DE69835594T2 - Zusammensetzungen zur behandlung von irds oder ards die 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy) benzamid und lungensurfactant enthalten - Google Patents
Zusammensetzungen zur behandlung von irds oder ards die 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy) benzamid und lungensurfactant enthalten Download PDFInfo
- Publication number
- DE69835594T2 DE69835594T2 DE69835594T DE69835594T DE69835594T2 DE 69835594 T2 DE69835594 T2 DE 69835594T2 DE 69835594 T DE69835594 T DE 69835594T DE 69835594 T DE69835594 T DE 69835594T DE 69835594 T2 DE69835594 T2 DE 69835594T2
- Authority
- DE
- Germany
- Prior art keywords
- cyclopropylmethoxy
- difluoromethoxybenzamide
- dichloropyrid
- surfactant
- lung
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Marine Sciences & Fisheries (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE69835594T DE69835594T2 (de) | 1997-02-17 | 1998-02-14 | Zusammensetzungen zur behandlung von irds oder ards die 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy) benzamid und lungensurfactant enthalten |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19705924 | 1997-02-17 | ||
| DE19705924A DE19705924A1 (de) | 1997-02-17 | 1997-02-17 | Neue Zusammensetzungen |
| EP97102639 | 1997-02-19 | ||
| EP97102639 | 1997-02-19 | ||
| DE69835594T DE69835594T2 (de) | 1997-02-17 | 1998-02-14 | Zusammensetzungen zur behandlung von irds oder ards die 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy) benzamid und lungensurfactant enthalten |
| PCT/EP1998/000847 WO1998035683A1 (en) | 1997-02-17 | 1998-02-14 | Compositions for the treatment of ards or irds containing 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide and lung surfactant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69835594D1 DE69835594D1 (de) | 2006-09-28 |
| DE69835594T2 true DE69835594T2 (de) | 2007-08-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69835594T Expired - Lifetime DE69835594T2 (de) | 1997-02-17 | 1998-02-14 | Zusammensetzungen zur behandlung von irds oder ards die 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy) benzamid und lungensurfactant enthalten |
Country Status (25)
| Country | Link |
|---|---|
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| EP (1) | EP0977577B1 (enExample) |
| JP (1) | JP4763104B2 (enExample) |
| KR (1) | KR100640025B1 (enExample) |
| CN (1) | CN1123345C (enExample) |
| AT (1) | ATE336254T1 (enExample) |
| AU (1) | AU734122B2 (enExample) |
| BR (1) | BR9807399B1 (enExample) |
| CA (1) | CA2276429C (enExample) |
| CZ (1) | CZ293871B6 (enExample) |
| DE (1) | DE69835594T2 (enExample) |
| DK (1) | DK0977577T3 (enExample) |
| EA (1) | EA001758B1 (enExample) |
| EE (1) | EE04094B1 (enExample) |
| ES (1) | ES2271990T3 (enExample) |
| HU (1) | HU227520B1 (enExample) |
| IL (1) | IL130658A (enExample) |
| NO (1) | NO323594B1 (enExample) |
| NZ (1) | NZ336569A (enExample) |
| PL (1) | PL190775B1 (enExample) |
| PT (1) | PT977577E (enExample) |
| SI (1) | SI0977577T1 (enExample) |
| TR (1) | TR199901772T2 (enExample) |
| UA (1) | UA50808C2 (enExample) |
| WO (1) | WO1998035683A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR199901772T2 (enExample) * | 1997-02-17 | 1999-09-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | |
| JP2001081031A (ja) * | 1999-08-30 | 2001-03-27 | Schering Ag | 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤 |
| EP1216052A1 (en) * | 1999-09-16 | 2002-06-26 | Byk Gulden Lomberg Chemische Fabrik GmbH | Combination of c1-inh and lung surfactant for the treatment of respiratory disorders |
| DE19957898A1 (de) * | 1999-12-01 | 2001-06-07 | Byk Gulden Lomberg Chem Fab | Neue Verwendung von Lungensurfactant |
| JP2003534328A (ja) | 2000-05-25 | 2003-11-18 | メルク フロスト カナダ アンド カンパニー | フルオロアルコキシ置換ベンズアミドジクロロピリジニルｎ−オキシドｐｄｅ４阻害剤 |
| WO2002094823A1 (en) | 2001-05-24 | 2002-11-28 | Merck Frosst Canada & Co. | 1-biaryl-1,8-napthyridin-4-one phosphodiesterase-4 inhibitors |
| US20030099601A1 (en) * | 2001-11-27 | 2003-05-29 | Gordon Marc S. | Inhalation lung surfactant therapy |
| WO2003053455A1 (en) * | 2001-12-12 | 2003-07-03 | Penn State Research Foundation | Surfactant prevention of lung complications from cancer chemotherapy |
| US20030170223A1 (en) * | 2002-02-01 | 2003-09-11 | Board Of Trustees Of Michigan State University | Pulmonary vasodilator surfactant compositions and method of use |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| US6822114B1 (en) | 2002-10-08 | 2004-11-23 | Albemarle Corporation | Process for production of fluoroalkoxy-substituted benzamides and their intermediates |
| PL214869B1 (pl) * | 2002-11-27 | 2013-09-30 | Nycomed Gmbh | Synergistyczna kombinacja zawierajaca roflumilast i (R, R)-formoterol |
| WO2004047829A1 (en) * | 2002-11-27 | 2004-06-10 | Altana Pharma Ag | New synergistic combination comprising roflumilast and formoterol |
| ES2335498T3 (es) | 2003-03-10 | 2010-03-29 | Nycomed Gmbh | Nuevo proceso para la preparacion de reflumilast. |
| US7238664B2 (en) | 2003-06-16 | 2007-07-03 | Altana Pharma Ag | Composition comprising a pulmonary surfactant and a PDE5 inhibitor for the treatment of lung diseases |
| EP1781323B1 (en) | 2004-08-06 | 2010-02-17 | Nycomed GmbH | Composition comprising a pulmonary surfactant and a tnf-derived peptide |
| EP2258350B1 (en) * | 2005-03-16 | 2014-12-24 | Takeda GmbH | Taste masked dosage form containing roflumilast |
| CN101657460A (zh) * | 2006-12-13 | 2010-02-24 | 基利得科学公司 | 用于治疗肺炎症和支气管收缩的作为抗炎性信号转导调节剂(AISTM’S)和β-激动剂的相互前药的单磷酸酯 |
| WO2009055788A1 (en) * | 2007-10-26 | 2009-04-30 | Aeris Therapeutics, Inc. | Pneumoreductive therapy and compositions useful therein |
| US20160199413A1 (en) * | 2013-08-01 | 2016-07-14 | Isletone Ab | Mscs in the treatment of inflammatory pulmonary diseases |
| CN104800214A (zh) * | 2014-01-27 | 2015-07-29 | 成都英诺新科技有限公司 | 一种罗氟司特吸入气雾剂复方及制备方法 |
| RU2728821C1 (ru) * | 2020-05-13 | 2020-07-31 | Федеральное государственное бюджетное учреждение науки "Научный центр биомедицинских технологий Федерального медико-биологического агентства" (ФГБУН НЦБМТ ФМБА России) | Способ лечения острого респираторного дистресс-синдрома даларгином и легочным сурфактантом |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4223040A (en) * | 1974-11-26 | 1980-09-16 | Carroll John M | Lauric acid for the prevention and treatment of mycobacterial diseases |
| JPS5795920A (en) * | 1980-12-04 | 1982-06-15 | Teijin Ltd | Remedy for respiratory disease |
| JPS5845299A (ja) * | 1981-09-10 | 1983-03-16 | 東京田辺製薬株式会社 | 新規な表面活性物質、その製造法及びそれを含有する呼吸窮迫疾候群治療剤 |
| ES532337A0 (es) * | 1983-05-11 | 1985-12-01 | Byk Gulden Lomberg Chem Fab | Procedimiento para la preparacion de 6-aril-3 (2h)piridazinonas |
| US4906476A (en) * | 1988-12-14 | 1990-03-06 | Liposome Technology, Inc. | Novel liposome composition for sustained release of steroidal drugs in lungs |
