BRPI0408707A - métodos e aparelhos para a comunicação e estabilização de partìculas pequenas - Google Patents

métodos e aparelhos para a comunicação e estabilização de partìculas pequenas

Info

Publication number
BRPI0408707A
BRPI0408707A BRPI0408707-0A BRPI0408707A BRPI0408707A BR PI0408707 A BRPI0408707 A BR PI0408707A BR PI0408707 A BRPI0408707 A BR PI0408707A BR PI0408707 A BRPI0408707 A BR PI0408707A
Authority
BR
Brazil
Prior art keywords
methods
stabilization
communication
small particles
fluid stream
Prior art date
Application number
BRPI0408707-0A
Other languages
English (en)
Inventor
James E Kipp
Joseph Chung Tak Wong
Monte Wisler
Rhonda Garcia
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of BRPI0408707A publication Critical patent/BRPI0408707A/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • Y10S516/925Phase inversion
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/84Manufacture, treatment, or detection of nanostructure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Colloid Chemistry (AREA)

Abstract

"MéTODOS E APARELHOS PARA A COMUNICAçãO E ESTABILIZAçãO DE PARTìCULAS PEQUENAS". A presente invenção refere-se a métodos e aparelhos para triturar e estabilizar partículas pequenas. Em uma concretização, um aparelho se move em um composto orgânico dissolvido em um solvente para formar uma suspensão de partículas em uma primeira corrente de fluido e se move a suspensão em uma segunda corrente de fluido, em que a segunda corrente de fluido é orientada e é posicionada com relação à primeira corrente para causar cisalhamente entre as correntes e misturação de pelo menos algumas das partículas na primeira e segunda correntes.
BRPI0408707-0A 2003-03-24 2004-03-24 métodos e aparelhos para a comunicação e estabilização de partìculas pequenas BRPI0408707A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45742403P 2003-03-24 2003-03-24
US10/806,050 US7511079B2 (en) 2003-03-24 2004-03-22 Methods and apparatuses for the comminution and stabilization of small particles
PCT/US2004/009242 WO2004084860A2 (en) 2003-03-24 2004-03-24 Methods for the comminution and stabilization of small particles in suspension

Publications (1)

Publication Number Publication Date
BRPI0408707A true BRPI0408707A (pt) 2006-03-07

Family

ID=33101285

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408707-0A BRPI0408707A (pt) 2003-03-24 2004-03-24 métodos e aparelhos para a comunicação e estabilização de partìculas pequenas

Country Status (10)

Country Link
US (1) US7511079B2 (pt)
EP (1) EP1605915A2 (pt)
JP (1) JP2006521396A (pt)
KR (1) KR20050115298A (pt)
AU (1) AU2004224307A1 (pt)
BR (1) BRPI0408707A (pt)
CA (1) CA2519536A1 (pt)
MX (1) MXPA05010045A (pt)
NO (1) NO20054908L (pt)
WO (1) WO2004084860A2 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006503865A (ja) * 2002-09-30 2006-02-02 アキュスフィア, インコーポレイテッド 吸入のための徐放性の多孔性微粒子
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US7511079B2 (en) 2003-03-24 2009-03-31 Baxter International Inc. Methods and apparatuses for the comminution and stabilization of small particles
CA2533887A1 (en) * 2003-09-30 2005-04-14 Acusphere, Inc. Injectable, oral, or topical sustained release pharmaceutical formulations
ES2338039T3 (es) * 2005-04-13 2010-05-03 ABBOTT GMBH & CO. KG Procedimiento para la obtencion cuidadosa de supensiones de particulas de elevada finura y particulas de elevada finura, asi como su aplicacion.
DE102005053862A1 (de) * 2005-11-04 2007-05-10 Pharmasol Gmbh Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel
US7913223B2 (en) * 2005-12-16 2011-03-22 Dialogic Corporation Method and system for development and use of a user-interface for operations, administration, maintenance and provisioning of a telecommunications system
US8946200B2 (en) * 2006-11-02 2015-02-03 Southwest Research Institute Pharmaceutically active nanosuspensions
US8282266B2 (en) 2007-06-27 2012-10-09 H R D Corporation System and process for inhibitor injection
US20090187135A1 (en) * 2008-01-18 2009-07-23 Eilaz Babaev Ultrasonic syringe
US8404850B2 (en) * 2008-03-13 2013-03-26 Southwest Research Institute Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors
US8187554B2 (en) * 2008-04-23 2012-05-29 Microfluidics International Corporation Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
US8722706B2 (en) * 2008-08-15 2014-05-13 Southwest Research Institute Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts
US8309134B2 (en) * 2008-10-03 2012-11-13 Southwest Research Institute Modified calcium phosphate nanoparticle formation
US9028873B2 (en) * 2010-02-08 2015-05-12 Southwest Research Institute Nanoparticles for drug delivery to the central nervous system
US10350556B2 (en) 2011-01-07 2019-07-16 Microfluidics International Corporation Low holdup volume mixing chamber
US9199209B2 (en) 2011-04-13 2015-12-01 Microfluidics International Corporation Interaction chamber with flow inlet optimization
US9079140B2 (en) 2011-04-13 2015-07-14 Microfluidics International Corporation Compact interaction chamber with multiple cross micro impinging jets
US10500282B2 (en) * 2012-12-19 2019-12-10 Kashiv Biosciences, Llc Supersaturated stabilized nanoparticles for poorly soluble drugs
JP6462403B2 (ja) * 2015-02-23 2019-01-30 大川原化工機株式会社 湿式分散器
US11191723B2 (en) 2018-06-22 2021-12-07 Delphi Scientific, Llc Apparatus, systems, and methods for continuous manufacturing of nanomaterials and high purity chemicals
CN112867707A (zh) * 2018-08-22 2021-05-28 艾弗林制药有限公司 吸入用尼达尼布和尼达尼布盐类的特定调配的组合物

