DK0966435T3 - Aminoindanderivater - Google Patents
AminoindanderivaterInfo
- Publication number
- DK0966435T3 DK0966435T3 DK97953541T DK97953541T DK0966435T3 DK 0966435 T3 DK0966435 T3 DK 0966435T3 DK 97953541 T DK97953541 T DK 97953541T DK 97953541 T DK97953541 T DK 97953541T DK 0966435 T3 DK0966435 T3 DK 0966435T3
- Authority
- DK
- Denmark
- Prior art keywords
- dementia
- alkyl
- compounds
- directed
- hydrogen
- Prior art date
Links
- XJEVHMGJSYVQBQ-UHFFFAOYSA-N 2,3-dihydro-1h-inden-1-amine Chemical class C1=CC=C2C(N)CCC2=C1 XJEVHMGJSYVQBQ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 2
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
- 208000009829 Lewy Body Disease Diseases 0.000 abstract 1
- 201000002832 Lewy body dementia Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 201000004810 Vascular dementia Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Centrifugal Separators (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11985396A IL119853A0 (en) | 1996-12-18 | 1996-12-18 | Aminoindan derivatives |
| IL12051097A IL120510A0 (en) | 1997-03-24 | 1997-03-24 | Phenylethylamine derivatives |
| PCT/US1997/024155 WO1998027055A1 (en) | 1996-12-18 | 1997-12-18 | Aminoindan derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0966435T3 true DK0966435T3 (da) | 2005-08-15 |
Family
ID=26323338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97953541T DK0966435T3 (da) | 1996-12-18 | 1997-12-18 | Aminoindanderivater |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US6303650B1 (enExample) |
| EP (2) | EP0966435B1 (enExample) |
| JP (1) | JP4222632B2 (enExample) |
| AT (2) | ATE377585T1 (enExample) |
| AU (1) | AU5726898A (enExample) |
| CA (1) | CA2275425C (enExample) |
| DE (2) | DE69738275T2 (enExample) |
| DK (1) | DK0966435T3 (enExample) |
| ES (1) | ES2241064T3 (enExample) |
| HU (1) | HU229507B1 (enExample) |
| IL (1) | IL130528A (enExample) |
| PT (1) | PT966435E (enExample) |
| WO (1) | WO1998027055A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE377585T1 (de) * | 1996-12-18 | 2007-11-15 | Teva Pharma | Aminoindanderivate |
| DE69921815T2 (de) * | 1998-06-03 | 2005-11-10 | Nissan Chemical Industries, Ltd. | Indanderivate |
| JP2003512426A (ja) | 1999-10-27 | 2003-04-02 | テバ ファーマシューティカル インダストリーズ リミティド | 双極性気分障害における躁病の治療のための１−アミノインダンの使用。 |
| WO2003072055A2 (en) * | 2002-02-27 | 2003-09-04 | Teva Pharmaceutical Industries, Ltd. | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective mao inhibitors |
| US20040010038A1 (en) * | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
| JP4757024B2 (ja) * | 2002-11-07 | 2011-08-24 | テクニオン リサーチ アンド ディベラップメント ファウンデイション リミテッド | 神経保護鉄キレート剤及びそれを含む医薬組成物 |
| CA2547053C (en) | 2003-11-25 | 2014-05-27 | Technion Research & Development Foundation Ltd. | Compositions and methods for treatment of cardiovascular disorders and diseases |
| US8097608B2 (en) | 2003-11-25 | 2012-01-17 | Technion Research And Development Foundation Ltd. | Methods for treatment of cardiovascular disorders and diseases |
| JP2005232148A (ja) * | 2004-02-03 | 2005-09-02 | Technion Research & Development Foundation Ltd | 神経保護剤としてプロパルギルアミンの使用 |
| EP1574498A1 (en) | 2004-02-19 | 2005-09-14 | PPG-Sipsy | Process for the synthesis of substituted alpha-aminoindan derivatives |
| EP1778196A4 (en) * | 2004-07-26 | 2008-12-17 | Teva Pharma | PHARMACEUTICAL DOSAGES CONTAINING RASAGILINE |
| WO2006014968A2 (en) * | 2004-07-27 | 2006-02-09 | Teva Pharmaceutical Industries, Ltd. | Propargyl nitroxydes and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders |
| US7262326B2 (en) | 2004-09-08 | 2007-08-28 | Teva Pharmaceuticals Industries Ltd. | Process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates |
| ES2420404T3 (es) * | 2005-02-17 | 2013-08-23 | Teva Pharmaceutical Industries Ltd. | Terapia de combinación con acetato de glatiramero y rasagilina para el tratamiento de esclerosis múltiple |
