DK1169117T4 - Fremgangsmåde til fremstilling af partikler ved anvendelse af en superkritisk fluid - Google Patents

Fremgangsmåde til fremstilling af partikler ved anvendelse af en superkritisk fluid

Info

Publication number
DK1169117T4
DK1169117T4 DK99962400T DK99962400T DK1169117T4 DK 1169117 T4 DK1169117 T4 DK 1169117T4 DK 99962400 T DK99962400 T DK 99962400T DK 99962400 T DK99962400 T DK 99962400T DK 1169117 T4 DK1169117 T4 DK 1169117T4
Authority
DK
Denmark
Prior art keywords
substance
supercritical fluid
compressible fluid
antisolvent
stream
Prior art date
Application number
DK99962400T
Other languages
Danish (da)
English (en)
Other versions
DK1169117T3 (da
Inventor
John Peter Warr
Andrew Robert Souter
Petrus Paulus Cornelis Avontuur
David Roy Merrified
Christopher Edmund Valder
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10844704&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1169117(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of DK1169117T3 publication Critical patent/DK1169117T3/da
Application granted granted Critical
Publication of DK1169117T4 publication Critical patent/DK1169117T4/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Glass Compositions (AREA)
DK99962400T 1998-12-21 1999-12-21 Fremgangsmåde til fremstilling af partikler ved anvendelse af en superkritisk fluid DK1169117T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9828204.9A GB9828204D0 (en) 1998-12-21 1998-12-21 Process
PCT/GB1999/004355 WO2000037169A1 (en) 1998-12-21 1999-12-21 Process and apparatus for producing particles using a supercritical fluid

Publications (2)

Publication Number Publication Date
DK1169117T3 DK1169117T3 (da) 2006-02-20
DK1169117T4 true DK1169117T4 (da) 2009-06-15

Family

ID=10844704

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99962400T DK1169117T4 (da) 1998-12-21 1999-12-21 Fremgangsmåde til fremstilling af partikler ved anvendelse af en superkritisk fluid

Country Status (11)

