DE69720057T2 - Vorrichtung und verfahren zur erhöhung des transdermalen wirkstoffeflusses - Google Patents

Vorrichtung und verfahren zur erhöhung des transdermalen wirkstoffeflusses

Info

Publication number
DE69720057T2
DE69720057T2 DE69720057T DE69720057T DE69720057T2 DE 69720057 T2 DE69720057 T2 DE 69720057T2 DE 69720057 T DE69720057 T DE 69720057T DE 69720057 T DE69720057 T DE 69720057T DE 69720057 T2 DE69720057 T2 DE 69720057T2
Authority
DE
Germany
Prior art keywords
agent
connecting medium
body surface
skin
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69720057T
Other languages
German (de)
English (en)
Other versions
DE69720057D1 (de
Inventor
J. Cormier
P. Neukermans
Felix Theeuwes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of DE69720057D1 publication Critical patent/DE69720057D1/de
Publication of DE69720057T2 publication Critical patent/DE69720057T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/20Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • A61B2010/008Interstitial fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303Constructional details
    • A61N1/306Arrangements where at least part of the apparatus is introduced into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Nonmetallic Welding Materials (AREA)
DE69720057T 1996-12-20 1997-12-16 Vorrichtung und verfahren zur erhöhung des transdermalen wirkstoffeflusses Expired - Lifetime DE69720057T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3344096P 1996-12-20 1996-12-20
PCT/US1997/023274 WO1998028037A1 (en) 1996-12-20 1997-12-16 Device and method for enhancing transdermal agent flux

Publications (2)

Publication Number Publication Date
DE69720057D1 DE69720057D1 (de) 2003-04-24
DE69720057T2 true DE69720057T2 (de) 2003-09-25

Family

ID=21870407

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69720057T Expired - Lifetime DE69720057T2 (de) 1996-12-20 1997-12-16 Vorrichtung und verfahren zur erhöhung des transdermalen wirkstoffeflusses

Country Status (11)

