CN1266433A - 用于抑制法呢基蛋白转移酶的苯并吡啶并环庚烷化合物 - Google Patents

用于抑制法呢基蛋白转移酶的苯并吡啶并环庚烷化合物 Download PDF

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Publication number
CN1266433A
CN1266433A CN98808124A CN98808124A CN1266433A CN 1266433 A CN1266433 A CN 1266433A CN 98808124 A CN98808124 A CN 98808124A CN 98808124 A CN98808124 A CN 98808124A CN 1266433 A CN1266433 A CN 1266433A
Authority
CN
China
Prior art keywords
compound
replacement
alkyl
alkoxy
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98808124A
Other languages
English (en)
Chinese (zh)
Inventor
A·B·科珀
R·J·多尔
V·M·吉里杰瓦拉贝汉
A·干古利
J·C·里德
J·J·巴德温
黄嘉瑜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN1266433A publication Critical patent/CN1266433A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN98808124A 1997-06-17 1998-06-15 用于抑制法呢基蛋白转移酶的苯并吡啶并环庚烷化合物 Pending CN1266433A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87774197A 1997-06-17 1997-06-17
US08/877,741 1997-06-17

Publications (1)

Publication Number Publication Date
CN1266433A true CN1266433A (zh) 2000-09-13

Family

ID=25370618

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98808124A Pending CN1266433A (zh) 1997-06-17 1998-06-15 用于抑制法呢基蛋白转移酶的苯并吡啶并环庚烷化合物

Country Status (18)

Country Link
EP (1) EP0989983B1 (https=)
JP (1) JP2002504144A (https=)
KR (1) KR100640672B1 (https=)
CN (1) CN1266433A (https=)
AR (1) AR012991A1 (https=)
AT (1) ATE273299T1 (https=)
AU (1) AU753658B2 (https=)
CA (1) CA2293714C (https=)
DE (1) DE69825589T2 (https=)
ES (1) ES2224408T3 (https=)
HU (1) HUP0003138A3 (https=)
IL (2) IL133386A0 (https=)
MY (1) MY143570A (https=)
NZ (1) NZ501376A (https=)
PE (1) PE104798A1 (https=)
TW (1) TW587935B (https=)
WO (1) WO1998057960A1 (https=)
ZA (1) ZA985203B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362188B1 (en) 1998-12-18 2002-03-26 Schering Corporation Farnesyl protein transferase inhibitors
HUP0202152A2 (en) * 1998-12-18 2002-10-28 Schering Corp Tricyclyc farnesyl protein transferase inhibitors
US6800636B2 (en) 1998-12-18 2004-10-05 Schering Corporation Farnesyl protein transferase inhibitors
TR200101754T2 (tr) * 1998-12-18 2002-05-21 Schering Corporation Farnezil protein transferaz inhibitörleri
US6372747B1 (en) 1998-12-18 2002-04-16 Schering Corporation Farnesyl protein transferase inhibitors
US6432959B1 (en) * 1998-12-23 2002-08-13 Schering Corporation Inhibitors of farnesyl-protein transferase
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
WO2002056884A2 (en) * 2001-01-22 2002-07-25 Schering Corporation Treatment of malaria with farnesyl protein transferase inhibitors
WO2002080895A2 (en) * 2001-04-06 2002-10-17 Schering Corporation Treatment of malaria with farsenyl protein transferase inhibitors
EP1542993B1 (en) 2002-09-20 2012-12-19 Merck Serono SA Piperazine derivatives and methods of use
EP1838324A2 (en) 2004-12-13 2007-10-03 Schering Corporation Novel farnesyl protein transferase inhibitors and their use to treat cancer
EP1833481A1 (en) 2004-12-14 2007-09-19 Schering Corporation Farnesyl protein transferase inhibitors and methods for treating proliferative diseases
ES2798289T3 (es) * 2012-01-25 2020-12-10 Novartis Ag Compuestos heterocíclicos y métodos para su uso
EP3541375B1 (en) * 2016-11-18 2023-08-23 Merck Sharp & Dohme LLC Factor xiia inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
CA2174105C (en) * 1993-10-15 2002-02-12 W. Robert Bishop Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
ES2224408T3 (es) 2005-03-01
CA2293714C (en) 2009-09-08
HUP0003138A3 (en) 2002-11-28
AR012991A1 (es) 2000-11-22
MY143570A (en) 2011-05-31
HUP0003138A2 (hu) 2001-06-28
KR100640672B1 (ko) 2006-11-02
DE69825589T2 (de) 2005-09-08
EP0989983A1 (en) 2000-04-05
EP0989983B1 (en) 2004-08-11
NZ501376A (en) 2002-03-28
CA2293714A1 (en) 1998-12-23
ATE273299T1 (de) 2004-08-15
DE69825589D1 (de) 2004-09-16
JP2002504144A (ja) 2002-02-05
PE104798A1 (es) 1999-11-06
KR20010013822A (ko) 2001-02-26
TW587935B (en) 2004-05-21
ZA985203B (en) 1999-01-05
AU8058098A (en) 1999-01-04
IL133386A0 (en) 2001-04-30
AU753658B2 (en) 2002-10-24
WO1998057960A1 (en) 1998-12-23
IL133386A (en) 2006-12-10

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WD01 Invention patent application deemed withdrawn after publication