DE69932948T3 - Verfahren zur Herstellung von Teilchen unter Verwendung eines überkritischen Fluids - Google Patents
Verfahren zur Herstellung von Teilchen unter Verwendung eines überkritischen Fluids Download PDFInfo
- Publication number
- DE69932948T3 DE69932948T3 DE69932948T DE69932948T DE69932948T3 DE 69932948 T3 DE69932948 T3 DE 69932948T3 DE 69932948 T DE69932948 T DE 69932948T DE 69932948 T DE69932948 T DE 69932948T DE 69932948 T3 DE69932948 T3 DE 69932948T3
- Authority
- DE
- Germany
- Prior art keywords
- substance
- mixture
- pressure
- compressible fluid
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 208
- 238000000034 method Methods 0.000 title claims abstract description 102
- 239000002245 particle Substances 0.000 title claims abstract description 44
- 230000008569 process Effects 0.000 title claims abstract description 27
- 239000000126 substance Substances 0.000 claims abstract description 91
- 239000000203 mixture Substances 0.000 claims abstract description 71
- 239000000463 material Substances 0.000 claims abstract description 67
- 239000012296 anti-solvent Substances 0.000 claims abstract description 60
- 239000000654 additive Substances 0.000 claims abstract description 50
- 239000002904 solvent Substances 0.000 claims abstract description 37
- 239000006185 dispersion Substances 0.000 claims abstract description 8
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 77
- 230000000996 additive effect Effects 0.000 claims description 42
- 239000001569 carbon dioxide Substances 0.000 claims description 37
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 37
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 18
- 238000011144 upstream manufacturing Methods 0.000 claims description 14
- 230000015572 biosynthetic process Effects 0.000 claims description 13
- 239000003607 modifier Substances 0.000 claims description 13
- 239000007787 solid Substances 0.000 claims description 13
- -1 alkyl ketones Chemical class 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000003960 organic solvent Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 239000008365 aqueous carrier Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000013529 heat transfer fluid Substances 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000011236 particulate material Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 238000009472 formulation Methods 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 47
- 239000007789 gas Substances 0.000 description 44
- 230000007704 transition Effects 0.000 description 21
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 239000007921 spray Substances 0.000 description 13
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- 239000007788 liquid Substances 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 230000001105 regulatory effect Effects 0.000 description 10
- 239000003570 air Substances 0.000 description 8
- 238000002156 mixing Methods 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000009833 condensation Methods 0.000 description 5
- 230000005494 condensation Effects 0.000 description 5
- 239000010419 fine particle Substances 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- XPDWGBQVDMORPB-UHFFFAOYSA-N Fluoroform Chemical compound FC(F)F XPDWGBQVDMORPB-UHFFFAOYSA-N 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- BLXXJMDCKKHMKV-UHFFFAOYSA-N Nabumetone Chemical compound C1=C(CCC(C)=O)C=CC2=CC(OC)=CC=C21 BLXXJMDCKKHMKV-UHFFFAOYSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 229960004270 nabumetone Drugs 0.000 description 4
- 238000007711 solidification Methods 0.000 description 4
- 230000008023 solidification Effects 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 235000011089 carbon dioxide Nutrition 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000002466 solution-enhanced dispersion by supercritical fluid Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- XWCDCDSDNJVCLO-UHFFFAOYSA-N Chlorofluoromethane Chemical class FCCl XWCDCDSDNJVCLO-UHFFFAOYSA-N 0.000 description 2
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- 229910018503 SF6 Inorganic materials 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- AFYPFACVUDMOHA-UHFFFAOYSA-N chlorotrifluoromethane Chemical compound FC(F)(F)Cl AFYPFACVUDMOHA-UHFFFAOYSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 150000008282 halocarbons Chemical class 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- NIQQIJXGUZVEBB-UHFFFAOYSA-N methanol;propan-2-one Chemical compound OC.CC(C)=O NIQQIJXGUZVEBB-UHFFFAOYSA-N 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000001046 rapid expansion of supercritical solution Methods 0.000 description 2
- 239000013557 residual solvent Substances 0.000 description 2
- 239000011343 solid material Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- SFZCNBIFKDRMGX-UHFFFAOYSA-N sulfur hexafluoride Chemical compound FS(F)(F)(F)(F)F SFZCNBIFKDRMGX-UHFFFAOYSA-N 0.000 description 2
- 229960000909 sulfur hexafluoride Drugs 0.000 description 2
- 230000003319 supportive effect Effects 0.000 description 2
- 229910052724 xenon Inorganic materials 0.000 description 2
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- 229960000878 docusate sodium Drugs 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 239000011551 heat transfer agent Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 235000020030 perry Nutrition 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9828204.9A GB9828204D0 (en) | 1998-12-21 | 1998-12-21 | Process |
| GB9828204 | 1998-12-21 | ||
| PCT/GB1999/004355 WO2000037169A1 (en) | 1998-12-21 | 1999-12-21 | Process and apparatus for producing particles using a supercritical fluid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE69932948D1 DE69932948D1 (de) | 2006-10-05 |
| DE69932948T2 DE69932948T2 (de) | 2007-01-11 |
| DE69932948T3 true DE69932948T3 (de) | 2009-08-13 |
Family
ID=10844704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69932948T Expired - Lifetime DE69932948T3 (de) | 1998-12-21 | 1999-12-21 | Verfahren zur Herstellung von Teilchen unter Verwendung eines überkritischen Fluids |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6830714B1 (enExample) |
| EP (1) | EP1169117B2 (enExample) |
| JP (1) | JP4718011B2 (enExample) |
| AT (1) | ATE306314T1 (enExample) |
| AU (1) | AU1876100A (enExample) |
| CY (1) | CY1105172T1 (enExample) |
| DE (1) | DE69932948T3 (enExample) |
| DK (1) | DK1169117T4 (enExample) |
| ES (1) | ES2251250T5 (enExample) |
| GB (1) | GB9828204D0 (enExample) |
| WO (1) | WO2000037169A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4874483B2 (ja) * | 1999-06-09 | 2012-02-15 | ロバート イー． シーバース | 超臨界流体補助ネブライゼーション及びバブル乾燥 |
| GB9920148D0 (en) * | 1999-08-25 | 1999-10-27 | Smithkline Beecham Plc | Novel composition |
| CH694686A5 (it) * | 2000-03-04 | 2005-06-15 | Eco2 Sa | Prodotto di micronizzazione di sostanze farmaceutiche. |
| AU2002221320B2 (en) * | 2000-12-08 | 2006-06-15 | The University Of Sydney | Synthesis of small particles |
| GB0102075D0 (en) | 2001-01-26 | 2001-03-14 | Astrazeneca Ab | Process |
| HU228083B1 (en) | 2001-02-26 | 2012-10-29 | Dompe Pha R Ma Spa Res & Mfg | Apparatus nozzle system and method for micron and submicron particle formation |
| DE10109829A1 (de) * | 2001-03-01 | 2002-09-05 | Celanese Ventures Gmbh | Polymermembran, Verfahren zu deren Herstellung sowie deren Verwendung |
| US6596206B2 (en) | 2001-03-30 | 2003-07-22 | Picoliter Inc. | Generation of pharmaceutical agent particles using focused acoustic energy |
| US6610223B2 (en) | 2001-03-30 | 2003-08-26 | Picoliter Inc. | Focused acoustic energy in the generation of solid particles |
| US6869551B2 (en) | 2001-03-30 | 2005-03-22 | Picoliter Inc. | Precipitation of solid particles from droplets formed using focused acoustic energy |
| WO2003004142A1 (en) * | 2001-07-02 | 2003-01-16 | Micro & Nano Materials Sagl | Process for the production of micro and/or nano particles |
| EP1461020A4 (en) | 2001-12-07 | 2008-10-29 | Map Pharmaceuticals Inc | SYNTHESIS OF SMALL PARTICLES |
| AU2002365617B2 (en) * | 2001-12-07 | 2008-04-03 | Map Pharmaceuticals, Inc. | Synthesis of small particles |
| AU2003221888B2 (en) * | 2002-04-11 | 2008-11-06 | Medimmune, Llc | Preservation of bioactive materials by spray drying |
| EP1494796B1 (en) * | 2002-04-12 | 2014-06-04 | Feyecon B.V. | Process for small particle formation |
| DE10248619A1 (de) * | 2002-10-18 | 2004-04-29 | Bayer Ag | Verfahren zur Herstellung pulverförmiger Wirkstoff-Formulierungen mit kompressiblen Fluiden |
| JP2004148174A (ja) * | 2002-10-29 | 2004-05-27 | Kobe Steel Ltd | 超臨界流体を利用して微粒子を製造する方法および装置 |
| JP3663408B2 (ja) * | 2003-06-30 | 2005-06-22 | 株式会社アイテック | 高温高圧水を用いる微粒子製造方法および微粒子製造装置 |
| KR100603974B1 (ko) | 2003-12-05 | 2006-07-25 | 김갑식 | 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법 |
| WO2005073285A1 (ja) * | 2004-01-28 | 2005-08-11 | Japan Science And Technology Agency | 超臨界流体からの貧溶媒中への急速膨張法を用いた微粒子製造法 |