| US5006343A (en) * | 1988-12-29 | 1991-04-09 | Benson Bradley J | Pulmonary administration of pharmaceutically active substances |
| KR100331255B1 (ko) * | 1993-07-02 | 2002-10-25 | 빅굴덴 롬베르그 케미쉐 화부리크 게엠베하 | 플루오로알콕시-치환된벤즈아미드및시클릭뉴클레오티드포스포디에스테라아제억제제로서의그의용도 |
| US5856196A (en) * | 1993-10-25 | 1999-01-05 | Beth Israel Hospital | Processes for quantitating phosphoglycerides in a lipid mixture and diagnostic uses therefor |
| GB9401460D0 (en) | 1994-01-26 | 1994-03-23 | Rhone Poulenc Rorer Ltd | Compositions of matter |
| DE4434629C1 (de) * | 1994-09-28 | 1996-06-27 | Byk Gulden Lomberg Chem Fab | Zusammensetzungen zur Behandlung von IRDS und ARDS |
| US5531219A (en) * | 1994-11-04 | 1996-07-02 | Alliance Pharmaceutical Corp. | Use of liquid fluorocarbons to facilitate pulmonary drug delivery |
| US5698537A (en) * | 1996-06-18 | 1997-12-16 | Clarion Pharmaceuticals Inc. | Method of lowering the viscosity of mucus |
| TR199901772T2 (enExample) * | 1997-02-17 | 1999-09-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | |
| US6180142B1 (en) * | 1998-08-21 | 2001-01-30 | The Regents Of The University Of California | Reduction of surfactant inactivation in pulmonary surfactant therapy |
| EP1206326A1 (en) * | 1999-06-29 | 2002-05-22 | L-Tech Corporation | Chemical film cleaning and drying |
-
1998
- 1998-02-14 TR TR1999/01772T patent/TR199901772T2/xx unknown
- 1998-02-14 WO PCT/EP1998/000847 patent/WO1998035683A1/en not_active Ceased
- 1998-02-14 CN CN98802597A patent/CN1123345C/zh not_active Expired - Lifetime
- 1998-02-14 HU HU0001043A patent/HU227520B1/hu unknown
- 1998-02-14 BR BRPI9807399-0A patent/BR9807399B1/pt not_active IP Right Cessation
- 1998-02-14 IL IL13065898A patent/IL130658A/en not_active IP Right Cessation
- 1998-02-14 PL PL335134A patent/PL190775B1/pl unknown
- 1998-02-14 EE EEP199900279A patent/EE04094B1/xx unknown
- 1998-02-14 SI SI9830863T patent/SI0977577T1/sl unknown
- 1998-02-14 PT PT98910670T patent/PT977577E/pt unknown
- 1998-02-14 UA UA99084669A patent/UA50808C2/uk unknown
- 1998-02-14 AU AU64973/98A patent/AU734122B2/en not_active Expired
- 1998-02-14 EA EA199900645A patent/EA001758B1/ru not_active IP Right Cessation
- 1998-02-14 CA CA002276429A patent/CA2276429C/en not_active Expired - Lifetime
- 1998-02-14 KR KR1019997007400A patent/KR100640025B1/ko not_active Expired - Fee Related
- 1998-02-14 AT AT98910670T patent/ATE336254T1/de active
- 1998-02-14 DK DK98910670T patent/DK0977577T3/da active
- 1998-02-14 JP JP53536698A patent/JP4763104B2/ja not_active Expired - Fee Related
- 1998-02-14 EP EP98910670A patent/EP0977577B1/en not_active Expired - Lifetime
- 1998-02-14 NZ NZ336569A patent/NZ336569A/en not_active IP Right Cessation
- 1998-02-14 CZ CZ19992914A patent/CZ293871B6/cs not_active IP Right Cessation
- 1998-02-14 ES ES98910670T patent/ES2271990T3/es not_active Expired - Lifetime
- 1998-02-14 DE DE69835594T patent/DE69835594T2/de not_active Expired - Lifetime
-
1999
- 1999-08-06 US US09/369,455 patent/US6436970B1/en not_active Expired - Lifetime
- 1999-08-11 NO NO993875A patent/NO323594B1/no not_active IP Right Cessation
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2002
- 2002-03-13 US US10/096,258 patent/US6998410B2/en not_active Expired - Fee Related
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Owner name: NYCOMED GMBH, 78467 KONSTANZ, DE |