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3685261A (en) * 1971-02-16 1972-08-22 Environeering Wet scrubber for contaminated gas
US4908154A (en) 1981-04-17 1990-03-13 Biotechnology Development Corporation Method of forming a microemulsion
CA1282405C (en) 1984-05-21 1991-04-02 Michael R. Violante Method for making uniformly sized particles from water-insoluble organic compounds
DE69112917T2 (de) 1990-06-15 1996-05-15 Merck & Co Inc Kristallisationsverfahren zur Verbesserung der Kristallstruktur und -grösse.
DE4241549A1 (de) * 1992-12-10 1994-06-16 Nied Roland Verfahren und Vorrichtung für die Prallzerkleinerung von Feststoffpartikeln
JPH07328471A (ja) * 1994-06-06 1995-12-19 Furukawa Co Ltd 粉砕装置
US5720551A (en) 1994-10-28 1998-02-24 Shechter; Tal Forming emulsions
SE9403846D0 (sv) 1994-11-09 1994-11-09 Univ Ohio State Res Found Small particle formation
DE4440337A1 (de) 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit
SE9501384D0 (sv) 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
US5833891A (en) 1996-10-09 1998-11-10 The University Of Kansas Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
JPH10137618A (ja) * 1996-11-14 1998-05-26 Ritsumeikan 微細粒子製造方法
US6159442A (en) 1997-08-05 2000-12-12 Mfic Corporation Use of multiple stream high pressure mixer/reactor
CA2314918A1 (en) 1997-12-17 1999-06-24 Universidad De Sevilla Device and method for creating dry particles
US6086376A (en) 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant
JP2934229B1 (ja) * 1998-05-14 1999-08-16 清二 加川 固液混合流体の破砕・分散装置
US8293277B2 (en) 1998-10-01 2012-10-23 Alkermes Pharma Ireland Limited Controlled-release nanoparticulate compositions
US6610317B2 (en) 1999-05-27 2003-08-26 Acusphere, Inc. Porous paclitaxel matrices and methods of manufacture thereof
DE10007816A1 (de) 2000-02-21 2001-09-06 Bayer Ag Verfahren zur Herstellung von Nanosuspensionen
EP1276465B1 (en) 2000-04-20 2014-03-12 Jagotec AG Improved water-insoluble drug particle process
DE60140625D1 (de) 2000-08-15 2010-01-07 Univ Illinois Verfahren zur herstellung von mikropartikeln
US6869617B2 (en) 2000-12-22 2005-03-22 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
IL156310A0 (en) * 2000-12-22 2004-01-04 Baxter Int Method for preparing submicron particle suspensions
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
JP2003001079A (ja) * 2001-06-18 2003-01-07 Karasawa Fine Ltd 粒子微細化装置
US7511079B2 (en) 2003-03-24 2009-03-31 Baxter International Inc. Methods and apparatuses for the comminution and stabilization of small particles

Also Published As

Publication number Publication date
NO20054908L (no) 2005-12-21
MXPA05010045A (es) 2005-10-26
CA2519536A1 (en) 2004-10-07
JP2006521396A (ja) 2006-09-21
NO20054908D0 (no) 2005-10-24
US20040266890A1 (en) 2004-12-30
WO2004084860A3 (en) 2005-03-24
WO2004084860A2 (en) 2004-10-07
EP1605915A2 (en) 2005-12-21
KR20050115298A (ko) 2005-12-07
US7511079B2 (en) 2009-03-31
AU2004224307A1 (en) 2004-10-07

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.