CN1123345C - 治疗ards或irds的组合物 - Google Patents
治疗ards或irds的组合物 Download PDFInfo
- Publication number
- CN1123345C CN1123345C CN98802597A CN98802597A CN1123345C CN 1123345 C CN1123345 C CN 1123345C CN 98802597 A CN98802597 A CN 98802597A CN 98802597 A CN98802597 A CN 98802597A CN 1123345 C CN1123345 C CN 1123345C
- Authority
- CN
- China
- Prior art keywords
- curosurf
- compositions
- ards
- methoxy
- irds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Marine Sciences & Fisheries (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Detergent Compositions (AREA)
Abstract
Description
对照组 | 化合物A*600μg/kg | 肺表面活性剂25mg/kg | 肺表面活性剂25mg/kg+化合物A*600μg/kg | 肺表面活性剂100mg/kg | 肺表面活性剂100mg/kg+化合物A*600μg/kg | |
A | 67±17 | 59±12 | 305±96 | 341±105 | 427±78 | 473±31 |
B | 75±24 | 311±111 | 359±74 | 457±58 | 478±43 |
肺表面活性剂25mg/kg | 肺表面活性剂25mg/kg+化合物A*6.0mg/kg | 肺表面活性剂100mg/kg | 肺表面活性剂100mg/kg+化合物A*6.0mg/kg | |
A | 305±96 | 407±65 | 427±78 | 502±32 |
B | 311±111 | 369±147 | 457±58 | 511±28 |
Claims (7)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19705924A DE19705924A1 (de) | 1997-02-17 | 1997-02-17 | Neue Zusammensetzungen |
DE19705924.4 | 1997-02-17 | ||
EP97102639.8 | 1997-02-19 | ||
EP97102639 | 1997-02-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1248169A CN1248169A (zh) | 2000-03-22 |
CN1123345C true CN1123345C (zh) | 2003-10-08 |
Family
ID=26033977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN98802597A Expired - Lifetime CN1123345C (zh) | 1997-02-17 | 1998-02-14 | 治疗ards或irds的组合物 |
Country Status (26)
Country | Link |
---|---|
US (2) | US6436970B1 (zh) |
EP (1) | EP0977577B1 (zh) |
JP (1) | JP4763104B2 (zh) |
KR (1) | KR100640025B1 (zh) |
CN (1) | CN1123345C (zh) |
AT (1) | ATE336254T1 (zh) |
AU (1) | AU734122B2 (zh) |
BR (1) | BR9807399B1 (zh) |
CA (1) | CA2276429C (zh) |
CZ (1) | CZ293871B6 (zh) |
DE (1) | DE69835594T2 (zh) |
DK (1) | DK0977577T3 (zh) |
EA (1) | EA001758B1 (zh) |
EE (1) | EE04094B1 (zh) |
ES (1) | ES2271990T3 (zh) |
HK (1) | HK1026145A1 (zh) |
HU (1) | HU227520B1 (zh) |
IL (1) | IL130658A (zh) |
NO (1) | NO323594B1 (zh) |
NZ (1) | NZ336569A (zh) |
PL (1) | PL190775B1 (zh) |
PT (1) | PT977577E (zh) |
SI (1) | SI0977577T1 (zh) |
TR (1) | TR199901772T2 (zh) |
UA (1) | UA50808C2 (zh) |
WO (1) | WO1998035683A1 (zh) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE336254T1 (de) * | 1997-02-17 | 2006-09-15 | Altana Pharma Ag | Zusammensetzungen zur behandlung von irds oder ards die 3-(calcopropylmethoxy)-n-(3,5-dichloro-4-pyridi yl)-4-(difluoromethoxy) benzamid und lungensurfactant enthalten |
WO2001019392A1 (en) * | 1999-09-16 | 2001-03-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Combination of c1-inh and lung surfactant for the treatment of respiratory disorders |
DE19957898A1 (de) * | 1999-12-01 | 2001-06-07 | Byk Gulden Lomberg Chem Fab | Neue Verwendung von Lungensurfactant |
JP2003534328A (ja) | 2000-05-25 | 2003-11-18 | メルク フロスト カナダ アンド カンパニー | フルオロアルコキシ置換ベンズアミドジクロロピリジニルn−オキシドpde4阻害剤 |
ES2247325T3 (es) | 2001-05-24 | 2006-03-01 | MERCK FROSST CANADA & CO. | Inhibidores de 1-biaril-1,8-naftiridin-4-ona fosfodiesterasa-4. |
US20030099601A1 (en) * | 2001-11-27 | 2003-05-29 | Gordon Marc S. | Inhalation lung surfactant therapy |
US6998384B2 (en) * | 2001-12-12 | 2006-02-14 | The Penn State Research Foundation | Surfactant prevention of lung complications from cancer chemotherapy |
US20030170223A1 (en) * | 2002-02-01 | 2003-09-11 | Board Of Trustees Of Michigan State University | Pulmonary vasodilator surfactant compositions and method of use |
MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
US6822114B1 (en) | 2002-10-08 | 2004-11-23 | Albemarle Corporation | Process for production of fluoroalkoxy-substituted benzamides and their intermediates |
RS51081B (sr) * | 2002-11-27 | 2010-10-31 | Nycomed Gmbh. | Nova sinergistička kombinacija koja uključuje roflumilast i formoterol |
EA009990B1 (ru) * | 2002-11-27 | 2008-04-28 | Никомед Гмбх | Синергетическая комбинация, включающая рофлумиласт и r,r-формотерол |
RS52908B (en) | 2003-03-10 | 2014-02-28 | Takeda Gmbh | NEW PROCEDURE FOR OBTAINING ROFLUMILAST |
WO2004110450A1 (en) * | 2003-06-16 | 2004-12-23 | Altana Pharma Ag | Composition comprising a pulmonary surfactant and a pde5 inhibitor for the treatment of lung diseases |
ATE457736T1 (de) * | 2004-08-06 | 2010-03-15 | Nycomed Gmbh | Zusammensetzung aus einem pulmonalen surfactant und einem von tnf stammenden peptid |
ES2421916T3 (es) * | 2005-03-16 | 2013-09-06 | Nycomed Gmbh | Forma farmacéutica de sabor enmascarado que contiene roflumilast |
JP2010513276A (ja) * | 2006-12-13 | 2010-04-30 | ギリード・サイエンシズ・インコーポレーテッド | 肺炎症および気管支収縮の治療のための抗炎症シグナル伝達モジュレーター(AISTM)およびβ−アゴニストの相互プロドラッグとしてのモノホスフェート |
WO2009055788A1 (en) * | 2007-10-26 | 2009-04-30 | Aeris Therapeutics, Inc. | Pneumoreductive therapy and compositions useful therein |
US20160199413A1 (en) * | 2013-08-01 | 2016-07-14 | Isletone Ab | Mscs in the treatment of inflammatory pulmonary diseases |
CN104800214A (zh) * | 2014-01-27 | 2015-07-29 | 成都英诺新科技有限公司 | 一种罗氟司特吸入气雾剂复方及制备方法 |
RU2728821C1 (ru) * | 2020-05-13 | 2020-07-31 | Федеральное государственное бюджетное учреждение науки "Научный центр биомедицинских технологий Федерального медико-биологического агентства" (ФГБУН НЦБМТ ФМБА России) | Способ лечения острого респираторного дистресс-синдрома даларгином и легочным сурфактантом |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4223040A (en) * | 1974-11-26 | 1980-09-16 | Carroll John M | Lauric acid for the prevention and treatment of mycobacterial diseases |
JPS5795920A (en) * | 1980-12-04 | 1982-06-15 | Teijin Ltd | Remedy for respiratory disease |
JPS5845299A (ja) * | 1981-09-10 | 1983-03-16 | 東京田辺製薬株式会社 | 新規な表面活性物質、その製造法及びそれを含有する呼吸窮迫疾候群治療剤 |
ES532337A0 (es) * | 1983-05-11 | 1985-12-01 | Byk Gulden Lomberg Chem Fab | Procedimiento para la preparacion de 6-aril-3 (2h)piridazinonas |
US4906476A (en) * | 1988-12-14 | 1990-03-06 | Liposome Technology, Inc. | Novel liposome composition for sustained release of steroidal drugs in lungs |
US5006343A (en) * | 1988-12-29 | 1991-04-09 | Benson Bradley J | Pulmonary administration of pharmaceutically active substances |
KR100331255B1 (ko) * | 1993-07-02 | 2002-10-25 | 빅굴덴 롬베르그 케미쉐 화부리크 게엠베하 | 플루오로알콕시-치환된벤즈아미드및시클릭뉴클레오티드포스포디에스테라아제억제제로서의그의용도 |
US5856196A (en) * | 1993-10-25 | 1999-01-05 | Beth Israel Hospital | Processes for quantitating phosphoglycerides in a lipid mixture and diagnostic uses therefor |
GB9401460D0 (en) | 1994-01-26 | 1994-03-23 | Rhone Poulenc Rorer Ltd | Compositions of matter |
DE4434629C1 (de) * | 1994-09-28 | 1996-06-27 | Byk Gulden Lomberg Chem Fab | Zusammensetzungen zur Behandlung von IRDS und ARDS |
US5531219A (en) * | 1994-11-04 | 1996-07-02 | Alliance Pharmaceutical Corp. | Use of liquid fluorocarbons to facilitate pulmonary drug delivery |
US5698537A (en) * | 1996-06-18 | 1997-12-16 | Clarion Pharmaceuticals Inc. | Method of lowering the viscosity of mucus |
ATE336254T1 (de) * | 1997-02-17 | 2006-09-15 | Altana Pharma Ag | Zusammensetzungen zur behandlung von irds oder ards die 3-(calcopropylmethoxy)-n-(3,5-dichloro-4-pyridi yl)-4-(difluoromethoxy) benzamid und lungensurfactant enthalten |
US6180142B1 (en) * | 1998-08-21 | 2001-01-30 | The Regents Of The University Of California | Reduction of surfactant inactivation in pulmonary surfactant therapy |
JP2003503830A (ja) * | 1999-06-29 | 2003-01-28 | エル−テック コーポレイション | 化学的膜洗浄及び乾燥 |
-
1998
- 1998-02-14 AT AT98910670T patent/ATE336254T1/de active
- 1998-02-14 EA EA199900645A patent/EA001758B1/ru not_active IP Right Cessation
- 1998-02-14 BR BRPI9807399-0A patent/BR9807399B1/pt not_active IP Right Cessation
- 1998-02-14 UA UA99084669A patent/UA50808C2/uk unknown
- 1998-02-14 EP EP98910670A patent/EP0977577B1/en not_active Expired - Lifetime
- 1998-02-14 DE DE69835594T patent/DE69835594T2/de not_active Expired - Lifetime
- 1998-02-14 SI SI9830863T patent/SI0977577T1/sl unknown
- 1998-02-14 PL PL335134A patent/PL190775B1/pl unknown
- 1998-02-14 JP JP53536698A patent/JP4763104B2/ja not_active Expired - Fee Related
- 1998-02-14 TR TR1999/01772T patent/TR199901772T2/xx unknown
- 1998-02-14 PT PT98910670T patent/PT977577E/pt unknown
- 1998-02-14 WO PCT/EP1998/000847 patent/WO1998035683A1/en active IP Right Grant
- 1998-02-14 CA CA002276429A patent/CA2276429C/en not_active Expired - Lifetime
- 1998-02-14 AU AU64973/98A patent/AU734122B2/en not_active Expired
- 1998-02-14 DK DK98910670T patent/DK0977577T3/da active
- 1998-02-14 EE EEP199900279A patent/EE04094B1/xx unknown
- 1998-02-14 CZ CZ19992914A patent/CZ293871B6/cs not_active IP Right Cessation
- 1998-02-14 KR KR1019997007400A patent/KR100640025B1/ko not_active IP Right Cessation
- 1998-02-14 HU HU0001043A patent/HU227520B1/hu unknown
- 1998-02-14 IL IL13065898A patent/IL130658A/en not_active IP Right Cessation
- 1998-02-14 ES ES98910670T patent/ES2271990T3/es not_active Expired - Lifetime
- 1998-02-14 CN CN98802597A patent/CN1123345C/zh not_active Expired - Lifetime
- 1998-02-14 NZ NZ336569A patent/NZ336569A/en not_active IP Right Cessation
-
1999
- 1999-08-06 US US09/369,455 patent/US6436970B1/en not_active Expired - Lifetime
- 1999-08-11 NO NO993875A patent/NO323594B1/no not_active IP Right Cessation
-
2000
- 2000-08-31 HK HK00105462A patent/HK1026145A1/xx not_active IP Right Cessation
-
2002
- 2002-03-13 US US10/096,258 patent/US6998410B2/en not_active Expired - Fee Related
Also Published As
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GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: NICOMEDES LIMITED LIABILITY COMPANY Free format text: FORMER NAME OR ADDRESS: OTANA MEDICINE AG |
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Address after: Konstanz Patentee after: NYCOMED GmbH Address before: The Federal Republic of Germany Konstanz Patentee before: ALTANA PHARMA AG |
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Owner name: NYCOMED INC. Free format text: FORMER NAME: NYCOMED GMBH |
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Address after: Konstanz Patentee after: NYCOMED GmbH Address before: Konstanz Patentee before: Nycomed GmbH |
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Address after: Konstanz Patentee after: TAKEDA GmbH Address before: Konstanz Patentee before: Nycomed GmbH |
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Owner name: NYCOMED ASSET MANAGEMENT GMBH Free format text: FORMER OWNER: TAKEDA GMBH Effective date: 20150619 Owner name: NYCOMED GERMANY HOLDING GMBH Free format text: FORMER OWNER: NYCOMED ASSET MANAGEMENT GMBH Effective date: 20150619 |
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Address after: Konstanz Patentee after: TAKEDA GmbH Address before: Konstanz Patentee before: Nycomed Germany holding LLC |
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