Country Link
EP (1) EP0957972B1 (https=)
JP (1) JP4153999B2 (https=)
KR (1) KR100453132B1 (https=)
CN (1) CN1133472C (https=)
AT (1) ATE234649T1 (https=)
AU (1) AU722574B2 (https=)
CA (1) CA2271167C (https=)
DE (1) DE69720057T2 (https=)
DK (1) DK0957972T3 (https=)
ES (1) ES2195190T3 (https=)
WO (1) WO1998028037A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0812150A4 (en) 1995-12-28 1999-03-10 Cygnus Therapeutic Systems CONTINUOUS MONITORING FOR PHYSIOLOGICAL SAMPLE COMPONENTS
CA2313698C (en) * 1997-12-11 2008-04-15 Alza Corporation Device for enhancing transdermal agent flux
EP1911488A3 (en) 1997-12-11 2008-12-03 Alza Corporation Device for enhancing transdermal agent flux
ES2314995T3 (es) 1997-12-11 2009-03-16 Alza Corporation Dispositivo para mejorar el flujo de agentes tansdermicos.
US7066884B2 (en) 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6532386B2 (en) * 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
PT1187629E (pt) 1999-04-19 2005-02-28 Glaxosmithkline Biolog Sa Composicao adjuvante que compreende saponina e um oligonucleotido imunoestimulador
US6558670B1 (en) 1999-04-19 2003-05-06 Smithkline Beechman Biologicals S.A. Vaccine adjuvants
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
CA2376128C (en) * 1999-06-04 2009-01-06 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
DK1189660T3 (da) * 1999-06-08 2006-08-21 Altea Therapeutics Corp Apparat til mikroperforering af biologiske membraner ved hjælp af tyndfilms-vævsgrænseflade-anordninger samt fremgangsmåde til fremstilling deraf
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
ES2253278T3 (es) 1999-12-10 2006-06-01 Alza Corporation Dispositivo y procedimiento para mejorar la perforacion cutanea con microprotuberancias.
MXPA02005765A (es) * 1999-12-10 2003-01-28 Alza Corp Aparato de tratamiento de piel para el suministro de farmaco transdermico sostenido.
US6622035B1 (en) * 2000-01-21 2003-09-16 Instrumentarium Corp. Electrode for measurement of weak bioelectrical signals
US7404815B2 (en) 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US7141034B2 (en) * 2000-06-08 2006-11-28 Altea Therapeutics Corporation Transdermal drug delivery device, method of making same and method of using same
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
JP2004506914A (ja) * 2000-08-24 2004-03-04 アルザ・コーポレーシヨン 経皮的核酸サンプリング方法
JP5507030B2 (ja) 2000-09-08 2014-05-28 アルザ・コーポレーシヨン 経路閉鎖を阻害することによる経皮的薬物流動の減少の抑制方法
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
PL360978A1 (en) 2000-10-13 2004-09-20 Alza Corporation Microblade array impact applicator
ATE416692T1 (de) * 2000-10-13 2008-12-15 Alza Corp Mikronadelelementhalter für schlagapplikator
DE60138411D1 (de) * 2000-10-13 2009-05-28 Alza Corp Vorrichtung und verfahren zum durchstechen der haut mit micronadeln
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
SI2266603T1 (sl) 2000-10-18 2012-12-31 Glaxosmithkline Biologicals S.A. Tumorska cepiva
NZ525551A (en) 2000-10-26 2005-09-30 Alza Corp Transdermal drug delivery devices having coated microprotrusions
EP1345646A2 (en) 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
AU2002231207A1 (en) 2000-12-21 2002-07-01 Biovalve Technologies, Inc. Microneedle array systems
WO2002074173A1 (en) 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
ATE444773T1 (de) 2001-04-20 2009-10-15 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
EP3251722B1 (en) 2001-04-20 2020-06-17 ALZA Corporation Microprojection array having a beneficial agent containing coating and method of forming the coating thereon
US8361037B2 (en) 2001-09-19 2013-01-29 Valeritas, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US8920375B2 (en) 2001-09-21 2014-12-30 Valeritas, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
KR20060038407A (ko) 2003-06-30 2006-05-03 알자 코포레이션 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제
BRPI0415466A (pt) * 2003-10-24 2006-12-19 Alza Corp método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos
AU2004287412A1 (en) 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
ES2377647T3 (es) 2003-10-31 2012-03-29 Alza Corporation Aplicador auto-actuado para ordenamiento de microproyecciones
KR20070010115A (ko) * 2003-11-13 2007-01-22 알자 코포레이션 경피전달용 조성물 및 장치
US20080226699A1 (en) * 2003-11-28 2008-09-18 Acrux Dds Pty Ltd Method and System for Rapid Transdermal Administration
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US7556821B2 (en) 2004-05-13 2009-07-07 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
WO2006020841A2 (en) * 2004-08-11 2006-02-23 Alza Corporation Apparatus and method for transdermal delivery of natriuretic peptides
NZ553776A (en) 2004-09-22 2010-05-28 Glaxosmithkline Biolog Sa Immunogenic composition comprising staphylococcal PNAG and Type 5 and/or 8 Capsular polysaccharide or oligosaccharide.
JP2008530230A (ja) * 2005-02-16 2008-08-07 アルザ・コーポレーシヨン エリスロポエチンに基づく剤の経皮送達のための装置および方法
WO2006105233A1 (en) * 2005-03-28 2006-10-05 Alza Corporation Microprojections with capillary control features and method
JP2008543528A (ja) * 2005-06-27 2008-12-04 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルカートリッジアセンブリ及び適用方法
US7432069B2 (en) 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
KR101515078B1 (ko) 2005-12-22 2015-04-24 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신
US8632801B2 (en) 2005-12-28 2014-01-21 Alza Corporation Stable therapeutic formulations
EP2476433A1 (en) 2006-03-30 2012-07-18 GlaxoSmithKline Biologicals S.A. Immunogenic composition
WO2007124393A2 (en) * 2006-04-20 2007-11-01 3M Innovative Properties Company Molded articles comprising microneedle arrays
DE102006028987A1 (de) * 2006-06-24 2007-12-27 Lts Lohmann Therapie-Systeme Ag Ultraschallverstärktes transdermales therapeutisches System
EP2433648A3 (en) 2006-10-12 2012-04-04 GlaxoSmithKline Biologicals S.A. Vaccine comprising an oil in water emulsion adjuvant
