ES2271990T3 - Composiciones para el tratamiento de ards o irds que contienen 3- (ciclopropilmetoxi) -n- (3,5-dicloro-4-piridinil) -4- (difluorometoxi) benzamina y un tensioactivo pulmonar. - Google Patents

Composiciones para el tratamiento de ards o irds que contienen 3- (ciclopropilmetoxi) -n- (3,5-dicloro-4-piridinil) -4- (difluorometoxi) benzamina y un tensioactivo pulmonar. Download PDF

Info

Publication number
ES2271990T3
ES2271990T3 ES98910670T ES98910670T ES2271990T3 ES 2271990 T3 ES2271990 T3 ES 2271990T3 ES 98910670 T ES98910670 T ES 98910670T ES 98910670 T ES98910670 T ES 98910670T ES 2271990 T3 ES2271990 T3 ES 2271990T3
Authority
ES
Spain
Prior art keywords
pulmonary
surfactant
cyclopropylmethoxy
dichloropyrid
difluoromethoxybenzamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98910670T
Other languages
English (en)
Spanish (es)
Inventor
Paul-Georg Germann
Ulrich Kilian
Rolf Beume
Hermann Amschler
Uwe Kruger
Dietrich Hafner
Klaus Eistetter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Altana Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19705924A external-priority patent/DE19705924A1/de
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Application granted granted Critical
Publication of ES2271990T3 publication Critical patent/ES2271990T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES98910670T 1997-02-17 1998-02-14 Composiciones para el tratamiento de ards o irds que contienen 3- (ciclopropilmetoxi) -n- (3,5-dicloro-4-piridinil) -4- (difluorometoxi) benzamina y un tensioactivo pulmonar. Expired - Lifetime ES2271990T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19705924 1997-02-17
DE19705924A DE19705924A1 (de) 1997-02-17 1997-02-17 Neue Zusammensetzungen
EP97102639 1997-02-19
EP97102639 1997-02-19

Publications (1)

Publication Number Publication Date
ES2271990T3 true ES2271990T3 (es) 2007-04-16

Family

ID=26033977

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98910670T Expired - Lifetime ES2271990T3 (es) 1997-02-17 1998-02-14 Composiciones para el tratamiento de ards o irds que contienen 3- (ciclopropilmetoxi) -n- (3,5-dicloro-4-piridinil) -4- (difluorometoxi) benzamina y un tensioactivo pulmonar.

Country Status (25)

Country Link
US (2) US6436970B1 (enExample)
EP (1) EP0977577B1 (enExample)
JP (1) JP4763104B2 (enExample)
KR (1) KR100640025B1 (enExample)
CN (1) CN1123345C (enExample)
AT (1) ATE336254T1 (enExample)
AU (1) AU734122B2 (enExample)
BR (1) BR9807399B1 (enExample)
CA (1) CA2276429C (enExample)
CZ (1) CZ293871B6 (enExample)
DE (1) DE69835594T2 (enExample)
DK (1) DK0977577T3 (enExample)
EA (1) EA001758B1 (enExample)
EE (1) EE04094B1 (enExample)
ES (1) ES2271990T3 (enExample)
HU (1) HU227520B1 (enExample)
IL (1) IL130658A (enExample)
NO (1) NO323594B1 (enExample)
NZ (1) NZ336569A (enExample)
PL (1) PL190775B1 (enExample)
PT (1) PT977577E (enExample)
SI (1) SI0977577T1 (enExample)
TR (1) TR199901772T2 (enExample)
UA (1) UA50808C2 (enExample)
WO (1) WO1998035683A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR199901772T2 (enExample) * 1997-02-17 1999-09-21 Byk Gulden Lomberg Chemische Fabrik Gmbh
JP2001081031A (ja) * 1999-08-30 2001-03-27 Schering Ag 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤
EP1216052A1 (en) * 1999-09-16 2002-06-26 Byk Gulden Lomberg Chemische Fabrik GmbH Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
DE19957898A1 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant
JP2003534328A (ja) 2000-05-25 2003-11-18 メルク フロスト カナダ アンド カンパニー フルオロアルコキシ置換ベンズアミドジクロロピリジニルｎ−オキシドｐｄｅ４阻害剤
WO2002094823A1 (en) 2001-05-24 2002-11-28 Merck Frosst Canada & Co. 1-biaryl-1,8-napthyridin-4-one phosphodiesterase-4 inhibitors
US20030099601A1 (en) * 2001-11-27 2003-05-29 Gordon Marc S. Inhalation lung surfactant therapy
WO2003053455A1 (en) * 2001-12-12 2003-07-03 Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US6822114B1 (en) 2002-10-08 2004-11-23 Albemarle Corporation Process for production of fluoroalkoxy-substituted benzamides and their intermediates
PL214869B1 (pl) * 2002-11-27 2013-09-30 Nycomed Gmbh Synergistyczna kombinacja zawierajaca roflumilast i (R, R)-formoterol
WO2004047829A1 (en) * 2002-11-27 2004-06-10 Altana Pharma Ag New synergistic combination comprising roflumilast and formoterol
ES2335498T3 (es) 2003-03-10 2010-03-29 Nycomed Gmbh Nuevo proceso para la preparacion de reflumilast.
US7238664B2 (en) 2003-06-16 2007-07-03 Altana Pharma Ag Composition comprising a pulmonary surfactant and a PDE5 inhibitor for the treatment of lung diseases
EP1781323B1 (en) 2004-08-06 2010-02-17 Nycomed GmbH Composition comprising a pulmonary surfactant and a tnf-derived peptide
EP2258350B1 (en) * 2005-03-16 2014-12-24 Takeda GmbH Taste masked dosage form containing roflumilast
CN101657460A (zh) * 2006-12-13 2010-02-24 基利得科学公司 用于治疗肺炎症和支气管收缩的作为抗炎性信号转导调节剂(AISTM’S)和β-激动剂的相互前药的单磷酸酯
WO2009055788A1 (en) * 2007-10-26 2009-04-30 Aeris Therapeutics, Inc. Pneumoreductive therapy and compositions useful therein
US20160199413A1 (en) * 2013-08-01 2016-07-14 Isletone Ab Mscs in the treatment of inflammatory pulmonary diseases
CN104800214A (zh) * 2014-01-27 2015-07-29 成都英诺新科技有限公司 一种罗氟司特吸入气雾剂复方及制备方法
RU2728821C1 (ru) * 2020-05-13 2020-07-31 Федеральное государственное бюджетное учреждение науки "Научный центр биомедицинских технологий Федерального медико-биологического агентства" (ФГБУН НЦБМТ ФМБА России) Способ лечения острого респираторного дистресс-синдрома даларгином и легочным сурфактантом

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4223040A (en) * 1974-11-26 1980-09-16 Carroll John M Lauric acid for the prevention and treatment of mycobacterial diseases
JPS5795920A (en) * 1980-12-04 1982-06-15 Teijin Ltd Remedy for respiratory disease
JPS5845299A (ja) * 1981-09-10 1983-03-16 東京田辺製薬株式会社 新規な表面活性物質、その製造法及びそれを含有する呼吸窮迫疾候群治療剤
ES532337A0 (es) * 1983-05-11 1985-12-01 Byk Gulden Lomberg Chem Fab Procedimiento para la preparacion de 6-aril-3 (2h)piridazinonas
US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
KR100331255B1 (ko) * 1993-07-02 2002-10-25 빅굴덴 롬베르그 케미쉐 화부리크 게엠베하 플루오로알콕시-치환된벤즈아미드및시클릭뉴클레오티드포스포디에스테라아제억제제로서의그의용도
US5856196A (en) * 1993-10-25 1999-01-05 Beth Israel Hospital Processes for quantitating phosphoglycerides in a lipid mixture and diagnostic uses therefor
GB9401460D0 (en) 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
DE4434629C1 (de) * 1994-09-28 1996-06-27 Byk Gulden Lomberg Chem Fab Zusammensetzungen zur Behandlung von IRDS und ARDS
US5531219A (en) * 1994-11-04 1996-07-02 Alliance Pharmaceutical Corp. Use of liquid fluorocarbons to facilitate pulmonary drug delivery
US5698537A (en) * 1996-06-18 1997-12-16 Clarion Pharmaceuticals Inc. Method of lowering the viscosity of mucus
TR199901772T2 (enExample) * 1997-02-17 1999-09-21 Byk Gulden Lomberg Chemische Fabrik Gmbh
US6180142B1 (en) * 1998-08-21 2001-01-30 The Regents Of The University Of California Reduction of surfactant inactivation in pulmonary surfactant therapy
EP1206326A1 (en) * 1999-06-29 2002-05-22 L-Tech Corporation Chemical film cleaning and drying

