CY1105172T1 - Διepγασια για παραγωγη σωματιδιων η οποια χρησιμοποιει ενα υπepκρισιμο ρευστο - Google Patents

Διepγασια για παραγωγη σωματιδιων η οποια χρησιμοποιει ενα υπepκρισιμο ρευστο

Info

Publication number
CY1105172T1
CY1105172T1 CY20061100001T CY061100001T CY1105172T1 CY 1105172 T1 CY1105172 T1 CY 1105172T1 CY 20061100001 T CY20061100001 T CY 20061100001T CY 061100001 T CY061100001 T CY 061100001T CY 1105172 T1 CY1105172 T1 CY 1105172T1
Authority
CY
Cyprus
Prior art keywords
antisolvent
fluid
producing particles
hyperpressure
compressible fluid
Prior art date
Application number
CY20061100001T
Other languages
English (en)
Inventor
David Roy Merrified
Christopher Edmund VALDER
John Peter Warr
Andrew Robert Souter
Petrus Paulus AVONTUUR
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10844704&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1105172(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of CY1105172T1 publication Critical patent/CY1105172T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium

Abstract

Μία διεργασία, και μία κατάλληλη συσκευή, για παραγωγή σωματιδίων ενός υλικού στην οποία ένα ρεύμα μίας διασποράς του υλικού σε ένα διαλύτη και ένα ρεύμα μίας αντιδιαλυτικής ουσίας συμπιεστού ρευστού αναμειγνύονται υπό συνθήκες τέτοιες ώστε η ουσία να είναι σε αντιδιαλυτική κατάσταση συμπιεστού ρευστού. Το μείγμα κατόπιν ρέει κατά μήκος ενός αγωγού (17) προς ένα στόμιο (18), από το οποίο ρέει σε μία κατάντι περιοχή στην οποία μία αντιδιαλυτική ουσία συμπιεστού ρευστού αποσυμπιέζεται και το υλικό απομονώνεται σε μία σωματιδιακή κατάσταση. Κατά προτίμηση η αντιδιαλυτική ουσία είναι ένα υπερκρίσιμο ρευστό. Η διεργασία και η συσκευή μπορούν να παράγουν ένα συμπαρασκεύασμα του υλικού με πρόσθετα τα οποία μπορούν να εισάγονται σε ένα κατάλληλο υδάτινο ή με βάση διαλύτη φέρον όχημα.
CY20061100001T 1998-12-21 2006-01-03 Διepγασια για παραγωγη σωματιδιων η οποια χρησιμοποιει ενα υπepκρισιμο ρευστο CY1105172T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9828204.9A GB9828204D0 (en) 1998-12-21 1998-12-21 Process
PCT/GB1999/004355 WO2000037169A1 (en) 1998-12-21 1999-12-21 Process and apparatus for producing particles using a supercritical fluid

Publications (1)

Publication Number Publication Date
CY1105172T1 true CY1105172T1 (el) 2010-03-03

Family

ID=10844704

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100001T CY1105172T1 (el) 1998-12-21 2006-01-03 Διepγασια για παραγωγη σωματιδιων η οποια χρησιμοποιει ενα υπepκρισιμο ρευστο

Country Status (11)

Country Link
US (1) US6830714B1 (el)
EP (1) EP1169117B2 (el)
JP (1) JP4718011B2 (el)
AT (1) ATE306314T1 (el)
AU (1) AU1876100A (el)
CY (1) CY1105172T1 (el)
DE (1) DE69932948T3 (el)
DK (1) DK1169117T4 (el)
ES (1) ES2251250T5 (el)
GB (1) GB9828204D0 (el)
WO (1) WO2000037169A1 (el)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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EP1185248B1 (en) * 1999-06-09 2012-05-02 Robert E. Sievers Supercritical fluid-assisted nebulization and bubble drying
GB9920148D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel composition
CH694686A5 (it) * 2000-03-04 2005-06-15 Eco2 Sa Prodotto di micronizzazione di sostanze farmaceutiche.
AU2002221320B2 (en) * 2000-12-08 2006-06-15 The University Of Sydney Synthesis of small particles
GB0102075D0 (en) 2001-01-26 2001-03-14 Astrazeneca Ab Process
ES2223034T3 (es) 2001-02-26 2005-02-16 Dompe S.P.A. Aparato y metodo para la formacion de particulas micronicas y submicronicas.
DE10109829A1 (de) * 2001-03-01 2002-09-05 Celanese Ventures Gmbh Polymermembran, Verfahren zu deren Herstellung sowie deren Verwendung
US6869551B2 (en) 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
US6596206B2 (en) 2001-03-30 2003-07-22 Picoliter Inc. Generation of pharmaceutical agent particles using focused acoustic energy
US6610223B2 (en) 2001-03-30 2003-08-26 Picoliter Inc. Focused acoustic energy in the generation of solid particles
US7276190B2 (en) 2001-07-02 2007-10-02 Micro & Nano Materials Sagl Process for the production of micro and/or nano particles
CA2466525C (en) 2001-12-07 2011-05-17 Eiffel Technologies Limited Synthesis of small particles
AU2002365617B2 (en) * 2001-12-07 2008-04-03 Map Pharmaceuticals, Inc. Synthesis of small particles
AU2003221888B2 (en) * 2002-04-11 2008-11-06 Medimmune, Llc Preservation of bioactive materials by spray drying
CA2482272C (en) * 2002-04-12 2011-08-16 Feyecon Development & Implementation B.V. Process for small particle formation
DE10248619A1 (de) * 2002-10-18 2004-04-29 Bayer Ag Verfahren zur Herstellung pulverförmiger Wirkstoff-Formulierungen mit kompressiblen Fluiden
JP2004148174A (ja) * 2002-10-29 2004-05-27 Kobe Steel Ltd 超臨界流体を利用して微粒子を製造する方法および装置
JP3663408B2 (ja) * 2003-06-30 2005-06-22 株式会社アイテック 高温高圧水を用いる微粒子製造方法および微粒子製造装置
KR100603974B1 (ko) 2003-12-05 2006-07-25 김갑식 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법
EP1717263A4 (en) * 2004-01-28 2008-03-26 Japan Science & Tech Agency PROCESS FOR PRODUCING FINE PARTICLES USING RAPID EXPANSION METHOD IN A LEAN SOLVENT FROM A SUPERCRITICAL FLUID
US8475845B2 (en) 2005-07-15 2013-07-02 Map Pharmaceuticals, Inc. Method of particle formation
CA2692946C (en) 2007-06-29 2014-11-18 Swetree Technologies Ab Method to prepare superhydrophobic surfaces on solid bodies by rapid expansion solutions
PL2229233T3 (pl) * 2007-12-07 2020-03-31 Xspray Pharma Ab (Publ) Sposób wytwarzania cząstek
US20100298602A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Systems and methods for microfluidic crystallization
US20100294986A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Supercritical fluid facilitated particle formation in microfluidic systems
GB0915106D0 (en) 2009-08-28 2009-10-07 Glaxo Group Ltd Process
KR101834940B1 (ko) 2010-03-22 2018-03-06 (주)바이오시네틱스 나노입자 제조방법
US9138705B2 (en) 2010-11-22 2015-09-22 Hong Kong Polytechnic University Method for precipitating a solute from a solution
DE102011105201A1 (de) * 2011-04-11 2012-10-11 Martin Ruda Luftkappe, Anordnung aus Haltering und Luftkappe und Farbleiteinrich-tung für eine Farbspritzpistole
US20150024209A1 (en) * 2012-03-12 2015-01-22 Sharp Kabushiki Kaisha Modified particle purification method and manufacturing method, modified particles, functional material, optical member, heat transfer member, and coverage rate analysis device and coverage rate analysis method
US10239009B2 (en) 2013-03-14 2019-03-26 Lawrence Livermore National Security, Llc Continuously-operable flow stream processing system and method
US8778181B1 (en) 2013-03-14 2014-07-15 Crititech, Inc. Equipment assembly for and method of processing particles
US20170050337A1 (en) * 2013-05-02 2017-02-23 Melior Innovations, Inc. Formation apparatus, systems and methods for manufacturing polymer derived ceramic structures
JP6429949B2 (ja) * 2017-01-26 2018-11-28 タナベウィルテック株式会社 微粒子製造装置および微粒子製造方法
AU2018255063A1 (en) 2017-04-21 2018-11-22 Bio-Synectics Inc. Method for preparing active material nanoparticles using lipid as lubricant for milling
CN112007584A (zh) * 2020-08-31 2020-12-01 胡勇刚 一种油脂的超临界颗粒制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
EP0885038B1 (en) † 1996-03-01 2011-06-15 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
GB9622173D0 (en) * 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
GB9703673D0 (en) † 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles

Also Published As

Publication number Publication date
GB9828204D0 (en) 1999-02-17
ATE306314T1 (de) 2005-10-15
JP2002532244A (ja) 2002-10-02
ES2251250T5 (es) 2009-07-06
WO2000037169A1 (en) 2000-06-29
AU1876100A (en) 2000-07-12
DE69932948D1 (de) 2006-10-05
ES2251250T3 (es) 2006-04-16
JP4718011B2 (ja) 2011-07-06
EP1169117B1 (en) 2005-10-12
EP1169117A1 (en) 2002-01-09
DK1169117T4 (da) 2009-06-15
US6830714B1 (en) 2004-12-14
EP1169117B2 (en) 2009-03-18
DK1169117T3 (da) 2006-02-20
DE69932948T2 (de) 2007-01-11
DE69932948T3 (de) 2009-08-13

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