KR100640672B1 - 파르네실 단백질 트랜스퍼라제의 억제에 유용한 벤즈피리도 사이클로헵탄 화합물 및 이를 포함하는 약제학적 조성물 - Google Patents

파르네실 단백질 트랜스퍼라제의 억제에 유용한 벤즈피리도 사이클로헵탄 화합물 및 이를 포함하는 약제학적 조성물 Download PDF

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KR100640672B1
KR100640672B1 KR1019997011842A KR19997011842A KR100640672B1 KR 100640672 B1 KR100640672 B1 KR 100640672B1 KR 1019997011842 A KR1019997011842 A KR 1019997011842A KR 19997011842 A KR19997011842 A KR 19997011842A KR 100640672 B1 KR100640672 B1 KR 100640672B1
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compound
mmol
reaction
compounds
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KR20010013822A (ko
Inventor
쿠퍼알란비.
돌로날드제이.
지리자발라반바이요어엠.
강걸리어쉬트
리더존씨.
볼드윈존제이.
후앙치아-유
Original Assignee
파마코페이아 드럭 디스커버리, 인크.
쉐링 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019997011842A 1997-06-17 1998-06-15 파르네실 단백질 트랜스퍼라제의 억제에 유용한 벤즈피리도 사이클로헵탄 화합물 및 이를 포함하는 약제학적 조성물 Expired - Fee Related KR100640672B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87774197A 1997-06-17 1997-06-17
US08/877,741 1997-06-17
PCT/US1998/011495 WO1998057960A1 (en) 1997-06-17 1998-06-15 Benzpyrido cycloheptane compounds useful for inhibition of farnesyl protein transferase

Publications (2)

Publication Number Publication Date
KR20010013822A KR20010013822A (ko) 2001-02-26
KR100640672B1 true KR100640672B1 (ko) 2006-11-02

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KR1019997011842A Expired - Fee Related KR100640672B1 (ko) 1997-06-17 1998-06-15 파르네실 단백질 트랜스퍼라제의 억제에 유용한 벤즈피리도 사이클로헵탄 화합물 및 이를 포함하는 약제학적 조성물

Country Status (18)

Country Link
EP (1) EP0989983B1 (https=)
JP (1) JP2002504144A (https=)
KR (1) KR100640672B1 (https=)
CN (1) CN1266433A (https=)
AR (1) AR012991A1 (https=)
AT (1) ATE273299T1 (https=)
AU (1) AU753658B2 (https=)
CA (1) CA2293714C (https=)
DE (1) DE69825589T2 (https=)
ES (1) ES2224408T3 (https=)
HU (1) HUP0003138A3 (https=)
IL (2) IL133386A0 (https=)
MY (1) MY143570A (https=)
NZ (1) NZ501376A (https=)
PE (1) PE104798A1 (https=)
TW (1) TW587935B (https=)
WO (1) WO1998057960A1 (https=)
ZA (1) ZA985203B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362188B1 (en) 1998-12-18 2002-03-26 Schering Corporation Farnesyl protein transferase inhibitors
HUP0202152A2 (en) * 1998-12-18 2002-10-28 Schering Corp Tricyclyc farnesyl protein transferase inhibitors
US6800636B2 (en) 1998-12-18 2004-10-05 Schering Corporation Farnesyl protein transferase inhibitors
TR200101754T2 (tr) * 1998-12-18 2002-05-21 Schering Corporation Farnezil protein transferaz inhibitörleri
US6372747B1 (en) 1998-12-18 2002-04-16 Schering Corporation Farnesyl protein transferase inhibitors
US6432959B1 (en) * 1998-12-23 2002-08-13 Schering Corporation Inhibitors of farnesyl-protein transferase
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
WO2002056884A2 (en) * 2001-01-22 2002-07-25 Schering Corporation Treatment of malaria with farnesyl protein transferase inhibitors
WO2002080895A2 (en) * 2001-04-06 2002-10-17 Schering Corporation Treatment of malaria with farsenyl protein transferase inhibitors
EP1542993B1 (en) 2002-09-20 2012-12-19 Merck Serono SA Piperazine derivatives and methods of use
EP1838324A2 (en) 2004-12-13 2007-10-03 Schering Corporation Novel farnesyl protein transferase inhibitors and their use to treat cancer
EP1833481A1 (en) 2004-12-14 2007-09-19 Schering Corporation Farnesyl protein transferase inhibitors and methods for treating proliferative diseases
ES2798289T3 (es) * 2012-01-25 2020-12-10 Novartis Ag Compuestos heterocíclicos y métodos para su uso
EP3541375B1 (en) * 2016-11-18 2023-08-23 Merck Sharp & Dohme LLC Factor xiia inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031478A1 (en) * 1995-04-07 1996-10-10 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
CA2174105C (en) * 1993-10-15 2002-02-12 W. Robert Bishop Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031478A1 (en) * 1995-04-07 1996-10-10 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

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Publication number Publication date
ES2224408T3 (es) 2005-03-01
CA2293714C (en) 2009-09-08
HUP0003138A3 (en) 2002-11-28
AR012991A1 (es) 2000-11-22
MY143570A (en) 2011-05-31
HUP0003138A2 (hu) 2001-06-28
DE69825589T2 (de) 2005-09-08
EP0989983A1 (en) 2000-04-05
EP0989983B1 (en) 2004-08-11
NZ501376A (en) 2002-03-28
CA2293714A1 (en) 1998-12-23
ATE273299T1 (de) 2004-08-15
DE69825589D1 (de) 2004-09-16
JP2002504144A (ja) 2002-02-05
CN1266433A (zh) 2000-09-13
PE104798A1 (es) 1999-11-06
KR20010013822A (ko) 2001-02-26
TW587935B (en) 2004-05-21
ZA985203B (en) 1999-01-05
AU8058098A (en) 1999-01-04
IL133386A0 (en) 2001-04-30
AU753658B2 (en) 2002-10-24
WO1998057960A1 (en) 1998-12-23
IL133386A (en) 2006-12-10

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