DE69738275T2 - Aminoindanderivate - Google Patents
Aminoindanderivate Download PDFInfo
- Publication number
- DE69738275T2 DE69738275T2 DE69738275T DE69738275T DE69738275T2 DE 69738275 T2 DE69738275 T2 DE 69738275T2 DE 69738275 T DE69738275 T DE 69738275T DE 69738275 T DE69738275 T DE 69738275T DE 69738275 T2 DE69738275 T2 DE 69738275T2
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- aminoindan
- dementia
- mice
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 239000001257 hydrogen Substances 0.000 claims abstract description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 14
- 239000000203 mixture Substances 0.000 claims description 21
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 10
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- 206010012289 Dementia Diseases 0.000 abstract description 12
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- C—CHEMISTRY; METALLURGY
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- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Centrifugal Separators (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11985396 | 1996-12-18 | ||
| IL11985396A IL119853A0 (en) | 1996-12-18 | 1996-12-18 | Aminoindan derivatives |
| IL12051097 | 1997-03-24 | ||
| IL12051097A IL120510A0 (en) | 1997-03-24 | 1997-03-24 | Phenylethylamine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69738275D1 DE69738275D1 (de) | 2007-12-20 |
| DE69738275T2 true DE69738275T2 (de) | 2008-08-28 |
Family
ID=26323338
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69738275T Expired - Lifetime DE69738275T2 (de) | 1996-12-18 | 1997-12-18 | Aminoindanderivate |
| DE69732984T Expired - Lifetime DE69732984T2 (de) | 1996-12-18 | 1997-12-18 | Aminoindanderivate |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69732984T Expired - Lifetime DE69732984T2 (de) | 1996-12-18 | 1997-12-18 | Aminoindanderivate |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US6303650B1 (enExample) |
| EP (2) | EP0966435B1 (enExample) |
| JP (1) | JP4222632B2 (enExample) |
| AT (2) | ATE377585T1 (enExample) |
| AU (1) | AU5726898A (enExample) |
| CA (1) | CA2275425C (enExample) |
| DE (2) | DE69738275T2 (enExample) |
| DK (1) | DK0966435T3 (enExample) |
| ES (1) | ES2241064T3 (enExample) |
| HU (1) | HU229507B1 (enExample) |
| IL (1) | IL130528A (enExample) |
| PT (1) | PT966435E (enExample) |
| WO (1) | WO1998027055A1 (enExample) |
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| US5646188A (en) | 1995-07-05 | 1997-07-08 | Teva Pharmaceutical Industries, Ltd. | Polyamine derivatives of 1-aminoindan |
| ATE377585T1 (de) * | 1996-12-18 | 2007-11-15 | Teva Pharma | Aminoindanderivate |
| US6251938B1 (en) | 1996-12-18 | 2001-06-26 | Teva Pharmaceutical Industries, Ltd., | Phenylethylamine derivatives |
| JP3002155B2 (ja) | 1997-06-25 | 2000-01-24 | 日本サーボ株式会社 | 景品懸吊装置 |
| US20040010038A1 (en) | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
-
1997
- 1997-12-18 AT AT05002578T patent/ATE377585T1/de not_active IP Right Cessation
- 1997-12-18 PT PT97953541T patent/PT966435E/pt unknown
- 1997-12-18 ES ES97953541T patent/ES2241064T3/es not_active Expired - Lifetime
- 1997-12-18 AU AU57268/98A patent/AU5726898A/en not_active Abandoned
- 1997-12-18 IL IL13052897A patent/IL130528A/en not_active IP Right Cessation
- 1997-12-18 DK DK97953541T patent/DK0966435T3/da active
- 1997-12-18 EP EP97953541A patent/EP0966435B1/en not_active Expired - Lifetime
- 1997-12-18 AT AT97953541T patent/ATE292619T1/de not_active IP Right Cessation
- 1997-12-18 DE DE69738275T patent/DE69738275T2/de not_active Expired - Lifetime
- 1997-12-18 WO PCT/US1997/024155 patent/WO1998027055A1/en not_active Ceased
- 1997-12-18 JP JP52804898A patent/JP4222632B2/ja not_active Expired - Fee Related
- 1997-12-18 CA CA002275425A patent/CA2275425C/en not_active Expired - Lifetime
- 1997-12-18 DE DE69732984T patent/DE69732984T2/de not_active Expired - Lifetime
- 1997-12-18 HU HU0101130A patent/HU229507B1/hu unknown
- 1997-12-18 EP EP05002578A patent/EP1535902B1/en not_active Expired - Lifetime
-
1999
- 1999-06-18 US US09/336,493 patent/US6303650B1/en not_active Expired - Lifetime
-
2001
- 2001-08-31 US US09/944,850 patent/US6462222B1/en not_active Expired - Lifetime
- 2001-08-31 US US09/944,912 patent/US6538025B2/en not_active Ceased
-
2005
- 2005-03-25 US US11/091,008 patent/USRE39616E1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4222632B2 (ja) | 2009-02-12 |
| EP1535902B1 (en) | 2007-11-07 |
| US6303650B1 (en) | 2001-10-16 |
| CA2275425C (en) | 2009-08-04 |
| US6538025B2 (en) | 2003-03-25 |
| CA2275425A1 (en) | 1998-06-25 |
| PT966435E (pt) | 2005-06-30 |
| DE69738275D1 (de) | 2007-12-20 |
| DE69732984D1 (de) | 2005-05-12 |
| WO1998027055A1 (en) | 1998-06-25 |
| DK0966435T3 (da) | 2005-08-15 |
| EP1535902A1 (en) | 2005-06-01 |
| IL130528A (en) | 2004-12-15 |
| ATE377585T1 (de) | 2007-11-15 |
| USRE39616E1 (en) | 2007-05-08 |
| HK1024462A1 (en) | 2000-10-13 |
| HU229507B1 (en) | 2014-01-28 |
| JP2001506269A (ja) | 2001-05-15 |
| EP0966435B1 (en) | 2005-04-06 |
| AU5726898A (en) | 1998-07-15 |
| HK1076098A1 (en) | 2006-01-06 |
| US20020188020A1 (en) | 2002-12-12 |
| ES2241064T3 (es) | 2005-10-16 |
| US6462222B1 (en) | 2002-10-08 |
| HUP0101130A3 (en) | 2003-02-28 |
| HUP0101130A2 (hu) | 2001-08-28 |
| EP0966435A1 (en) | 1999-12-29 |
| DE69732984T2 (de) | 2006-02-16 |
| ATE292619T1 (de) | 2005-04-15 |
| EP0966435A4 (en) | 2003-04-16 |
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Owner name: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD, IL Owner name: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEB, IL |