DE69825589T2 - Benzpyrido cycloheptan derivate mit farnesyl protein transferase inhibierender wirkung - Google Patents
Benzpyrido cycloheptan derivate mit farnesyl protein transferase inhibierender wirkung Download PDFInfo
- Publication number
- DE69825589T2 DE69825589T2 DE69825589T DE69825589T DE69825589T2 DE 69825589 T2 DE69825589 T2 DE 69825589T2 DE 69825589 T DE69825589 T DE 69825589T DE 69825589 T DE69825589 T DE 69825589T DE 69825589 T2 DE69825589 T2 DE 69825589T2
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- alkyl
- compound
- aryl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 C*N1CC(C([*+])=O)N(*)CC1 Chemical compound C*N1CC(C([*+])=O)N(*)CC1 0.000 description 2
- DDUJPWHDOQZOOQ-UHFFFAOYSA-N C[n]1cnc(CCC=N)c1 Chemical compound C[n]1cnc(CCC=N)c1 DDUJPWHDOQZOOQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87774197A | 1997-06-17 | 1997-06-17 | |
| US877741 | 1997-06-17 | ||
| PCT/US1998/011495 WO1998057960A1 (en) | 1997-06-17 | 1998-06-15 | Benzpyrido cycloheptane compounds useful for inhibition of farnesyl protein transferase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69825589D1 DE69825589D1 (de) | 2004-09-16 |
| DE69825589T2 true DE69825589T2 (de) | 2005-09-08 |
Family
ID=25370618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69825589T Expired - Lifetime DE69825589T2 (de) | 1997-06-17 | 1998-06-15 | Benzpyrido cycloheptan derivate mit farnesyl protein transferase inhibierender wirkung |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0989983B1 (https=) |
| JP (1) | JP2002504144A (https=) |
| KR (1) | KR100640672B1 (https=) |
| CN (1) | CN1266433A (https=) |
| AR (1) | AR012991A1 (https=) |
| AT (1) | ATE273299T1 (https=) |
| AU (1) | AU753658B2 (https=) |
| CA (1) | CA2293714C (https=) |
| DE (1) | DE69825589T2 (https=) |
| ES (1) | ES2224408T3 (https=) |
| HU (1) | HUP0003138A3 (https=) |
| IL (2) | IL133386A0 (https=) |
| MY (1) | MY143570A (https=) |
| NZ (1) | NZ501376A (https=) |
| PE (1) | PE104798A1 (https=) |
| TW (1) | TW587935B (https=) |
| WO (1) | WO1998057960A1 (https=) |
| ZA (1) | ZA985203B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6362188B1 (en) | 1998-12-18 | 2002-03-26 | Schering Corporation | Farnesyl protein transferase inhibitors |
| HUP0202152A2 (en) * | 1998-12-18 | 2002-10-28 | Schering Corp | Tricyclyc farnesyl protein transferase inhibitors |
| US6800636B2 (en) | 1998-12-18 | 2004-10-05 | Schering Corporation | Farnesyl protein transferase inhibitors |
| TR200101754T2 (tr) * | 1998-12-18 | 2002-05-21 | Schering Corporation | Farnezil protein transferaz inhibitörleri |
| US6372747B1 (en) | 1998-12-18 | 2002-04-16 | Schering Corporation | Farnesyl protein transferase inhibitors |
| US6432959B1 (en) * | 1998-12-23 | 2002-08-13 | Schering Corporation | Inhibitors of farnesyl-protein transferase |
| US7342016B2 (en) | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
| WO2002056884A2 (en) * | 2001-01-22 | 2002-07-25 | Schering Corporation | Treatment of malaria with farnesyl protein transferase inhibitors |
| WO2002080895A2 (en) * | 2001-04-06 | 2002-10-17 | Schering Corporation | Treatment of malaria with farsenyl protein transferase inhibitors |
| EP1542993B1 (en) | 2002-09-20 | 2012-12-19 | Merck Serono SA | Piperazine derivatives and methods of use |
