HUP0001043A2 - ARDS és IRDS kezelésére szolgáló, 3-(ciklopropil-metoxi)-N-(3,5-diklór-4-piridinil)-4-(difluor-metoxi)-benzamidot és tüdőfelületaktív anyagot tartalmazó kompozíció - Google Patents

ARDS és IRDS kezelésére szolgáló, 3-(ciklopropil-metoxi)-N-(3,5-diklór-4-piridinil)-4-(difluor-metoxi)-benzamidot és tüdőfelületaktív anyagot tartalmazó kompozíció

Info

Publication number
HUP0001043A2
HUP0001043A2 HU0001043A HUP0001043A HUP0001043A2 HU P0001043 A2 HUP0001043 A2 HU P0001043A2 HU 0001043 A HU0001043 A HU 0001043A HU P0001043 A HUP0001043 A HU P0001043A HU P0001043 A2 HUP0001043 A2 HU P0001043A2
Authority
HU
Hungary
Prior art keywords
irds
ards
treatment
difluoromethoxy
benzamide
Prior art date
Application number
HU0001043A
Other languages
English (en)
Inventor
Hermann Amschler
Rolf Beume
Klaus Eistetter
Paul-Georg Germann
Dietrich Häfner
Ulrich Kilian
Uwe Krüger
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19705924A external-priority patent/DE19705924A1/de
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh. filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh.
Publication of HUP0001043A2 publication Critical patent/HUP0001043A2/hu
Publication of HUP0001043A3 publication Critical patent/HUP0001043A3/hu
Publication of HU227520B1 publication Critical patent/HU227520B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Detergent Compositions (AREA)

Abstract

A találmány szerinti, IRDS és ARDS kezelésére alkalmas új kőmpőzícióN-(3,5-diklór-pirid-4-il)-3-(ciklőprőpil-metőxi)-4-(diflűőr-metőxi)-benzamidőt és/vagy gyógyászatilag alkalmas sóját és valamelyfelületaktív anyagőt tartalmaz. ŕ
HU0001043A 1997-02-17 1998-02-14 ARDS és IRDS kezelésére szolgáló, 3-(ciklopropil-metoxi)-N-(3,5-diklór-4-piridinil)-4-(difluor-metoxi)-benzamidot és tüdõfelületaktív anyagot tartalmazó kompozíció HU227520B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19705924A DE19705924A1 (de) 1997-02-17 1997-02-17 Neue Zusammensetzungen
EP97102639 1997-02-19
PCT/EP1998/000847 WO1998035683A1 (en) 1997-02-17 1998-02-14 Compositions for the treatment of ards or irds containing 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide and lung surfactant

Publications (3)

Publication Number Publication Date
HUP0001043A2 true HUP0001043A2 (hu) 2000-09-28
HUP0001043A3 HUP0001043A3 (en) 2002-12-28
HU227520B1 HU227520B1 (hu) 2011-07-28

Family

ID=26033977

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001043A HU227520B1 (hu) 1997-02-17 1998-02-14 ARDS és IRDS kezelésére szolgáló, 3-(ciklopropil-metoxi)-N-(3,5-diklór-4-piridinil)-4-(difluor-metoxi)-benzamidot és tüdõfelületaktív anyagot tartalmazó kompozíció

Country Status (26)

