DE69915346T2 - Umwandlung von flüssigkeitsgefüllten gelatinkapseln in systeme mit gesteuerter wirkstoffabgabe durch mehrfache beschichtungen - Google Patents
Umwandlung von flüssigkeitsgefüllten gelatinkapseln in systeme mit gesteuerter wirkstoffabgabe durch mehrfache beschichtungen Download PDFInfo
- Publication number
- DE69915346T2 DE69915346T2 DE69915346T DE69915346T DE69915346T2 DE 69915346 T2 DE69915346 T2 DE 69915346T2 DE 69915346 T DE69915346 T DE 69915346T DE 69915346 T DE69915346 T DE 69915346T DE 69915346 T2 DE69915346 T2 DE 69915346T2
- Authority
- DE
- Germany
- Prior art keywords
- layer
- dosage form
- gelatin capsule
- barrier layer
- expandable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 238000006243 chemical reaction Methods 0.000 title abstract 2
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- 230000004888 barrier function Effects 0.000 claims abstract description 103
- 239000007788 liquid Substances 0.000 claims abstract description 73
- 239000002775 capsule Substances 0.000 claims abstract description 67
- 239000000203 mixture Substances 0.000 claims abstract description 66
- 238000000034 method Methods 0.000 claims abstract description 35
- 239000002131 composite material Substances 0.000 claims abstract description 20
- 238000013270 controlled release Methods 0.000 claims abstract description 18
- 238000009472 formulation Methods 0.000 claims abstract description 18
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- 239000000463 material Substances 0.000 claims description 26
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- 238000000576 coating method Methods 0.000 claims description 20
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- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims description 4
- CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 claims description 4
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- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
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- USFMMZYROHDWPJ-UHFFFAOYSA-N trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium Chemical compound CC(=C)C(=O)OCC[N+](C)(C)C USFMMZYROHDWPJ-UHFFFAOYSA-N 0.000 description 1
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- WDRCVXGINNJWPH-UHFFFAOYSA-N tris(6-methylheptyl) benzene-1,2,4-tricarboxylate Chemical compound CC(C)CCCCCOC(=O)C1=CC=C(C(=O)OCCCCCC(C)C)C(C(=O)OCCCCCC(C)C)=C1 WDRCVXGINNJWPH-UHFFFAOYSA-N 0.000 description 1
- YPDXSCXISVYHOB-UHFFFAOYSA-N tris(7-methyloctyl) benzene-1,2,4-tricarboxylate Chemical compound CC(C)CCCCCCOC(=O)C1=CC=C(C(=O)OCCCCCCC(C)C)C(C(=O)OCCCCCCC(C)C)=C1 YPDXSCXISVYHOB-UHFFFAOYSA-N 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11263498P | 1998-12-17 | 1998-12-17 | |
| US112634P | 1998-12-17 | ||
| PCT/US1999/030341 WO2000035419A2 (en) | 1998-12-17 | 1999-12-10 | Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69915346D1 DE69915346D1 (de) | 2004-04-08 |
| DE69915346T2 true DE69915346T2 (de) | 2004-07-22 |
Family
ID=22345016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69915346T Expired - Lifetime DE69915346T2 (de) | 1998-12-17 | 1999-12-10 | Umwandlung von flüssigkeitsgefüllten gelatinkapseln in systeme mit gesteuerter wirkstoffabgabe durch mehrfache beschichtungen |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6419952B2 (enExample) |
| EP (1) | EP1140012B1 (enExample) |
| JP (1) | JP2002532406A (enExample) |
| KR (1) | KR100634069B1 (enExample) |
| CN (1) | CN1161101C (enExample) |
| AT (1) | ATE260642T1 (enExample) |
| AU (1) | AU765909C (enExample) |
| CA (1) | CA2354472C (enExample) |
| CO (1) | CO5271648A1 (enExample) |
| DE (1) | DE69915346T2 (enExample) |
| DK (1) | DK1140012T3 (enExample) |
| ES (1) | ES2213404T3 (enExample) |
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| NO (1) | NO20012959L (enExample) |
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- 1999-12-10 DE DE69915346T patent/DE69915346T2/de not_active Expired - Lifetime
- 1999-12-10 PT PT99966463T patent/PT1140012E/pt unknown
- 1999-12-10 EP EP99966463A patent/EP1140012B1/en not_active Expired - Lifetime
- 1999-12-10 JP JP2000587740A patent/JP2002532406A/ja active Pending
- 1999-12-10 DK DK99966463T patent/DK1140012T3/da active
- 1999-12-10 AU AU21994/00A patent/AU765909C/en not_active Ceased
- 1999-12-10 WO PCT/US1999/030341 patent/WO2000035419A2/en not_active Ceased
- 1999-12-10 ES ES99966463T patent/ES2213404T3/es not_active Expired - Lifetime
- 1999-12-10 CA CA002354472A patent/CA2354472C/en not_active Expired - Fee Related
- 1999-12-10 HU HU0104721A patent/HUP0104721A3/hu unknown
- 1999-12-10 AT AT99966463T patent/ATE260642T1/de active
- 1999-12-10 KR KR1020017007565A patent/KR100634069B1/ko not_active Expired - Fee Related
- 1999-12-10 IL IL14369199A patent/IL143691A0/xx active IP Right Grant
- 1999-12-10 NZ NZ512410A patent/NZ512410A/xx not_active IP Right Cessation
- 1999-12-14 CO CO99078060A patent/CO5271648A1/es not_active Application Discontinuation
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2001
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- 2001-06-15 ZA ZA200104928A patent/ZA200104928B/en unknown
- 2001-06-15 NO NO20012959A patent/NO20012959L/no not_active Application Discontinuation
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006032427A1 (de) * | 2006-07-13 | 2008-01-17 | Neuraxpharm Arzneimittel Gmbh U. Co. Kg | Verwendung von Zusammensetzungen von Clozapin, Quetiapin, schwer oder sehr schwer löslichen Säureadditionssalzen von Quetiapin und/oder Olanzapin zur Herstellung von Lösungen zur oralen Verabreichung |
| DE102006032426A1 (de) * | 2006-07-13 | 2008-01-17 | Neuraxpharm Arzneimittel Gmbh U. Co. Kg | Verwendung von Zusammensetzungen von Clozapin, Quetiapin, schwer oder sehr schwer löslichen Säureadditionssalzen von Quetiapin und/oder Olanzapin zur Herstellung von Lösungen zur oralen Verabreichung |
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