JP2002504144A - ファルネシルタンパク質トランスフェラーゼの阻害に有用なベンズピリドシクロヘプタン化合物 - Google Patents

ファルネシルタンパク質トランスフェラーゼの阻害に有用なベンズピリドシクロヘプタン化合物

Info

Publication number
JP2002504144A
JP2002504144A JP50449099A JP50449099A JP2002504144A JP 2002504144 A JP2002504144 A JP 2002504144A JP 50449099 A JP50449099 A JP 50449099A JP 50449099 A JP50449099 A JP 50449099A JP 2002504144 A JP2002504144 A JP 2002504144A
Authority
JP
Japan
Prior art keywords
compound
substituted
alkyl
aryl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP50449099A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002504144A5 (https=
Inventor
ビー． クーパー，アラン
ジェイ． ドール，ロナルド
エム． ギリジャバラバン，ビヨール
ガングリー，アシット
シー． リーダー，ジョン
ジェイ． ボルドウィン，ジョン
ファン，チャ−ユ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2002504144A publication Critical patent/JP2002504144A/ja
Publication of JP2002504144A5 publication Critical patent/JP2002504144A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP50449099A 1997-06-17 1998-06-15 ファルネシルタンパク質トランスフェラーゼの阻害に有用なベンズピリドシクロヘプタン化合物 Ceased JP2002504144A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87774197A 1997-06-17 1997-06-17
US08/877,741 1997-06-17
PCT/US1998/011495 WO1998057960A1 (en) 1997-06-17 1998-06-15 Benzpyrido cycloheptane compounds useful for inhibition of farnesyl protein transferase

Publications (2)

Publication Number Publication Date
JP2002504144A true JP2002504144A (ja) 2002-02-05
JP2002504144A5 JP2002504144A5 (https=) 2005-12-22

Family

ID=25370618

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50449099A Ceased JP2002504144A (ja) 1997-06-17 1998-06-15 ファルネシルタンパク質トランスフェラーゼの阻害に有用なベンズピリドシクロヘプタン化合物

Country Status (18)

Country Link
EP (1) EP0989983B1 (https=)
JP (1) JP2002504144A (https=)
KR (1) KR100640672B1 (https=)
CN (1) CN1266433A (https=)
AR (1) AR012991A1 (https=)
AT (1) ATE273299T1 (https=)
AU (1) AU753658B2 (https=)
CA (1) CA2293714C (https=)
DE (1) DE69825589T2 (https=)
ES (1) ES2224408T3 (https=)
HU (1) HUP0003138A3 (https=)
IL (2) IL133386A0 (https=)
MY (1) MY143570A (https=)
NZ (1) NZ501376A (https=)
PE (1) PE104798A1 (https=)
TW (1) TW587935B (https=)
WO (1) WO1998057960A1 (https=)
ZA (1) ZA985203B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006503857A (ja) * 2002-09-20 2006-02-02 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ ピペラジン誘導体及び使用方法
JP2008523148A (ja) * 2004-12-14 2008-07-03 シェーリング コーポレイション ファルネシルプロテイントランスフェラーゼインヒビターおよび増殖性疾患を処置するための方法
JP2015504900A (ja) * 2012-01-25 2015-02-16 スピニフェクス ファーマシューティカルズ ピーティーワイ リミテッド 複素環式化合物およびその使用方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362188B1 (en) 1998-12-18 2002-03-26 Schering Corporation Farnesyl protein transferase inhibitors
HUP0202152A2 (en) * 1998-12-18 2002-10-28 Schering Corp Tricyclyc farnesyl protein transferase inhibitors
US6800636B2 (en) 1998-12-18 2004-10-05 Schering Corporation Farnesyl protein transferase inhibitors
TR200101754T2 (tr) * 1998-12-18 2002-05-21 Schering Corporation Farnezil protein transferaz inhibitörleri
US6372747B1 (en) 1998-12-18 2002-04-16 Schering Corporation Farnesyl protein transferase inhibitors
US6432959B1 (en) * 1998-12-23 2002-08-13 Schering Corporation Inhibitors of farnesyl-protein transferase
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
WO2002056884A2 (en) * 2001-01-22 2002-07-25 Schering Corporation Treatment of malaria with farnesyl protein transferase inhibitors
WO2002080895A2 (en) * 2001-04-06 2002-10-17 Schering Corporation Treatment of malaria with farsenyl protein transferase inhibitors
EP1838324A2 (en) 2004-12-13 2007-10-03 Schering Corporation Novel farnesyl protein transferase inhibitors and their use to treat cancer
EP3541375B1 (en) * 2016-11-18 2023-08-23 Merck Sharp & Dohme LLC Factor xiia inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
CA2174105C (en) * 1993-10-15 2002-02-12 W. Robert Bishop Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006503857A (ja) * 2002-09-20 2006-02-02 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ ピペラジン誘導体及び使用方法
JP2011088926A (ja) * 2002-09-20 2011-05-06 Merck Serono Sa ピペラジン誘導体及び使用方法
JP2008523148A (ja) * 2004-12-14 2008-07-03 シェーリング コーポレイション ファルネシルプロテイントランスフェラーゼインヒビターおよび増殖性疾患を処置するための方法
JP2015504900A (ja) * 2012-01-25 2015-02-16 スピニフェクス ファーマシューティカルズ ピーティーワイ リミテッド 複素環式化合物およびその使用方法
JP2018076297A (ja) * 2012-01-25 2018-05-17 ノバルティス アーゲー 複素環式化合物およびその使用方法

Also Published As

Publication number Publication date
ES2224408T3 (es) 2005-03-01
CA2293714C (en) 2009-09-08
HUP0003138A3 (en) 2002-11-28
AR012991A1 (es) 2000-11-22
MY143570A (en) 2011-05-31
HUP0003138A2 (hu) 2001-06-28
KR100640672B1 (ko) 2006-11-02
DE69825589T2 (de) 2005-09-08
EP0989983A1 (en) 2000-04-05
EP0989983B1 (en) 2004-08-11
NZ501376A (en) 2002-03-28
CA2293714A1 (en) 1998-12-23
ATE273299T1 (de) 2004-08-15
DE69825589D1 (de) 2004-09-16
CN1266433A (zh) 2000-09-13
PE104798A1 (es) 1999-11-06
KR20010013822A (ko) 2001-02-26
TW587935B (en) 2004-05-21
ZA985203B (en) 1999-01-05
AU8058098A (en) 1999-01-04
IL133386A0 (en) 2001-04-30
AU753658B2 (en) 2002-10-24
WO1998057960A1 (en) 1998-12-23
IL133386A (en) 2006-12-10

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