Country Link
US (2) US6436970B1 (hu)
EP (1) EP0977577B1 (hu)
JP (1) JP4763104B2 (hu)
KR (1) KR100640025B1 (hu)
CN (1) CN1123345C (hu)
AT (1) ATE336254T1 (hu)
AU (1) AU734122B2 (hu)
BR (1) BR9807399B1 (hu)
CA (1) CA2276429C (hu)
CZ (1) CZ293871B6 (hu)
DE (1) DE69835594T2 (hu)
DK (1) DK0977577T3 (hu)
EA (1) EA001758B1 (hu)
EE (1) EE04094B1 (hu)
ES (1) ES2271990T3 (hu)
HK (1) HK1026145A1 (hu)
HU (1) HU227520B1 (hu)
IL (1) IL130658A (hu)
NO (1) NO323594B1 (hu)
NZ (1) NZ336569A (hu)
PL (1) PL190775B1 (hu)
PT (1) PT977577E (hu)
SI (1) SI0977577T1 (hu)
TR (1) TR199901772T2 (hu)
UA (1) UA50808C2 (hu)
WO (1) WO1998035683A1 (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1123345C (zh) * 1997-02-17 2003-10-08 奥坦纳医药公司 治疗ards或irds的组合物
CA2384861A1 (en) 1999-09-16 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
DE19957898A1 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant
AU2001261962B2 (en) 2000-05-25 2005-04-21 Merck Frosst Canada Ltd Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor
EP1397359B1 (en) 2001-05-24 2005-08-31 Merck Frosst Canada & Co. 1-biaryl-1,8-napthyridin-4-one phosphodiesterase-4 inhibitors
US20030099601A1 (en) * 2001-11-27 2003-05-29 Gordon Marc S. Inhalation lung surfactant therapy
AU2002357168A1 (en) * 2001-12-12 2003-07-09 Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US6822114B1 (en) 2002-10-08 2004-11-23 Albemarle Corporation Process for production of fluoroalkoxy-substituted benzamides and their intermediates
US20060199865A1 (en) * 2002-11-27 2006-09-07 Rolf Beume Synergistic combination comprising roflumilast and (r,r) - formoterol
ME00489B (me) * 2002-11-27 2011-10-10 Astrazeneca Ab NOVA SINERGIČKA KOMBINACIJA KOJA UKLJUČUJE ROFLUMILAST l FERMOTEROL
EP1606261B1 (en) 2003-03-10 2009-11-04 Nycomed GmbH Novel process for the preparation of roflumilast
WO2004110450A1 (en) * 2003-06-16 2004-12-23 Altana Pharma Ag Composition comprising a pulmonary surfactant and a pde5 inhibitor for the treatment of lung diseases
AU2005268755B2 (en) * 2004-08-06 2011-04-07 Takeda Gmbh Composition comprising a pulmonary surfactant and a TNF-derived peptide
EP1861074B1 (en) * 2005-03-16 2013-04-24 Takeda GmbH Taste masked dosage form containing roflumilast
CN101657460A (zh) * 2006-12-13 2010-02-24 基利得科学公司 用于治疗肺炎症和支气管收缩的作为抗炎性信号转导调节剂(AISTM’S)和β-激动剂的相互前药的单磷酸酯
WO2009055788A1 (en) * 2007-10-26 2009-04-30 Aeris Therapeutics, Inc. Pneumoreductive therapy and compositions useful therein
US20160199413A1 (en) * 2013-08-01 2016-07-14 Isletone Ab Mscs in the treatment of inflammatory pulmonary diseases
CN104800214A (zh) * 2014-01-27 2015-07-29 成都英诺新科技有限公司 一种罗氟司特吸入气雾剂复方及制备方法
RU2728821C1 (ru) * 2020-05-13 2020-07-31 Федеральное государственное бюджетное учреждение науки "Научный центр биомедицинских технологий Федерального медико-биологического агентства" (ФГБУН НЦБМТ ФМБА России) Способ лечения острого респираторного дистресс-синдрома даларгином и легочным сурфактантом

