NO20054908L - Fremgangsmate for findeling og stabilisering av sma partikler i suspensjon - Google Patents

Fremgangsmate for findeling og stabilisering av sma partikler i suspensjon

Info

Publication number
NO20054908L
NO20054908L NO20054908A NO20054908A NO20054908L NO 20054908 L NO20054908 L NO 20054908L NO 20054908 A NO20054908 A NO 20054908A NO 20054908 A NO20054908 A NO 20054908A NO 20054908 L NO20054908 L NO 20054908L
Authority
NO
Norway
Prior art keywords
suspension
small particles
comminuting
liquid stream
stabilizing small
Prior art date
Application number
NO20054908A
Other languages
English (en)
Other versions
NO20054908D0 (no
Inventor
James E Kipp
Joseph Chung Tak Wong
Monte Wisler
Rhonda Garcia
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of NO20054908D0 publication Critical patent/NO20054908D0/no
Publication of NO20054908L publication Critical patent/NO20054908L/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • Y10S516/925Phase inversion
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/84Manufacture, treatment, or detection of nanostructure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Colloid Chemistry (AREA)

Abstract

Fremgangsmåte og apparatur for finoppdeling og stabilisering av små partikler. I en apparatur ifølge en utførelsesform blir en organisk forbindelse oppløst i et løsningsmiddel slik at det dannes en partikkelsuspensjon beveget som en første væskestrøm, og suspensjonen beveges som en andre væskestrøm, hvor den andre væskestrøm er orientert og posisjonert med hensyn til den første strøm slik at det medfører skjærvirkning mellom strømmene og blanding av minst noen av partiklene i den første og andre strøm.
NO20054908A 2003-03-24 2005-10-24 Fremgangsmate for findeling og stabilisering av sma partikler i suspensjon NO20054908L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45742403P 2003-03-24 2003-03-24
US10/806,050 US7511079B2 (en) 2003-03-24 2004-03-22 Methods and apparatuses for the comminution and stabilization of small particles
PCT/US2004/009242 WO2004084860A2 (en) 2003-03-24 2004-03-24 Methods for the comminution and stabilization of small particles in suspension

Publications (2)

Publication Number Publication Date
NO20054908D0 NO20054908D0 (no) 2005-10-24
NO20054908L true NO20054908L (no) 2005-12-21

Family

ID=33101285

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20054908A NO20054908L (no) 2003-03-24 2005-10-24 Fremgangsmate for findeling og stabilisering av sma partikler i suspensjon

Country Status (10)