Also Published As

Publication number Publication date
HUP0001043A3 (en) 2002-12-28
NO323594B1 (no) 2007-06-11
EP0977577A1 (en) 2000-02-09
DE69835594T2 (de) 2007-08-16
EP0977577B1 (en) 2006-08-16
PL335134A1 (en) 2000-04-10
EE04094B1 (et) 2003-08-15
CA2276429A1 (en) 1998-08-20
IL130658A (en) 2004-07-25
PT977577E (pt) 2007-02-28
EA001758B1 (ru) 2001-08-27
UA50808C2 (uk) 2002-11-15
BR9807399B1 (pt) 2011-04-19
WO1998035683A1 (en) 1998-08-20
TR199901772T2 (enExample) 1999-09-21
AU734122B2 (en) 2001-06-07
CZ293871B6 (cs) 2004-08-18
SI0977577T1 (sl) 2007-02-28
HUP0001043A2 (hu) 2000-09-28
HU227520B1 (hu) 2011-07-28
EE9900279A (et) 2000-02-15
CN1123345C (zh) 2003-10-08
US6436970B1 (en) 2002-08-20
NO993875L (no) 1999-08-11
BR9807399A (pt) 2000-03-14
DK0977577T3 (da) 2006-12-18
EA199900645A1 (ru) 2000-04-24
IL130658A0 (en) 2000-06-01
KR20000071112A (ko) 2000-11-25
JP2001512452A (ja) 2001-08-21
US6998410B2 (en) 2006-02-14
CA2276429C (en) 2007-06-19
NO993875D0 (no) 1999-08-11
HK1026145A1 (en) 2000-12-08
NZ336569A (en) 2001-04-27
AU6497398A (en) 1998-09-08
PL190775B1 (pl) 2006-01-31
KR100640025B1 (ko) 2006-10-31
CZ291499A3 (cs) 2000-02-16
US20020132835A1 (en) 2002-09-19
JP4763104B2 (ja) 2011-08-31
ATE336254T1 (de) 2006-09-15
DE69835594D1 (de) 2006-09-28
CN1248169A (zh) 2000-03-22

Similar Documents

Publication Publication Date Title
ES2271990T3 (es) Composiciones para el tratamiento de ards o irds que contienen 3- (ciclopropilmetoxi) -n- (3,5-dicloro-4-piridinil) -4- (difluorometoxi) benzamina y un tensioactivo pulmonar.
CA2384861A1 (en) Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
EP1131055B1 (en) Treatment set containing lungsurfactant compositions
US7247317B2 (en) Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ARDS) and infant respiratory distress syndrome (IRDS)
JP2003522138A (ja) 慢性肺疾患の予防および治療のための肺表面活性剤の新規使用
ES2262656T3 (es) Uso de un agente tensioactivo pulmonar recombinante para el tratamiento precoz de enfermedades pulmonares agudas.
ES2346048T3 (es) Nueva utilizacion de un agente tensioactivo pulmonar.
JP4503835B2 (ja) 急性または成人型呼吸窮迫症候群（ａｒｄｓ）および新生児呼吸窮迫症候群（ｉｒｄｓ）の治療のための、フェニルアミノチオフェン酢酸誘導体を含有する組成物
US20040254112A1 (en) Use of pulmonary surfactant for the early treatment of acute pulmonary diseases
HK1026145B (en) A composition for the treatment of irds and ards