Country Link
US (1) US6830714B1 (enExample)
EP (1) EP1169117B2 (enExample)
JP (1) JP4718011B2 (enExample)
AT (1) ATE306314T1 (enExample)
AU (1) AU1876100A (enExample)
CY (1) CY1105172T1 (enExample)
DE (1) DE69932948T3 (enExample)
DK (1) DK1169117T4 (enExample)
ES (1) ES2251250T5 (enExample)
GB (1) GB9828204D0 (enExample)
WO (1) WO2000037169A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1049621A1 (zh) * 1999-06-09 2003-05-23 罗伯特‧E‧希弗斯 超临界流体辅助的喷雾和鼓泡乾燥
GB9920148D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel composition
CH694686A5 (it) * 2000-03-04 2005-06-15 Eco2 Sa Prodotto di micronizzazione di sostanze farmaceutiche.
AU2002221320B2 (en) * 2000-12-08 2006-06-15 The University Of Sydney Synthesis of small particles
GB0102075D0 (en) 2001-01-26 2001-03-14 Astrazeneca Ab Process
BR0207570B1 (pt) 2001-02-26 2013-02-05 aparelho para formaÇço de partÍculas micronizadas e submicronizadas de uma substÂncia, bocal, e, processo realizado usando o aparelho.
DE10109829A1 (de) * 2001-03-01 2002-09-05 Celanese Ventures Gmbh Polymermembran, Verfahren zu deren Herstellung sowie deren Verwendung
US6869551B2 (en) 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
US6596206B2 (en) 2001-03-30 2003-07-22 Picoliter Inc. Generation of pharmaceutical agent particles using focused acoustic energy
US6610223B2 (en) 2001-03-30 2003-08-26 Picoliter Inc. Focused acoustic energy in the generation of solid particles
EP1401563B2 (en) * 2001-07-02 2015-09-16 Micro & Nano Materials SAGL Process for the production of micro and/or nano particles
EP1461020A4 (en) 2001-12-07 2008-10-29 Map Pharmaceuticals Inc SYNTHESIS OF SMALL PARTICLES
AU2002365617B2 (en) * 2001-12-07 2008-04-03 Map Pharmaceuticals, Inc. Synthesis of small particles
JP2006512102A (ja) * 2002-04-11 2006-04-13 メディミューン・ヴァクシンズ・インコーポレーテッド 噴霧乾燥による生物活性材料の防腐
WO2003086606A1 (en) * 2002-04-12 2003-10-23 Feyecon Development & Implementation B.V. Process for small particle formation
DE10248619A1 (de) * 2002-10-18 2004-04-29 Bayer Ag Verfahren zur Herstellung pulverförmiger Wirkstoff-Formulierungen mit kompressiblen Fluiden
JP2004148174A (ja) * 2002-10-29 2004-05-27 Kobe Steel Ltd 超臨界流体を利用して微粒子を製造する方法および装置
JP3663408B2 (ja) * 2003-06-30 2005-06-22 株式会社アイテック 高温高圧水を用いる微粒子製造方法および微粒子製造装置
KR100603974B1 (ko) 2003-12-05 2006-07-25 김갑식 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법
AU2005209541B2 (en) * 2004-01-28 2007-07-12 Japan Science And Technology Agency A method for producing fine particles using method of rapid expansion into poor solvent from supercritical fluid
AU2006272438B2 (en) 2005-07-15 2011-08-04 Map Pharmaceuticals, Inc. Method of particle formation
EP2164647B1 (en) 2007-06-29 2013-11-06 Cellutech AB Method to prepare superhydrophobic surfaces on solid bodies by rapid expansion solutions
US8585943B2 (en) * 2007-12-07 2013-11-19 Xspray Microparticles Ab Method and arrangement for the production of particles
US20100298602A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Systems and methods for microfluidic crystallization
US20100294986A1 (en) * 2009-05-19 2010-11-25 Massachusetts Institute Of Technology Supercritical fluid facilitated particle formation in microfluidic systems
GB0915106D0 (en) 2009-08-28 2009-10-07 Glaxo Group Ltd Process
EP2551237B1 (en) 2010-03-22 2024-09-04 Bio-Synectics Inc. Method for preparing nano-particles
US9138705B2 (en) 2010-11-22 2015-09-22 Hong Kong Polytechnic University Method for precipitating a solute from a solution
DE102011105201A1 (de) * 2011-04-11 2012-10-11 Martin Ruda Luftkappe, Anordnung aus Haltering und Luftkappe und Farbleiteinrich-tung für eine Farbspritzpistole
WO2013136974A1 (ja) * 2012-03-12 2013-09-19 シャープ株式会社 修飾微粒子の精製方法および製造方法、修飾微粒子、機能性材料、光学部材、熱伝部材、ならびに、被覆率分析装置および被覆率分析方法
US10239009B2 (en) 2013-03-14 2019-03-26 Lawrence Livermore National Security, Llc Continuously-operable flow stream processing system and method
US8778181B1 (en) 2013-03-14 2014-07-15 Crititech, Inc. Equipment assembly for and method of processing particles
US20170050337A1 (en) * 2013-05-02 2017-02-23 Melior Innovations, Inc. Formation apparatus, systems and methods for manufacturing polymer derived ceramic structures
JP6429949B2 (ja) * 2017-01-26 2018-11-28 タナベウィルテック株式会社 微粒子製造装置および微粒子製造方法
EP3613415B1 (en) 2017-04-21 2022-11-09 Bio-Synectics Inc. Method for preparing active material nanoparticles using lipid as lubricant for milling
CN112007584A (zh) * 2020-08-31 2020-12-01 胡勇刚 一种油脂的超临界颗粒制备工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01176437A (ja) * 1987-12-29 1989-07-12 Ono Pharmaceut Co Ltd 有機物質の微粒化方法
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
EP0885038B1 (en) 1996-03-01 2011-06-15 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
GB9622173D0 (en) * 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles

Also Published As

Publication number Publication date
WO2000037169A1 (en) 2000-06-29
CY1105172T1 (el) 2010-03-03
DE69932948T2 (de) 2007-01-11
EP1169117A1 (en) 2002-01-09
EP1169117B1 (en) 2005-10-12
ES2251250T5 (es) 2009-07-06
DK1169117T3 (da) 2006-02-20
ATE306314T1 (de) 2005-10-15
ES2251250T3 (es) 2006-04-16
EP1169117B2 (en) 2009-03-18
JP2002532244A (ja) 2002-10-02
JP4718011B2 (ja) 2011-07-06
AU1876100A (en) 2000-07-12
GB9828204D0 (en) 1999-02-17
US6830714B1 (en) 2004-12-14
DE69932948T3 (de) 2009-08-13
DE69932948D1 (de) 2006-10-05

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