Country Link
US (1) US7511079B2 (no)
EP (1) EP1605915A2 (no)
JP (1) JP2006521396A (no)
KR (1) KR20050115298A (no)
AU (1) AU2004224307A1 (no)
BR (1) BRPI0408707A (no)
CA (1) CA2519536A1 (no)
MX (1) MXPA05010045A (no)
NO (1) NO20054908L (no)
WO (1) WO2004084860A2 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1556018A1 (en) * 2002-09-30 2005-07-27 Acusphere, Inc. Sustained release porous microparticles for inhalation
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US7511079B2 (en) 2003-03-24 2009-03-31 Baxter International Inc. Methods and apparatuses for the comminution and stabilization of small particles
JP2007533634A (ja) * 2003-09-30 2007-11-22 アキュスフィア, インコーポレイテッド 注射、経口、または局所用の徐放性医薬製剤
ES2338039T3 (es) * 2005-04-13 2010-05-03 ABBOTT GMBH & CO. KG Procedimiento para la obtencion cuidadosa de supensiones de particulas de elevada finura y particulas de elevada finura, asi como su aplicacion.
DE102005053862A1 (de) * 2005-11-04 2007-05-10 Pharmasol Gmbh Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel
US7913223B2 (en) * 2005-12-16 2011-03-22 Dialogic Corporation Method and system for development and use of a user-interface for operations, administration, maintenance and provisioning of a telecommunications system
US8946200B2 (en) * 2006-11-02 2015-02-03 Southwest Research Institute Pharmaceutically active nanosuspensions
US8282266B2 (en) * 2007-06-27 2012-10-09 H R D Corporation System and process for inhibitor injection
US20090187135A1 (en) * 2008-01-18 2009-07-23 Eilaz Babaev Ultrasonic syringe
US8404850B2 (en) * 2008-03-13 2013-03-26 Southwest Research Institute Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors
US8187554B2 (en) 2008-04-23 2012-05-29 Microfluidics International Corporation Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
US8722706B2 (en) * 2008-08-15 2014-05-13 Southwest Research Institute Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts
US8309134B2 (en) * 2008-10-03 2012-11-13 Southwest Research Institute Modified calcium phosphate nanoparticle formation
US9028873B2 (en) * 2010-02-08 2015-05-12 Southwest Research Institute Nanoparticles for drug delivery to the central nervous system
US10350556B2 (en) 2011-01-07 2019-07-16 Microfluidics International Corporation Low holdup volume mixing chamber
US9079140B2 (en) 2011-04-13 2015-07-14 Microfluidics International Corporation Compact interaction chamber with multiple cross micro impinging jets
US9199209B2 (en) 2011-04-13 2015-12-01 Microfluidics International Corporation Interaction chamber with flow inlet optimization
EP2934484A1 (en) * 2012-12-19 2015-10-28 Kashiv Pharma, LLC Supersaturated stabilized nanoparticles for poorly soluble drugs
JP6462403B2 (ja) * 2015-02-23 2019-01-30 大川原化工機株式会社 湿式分散器
CA3075827C (en) 2018-06-22 2021-11-16 Delphi Scientific, Llc Apparatus, systems, and methods for continuous manufacturing of nanomaterials and high purity chemicals
WO2020041631A1 (en) * 2018-08-22 2020-02-27 Avalyn Pharma Inc. Specially formulated compositions of inhaled nintedanib and nintedanib salts

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3685261A (en) * 1971-02-16 1972-08-22 Environeering Wet scrubber for contaminated gas
US4908154A (en) * 1981-04-17 1990-03-13 Biotechnology Development Corporation Method of forming a microemulsion
CA1282405C (en) 1984-05-21 1991-04-02 Michael R. Violante Method for making uniformly sized particles from water-insoluble organic compounds
IE67187B1 (en) * 1990-06-15 1996-03-06 Merck & Co Inc A crystallization method to improve crystal structure and size
DE4241549A1 (de) * 1992-12-10 1994-06-16 Nied Roland Verfahren und Vorrichtung für die Prallzerkleinerung von Feststoffpartikeln
JPH07328471A (ja) * 1994-06-06 1995-12-19 Furukawa Co Ltd 粉砕装置
US5720551A (en) * 1994-10-28 1998-02-24 Shechter; Tal Forming emulsions
SE9403846D0 (sv) * 1994-11-09 1994-11-09 Univ Ohio State Res Found Small particle formation
DE4440337A1 (de) * 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
US5833891A (en) * 1996-10-09 1998-11-10 The University Of Kansas Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
JPH10137618A (ja) * 1996-11-14 1998-05-26 Ritsumeikan 微細粒子製造方法
DE69813254T2 (de) * 1997-08-05 2004-04-01 Microfluidics International Corp., Newton Hochdruck mischer-reaktor mit mehrfachströmen
EP1293259A3 (en) 1997-12-17 2004-01-07 Universidad De Sevilla Device and method for creating aerosols for drug delivery
US6086376A (en) * 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant
JP2934229B1 (ja) * 1998-05-14 1999-08-16 清二 加川 固液混合流体の破砕・分散装置
US8293277B2 (en) * 1998-10-01 2012-10-23 Alkermes Pharma Ireland Limited Controlled-release nanoparticulate compositions
US6610317B2 (en) * 1999-05-27 2003-08-26 Acusphere, Inc. Porous paclitaxel matrices and methods of manufacture thereof
DE10007816A1 (de) 2000-02-21 2001-09-06 Bayer Ag Verfahren zur Herstellung von Nanosuspensionen
EP1276465B1 (en) * 2000-04-20 2014-03-12 Jagotec AG Improved water-insoluble drug particle process
KR100867392B1 (ko) * 2000-08-15 2008-11-06 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 마이크로입자
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
EP1642571A3 (en) * 2000-12-22 2007-06-27 Baxter International Inc. Method for preparing submicron particle suspensions
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US7037528B2 (en) * 2000-12-22 2006-05-02 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
JP2003001079A (ja) * 2001-06-18 2003-01-07 Karasawa Fine Ltd 粒子微細化装置
US7511079B2 (en) 2003-03-24 2009-03-31 Baxter International Inc. Methods and apparatuses for the comminution and stabilization of small particles

Also Published As

Publication number Publication date
KR20050115298A (ko) 2005-12-07
AU2004224307A1 (en) 2004-10-07
NO20054908D0 (no) 2005-10-24
US7511079B2 (en) 2009-03-31
CA2519536A1 (en) 2004-10-07
WO2004084860A2 (en) 2004-10-07
MXPA05010045A (es) 2005-10-26
JP2006521396A (ja) 2006-09-21
US20040266890A1 (en) 2004-12-30
BRPI0408707A (pt) 2006-03-07
WO2004084860A3 (en) 2005-03-24
EP1605915A2 (en) 2005-12-21

Similar Documents

Publication Publication Date Title
NO20054908L (no) Fremgangsmate for findeling og stabilisering av sma partikler i suspensjon
DK1169117T3 (da) Fremgangsmåde til fremstilling af partikler ved anvendelse af en superkritisk fluid
AR044140A1 (es) Proceso de solidificacion con antisolvente, particulas cristalinas obtenidas por dicho proceso y forma de dosificacion farmaceutica que las comprende
CO5670354A2 (es) Proceso para la elaboracion de aripiprazol esteril de tamaño particula promedio deseado
WO2006138632A3 (en) In-stream spectroscopic elemental analysis of particles being conducted within a gaseous stream
DK1440082T3 (da) Behandling med superkritiske væsker: Fremstilling af proteinmikropartikler og deres stabilisering
DK1416917T3 (da) Vandig dispersion, der omfatter stabile nanopartikler af et vanduoplöseligt aktivt stof og en excipiens som middellangkædede triglycerider (MCT)
DK1667790T3 (da) Apparat og fremgangsmåde til fremstilling af partikler
EP2241308A3 (en) Method for coating fine particle with lipid membrane
EP1362634A4 (en) PROCESS FOR PREPARING EMULSION AND MICROCAPSULES AND APPARATUS THEREFOR
BR0207570B1 (pt) aparelho para formaÇço de partÍculas micronizadas e submicronizadas de uma substÂncia, bocal, e, processo realizado usando o aparelho.
ATE324102T1 (de) Pulververarbeitung mit unter druck stehenden gasförmigen fluids
DE602004030217D1 (de) System und verfahren zur behandlung von flugasche
NO976031D0 (no) Lavviskös, höykonsentrert friksjonsreduserende middel og fremstilling derav
EA201791908A1 (ru) Стабильная в углеводородном растворителе композиция дисперсии присадки, понижающей температуру застывания
Zhang et al. Bubble meets droplet: particle‐assisted reconfiguration of wetting morphologies in colloidal multiphase systems
MX2018013702A (es) Eliminacion de particulas submicronicas de corrientes de gas.
TW200701992A (en) Lignane compound-containing oil-in-water emulsion and composition comprising the same
CY1110638T1 (el) Διαδικασια για την παραγωγη ενος ακατεργαστου μειγματος πυροσυσσωματωσης
WO2005042408A3 (en) Treatment of particle-bearing liquid
SE0303476D0 (sv) Device, method and use for the formation of small particles
BR0213220A (pt) Processo de preparação de compostos de interação de uma substância ativa pouco solúvel em um meio aquoso com um suporte poroso, e, composto de interação de interação de uma substância ativa pouco solúvel em um meio aquoso em um suporte aquoso
FI20040986A0 (fi) Menetelmä ja laitteisto kemikaalin syöttämiseksi nestevirtaan
Aksenov et al. Formation of C 60 fullerene clusters in nitrogen-containing solvents
WO2006101666A3 (en) Pure particle generator

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application