is hydroxyl, lower alkoxy, halogen) is reduced with a reducing reagent such as vitride [sodium bis(2-methoxyethoxy)aluminum hydride] in an organic solvent such as tetrahydrofuran to give the compound of formula I where R1 is -CH2OH.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10849880A JPS5732238A (en) | 1980-08-06 | 1980-08-06 | Biphenyl derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10849880A JPS5732238A (en) | 1980-08-06 | 1980-08-06 | Biphenyl derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5732238A true JPS5732238A (en) | 1982-02-20 |
Family
ID=14486292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10849880A Pending JPS5732238A (en) | 1980-08-06 | 1980-08-06 | Biphenyl derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5732238A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0382213A2 (en) * | 1989-02-08 | 1990-08-16 | Otsuka Pharmaceutical Co., Ltd. | Biphenyl derivative, nerve cell degeneration repairing or protecting agent and process for preparing a phenyl derivative contained in the agent |
-
1980
- 1980-08-06 JP JP10849880A patent/JPS5732238A/en active Pending
Non-Patent Citations (1)
Title |
---|
CHEMICAL ABSTRACTS * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0382213A2 (en) * | 1989-02-08 | 1990-08-16 | Otsuka Pharmaceutical Co., Ltd. | Biphenyl derivative, nerve cell degeneration repairing or protecting agent and process for preparing a phenyl derivative contained in the agent |
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