JP4718011B2 - 超臨界流体を用いる粒子の製法およびその装置 - Google Patents

超臨界流体を用いる粒子の製法およびその装置 Download PDF

Info

Publication number
JP4718011B2
JP4718011B2 JP2000589274A JP2000589274A JP4718011B2 JP 4718011 B2 JP4718011 B2 JP 4718011B2 JP 2000589274 A JP2000589274 A JP 2000589274A JP 2000589274 A JP2000589274 A JP 2000589274A JP 4718011 B2 JP4718011 B2 JP 4718011B2
Authority
JP
Japan
Prior art keywords
conduit
mixture
pressure
solvent
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000589274A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002532244A5 (enExample
JP2002532244A (ja
Inventor
デイビッド・ロイ・メリフィード
クリストファー・エドモンド・バルダー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10844704&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP4718011(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of JP2002532244A publication Critical patent/JP2002532244A/ja
Publication of JP2002532244A5 publication Critical patent/JP2002532244A5/ja
Application granted granted Critical
Publication of JP4718011B2 publication Critical patent/JP4718011B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Glass Compositions (AREA)
JP2000589274A 1998-12-21 1999-12-21 超臨界流体を用いる粒子の製法およびその装置 Expired - Fee Related JP4718011B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9828204.9A GB9828204D0 (en) 1998-12-21 1998-12-21 Process
GB9828204.9 1998-12-21
PCT/GB1999/004355 WO2000037169A1 (en) 1998-12-21 1999-12-21 Process and apparatus for producing particles using a supercritical fluid

Publications (3)

Publication Number Publication Date
JP2002532244A JP2002532244A (ja) 2002-10-02
JP2002532244A5 JP2002532244A5 (enExample) 2007-02-15
JP4718011B2 true JP4718011B2 (ja) 2011-07-06

Family

ID=10844704

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000589274A Expired - Fee Related JP4718011B2 (ja) 1998-12-21 1999-12-21 超臨界流体を用いる粒子の製法およびその装置

Country Status (11)

Country Link
US (1) US6830714B1 (enExample)
EP (1) EP1169117B2 (enExample)
JP (1) JP4718011B2 (enExample)
AT (1) ATE306314T1 (enExample)
AU (1) AU1876100A (enExample)
CY (1) CY1105172T1 (enExample)
DE (1) DE69932948T3 (enExample)
DK (1) DK1169117T4 (enExample)
ES (1) ES2251250T5 (enExample)
GB (1) GB9828204D0 (enExample)
WO (1) WO2000037169A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1049621A1 (zh) * 1999-06-09 2003-05-23 罗伯特‧E‧希弗斯 超临界流体辅助的喷雾和鼓泡乾燥
GB9920148D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel composition
CH694686A5 (it) * 2000-03-04 2005-06-15 Eco2 Sa Prodotto di micronizzazione di sostanze farmaceutiche.
AU2002221320B2 (en) * 2000-12-08 2006-06-15 The University Of Sydney Synthesis of small particles
GB0102075D0 (en) 2001-01-26 2001-03-14 Astrazeneca Ab Process
BR0207570B1 (pt) 2001-02-26 2013-02-05 aparelho para formaÇço de partÍculas micronizadas e submicronizadas de uma substÂncia, bocal, e, processo realizado usando o aparelho.
DE10109829A1 (de) * 2001-03-01 2002-09-05 Celanese Ventures Gmbh Polymermembran, Verfahren zu deren Herstellung sowie deren Verwendung
US6869551B2 (en) 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
US6596206B2 (en) 2001-03-30 2003-07-22 Picoliter Inc. Generation of pharmaceutical agent particles using focused acoustic energy
US6610223B2 (en) 2001-03-30 2003-08-26 Picoliter Inc. Focused acoustic energy in the generation of solid particles
EP1401563B2 (en) * 2001-07-02 2015-09-16 Micro & Nano Materials SAGL Process for the production of micro and/or nano particles
EP1461020A4 (en) 2001-12-07 2008-10-29 Map Pharmaceuticals Inc SYNTHESIS OF SMALL PARTICLES
AU2002365617B2 (en) * 2001-12-07 2008-04-03 Map Pharmaceuticals, Inc. Synthesis of small particles
JP2006512102A (ja) * 2002-04-11 2006-04-13 メディミューン・ヴァクシンズ・インコーポレーテッド 噴霧乾燥による生物活性材料の防腐
WO2003086606A1 (en) * 2002-04-12 2003-10-23 Feyecon Development & Implementation B.V. Process for small particle formation
DE10248619A1 (de) * 2002-10-18 2004-04-29 Bayer Ag Verfahren zur Herstellung pulverförmiger Wirkstoff-Formulierungen mit kompressiblen Fluiden
JP2004148174A (ja) * 2002-10-29 2004-05-27 Kobe Steel Ltd 超臨界流体を利用して微粒子を製造する方法および装置
JP3663408B2 (ja) * 2003-06-30 2005-06-22 株式会社アイテック 高温高圧水を用いる微粒子製造方法および微粒子製造装置
KR100603974B1 (ko) 2003-12-05 2006-07-25 김갑식 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법
AU2005209541B2 (en) * 2004-01-28 2007-07-12 Japan Science And Technology Agency A method for producing fine particles using method of rapid expansion into poor solvent from supercritical fluid
AU2006272438B2 (en) 2005-07-15 2011-08-04 Map Pharmaceuticals, Inc. Method of particle formation
EP2164647B1 (en) 2007-06-29 2013-11-06 Cellutech AB Method to prepare superhydrophobic surfaces on solid bodies by rapid expansion solutions
US8585943B2 (en) * 2007-12-07 2013-11-19 Xspray Microparticles Ab Method and arrangement for the production of particles
US20100298602A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Systems and methods for microfluidic crystallization
US20100294986A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Supercritical fluid facilitated particle formation in microfluidic systems
GB0915106D0 (en) 2009-08-28 2009-10-07 Glaxo Group Ltd Process
EP2551237B1 (en) 2010-03-22 2024-09-04 Bio-Synectics Inc. Method for preparing nano-particles
US9138705B2 (en) 2010-11-22 2015-09-22 Hong Kong Polytechnic University Method for precipitating a solute from a solution
DE102011105201A1 (de) * 2011-04-11 2012-10-11 Martin Ruda Luftkappe, Anordnung aus Haltering und Luftkappe und Farbleiteinrich-tung für eine Farbspritzpistole
WO2013136974A1 (ja) * 2012-03-12 2013-09-19 シャープ株式会社 修飾微粒子の精製方法および製造方法、修飾微粒子、機能性材料、光学部材、熱伝部材、ならびに、被覆率分析装置および被覆率分析方法
US10239009B2 (en) 2013-03-14 2019-03-26 Lawrence Livermore National Security, Llc Continuously-operable flow stream processing system and method
US8778181B1 (en) 2013-03-14 2014-07-15 Crititech, Inc. Equipment assembly for and method of processing particles
US20170050337A1 (en) * 2013-05-02 2017-02-23 Melior Innovations, Inc. Formation apparatus, systems and methods for manufacturing polymer derived ceramic structures
JP6429949B2 (ja) * 2017-01-26 2018-11-28 タナベウィルテック株式会社 微粒子製造装置および微粒子製造方法
EP3613415B1 (en) 2017-04-21 2022-11-09 Bio-Synectics Inc. Method for preparing active material nanoparticles using lipid as lubricant for milling
CN112007584A (zh) * 2020-08-31 2020-12-01 胡勇刚 一种油脂的超临界颗粒制备工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01176437A (ja) * 1987-12-29 1989-07-12 Ono Pharmaceut Co Ltd 有機物質の微粒化方法
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
EP0885038B1 (en) 1996-03-01 2011-06-15 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
GB9622173D0 (en) * 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles

Also Published As

Publication number Publication date
WO2000037169A1 (en) 2000-06-29
CY1105172T1 (el) 2010-03-03
DE69932948T2 (de) 2007-01-11
EP1169117A1 (en) 2002-01-09
EP1169117B1 (en) 2005-10-12
ES2251250T5 (es) 2009-07-06
DK1169117T3 (da) 2006-02-20
ATE306314T1 (de) 2005-10-15
ES2251250T3 (es) 2006-04-16
EP1169117B2 (en) 2009-03-18
JP2002532244A (ja) 2002-10-02
AU1876100A (en) 2000-07-12
GB9828204D0 (en) 1999-02-17
US6830714B1 (en) 2004-12-14
DE69932948T3 (de) 2009-08-13
DE69932948D1 (de) 2006-10-05
DK1169117T4 (da) 2009-06-15

Similar Documents

Publication Publication Date Title
US6830714B1 (en) Process and apparatus for producing particles using a supercritical fluid
US5851453A (en) Method and apparatus for the formation of particles
JP3839042B2 (ja) 大きさが調整された粒子を有するサルメテロールキシナフォエート
US5833891A (en) Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
US7208106B2 (en) Method of forming particles
EP0885038B1 (en) Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
US6858166B2 (en) Powder processing with pressurized gaseous fluids
US7635442B2 (en) Apparatus and method for micron and submicron particle formation
US20040071783A1 (en) Methods and apparatus for particle formation
Subra et al. Powders elaboration in supercritical media: comparison with conventional routes
JP2004511530A (ja) ホスト分子に包接された活性成分からなる微細粒子の製造方法
Reverchon et al. Supercritical fluid processing of polymers: composite particles and porous materials elaboration
Chafidz et al. Formation of fine particles using supercritical fluid (SCF) process: Short review
JP2002505617A (ja) 高密度流体（例えば、超臨界流体）による物質の処理
Foster et al. Particle engineering by dense gas technologies applied to pharmaceuticals
US20050206022A1 (en) Process for small particle formation
CA2247900C (en) Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
Bolten et al. NOVEL MATERIALS FOR CONTROLLED RELEASE (CPD)
Gokhale Nanoparticles: Drug Delivery Technology and Formulation
HK1004216B (en) Salmeterol xinafoate with controlled particle size
MXPA98007095A (en) Methods and apparatus for the precipitation of particles and coatings that use antidisolvents almost criticos and supercriti
GB2339165A (en) Method and apparatus for particle formation using supercritical fluids

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20061221

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20061221

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100202

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100506

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100513

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100602

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100609

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100702

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100709

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100802

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100831

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20101130

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20101207

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20101228

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110111

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110131

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20110301

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20110331

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140408

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees