JP4718011B2 - 超臨界流体を用いる粒子の製法およびその装置 - Google Patents

超臨界流体を用いる粒子の製法およびその装置 Download PDF

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Publication number
JP4718011B2
JP4718011B2 JP2000589274A JP2000589274A JP4718011B2 JP 4718011 B2 JP4718011 B2 JP 4718011B2 JP 2000589274 A JP2000589274 A JP 2000589274A JP 2000589274 A JP2000589274 A JP 2000589274A JP 4718011 B2 JP4718011 B2 JP 4718011B2
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conduit
mixture
pressure
solvent
flow
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JP2000589274A
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English (en)
Japanese (ja)
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JP2002532244A5 (enExample
JP2002532244A (ja
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デイビッド・ロイ・メリフィード
クリストファー・エドモンド・バルダー
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SmithKline Beecham Ltd
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SmithKline Beecham Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicinal Preparation (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
JP2000589274A 1998-12-21 1999-12-21 超臨界流体を用いる粒子の製法およびその装置 Expired - Fee Related JP4718011B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9828204.9A GB9828204D0 (en) 1998-12-21 1998-12-21 Process
GB9828204.9 1998-12-21
PCT/GB1999/004355 WO2000037169A1 (en) 1998-12-21 1999-12-21 Process and apparatus for producing particles using a supercritical fluid

Publications (3)

Publication Number Publication Date
JP2002532244A JP2002532244A (ja) 2002-10-02
JP2002532244A5 JP2002532244A5 (enExample) 2007-02-15
JP4718011B2 true JP4718011B2 (ja) 2011-07-06

Family

ID=10844704

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000589274A Expired - Fee Related JP4718011B2 (ja) 1998-12-21 1999-12-21 超臨界流体を用いる粒子の製法およびその装置

Country Status (11)

Country Link
US (1) US6830714B1 (enExample)
EP (1) EP1169117B2 (enExample)
JP (1) JP4718011B2 (enExample)
AT (1) ATE306314T1 (enExample)
AU (1) AU1876100A (enExample)
CY (1) CY1105172T1 (enExample)
DE (1) DE69932948T3 (enExample)
DK (1) DK1169117T4 (enExample)
ES (1) ES2251250T5 (enExample)
GB (1) GB9828204D0 (enExample)
WO (1) WO2000037169A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075281A2 (en) * 1999-06-09 2000-12-14 University Technology Corporation Supercritical fluid-assisted nebulization and bubble drying
GB9920148D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel composition
CH694686A5 (it) * 2000-03-04 2005-06-15 Eco2 Sa Prodotto di micronizzazione di sostanze farmaceutiche.
AU2002221320B2 (en) * 2000-12-08 2006-06-15 The University Of Sydney Synthesis of small particles
GB0102075D0 (en) 2001-01-26 2001-03-14 Astrazeneca Ab Process
SI1363726T1 (en) 2001-02-26 2005-02-28 Dompe S.P.A. Apparatus and method for micron and submicron particle formation
DE10109829A1 (de) * 2001-03-01 2002-09-05 Celanese Ventures Gmbh Polymermembran, Verfahren zu deren Herstellung sowie deren Verwendung
US6610223B2 (en) 2001-03-30 2003-08-26 Picoliter Inc. Focused acoustic energy in the generation of solid particles
US6869551B2 (en) 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
US6596206B2 (en) 2001-03-30 2003-07-22 Picoliter Inc. Generation of pharmaceutical agent particles using focused acoustic energy
DK1401563T4 (en) * 2001-07-02 2016-01-11 Cerbios Pharma Sa A process for producing micro and / or nano-particles
WO2003047553A1 (en) 2001-12-07 2003-06-12 Eiffel Technologies Limited Synthesis of small particles
AU2002365617B2 (en) * 2001-12-07 2008-04-03 Map Pharmaceuticals, Inc. Synthesis of small particles
KR20050011741A (ko) * 2002-04-11 2005-01-29 메드이뮨 백신즈 인코포레이티드 분무 건조에 의한 생물학적 활성 물질의 보존
CA2482272C (en) * 2002-04-12 2011-08-16 Feyecon Development & Implementation B.V. Process for small particle formation
DE10248619A1 (de) * 2002-10-18 2004-04-29 Bayer Ag Verfahren zur Herstellung pulverförmiger Wirkstoff-Formulierungen mit kompressiblen Fluiden
JP2004148174A (ja) * 2002-10-29 2004-05-27 Kobe Steel Ltd 超臨界流体を利用して微粒子を製造する方法および装置
JP3663408B2 (ja) * 2003-06-30 2005-06-22 株式会社アイテック 高温高圧水を用いる微粒子製造方法および微粒子製造装置
KR100603974B1 (ko) 2003-12-05 2006-07-25 김갑식 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법
US20070102836A1 (en) * 2004-01-28 2007-05-10 Japan Science And Technology Agency Method for producing fine particles using method of rapid expansion into poor solvent from supercritical fluid
WO2007009164A1 (en) 2005-07-15 2007-01-25 Eiffel Technologies Limited Method of particle formation
ES2444703T3 (es) * 2007-06-29 2014-02-26 Cellutech Ab Métodos para preparar superficies superhidrofóbicas sobre cuerpos sólidos mediante soluciones de expansión rápida
WO2009072950A1 (en) * 2007-12-07 2009-06-11 Xspray Microparticles Ab Method and arrangement for the production of particles
US20100294986A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Supercritical fluid facilitated particle formation in microfluidic systems
US20100298602A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Systems and methods for microfluidic crystallization
GB0915106D0 (en) 2009-08-28 2009-10-07 Glaxo Group Ltd Process
AU2011230144B2 (en) 2010-03-22 2015-01-22 Bio-Synectics Inc. Method for preparing nano-particles
US9138705B2 (en) 2010-11-22 2015-09-22 Hong Kong Polytechnic University Method for precipitating a solute from a solution
DE102011105201A1 (de) * 2011-04-11 2012-10-11 Martin Ruda Luftkappe, Anordnung aus Haltering und Luftkappe und Farbleiteinrich-tung für eine Farbspritzpistole
WO2013136974A1 (ja) * 2012-03-12 2013-09-19 シャープ株式会社 修飾微粒子の精製方法および製造方法、修飾微粒子、機能性材料、光学部材、熱伝部材、ならびに、被覆率分析装置および被覆率分析方法
US8778181B1 (en) 2013-03-14 2014-07-15 Crititech, Inc. Equipment assembly for and method of processing particles
US10239009B2 (en) 2013-03-14 2019-03-26 Lawrence Livermore National Security, Llc Continuously-operable flow stream processing system and method
US20170050337A1 (en) * 2013-05-02 2017-02-23 Melior Innovations, Inc. Formation apparatus, systems and methods for manufacturing polymer derived ceramic structures
JP6429949B2 (ja) * 2017-01-26 2018-11-28 タナベウィルテック株式会社 微粒子製造装置および微粒子製造方法
RU2018138121A (ru) 2017-04-21 2021-05-21 Байо-Сайнектикс Инк. Способ приготовления наночастицы активного ингредиента с использованием липида в качестве смазывающего вещества в процессе помола
CN112007584A (zh) * 2020-08-31 2020-12-01 胡勇刚 一种油脂的超临界颗粒制备工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01176437A (ja) * 1987-12-29 1989-07-12 Ono Pharmaceut Co Ltd 有機物質の微粒化方法
US5639441A (en) † 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
EP0885038B1 (en) † 1996-03-01 2011-06-15 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
GB9622173D0 (en) * 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles

Also Published As

Publication number Publication date
CY1105172T1 (el) 2010-03-03
AU1876100A (en) 2000-07-12
ES2251250T3 (es) 2006-04-16
DE69932948T2 (de) 2007-01-11
JP2002532244A (ja) 2002-10-02
EP1169117A1 (en) 2002-01-09
DK1169117T4 (da) 2009-06-15
EP1169117B1 (en) 2005-10-12
ATE306314T1 (de) 2005-10-15
US6830714B1 (en) 2004-12-14
EP1169117B2 (en) 2009-03-18
WO2000037169A1 (en) 2000-06-29
GB9828204D0 (en) 1999-02-17
DE69932948T3 (de) 2009-08-13
DE69932948D1 (de) 2006-10-05
DK1169117T3 (da) 2006-02-20
ES2251250T5 (es) 2009-07-06

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