| EP1838324A2 (en) | 2004-12-13 | 2007-10-03 | Schering Corporation | Novel farnesyl protein transferase inhibitors and their use to treat cancer |
| EP1833481A1 (en) | 2004-12-14 | 2007-09-19 | Schering Corporation | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases |
| ES2798289T3 (es) * | 2012-01-25 | 2020-12-10 | Novartis Ag | Compuestos heterocíclicos y métodos para su uso |
| EP3541375B1 (en) * | 2016-11-18 | 2023-08-23 | Merck Sharp & Dohme LLC | Factor xiia inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| CA2174105C (en) * | 1993-10-15 | 2002-02-12 | W. Robert Bishop | Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL117797A0 (en) * | 1995-04-07 | 1996-08-04 | Pharmacopeia Inc | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| US5712280A (en) * | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
-
1998
- 1998-06-15 CN CN98808124A patent/CN1266433A/zh active Pending
- 1998-06-15 NZ NZ501376A patent/NZ501376A/en not_active IP Right Cessation
- 1998-06-15 AT AT98928886T patent/ATE273299T1/de not_active IP Right Cessation
- 1998-06-15 PE PE1998000505A patent/PE104798A1/es not_active Application Discontinuation
- 1998-06-15 JP JP50449099A patent/JP2002504144A/ja not_active Ceased
- 1998-06-15 KR KR1019997011842A patent/KR100640672B1/ko not_active Expired - Fee Related
- 1998-06-15 ZA ZA985203A patent/ZA985203B/xx unknown
- 1998-06-15 DE DE69825589T patent/DE69825589T2/de not_active Expired - Lifetime
- 1998-06-15 HU HU0003138A patent/HUP0003138A3/hu unknown
- 1998-06-15 ES ES98928886T patent/ES2224408T3/es not_active Expired - Lifetime
- 1998-06-15 IL IL13338698A patent/IL133386A0/xx active IP Right Grant
- 1998-06-15 TW TW087109501A patent/TW587935B/zh not_active IP Right Cessation
- 1998-06-15 EP EP98928886A patent/EP0989983B1/en not_active Expired - Lifetime
- 1998-06-15 CA CA002293714A patent/CA2293714C/en not_active Expired - Fee Related
- 1998-06-15 WO PCT/US1998/011495 patent/WO1998057960A1/en not_active Ceased
- 1998-06-15 AU AU80580/98A patent/AU753658B2/en not_active Ceased
- 1998-06-16 AR ARP980102862A patent/AR012991A1/es unknown
- 1998-06-16 MY MYPI98002697A patent/MY143570A/en unknown
-
1999
- 1999-12-08 IL IL133386A patent/IL133386A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2224408T3 (es) | 2005-03-01 |
| CA2293714C (en) | 2009-09-08 |
| HUP0003138A3 (en) | 2002-11-28 |
| AR012991A1 (es) | 2000-11-22 |
| MY143570A (en) | 2011-05-31 |
| HUP0003138A2 (hu) | 2001-06-28 |
| KR100640672B1 (ko) | 2006-11-02 |
| EP0989983A1 (en) | 2000-04-05 |
| EP0989983B1 (en) | 2004-08-11 |
| NZ501376A (en) | 2002-03-28 |
| CA2293714A1 (en) | 1998-12-23 |
| ATE273299T1 (de) | 2004-08-15 |
| DE69825589D1 (de) | 2004-09-16 |
| JP2002504144A (ja) | 2002-02-05 |
| CN1266433A (zh) | 2000-09-13 |
| PE104798A1 (es) | 1999-11-06 |
| KR20010013822A (ko) | 2001-02-26 |
| TW587935B (en) | 2004-05-21 |
| ZA985203B (en) | 1999-01-05 |
| AU8058098A (en) | 1999-01-04 |
| IL133386A0 (en) | 2001-04-30 |
| AU753658B2 (en) | 2002-10-24 |
| WO1998057960A1 (en) | 1998-12-23 |
| IL133386A (en) | 2006-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: PHARMACOPEIA, LLC (N.D.GES.D. STAATES DELAWARE, US Owner name: SCHERING CORP., KENILWORTH, N.J., US |