| EP1851188A1 (en) | 2005-02-22 | 2007-11-07 | Teva Pharmaceutical Industries Limited | Improved process for the synthesis of enantiomeric indanylamine derivatives |
| AU2006216696B2 (en) | 2005-02-23 | 2011-08-18 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations of improved content uniformity |
| JP2008531571A (ja) * | 2005-02-24 | 2008-08-14 | テバ ファーマシューティカル インダストリーズ リミティド | 酒石酸ラドスチジルの結晶、その製造方法、および医薬組成物 |
| WO2006091836A1 (en) | 2005-02-24 | 2006-08-31 | Teva Pharmaceutical Industries, Ltd. | Formulations of ladostigil tartrate |
| WO2006130726A2 (en) * | 2005-06-01 | 2006-12-07 | Teva Pharmaceutical Industries, Ltd. | Use of ladostigil for the treatment of multiple sclerosis |
| NZ564130A (en) * | 2005-06-02 | 2009-12-24 | Jenrin Discovery | N-propargyl-1-aminoindan compounds useful for treating obesity |
| US7539261B2 (en) * | 2005-08-22 | 2009-05-26 | Nec Laboratories America, Inc. | Multi-layer coded modulation for non-ergodic block fading channels |
| US20070088082A1 (en) * | 2005-09-28 | 2007-04-19 | Judith Aronhime | Polymorphic forms of ladostigil tartrate |
| WO2007038677A2 (en) * | 2005-09-28 | 2007-04-05 | Teva Pharmaceutical Industries Ltd. | Methods for preparation of ladostigil tartrate crystalline form a1 |
| US8263655B2 (en) * | 2005-10-06 | 2012-09-11 | Technion Research And Development Foundation Ltd | Methods for treatment of renal failure |
| US20070238893A1 (en) * | 2005-11-04 | 2007-10-11 | Lee Boulton | Asymmetric hydrogenation of acyl enamides |
| US20070238895A1 (en) * | 2005-11-07 | 2007-10-11 | Lee Boulton | N-protected aminoindanes and methods of their preparation |
| JP2009521402A (ja) * | 2005-11-17 | 2009-06-04 | テバ ファーマシューティカル インダストリーズ リミティド | プロパルギル化アミノインダンの分離のための方法 |
| US7572834B1 (en) | 2005-12-06 | 2009-08-11 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations and processes for their preparation |
| AU2006326642B2 (en) * | 2005-12-09 | 2012-05-03 | Technion Research And Development Foundation Ltd. | Use of low-dose ladostigil for neuroprotection |
| US20070135518A1 (en) * | 2005-12-09 | 2007-06-14 | Marta Weinstock-Rosin | Use of low-dose ladostigil for neuroprotection |
| EP1991214B1 (en) | 2006-02-21 | 2015-08-05 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline for the treatment of multiple system atrophy |
| TW200744576A (en) | 2006-02-24 | 2007-12-16 | Teva Pharma | Propargylated aminoindans, processes for preparation, and uses thereof |
| US20070232691A1 (en) * | 2006-03-31 | 2007-10-04 | Tamar Goren | Use of ladostigil for the treatment of schizophrenia |
| US8946300B2 (en) | 2006-04-03 | 2015-02-03 | Teva Pharmaceutical Industries, Ltd. | Use of rasagilline for the treatment of restless legs syndrome |
| EP1892233A1 (de) * | 2006-08-18 | 2008-02-27 | Ratiopharm GmbH | Neue Salze des Wirkstoffs Rasagilin |
| ATE528989T1 (de) * | 2006-12-14 | 2011-11-15 | Teva Pharma | Kristalline feste rasagilin-base |
| US7547806B2 (en) | 2006-12-14 | 2009-06-16 | Teva Pharmaceutical Industries, Ltd. | Tannate salt of rasagiline |
| EP1987816A1 (de) * | 2007-04-30 | 2008-11-05 | Ratiopharm GmbH | Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff |
| US8188149B2 (en) * | 2007-09-17 | 2012-05-29 | Teva Pharmaceutical Industries, Ltd. | Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss |
| NZ586025A (en) * | 2008-01-11 | 2012-08-31 | Teva Pharma | Rasagiline mesylate tablet coated with a composisiton comprising methacrylic acid - ethyl acrylate copolymer and triethyl citrate |
| WO2009151594A1 (en) * | 2008-06-10 | 2009-12-17 | Teva Pharmaceutical Industries, Ltd. | Rasagiline soft gelatin capsules |
| JP2011522892A (ja) * | 2008-06-13 | 2011-08-04 | テバ ファーマシューティカル インダストリーズ リミティド | パーキンソン病緩和のためのラサギリン |
| JP2011525489A (ja) * | 2008-06-19 | 2011-09-22 | テバ ファーマシューティカル インダストリーズ リミティド | ラサリジン塩基の精製方法 |