| EP1904219A4 (en) * | 2005-07-15 | 2011-07-27 | Map Pharmaceuticals Inc | METHOD FOR FORMING PARTICLES |
| WO2009005465A1 (en) * | 2007-06-29 | 2009-01-08 | Swetree Technologies Ab | Method to prepare superhydrophobic surfaces on solid bodies by rapid expansion solutions |
| US8585943B2 (en) * | 2007-12-07 | 2013-11-19 | Xspray Microparticles Ab | Method and arrangement for the production of particles |
| US20100298602A1 (en) * | 2009-05-19 | 2010-11-25 | Massachusetts Institute Of Technology | Systems and methods for microfluidic crystallization |
| US20100294986A1 (en) * | 2009-05-19 | 2010-11-25 | Massachusetts Institute Of Technology | Supercritical fluid facilitated particle formation in microfluidic systems |
| GB0915106D0 (en) | 2009-08-28 | 2009-10-07 | Glaxo Group Ltd | Process |
| JP5793179B2 (ja) | 2010-03-22 | 2015-10-14 | バイオ−シネクティクス インク．Ｂｉｏ−Ｓｙｎｅｃｔｉｃｓ Ｉｎｃ． | ナノ粒子の製造方法 |
| US9138705B2 (en) | 2010-11-22 | 2015-09-22 | Hong Kong Polytechnic University | Method for precipitating a solute from a solution |
| DE102011105201A1 (de) * | 2011-04-11 | 2012-10-11 | Martin Ruda | Luftkappe, Anordnung aus Haltering und Luftkappe und Farbleiteinrich-tung für eine Farbspritzpistole |
| US20150024209A1 (en) * | 2012-03-12 | 2015-01-22 | Sharp Kabushiki Kaisha | Modified particle purification method and manufacturing method, modified particles, functional material, optical member, heat transfer member, and coverage rate analysis device and coverage rate analysis method |
| US8778181B1 (en) * | 2013-03-14 | 2014-07-15 | Crititech, Inc. | Equipment assembly for and method of processing particles |
| US10239009B2 (en) | 2013-03-14 | 2019-03-26 | Lawrence Livermore National Security, Llc | Continuously-operable flow stream processing system and method |
| US20170050337A1 (en) * | 2013-05-02 | 2017-02-23 | Melior Innovations, Inc. | Formation apparatus, systems and methods for manufacturing polymer derived ceramic structures |
| JP6429949B2 (ja) * | 2017-01-26 | 2018-11-28 | タナベウィルテック株式会社 | 微粒子製造装置および微粒子製造方法 |
| JP2020517578A (ja) | 2017-04-21 | 2020-06-18 | バイオ−シネクティクス インク．Ｂｉｏ−Ｓｙｎｅｃｔｉｃｓ Ｉｎｃ． | 脂質を製粉工程の潤滑剤として用いる活性物質のナノ粒子の製造方法 |
| CN112007584A (zh) * | 2020-08-31 | 2020-12-01 | 胡勇刚 | 一种油脂的超临界颗粒制备工艺 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01176437A (ja) * | 1987-12-29 | 1989-07-12 | Ono Pharmaceut Co Ltd | 有機物質の微粒化方法 |
| US5639441A (en) * | 1992-03-06 | 1997-06-17 | Board Of Regents Of University Of Colorado | Methods for fine particle formation |
| GB9313642D0 (en) † | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| GB9413202D0 (en) * | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
| EP0885038B1 (en) † | 1996-03-01 | 2011-06-15 | The University Of Kansas | Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents |
| GB9622173D0 (en) * | 1996-10-24 | 1996-12-18 | Glaxo Group Ltd | Particulate Products |
| GB9703673D0 (en) † | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
-
1998
- 1998-12-21 GB GBGB9828204.9A patent/GB9828204D0/en not_active Ceased
-
1999
- 1999-12-21 JP JP2000589274A patent/JP4718011B2/ja not_active Expired - Fee Related
- 1999-12-21 EP EP99962400A patent/EP1169117B2/en not_active Expired - Lifetime
- 1999-12-21 US US09/868,581 patent/US6830714B1/en not_active Expired - Lifetime
- 1999-12-21 DE DE69932948T patent/DE69932948T3/de not_active Expired - Lifetime
- 1999-12-21 ES ES99962400T patent/ES2251250T5/es not_active Expired - Lifetime
- 1999-12-21 DK DK99962400T patent/DK1169117T4/da active
- 1999-12-21 WO PCT/GB1999/004355 patent/WO2000037169A1/en not_active Ceased
- 1999-12-21 AT AT99962400T patent/ATE306314T1/de active
- 1999-12-21 AU AU18761/00A patent/AU1876100A/en not_active Abandoned
-
2006
- 2006-01-03 CY CY20061100001T patent/CY1105172T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1169117T3 (da) | 2006-02-20 |
| CY1105172T1 (el) | 2010-03-03 |
| JP2002532244A (ja) | 2002-10-02 |
| ES2251250T5 (es) | 2009-07-06 |
| DK1169117T4 (da) | 2009-06-15 |
| AU1876100A (en) | 2000-07-12 |
| ATE306314T1 (de) | 2005-10-15 |
| JP4718011B2 (ja) | 2011-07-06 |
| EP1169117B1 (en) | 2005-10-12 |
| WO2000037169A1 (en) | 2000-06-29 |
| GB9828204D0 (en) | 1999-02-17 |
| US6830714B1 (en) | 2004-12-14 |
| DE69932948D1 (de) | 2006-10-05 |
| ES2251250T3 (es) | 2006-04-16 |
| EP1169117B2 (en) | 2009-03-18 |
| DE69932948T2 (de) | 2007-01-11 |
| EP1169117A1 (en) | 2002-01-09 |
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