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4223040A (en) * 1974-11-26 1980-09-16 Carroll John M Lauric acid for the prevention and treatment of mycobacterial diseases
JPS5795920A (en) * 1980-12-04 1982-06-15 Teijin Ltd Remedy for respiratory disease
JPS5845299A (ja) * 1981-09-10 1983-03-16 東京田辺製薬株式会社 新規な表面活性物質、その製造法及びそれを含有する呼吸窮迫疾候群治療剤
GR82072B (hu) * 1983-05-11 1984-12-13 Byk Gulden Lomberg Chem Fab
US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
EP0706513B1 (de) * 1993-07-02 2002-05-15 Byk Gulden Lomberg Chemische Fabrik GmbH Fluoralkoxy substituierte benzamide und ihre verwendung als zyklisch-nukleotid phosphodiesterase-inhibitoren
US5856196A (en) * 1993-10-25 1999-01-05 Beth Israel Hospital Processes for quantitating phosphoglycerides in a lipid mixture and diagnostic uses therefor
GB9401460D0 (en) 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
DE4434629C1 (de) * 1994-09-28 1996-06-27 Byk Gulden Lomberg Chem Fab Zusammensetzungen zur Behandlung von IRDS und ARDS
US5531219A (en) * 1994-11-04 1996-07-02 Alliance Pharmaceutical Corp. Use of liquid fluorocarbons to facilitate pulmonary drug delivery
US5698537A (en) * 1996-06-18 1997-12-16 Clarion Pharmaceuticals Inc. Method of lowering the viscosity of mucus
CN1123345C (zh) * 1997-02-17 2003-10-08 奥坦纳医药公司 治疗ards或irds的组合物
US6180142B1 (en) * 1998-08-21 2001-01-30 The Regents Of The University Of California Reduction of surfactant inactivation in pulmonary surfactant therapy
JP2003503830A (ja) * 1999-06-29 2003-01-28 エル−テック コーポレイション 化学的膜洗浄及び乾燥

Also Published As

Publication number Publication date
PT977577E (pt) 2007-02-28
IL130658A0 (en) 2000-06-01
PL190775B1 (pl) 2006-01-31
CZ291499A3 (cs) 2000-02-16
IL130658A (en) 2004-07-25
CN1123345C (zh) 2003-10-08
EE9900279A (et) 2000-02-15
EE04094B1 (et) 2003-08-15
BR9807399B1 (pt) 2011-04-19
DE69835594T2 (de) 2007-08-16
JP2001512452A (ja) 2001-08-21
SI0977577T1 (sl) 2007-02-28
PL335134A1 (en) 2000-04-10
NZ336569A (en) 2001-04-27
AU734122B2 (en) 2001-06-07
EA199900645A1 (ru) 2000-04-24
UA50808C2 (uk) 2002-11-15
TR199901772T2 (hu) 1999-09-21
ES2271990T3 (es) 2007-04-16
JP4763104B2 (ja) 2011-08-31
DK0977577T3 (da) 2006-12-18
EP0977577A1 (en) 2000-02-09
CZ293871B6 (cs) 2004-08-18
CA2276429C (en) 2007-06-19
DE69835594D1 (de) 2006-09-28
CN1248169A (zh) 2000-03-22
NO993875L (no) 1999-08-11
AU6497398A (en) 1998-09-08
CA2276429A1 (en) 1998-08-20
US6998410B2 (en) 2006-02-14
US6436970B1 (en) 2002-08-20
BR9807399A (pt) 2000-03-14
WO1998035683A1 (en) 1998-08-20
KR20000071112A (ko) 2000-11-25
HUP0001043A3 (en) 2002-12-28
US20020132835A1 (en) 2002-09-19
EA001758B1 (ru) 2001-08-27
NO323594B1 (no) 2007-06-11
NO993875D0 (no) 1999-08-11
HK1026145A1 (en) 2000-12-08
KR100640025B1 (ko) 2006-10-31
ATE336254T1 (de) 2006-09-15
HU227520B1 (hu) 2011-07-28
EP0977577B1 (en) 2006-08-16

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: ALTANA PHARMA AG, DE

Free format text: FORMER OWNER(S): BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH., DE

HC9A Change of name, address

Owner name: TAKEDA GMBH, DE

Free format text: FORMER OWNER(S): ALTANA PHARMA AG, DE; BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH., DE; NYCOMED GMBH, DE

GB9A Succession in title

Owner name: TAKEDA GMBH, DE

Free format text: FORMER OWNER(S): ALTANA PHARMA AG, DE; BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH., DE; NYCOMED GMBH, DE; TAKEDA GMBH, DE

GB9A Succession in title

Owner name: ASTRAZENECA AB, SE

Free format text: FORMER OWNER(S): ALTANA PHARMA AG, DE; BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH., DE; NYCOMED GMBH, DE; TAKEDA GMBH, DE; TAKEDA GMBH, DE