| EP2299992A4 (en) | 2008-06-19 | 2015-10-21 | Teva Pharma | PROCESS FOR THE PREPARATION AND DRYING OF A SOLID RASAGILINE BASE |
| US20100189788A1 (en) * | 2009-01-23 | 2010-07-29 | Teva Pharmaceutical Industries, Ltd. | Delayed release rasagiline base formulation |
| HRP20140845T1 (hr) | 2009-07-09 | 2014-11-07 | Ratiopharm Gmbh | Soli rasagilina i farmaceutski pripravci od njih |
| US9943489B2 (en) | 2010-02-03 | 2018-04-17 | Pharmatwob Ltd. | Extended release formulations of rasagiline and uses thereof |
| RU2013108256A (ru) | 2010-07-27 | 2014-09-10 | Тева Фармасьютикал Индастриз Лтд. | Дисперсии цитрата разагилина |
| RU2587330C2 (ru) | 2010-07-27 | 2016-06-20 | Тева Фармасьютикал Индастриз Лтд. | Применение разагилина для лечения обонятельной дисфункции |
| US9339469B2 (en) | 2011-10-10 | 2016-05-17 | Teva Pharmaceutical Industries, Ltd. | R(+)-N-methyl-propargyl-aminoindan |
| EA201490761A1 (ru) | 2011-10-10 | 2014-11-28 | Тева Фармасьютикал Индастриз Лтд. | R(+)-n-формилпропаргиламиноиндан |
| CN104379142B (zh) * | 2012-02-12 | 2018-02-13 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 用于免疫调节的拉多替吉治疗 |
| JP2015529196A (ja) | 2012-08-17 | 2015-10-05 | テバ ファーマシューティカル インダストリーズ リミティド | ラサギリンの非経口製剤 |
| CN121001985A (zh) * | 2023-03-31 | 2025-11-21 | 三井化学株式会社 | 氨基甲酸酯化合物 |
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-
1997
- 1997-12-18 AT AT05002578T patent/ATE377585T1/de not_active IP Right Cessation
- 1997-12-18 PT PT97953541T patent/PT966435E/pt unknown
- 1997-12-18 ES ES97953541T patent/ES2241064T3/es not_active Expired - Lifetime
- 1997-12-18 AU AU57268/98A patent/AU5726898A/en not_active Abandoned
- 1997-12-18 IL IL13052897A patent/IL130528A/en not_active IP Right Cessation
- 1997-12-18 DK DK97953541T patent/DK0966435T3/da active
- 1997-12-18 EP EP97953541A patent/EP0966435B1/en not_active Expired - Lifetime
- 1997-12-18 AT AT97953541T patent/ATE292619T1/de not_active IP Right Cessation
- 1997-12-18 DE DE69738275T patent/DE69738275T2/de not_active Expired - Lifetime
- 1997-12-18 WO PCT/US1997/024155 patent/WO1998027055A1/en not_active Ceased
- 1997-12-18 JP JP52804898A patent/JP4222632B2/ja not_active Expired - Fee Related
- 1997-12-18 CA CA002275425A patent/CA2275425C/en not_active Expired - Lifetime
- 1997-12-18 DE DE69732984T patent/DE69732984T2/de not_active Expired - Lifetime
- 1997-12-18 HU HU0101130A patent/HU229507B1/hu unknown
- 1997-12-18 EP EP05002578A patent/EP1535902B1/en not_active Expired - Lifetime
-
1999
- 1999-06-18 US US09/336,493 patent/US6303650B1/en not_active Expired - Lifetime
-
2001
- 2001-08-31 US US09/944,850 patent/US6462222B1/en not_active Expired - Lifetime
- 2001-08-31 US US09/944,912 patent/US6538025B2/en not_active Ceased
-
2005
- 2005-03-25 US US11/091,008 patent/USRE39616E1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4222632B2 (ja) | 2009-02-12 |
| EP1535902B1 (en) | 2007-11-07 |
| US6303650B1 (en) | 2001-10-16 |
| CA2275425C (en) | 2009-08-04 |
| US6538025B2 (en) | 2003-03-25 |
| CA2275425A1 (en) | 1998-06-25 |
| PT966435E (pt) | 2005-06-30 |
| DE69738275D1 (de) | 2007-12-20 |
| DE69732984D1 (de) | 2005-05-12 |
| WO1998027055A1 (en) | 1998-06-25 |
| EP1535902A1 (en) | 2005-06-01 |
| IL130528A (en) | 2004-12-15 |
| ATE377585T1 (de) | 2007-11-15 |
| USRE39616E1 (en) | 2007-05-08 |
| HK1024462A1 (en) | 2000-10-13 |
| HU229507B1 (en) | 2014-01-28 |
| JP2001506269A (ja) | 2001-05-15 |
| EP0966435B1 (en) | 2005-04-06 |
| AU5726898A (en) | 1998-07-15 |
| HK1076098A1 (en) | 2006-01-06 |
| US20020188020A1 (en) | 2002-12-12 |
| ES2241064T3 (es) | 2005-10-16 |
| US6462222B1 (en) | 2002-10-08 |
| HUP0101130A3 (en) | 2003-02-28 |
| HUP0101130A2 (hu) | 2001-08-28 |
| DE69738275T2 (de) | 2008-08-28 |
| EP0966435A1 (en) | 1999-12-29 |
| DE69732984T2 (de) | 2006-02-16 |
| ATE292619T1 (de) | 2005-04-15 |
| EP0966435A4 (en) | 2003-04-16 |
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