EA015817B1 (ru) 2006-10-12 2011-12-30 Глаксосмитклайн Байолоджикалс С.А. Иммуногенная композиция, содержащая адъювант в виде эмульсии "масло в воде"
NZ580997A (en) 2007-04-27 2011-08-26 Echo Therapeutics Inc Dermal abrasion device with feedback electrode to deliver data on skin thickness and removable abrasion heads
WO2008137747A1 (en) 2007-05-02 2008-11-13 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
JP5298011B2 (ja) 2007-05-15 2013-09-25 久光製薬株式会社 マイクロニードルのコーティング方法
CA2690708A1 (en) 2007-06-26 2008-12-31 Glaxosmithkline Biologicals S.A. Vaccine
CA2745339C (en) 2007-12-24 2016-06-28 The University Of Queensland Coating method
AU2009212106B9 (en) 2008-02-07 2014-05-22 Vaxxas Pty Limited Patch production
GB0802447D0 (en) * 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
ES2553113T3 (es) 2008-04-16 2015-12-04 Glaxosmithkline Biologicals S.A. Vacuna
WO2009140735A1 (en) * 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents.
CN102223876A (zh) 2008-09-26 2011-10-19 纳米生物公司 纳米乳剂治疗性组合物及其使用方法
CA2743904A1 (en) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
KR101634836B1 (ko) 2008-12-26 2016-06-29 히사미쓰 세이야꾸 가부시키가이샤 마이크로 니들 디바이스
US20120004626A1 (en) 2009-01-30 2012-01-05 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
ES2691259T3 (es) 2009-06-10 2018-11-26 Hisamitsu Pharmaceutical Co., Inc. Dispositivo de microagujas
CA2765511C (en) 2009-06-16 2015-05-12 The Regents Of The University Of Michigan Nanoemulsion vaccines
KR101686692B1 (ko) 2009-07-23 2016-12-14 히사미쓰 세이야꾸 가부시키가이샤 마이크로니들 어레이
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
CN102770176B (zh) 2010-02-24 2015-11-25 久光制药株式会社 微针装置及其制造方法
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
KR101741294B1 (ko) 2010-05-28 2017-05-29 히사미쓰 세이야꾸 가부시키가이샤 미소 돌기가 형성된 어레이를 갖는 디바이스
ES2728479T3 (es) 2010-05-28 2019-10-24 Hisamitsu Pharmaceutical Co Matriz con protuberancias finas
US8658603B2 (en) 2010-06-16 2014-02-25 The Regents Of The University Of Michigan Compositions and methods for inducing an immune response
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
JP5675952B2 (ja) 2011-02-24 2015-02-25 久光製薬株式会社 マイクロニードルデバイス用glp−1アナログ組成物
US8696637B2 (en) * 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
CN103533953A (zh) 2011-05-17 2014-01-22 葛兰素史密丝克莱恩生物有限公司 针对肺炎链球菌的疫苗
AU2012323782B2 (en) 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
CN103874518A (zh) 2011-10-12 2014-06-18 3M创新有限公司 一体化微针阵列递送系统
JP2013153959A (ja) * 2012-01-30 2013-08-15 Toppan Printing Co Ltd 針状体の構造
CN103356243A (zh) * 2012-03-27 2013-10-23 马广 新型皮肤采样器
US9982034B2 (en) 2012-10-24 2018-05-29 Platelet Targeted Therapeutics, Llc Platelet targeted treatment
EP3027263A1 (en) 2013-07-30 2016-06-08 ZP Opco, Inc. Low-profile microneedle patch applicator
KR101977449B1 (ko) 2013-11-01 2019-05-10 유니버시티에트 이 오슬로 알부민 변이체 및 이의 용도
WO2015071769A2 (en) 2013-11-13 2015-05-21 University Of Oslo Outer membrane vesicles and uses thereof
DK3069138T3 (en) 2013-11-15 2019-04-08 Univ Oslo Hf CTL PEPTID EPITOPES AND ANTIGEN-SPECIFIC T-CELLS, METHODS OF RECOGNITION THEREOF, AND APPLICATIONS THEREOF
EP4112076A1 (en) 2014-10-10 2023-01-04 The Regents of The University of Michigan Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease
AU2015252119A1 (en) 2014-11-07 2016-05-26 Takeda Vaccines, Inc. Hand, foot, and mouth vaccines and methods of manufacture and use thereof
AR102547A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso
WO2016123665A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
CN107530416A (zh) 2015-03-05 2018-01-02 西北大学 非神经侵染的病毒及其用途
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
CA2999538A1 (en) 2015-09-28 2017-04-06 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
US12076397B2 (en) 2016-05-10 2024-09-03 The Regents Of The University Of Michigan Emulsion adjuvant for intramuscular, intradermal and subcutaneous administration
US11173207B2 (en) 2016-05-19 2021-11-16 The Regents Of The University Of Michigan Adjuvant compositions
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
US20190350840A1 (en) 2016-12-26 2019-11-21 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
KR102343698B1 (ko) 2017-02-24 2021-12-24 히사미쓰 세이야꾸 가부시키가이샤 마이크로니들 디바이스
ES2960937T3 (es) 2017-03-31 2024-03-07 Vaxxas Pty Ltd Dispositivo y método para recubrir superficies
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
MX2019015524A (es) 2017-06-23 2020-09-10 Univ Maryland Composiciones inmunogenicas.
GB201711635D0 (en) 2017-07-19 2017-08-30 Glaxosmithkline Biologicals Sa Immunogenic composition
EP4473998A3 (en) 2017-08-04 2025-02-26 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
EP3678699A1 (en) 2017-09-07 2020-07-15 University Of Oslo Vaccine molecules
EP3678698A1 (en) 2017-09-07 2020-07-15 University Of Oslo Vaccine molecules
KR20200117981A (ko) 2017-11-03 2020-10-14 다케다 백신즈 인코포레이티드 지카 백신 및 면역원성 조성물, 그리고 이를 이용하는 방법들
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
KR102437993B1 (ko) 2018-06-26 2022-08-29 히사미쓰 세이야꾸 가부시키가이샤 마이크로 니들 디바이스 및 그것을 제조하는 방법
WO2021206294A1 (ko) * 2020-04-06 2021-10-14 (주)일론 화장품 흡수 유도용 미세바늘이 장착된 화장품 주입기 및 이의 제작방법
WO2023039108A1 (en) 2021-09-08 2023-03-16 Affinivax, Inc. Coronavirus vaccine
EP4705319A1 (en) 2023-05-04 2026-03-11 Affinivax, Inc. Rhizavidin variants
WO2025193903A1 (en) 2024-03-15 2025-09-18 Affinivax, Inc. Pneumococcal polysaccharide compositions and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
AU657681B2 (en) 1990-03-30 1995-03-23 Alza Corporation Device and method for iontophoretic drug delivery
MX9101782A (es) 1990-10-29 1992-06-05 Alza Corp Dispositivo de suministro iontoforetico y metodo para hidratar el mismo
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
JPH10510175A (ja) * 1994-12-09 1998-10-06 ノバルティス アクチェンゲゼルシャフト 経皮システム
AU5869796A (en) * 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin

Also Published As

Publication number Publication date
ATE234649T1 (de) 2003-04-15
WO1998028037A1 (en) 1998-07-02
CA2271167A1 (en) 1998-07-02
CN1233967A (zh) 1999-11-03
EP0957972A1 (en) 1999-11-24
KR20000053006A (ko) 2000-08-25
DK0957972T3 (da) 2003-07-21
EP0957972B1 (en) 2003-03-19
AU5529498A (en) 1998-07-17
ES2195190T3 (es) 2003-12-01
DE69720057D1 (de) 2003-04-24
JP2001506904A (ja) 2001-05-29
JP4153999B2 (ja) 2008-09-24
CN1133472C (zh) 2004-01-07
AU722574B2 (en) 2000-08-10
CA2271167C (en) 2007-01-09
KR100453132B1 (ko) 2004-10-15

Similar Documents

Publication Publication Date Title
DE69720057T2 (de) Vorrichtung und verfahren zur erhöhung des transdermalen wirkstoffeflusses
DE69719761T2 (de) Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
DE69502281T2 (de) Verminderung der hautreizung während einer iontophoretischen abgabe von medikamenten
DE69806963T2 (de) Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
US6918901B1 (en) Device and method for enhancing transdermal agent flux
DE69535556T2 (de) Zusammensetzungen, vorrichtung und verfahren zur elektrotransport-wirkstoffabgabe
DE69519393T2 (de) Zusammensetzung und verfahren zur förderung von transdermaler elektrotransport-darreichung
DE69831268T2 (de) Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
DE69102699T2 (de) Iontophoretische abgabevorrichtung.
DE69212468T2 (de) Gerät zur verminderung der empfindung während der iontophoretischen arneimittelverabreichung
DE69204676T2 (de) Transdermale abgabevorrichtung.
DE69921090T2 (de) Konfigurierte Elektrodenanordnung mit verbesserter elektrischer Leitung
DE69109690T2 (de) Elektrode zur iontophoretischen verabreichung von medikamenten und verfahren zur hydratation derselben.
DE69014653T2 (de) Verfahren und vorrichtung zur iontophoretischen abgabe von medikamenten.
DE69133328T2 (de) Vorrichtung zur iontophoretischen verabreichung
DE69401938T2 (de) Vorrichtung bei elektroübertragungslieferung von wirkstoff
DE69101317T2 (de) Iontophoretische verabreichungsvorrichtung.
DE69806270T2 (de) Wasserfreies reservoir für gerät zur transdermalen elektrolytischen medikamentverabreichung
DE69823869T2 (de) Pharmazeutische hydrogelformulierungen, vorrichtungen zur arzneistoffabgabe und verfahren
DE69410279T2 (de) Reduktion von hautirritationen und hautwiderstand während einer iontophoresebehandlung
DE69314634T2 (de) Vorrichtung zur iontophoretischen verabreichung von medikamenten
DE69605298T2 (de) Herstellung von formulierungen zur arzneiverabreichung mittels elektrotransport
DE69623608T2 (de) Zusammensetzung zur verbesserten elektroübertragunslieferung von wirkstoff
DE69328042T2 (de) Elektrotransporteinrichtung
DE69737723T2 (de) Behalter zur iontophoretischen verabreichung von medikamenten mit inerten material-bestandteilen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition